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The map label for this gene is mhpC [C]

Identifier: 159896707

GI number: 159896707

Start: 203292

End: 204662

Strand: Direct

Name: mhpC [C]

Synonym: Haur_0174

Alternate gene names: 159896707

Gene position: 203292-204662 (Clockwise)

Preceding gene: 159896704

Following gene: 159896708

Centisome position: 3.2

GC content: 51.71

Gene sequence:

>1371_bases
ATGTCAACCTATGTCATCGACGGACAGGAACTGCATATCCGCGATAATCGCCGTAATGCCCCCGTCGCCTTATTAATTCA
TGGCTGGTCGAGTTCATGGTTTACTTGGACTCCCCTGTTGCAAGCTCTGGGCACACGCTATTCGTATATGGCGGTCGATT
TGCCTGGCTATGGGCGGTCGCCTGCGCCCAAACACCCAATTACCATCGATTGGTATGCCGATTTGATGGCCAAATTGATC
GAGGAAGCCAGCGATCGGCCTGTCGTGGTGCTTGGGCATTCGATGGGCGGCCAAATTGCCATGACTTTAGCCCTGCGCCA
CCCGATGCTGGTCGAACGTTTGATTTTGCTCAATCCAGTGGTCAGCGGGCGACTATCAACCTTTATCAATTTGTTTGTGG
CTCCGCATATTTTGCTCGAACGCACGCGATTGGGCGGCAAAATTTTGAGTTATCTCGAAAATACGCCGTTAAGCTATATC
AATCAATTGATGAAGCCGATTCTCTTTGCTGAACGCGCCGCAATTTCGCAGCAAGATTATGATCGGATTCGCGCTGATGC
GCGGCGGCCAGGCCAAGGCAGAGTTCGCGCCGCTTGCTACGAAGCGATGAAAATGGGCGATCTGCGTGGCAAACTCAAGC
AAATTCAGCCGCCAGCTCAAGTGATTTGGGGTGCTGAGGATAATACTGTGCCGTTGCGTGATGCTGGTGCGGTAGCCGAC
GAATGGCCGCAAGCTGATTTGCGCTTGATTCCAAATGCTGGGCATTGGCCGCATTTTGAGCAATATGAAACCACGATGCG
CTATATTGCCTCATTTTTGGGCTTGCCAATTTTGCCAAGCCTGCCAAACGATCAAGTACAACAGCAGCGTGATCTTGATG
TTGGAGAAATTGCCCAGTTCCTCTCGAATACTGAGTTAGGCCAAGATTTAAGTGAATCGCAGCGCTTACGGGTGGCGGGC
TTGTGTCATCAACATCATTTTGCCCCGCAAGATGTCTTGGCGCTCGAAGATTCGAGCGGCGATGAATTATTTATTGTGCA
AGATGGCCAAGTTGATGTCTTGGTGCGAATCAGCAATGAACTTGGGATCGAGGAATCGCGGCGGGTTAATGTGCTAATGG
CGGGCCAAATCGCTGGCGAAATGGCCTTGATTCAAGGCAAAGGTGGCCGCCGTACCGCCGATTTACGCGCTGGCAAGTCG
GGCGCAACCGTGCTGTCGATCGATAGCCGCTATCTGTTTGCTTTGTTTGAAGATGATGCCTCGTTGGGCCTGAAGTTGAT
GCAAAATCTGGCTCGCTCGTTGGTGCAACGGTTGCGGGTGCAAAATTGGCAATTGCAACTAGCTGAACAACGCGCCGAAG
TTCATCGCTAA

Upstream 100 bases:

>100_bases
CCCTAACTTCTACTAACTAGCCTCGTATCTAGGGAACCCACTTGCCTCAATATGCTACAATAGCCCAATTATGTAATTGT
TCCTGCAATGAGGGTAGTGC

Downstream 100 bases:

>100_bases
ACAACCGCAAAATCATGACTTTTGGCTTGAACGCTACTGTTTTACCGGTGGCGTTTTTCGTGTACCATTTGCCATGAACC
ACAAATTGTAGGGTGTTGTG

Product: cyclic nucleotide-binding protein

Products: 2-oxopent-4-enoate; succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSTYVIDGQELHIRDNRRNAPVALLIHGWSSSWFTWTPLLQALGTRYSYMAVDLPGYGRSPAPKHPITIDWYADLMAKLI
EEASDRPVVVLGHSMGGQIAMTLALRHPMLVERLILLNPVVSGRLSTFINLFVAPHILLERTRLGGKILSYLENTPLSYI
NQLMKPILFAERAAISQQDYDRIRADARRPGQGRVRAACYEAMKMGDLRGKLKQIQPPAQVIWGAEDNTVPLRDAGAVAD
EWPQADLRLIPNAGHWPHFEQYETTMRYIASFLGLPILPSLPNDQVQQQRDLDVGEIAQFLSNTELGQDLSESQRLRVAG
LCHQHHFAPQDVLALEDSSGDELFIVQDGQVDVLVRISNELGIEESRRVNVLMAGQIAGEMALIQGKGGRRTADLRAGKS
GATVLSIDSRYLFALFEDDASLGLKLMQNLARSLVQRLRVQNWQLQLAEQRAEVHR

Sequences:

>Translated_456_residues
MSTYVIDGQELHIRDNRRNAPVALLIHGWSSSWFTWTPLLQALGTRYSYMAVDLPGYGRSPAPKHPITIDWYADLMAKLI
EEASDRPVVVLGHSMGGQIAMTLALRHPMLVERLILLNPVVSGRLSTFINLFVAPHILLERTRLGGKILSYLENTPLSYI
NQLMKPILFAERAAISQQDYDRIRADARRPGQGRVRAACYEAMKMGDLRGKLKQIQPPAQVIWGAEDNTVPLRDAGAVAD
EWPQADLRLIPNAGHWPHFEQYETTMRYIASFLGLPILPSLPNDQVQQQRDLDVGEIAQFLSNTELGQDLSESQRLRVAG
LCHQHHFAPQDVLALEDSSGDELFIVQDGQVDVLVRISNELGIEESRRVNVLMAGQIAGEMALIQGKGGRRTADLRAGKS
GATVLSIDSRYLFALFEDDASLGLKLMQNLARSLVQRLRVQNWQLQLAEQRAEVHR
>Mature_455_residues
STYVIDGQELHIRDNRRNAPVALLIHGWSSSWFTWTPLLQALGTRYSYMAVDLPGYGRSPAPKHPITIDWYADLMAKLIE
EASDRPVVVLGHSMGGQIAMTLALRHPMLVERLILLNPVVSGRLSTFINLFVAPHILLERTRLGGKILSYLENTPLSYIN
QLMKPILFAERAAISQQDYDRIRADARRPGQGRVRAACYEAMKMGDLRGKLKQIQPPAQVIWGAEDNTVPLRDAGAVADE
WPQADLRLIPNAGHWPHFEQYETTMRYIASFLGLPILPSLPNDQVQQQRDLDVGEIAQFLSNTELGQDLSESQRLRVAGL
CHQHHFAPQDVLALEDSSGDELFIVQDGQVDVLVRISNELGIEESRRVNVLMAGQIAGEMALIQGKGGRRTADLRAGKSG
ATVLSIDSRYLFALFEDDASLGLKLMQNLARSLVQRLRVQNWQLQLAEQRAEVHR

Specific function: 3-hydroxyphenylpropionate degradation. [C]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dmpD/todF/xylF esterase family [H]

Homologues:

Organism=Homo sapiens, GI218777840, Length=285, Percent_Identity=24.9122807017544, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI13376164, Length=285, Percent_Identity=24.9122807017544, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI218777837, Length=109, Percent_Identity=30.2752293577982, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.7.1.- [C]

Molecular weight: Translated: 51069; Mature: 50938

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50042 CNMP_BINDING_3 ; PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTYVIDGQELHIRDNRRNAPVALLIHGWSSSWFTWTPLLQALGTRYSYMAVDLPGYGRS
CCEEEECCCEEEEECCCCCCCEEEEEECCCCCCEEHHHHHHHHCCCEEEEEEECCCCCCC
PAPKHPITIDWYADLMAKLIEEASDRPVVVLGHSMGGQIAMTLALRHPMLVERLILLNPV
CCCCCCEEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEHHHHHCHHHHHHHHHHHHH
VSGRLSTFINLFVAPHILLERTRLGGKILSYLENTPLSYINQLMKPILFAERAAISQQDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHH
DRIRADARRPGQGRVRAACYEAMKMGDLRGKLKQIQPPAQVIWGAEDNTVPLRDAGAVAD
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEECCCCCCCCCC
EWPQADLRLIPNAGHWPHFEQYETTMRYIASFLGLPILPSLPNDQVQQQRDLDVGEIAQF
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHH
LSNTELGQDLSESQRLRVAGLCHQHHFAPQDVLALEDSSGDELFIVQDGQVDVLVRISNE
HHCCCCCCCHHHHCCCHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCC
LGIEESRRVNVLMAGQIAGEMALIQGKGGRRTADLRAGKSGATVLSIDSRYLFALFEDDA
CCCCCCCEEEEEEECCCCCCEEEEECCCCCEEHHCCCCCCCCEEEEECCCEEEEEECCCH
SLGLKLMQNLARSLVQRLRVQNWQLQLAEQRAEVHR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
STYVIDGQELHIRDNRRNAPVALLIHGWSSSWFTWTPLLQALGTRYSYMAVDLPGYGRS
CEEEECCCEEEEECCCCCCCEEEEEECCCCCCEEHHHHHHHHCCCEEEEEEECCCCCCC
PAPKHPITIDWYADLMAKLIEEASDRPVVVLGHSMGGQIAMTLALRHPMLVERLILLNPV
CCCCCCEEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEHHHHHCHHHHHHHHHHHHH
VSGRLSTFINLFVAPHILLERTRLGGKILSYLENTPLSYINQLMKPILFAERAAISQQDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHH
DRIRADARRPGQGRVRAACYEAMKMGDLRGKLKQIQPPAQVIWGAEDNTVPLRDAGAVAD
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEECCCCCCCCCC
EWPQADLRLIPNAGHWPHFEQYETTMRYIASFLGLPILPSLPNDQVQQQRDLDVGEIAQF
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHH
LSNTELGQDLSESQRLRVAGLCHQHHFAPQDVLALEDSSGDELFIVQDGQVDVLVRISNE
HHCCCCCCCHHHHCCCHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCC
LGIEESRRVNVLMAGQIAGEMALIQGKGGRRTADLRAGKSGATVLSIDSRYLFALFEDDA
CCCCCCCEEEEEEECCCCCCEEEEECCCCCEEHHCCCCCCCCEEEEECCCEEEEEECCCH
SLGLKLMQNLARSLVQRLRVQNWQLQLAEQRAEVHR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-hydroxy-6-ketononadienedicarboxylate; H2O [C]

Specific reaction: 2-hydroxy-6-ketononadienedicarboxylate + H2O = 2-oxopent-4-enoate + succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]