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The map label for this gene is hisD [H]

Identifier: 159041971

GI number: 159041971

Start: 1482348

End: 1483547

Strand: Reverse

Name: hisD [H]

Synonym: Cmaq_1407

Alternate gene names: 159041971

Gene position: 1483547-1482348 (Counterclockwise)

Preceding gene: 159041975

Following gene: 159041970

Centisome position: 71.41

GC content: 50.0

Gene sequence:

>1200_bases
GTGAGGGTTAGTAGGGGGGATTTACTAAGCCTCTTAAGGAAGGCCACCGACATGGATCAGTACGTTGATAGGGTTAGGGG
TATTATTAATGATGTTAAGGAGCATGGTGATGAGGCATTACTCAGATTAACAAGTGAACTGGATGGCGTTAAGTTAAGCT
CCATTGAGTTGAGTCAAAGTGAATTGAGGGCATTAGCCAGTGGTATTGAGCCAAGGGTTAGGGAGGCTTTGGATGAGGTA
ATGGCCTCGGTGGAGTCTTTCAATACTGGTGTTAAGCCAAGGGACTTTGAGGATTACCACAGGGGCTTGAGGAGGGGGGT
TAAGTGGGTGCCTTTAAGTAGAGTTGGCTTATACGTGCCTAAGGGCTACTTCTCAACACTGGTTATGACAGGGGTCTTAG
CTAAGGTGGCTGGTGTTGAGGAGATAATTGCTGTGACACCACCTAGGCGTGATGGCTTAATTGATCCTGAAATCGCCTAC
GTGGCCTTAAGGTTGAATGCAAGGGTTTTCAGGGTTGGTGGGGCGCAGGCCGTGGCTGCATTAGCCTTCGGCACCGAGTC
GGTGCCAAGGGTGGATAAGATTATTGGTCCAGGTAACGCCTACGTGCAGGCGGCTAAGCTACTGGTTTCAAGCCACGTGG
GTATTGATGGTGTAGAAGGACCCACTGAATTAGTAACCTGCGCTGACCCAGGTATTAAACCAATCACCGTGGCCCTGGAC
TTGGCTGCTCAACTTGAGCACGCCGGGGCAGTGGGTGTGGTGGTTACTTGGAGTGAAGGGTACTTAACGGCTATTGAAGA
TGAGTTAAGTAAGTTAACTAATGCACCATACTTCTCAACACTGGTTAATGAACCTAGTGAATGCGTTAACGTGATTAATG
AGGTGGCGCCGGAGCATGCATCAATATGGGGTGTTAAAATACCCATTGAGGGTATTAGGAATGCTGGGGCAGTATCAATA
ATGGCTCCCTCAGCCCTAGTGGATTACGCCGCTGGGCCAAGCCACGTCCTGCCCACGGGTGGTTCAGCTAGGTGGAGGGG
TGTTTTAACGCCAATGGACTTCATGAAACCCATAGCCTACGTGGAACCCACCAGTGGGGATGAGGCTAGGAGGCTTGGTG
AATTAGGGGCAGTACTGGGTTTAAGGGAGGGGTTTAGGAGGCATTCAGAGGCATTAACGAATTGGATTAACGAGGAGTGA

Upstream 100 bases:

>100_bases
AACCCTAACCCATGAGGCTTACCCACTAGTTGCTTGAACCCGTTTTAGAAGTATTATTCAAGGTGCAATACATTATTAAG
CAGTTGGGTGCCGGGGTATT

Downstream 100 bases:

>100_bases
AACCCTCAAGCAAAGTACCTGGTGTTTATTTAGGCAAAGCATTTATACCGTTGCCTAATAATGCCTAGGTGGATGATTGC
GACTTCCTTAAGGTGCTGGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MRVSRGDLLSLLRKATDMDQYVDRVRGIINDVKEHGDEALLRLTSELDGVKLSSIELSQSELRALASGIEPRVREALDEV
MASVESFNTGVKPRDFEDYHRGLRRGVKWVPLSRVGLYVPKGYFSTLVMTGVLAKVAGVEEIIAVTPPRRDGLIDPEIAY
VALRLNARVFRVGGAQAVAALAFGTESVPRVDKIIGPGNAYVQAAKLLVSSHVGIDGVEGPTELVTCADPGIKPITVALD
LAAQLEHAGAVGVVVTWSEGYLTAIEDELSKLTNAPYFSTLVNEPSECVNVINEVAPEHASIWGVKIPIEGIRNAGAVSI
MAPSALVDYAAGPSHVLPTGGSARWRGVLTPMDFMKPIAYVEPTSGDEARRLGELGAVLGLREGFRRHSEALTNWINEE

Sequences:

>Translated_399_residues
MRVSRGDLLSLLRKATDMDQYVDRVRGIINDVKEHGDEALLRLTSELDGVKLSSIELSQSELRALASGIEPRVREALDEV
MASVESFNTGVKPRDFEDYHRGLRRGVKWVPLSRVGLYVPKGYFSTLVMTGVLAKVAGVEEIIAVTPPRRDGLIDPEIAY
VALRLNARVFRVGGAQAVAALAFGTESVPRVDKIIGPGNAYVQAAKLLVSSHVGIDGVEGPTELVTCADPGIKPITVALD
LAAQLEHAGAVGVVVTWSEGYLTAIEDELSKLTNAPYFSTLVNEPSECVNVINEVAPEHASIWGVKIPIEGIRNAGAVSI
MAPSALVDYAAGPSHVLPTGGSARWRGVLTPMDFMKPIAYVEPTSGDEARRLGELGAVLGLREGFRRHSEALTNWINEE
>Mature_399_residues
MRVSRGDLLSLLRKATDMDQYVDRVRGIINDVKEHGDEALLRLTSELDGVKLSSIELSQSELRALASGIEPRVREALDEV
MASVESFNTGVKPRDFEDYHRGLRRGVKWVPLSRVGLYVPKGYFSTLVMTGVLAKVAGVEEIIAVTPPRRDGLIDPEIAY
VALRLNARVFRVGGAQAVAALAFGTESVPRVDKIIGPGNAYVQAAKLLVSSHVGIDGVEGPTELVTCADPGIKPITVALD
LAAQLEHAGAVGVVVTWSEGYLTAIEDELSKLTNAPYFSTLVNEPSECVNVINEVAPEHASIWGVKIPIEGIRNAGAVSI
MAPSALVDYAAGPSHVLPTGGSARWRGVLTPMDFMKPIAYVEPTSGDEARRLGELGAVLGLREGFRRHSEALTNWINEE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=414, Percent_Identity=33.5748792270531, Blast_Score=186, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6319819, Length=415, Percent_Identity=32.7710843373494, Blast_Score=174, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 42935; Mature: 42935

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVSRGDLLSLLRKATDMDQYVDRVRGIINDVKEHGDEALLRLTSELDGVKLSSIELSQS
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHH
ELRALASGIEPRVREALDEVMASVESFNTGVKPRDFEDYHRGLRRGVKWVPLSRVGLYVP
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEECCHHHHCEECC
KGYFSTLVMTGVLAKVAGVEEIIAVTPPRRDGLIDPEIAYVALRLNARVFRVGGAQAVAA
CHHHHHHHHHHHHHHHHCHHHHHEECCCCCCCCCCCCCEEEEEEECCEEEEECCHHHHHH
LAFGTESVPRVDKIIGPGNAYVQAAKLLVSSHVGIDGVEGPTELVTCADPGIKPITVALD
HHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCEEHHHHH
LAAQLEHAGAVGVVVTWSEGYLTAIEDELSKLTNAPYFSTLVNEPSECVNVINEVAPEHA
HHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCH
SIWGVKIPIEGIRNAGAVSIMAPSALVDYAAGPSHVLPTGGSARWRGVLTPMDFMKPIAY
HEEEEEEEHHHCCCCCEEEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCE
VEPTSGDEARRLGELGAVLGLREGFRRHSEALTNWINEE
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVSRGDLLSLLRKATDMDQYVDRVRGIINDVKEHGDEALLRLTSELDGVKLSSIELSQS
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHH
ELRALASGIEPRVREALDEVMASVESFNTGVKPRDFEDYHRGLRRGVKWVPLSRVGLYVP
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEECCHHHHCEECC
KGYFSTLVMTGVLAKVAGVEEIIAVTPPRRDGLIDPEIAYVALRLNARVFRVGGAQAVAA
CHHHHHHHHHHHHHHHHCHHHHHEECCCCCCCCCCCCCEEEEEEECCEEEEECCHHHHHH
LAFGTESVPRVDKIIGPGNAYVQAAKLLVSSHVGIDGVEGPTELVTCADPGIKPITVALD
HHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCEEHHHHH
LAAQLEHAGAVGVVVTWSEGYLTAIEDELSKLTNAPYFSTLVNEPSECVNVINEVAPEHA
HHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCH
SIWGVKIPIEGIRNAGAVSIMAPSALVDYAAGPSHVLPTGGSARWRGVLTPMDFMKPIAY
HEEEEEEEHHHCCCCCEEEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCE
VEPTSGDEARRLGELGAVLGLREGFRRHSEALTNWINEE
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9209067; 10701121; 11427726 [H]