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The map label for this gene is uvrC [H]

Identifier: 159896596

GI number: 159896596

Start: 80277

End: 82202

Strand: Direct

Name: uvrC [H]

Synonym: Haur_0063

Alternate gene names: 159896596

Gene position: 80277-82202 (Clockwise)

Preceding gene: 159896595

Following gene: 159896597

Centisome position: 1.26

GC content: 49.69

Gene sequence:

>1926_bases
ATGCCAGATTTATCTCATACGAATATTGCCAATCATGCGTTGTTTGAAGAACGCTTGCGCAACTTGCCACTCTCGCCAGG
CGTGTATATCTACCGCGATCAGGCCAATACGATCATCTACGTGGGCAAATCCAAAAGCCTGCGGGATCGGGTGCGTTCGT
ATTTTGGTGCGCCGCGTGGCCTAACCAGCAAAACCCGACGGTTGGTGCAAAATATCGCCGATTTTGAGTTTATTACTACC
GATACCGAGCTAGAAGCGCTACTTTTAGAAATGAATCTGATCAAAAAGCATCGCCCACGCTACAATGTGTTGCTCAAGGA
TGACAAAAGTTATCCCTATATCAAAATTACCAAAGAAGCATGGCCAAGGGTTTTACGAGTGCGCAAAGTGATTGAAGATG
GTGGCATTTATTTCGGGCCATTTGCCAAAGCTAGCAGCGTTTATGCCACAATTGAGTTATTAAATAAATTATTTGCTTTT
CGTTTATGCAACGATGATATGTTTAAAAAGCACGAGCGCCGCAATCGGGCTTGTATGTATTATGATATTAAACGCTGTCT
TGGGCCATGTGCCAACAACTGTACCACCGAAGAATATAGCACTGCAATTAATCAAGTACGCTTATTTTTAGGTGGCAAGC
CTGAAGCAATTTTACGTGACCTAAAAGTGAAAATGAACCAAGCTGCCGAAGATTTACAATTTGAACGCGCGGCCTATGTT
CGCGATCAAATCAAGGCAGTCGAACGGGTGATGGAGCGCCAAAAAGTGCTGAATACCGCCGCCAGTGACCAAGATGTAAT
TGCTTTTGCCCGTGATGAAGGTAAAGCGGTGGTGCAGGTGTTCTACATTCGTGGTGGCAAGTTGATTGGCTCGGAGCCAT
TTACGCTGCAAGGCACGGAGGAAGAACATCCCGAAGCCTTGATGAGTTCGTTCTTGACCCAATTTTATGATGCCGCCGCC
GATATTCCGCCCAATATTCTGCTGCCCGATTATCCCGAAGAAACCCAAATTATTGAGCAATGGCTGGAAAGCAAGGGCGG
ACATAAAGTGAGTTTGCAAGTGCCACGACGCGGCGATAAAAAAGATTTGGTCGATTTGGCGGCCCGCAATGCCAGCCAAA
CCCTCGATCAATTGCGCTTGCAATGGCTCAACGCCGAACAACGGGCAACAGCCGGGCTGAGTCAATTGCGCGAATTATTG
AATTTAGCCGAATTGCCCCAACGCATCGAATGCTACGACATCTCGAATACCCAAGGCACCAATTCGGTGGGCAGTATGGT
GGTGTTTGAGCAGGGCGAGCCAGCCAAAAAGCACTATCGCCGTTTCAAAATCAAAACCGTTGAAGGTGCTAATGATGTGG
CCTCGCTCAGCGAAGTGCTACAACGCCGGTTTGCCCGCGCCGATGATACTGGCCAAACGGACGAGCCAGAATCAACCGAG
CAAACCAGCGCCGAGCCAACTAATAACGACGAAACTTGGGCGGTATTGCCCGATCTGATTTTGATCGACGGTGGGATCGG
CCAAGTCAATGCTGCAGCCAAAACTTTGGCAGCGGCTGGTTTTGAGCATATTCCGGTGGTTGGCTTGGTCAAGGGCGATA
CCAAAGGCCACTTGCCCTATGGTTTGGTCAAACCTGGCCAGCGTGTGCCAATCGCCTTTGCCCAAAACGATCCAGGCTTG
CATCTCGTTCAGCGCATCGACGAAGAAGCCCATCGCTTTGCGATTAGCTATCACCGTAAATTGCGCACTAAAGGCATGCT
GCGCTCGACCATGGAAGATATTCCAGGTATTGGCCCCAAACGCAAAAAAGCGTTGATCAACGCCTTTGGCTCGCTGGAGG
GCATTCGCAACGCCAGCATCGAGGAGCTAGCCGCCGTGCCTGGCATGACCCGCAAAGCCGCCGAGGAGATCAAAGGGCTG
TTGTAG

Upstream 100 bases:

>100_bases
GTTTAATCTATTTTTGAGTTGAGCCGACTAGCAGAGCAGGCTGGTCGGCTTTTAACATGGTGCTAAAAGATGCGGTATAA
TTAGCACAGAGGTGCGAAAA

Downstream 100 bases:

>100_bases
CAAGGCAAAAATCAAAAGGCAGAAGGCAAAAAAGAGGAACGAAAGTTTAACGCAGCGGCGCAGAGGGACGTGAGAGGTCA
GAATTCAGGGATCAGGGGTC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MPDLSHTNIANHALFEERLRNLPLSPGVYIYRDQANTIIYVGKSKSLRDRVRSYFGAPRGLTSKTRRLVQNIADFEFITT
DTELEALLLEMNLIKKHRPRYNVLLKDDKSYPYIKITKEAWPRVLRVRKVIEDGGIYFGPFAKASSVYATIELLNKLFAF
RLCNDDMFKKHERRNRACMYYDIKRCLGPCANNCTTEEYSTAINQVRLFLGGKPEAILRDLKVKMNQAAEDLQFERAAYV
RDQIKAVERVMERQKVLNTAASDQDVIAFARDEGKAVVQVFYIRGGKLIGSEPFTLQGTEEEHPEALMSSFLTQFYDAAA
DIPPNILLPDYPEETQIIEQWLESKGGHKVSLQVPRRGDKKDLVDLAARNASQTLDQLRLQWLNAEQRATAGLSQLRELL
NLAELPQRIECYDISNTQGTNSVGSMVVFEQGEPAKKHYRRFKIKTVEGANDVASLSEVLQRRFARADDTGQTDEPESTE
QTSAEPTNNDETWAVLPDLILIDGGIGQVNAAAKTLAAAGFEHIPVVGLVKGDTKGHLPYGLVKPGQRVPIAFAQNDPGL
HLVQRIDEEAHRFAISYHRKLRTKGMLRSTMEDIPGIGPKRKKALINAFGSLEGIRNASIEELAAVPGMTRKAAEEIKGL
L

Sequences:

>Translated_641_residues
MPDLSHTNIANHALFEERLRNLPLSPGVYIYRDQANTIIYVGKSKSLRDRVRSYFGAPRGLTSKTRRLVQNIADFEFITT
DTELEALLLEMNLIKKHRPRYNVLLKDDKSYPYIKITKEAWPRVLRVRKVIEDGGIYFGPFAKASSVYATIELLNKLFAF
RLCNDDMFKKHERRNRACMYYDIKRCLGPCANNCTTEEYSTAINQVRLFLGGKPEAILRDLKVKMNQAAEDLQFERAAYV
RDQIKAVERVMERQKVLNTAASDQDVIAFARDEGKAVVQVFYIRGGKLIGSEPFTLQGTEEEHPEALMSSFLTQFYDAAA
DIPPNILLPDYPEETQIIEQWLESKGGHKVSLQVPRRGDKKDLVDLAARNASQTLDQLRLQWLNAEQRATAGLSQLRELL
NLAELPQRIECYDISNTQGTNSVGSMVVFEQGEPAKKHYRRFKIKTVEGANDVASLSEVLQRRFARADDTGQTDEPESTE
QTSAEPTNNDETWAVLPDLILIDGGIGQVNAAAKTLAAAGFEHIPVVGLVKGDTKGHLPYGLVKPGQRVPIAFAQNDPGL
HLVQRIDEEAHRFAISYHRKLRTKGMLRSTMEDIPGIGPKRKKALINAFGSLEGIRNASIEELAAVPGMTRKAAEEIKGL
L
>Mature_640_residues
PDLSHTNIANHALFEERLRNLPLSPGVYIYRDQANTIIYVGKSKSLRDRVRSYFGAPRGLTSKTRRLVQNIADFEFITTD
TELEALLLEMNLIKKHRPRYNVLLKDDKSYPYIKITKEAWPRVLRVRKVIEDGGIYFGPFAKASSVYATIELLNKLFAFR
LCNDDMFKKHERRNRACMYYDIKRCLGPCANNCTTEEYSTAINQVRLFLGGKPEAILRDLKVKMNQAAEDLQFERAAYVR
DQIKAVERVMERQKVLNTAASDQDVIAFARDEGKAVVQVFYIRGGKLIGSEPFTLQGTEEEHPEALMSSFLTQFYDAAAD
IPPNILLPDYPEETQIIEQWLESKGGHKVSLQVPRRGDKKDLVDLAARNASQTLDQLRLQWLNAEQRATAGLSQLRELLN
LAELPQRIECYDISNTQGTNSVGSMVVFEQGEPAKKHYRRFKIKTVEGANDVASLSEVLQRRFARADDTGQTDEPESTEQ
TSAEPTNNDETWAVLPDLILIDGGIGQVNAAAKTLAAAGFEHIPVVGLVKGDTKGHLPYGLVKPGQRVPIAFAQNDPGLH
LVQRIDEEAHRFAISYHRKLRTKGMLRSTMEDIPGIGPKRKKALINAFGSLEGIRNASIEELAAVPGMTRKAAEEIKGLL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=628, Percent_Identity=38.0573248407643, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1788037, Length=190, Percent_Identity=27.3684210526316, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 72068; Mature: 71937

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLSHTNIANHALFEERLRNLPLSPGVYIYRDQANTIIYVGKSKSLRDRVRSYFGAPRG
CCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHCCCCC
LTSKTRRLVQNIADFEFITTDTELEALLLEMNLIKKHRPRYNVLLKDDKSYPYIKITKEA
CCHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECHHH
WPRVLRVRKVIEDGGIYFGPFAKASSVYATIELLNKLFAFRLCNDDMFKKHERRNRACMY
HHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHH
YDIKRCLGPCANNCTTEEYSTAINQVRLFLGGKPEAILRDLKVKMNQAAEDLQFERAAYV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDQIKAVERVMERQKVLNTAASDQDVIAFARDEGKAVVQVFYIRGGKLIGSEPFTLQGTE
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEECCEEECCCCCEECCCC
EEHPEALMSSFLTQFYDAAADIPPNILLPDYPEETQIIEQWLESKGGHKVSLQVPRRGDK
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCH
KDLVDLAARNASQTLDQLRLQWLNAEQRATAGLSQLRELLNLAELPQRIECYDISNTQGT
HHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
NSVGSMVVFEQGEPAKKHYRRFKIKTVEGANDVASLSEVLQRRFARADDTGQTDEPESTE
CCCCCEEEEECCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
QTSAEPTNNDETWAVLPDLILIDGGIGQVNAAAKTLAAAGFEHIPVVGLVKGDTKGHLPY
CCCCCCCCCCCCEEECCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC
GLVKPGQRVPIAFAQNDPGLHLVQRIDEEAHRFAISYHRKLRTKGMLRSTMEDIPGIGPK
CCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
RKKALINAFGSLEGIRNASIEELAAVPGMTRKAAEEIKGLL
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
PDLSHTNIANHALFEERLRNLPLSPGVYIYRDQANTIIYVGKSKSLRDRVRSYFGAPRG
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHCCCCC
LTSKTRRLVQNIADFEFITTDTELEALLLEMNLIKKHRPRYNVLLKDDKSYPYIKITKEA
CCHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECHHH
WPRVLRVRKVIEDGGIYFGPFAKASSVYATIELLNKLFAFRLCNDDMFKKHERRNRACMY
HHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHH
YDIKRCLGPCANNCTTEEYSTAINQVRLFLGGKPEAILRDLKVKMNQAAEDLQFERAAYV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDQIKAVERVMERQKVLNTAASDQDVIAFARDEGKAVVQVFYIRGGKLIGSEPFTLQGTE
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEECCEEECCCCCEECCCC
EEHPEALMSSFLTQFYDAAADIPPNILLPDYPEETQIIEQWLESKGGHKVSLQVPRRGDK
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCH
KDLVDLAARNASQTLDQLRLQWLNAEQRATAGLSQLRELLNLAELPQRIECYDISNTQGT
HHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
NSVGSMVVFEQGEPAKKHYRRFKIKTVEGANDVASLSEVLQRRFARADDTGQTDEPESTE
CCCCCEEEEECCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
QTSAEPTNNDETWAVLPDLILIDGGIGQVNAAAKTLAAAGFEHIPVVGLVKGDTKGHLPY
CCCCCCCCCCCCEEECCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC
GLVKPGQRVPIAFAQNDPGLHLVQRIDEEAHRFAISYHRKLRTKGMLRSTMEDIPGIGPK
CCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
RKKALINAFGSLEGIRNASIEELAAVPGMTRKAAEEIKGLL
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA