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The map label for this gene is hemC

Identifier: 159041687

GI number: 159041687

Start: 1176885

End: 1177802

Strand: Reverse

Name: hemC

Synonym: Cmaq_1121

Alternate gene names: 159041687

Gene position: 1177802-1176885 (Counterclockwise)

Preceding gene: 159041688

Following gene: 159041681

Centisome position: 56.69

GC content: 45.42

Gene sequence:

>918_bases
ATGATTATTAGGATAGCCACGAGGGGTTCGGCGTTATCCCTTAAGCAAACTAAGATAGTTATGGATAGGATACTTGAGTT
TAATAAGGATGTTGAGTTTAAGCTAATTATAGTTAAGACTACTGGTGATGTTGACTTAAGTAAGCCACTTTATGAAATAG
GGGTTAAGGGTATTTTCGAGAGGGAGGTTAATCAGGCAGTGCTCAGGGGTGAGGCTGATGTGGCTGTACATAGTTTAAAG
GATATGCCGGCTCAAATAAGTAATGACTTAACACTAGTAATGACACCTCCAAGGGATAATCCGAGGGATGCCTTAGTATC
CCTCAGGCAGTACACGGTGGATACATTACCCCTCAACTCAATTGTTGGTACATCAAGCCTTAGGAGGAGGGGATTCCTAC
TCTCCCTAAGGCGTGACGTTACGGTGAAGCCCATTAGGGGTAATGTTGATACGAGGATTAGGAAGCTTAATAATGGTGAA
TACGATGCCTTAATCATGGCTGCCGCAGGCCTGGAGAGACTTAGCATTAATGCTAATGTAAGTGAAATAAGCCCTGAATT
AATGCCACCAGCCCCTGGACAAGGTATAATTGGTGTTGTTGCAAGGAGGGATAGGGATGATTTAATTAAGGTACTGAGGC
GTAGTAGTGATGAGGAAACATTCAAGGAGGCTGCGGCTGAGCGTGCTTTCCTAAGTAGAATAGGGGCTGGTTGCCACGTA
CCCTTAGGGGGCTTGGCGTTACTGGATGATGGATACTTCGACTTCACTTATGGGGTAGTGGATCCTGATGGTGTTGAGAA
GTTCATTAACTCAACCAGGATTGATGCCAGGAACCCTGAGGAGGCTGGTAGGGTGGCTGCTGAAGATTTACTGAGGAATG
CCCGTGGATTGGTGGCTAGGTTGCTTAAGTACTCCTAA

Upstream 100 bases:

>100_bases
AGGAGACTAGTGTTAAGGTACCTAGGGTGGTTGATTCTATTCGCGTCATTTAAGTTTACGAAGCAAAGGTTTATCAGTGA
GTCATGGGGGAACGTTACTG

Downstream 100 bases:

>100_bases
TTCCTTAGCGCAGTTGAGGCAGTACCTAATTAACCCAACCCTAACGCTATGTACCCTGCATATTGGTTTACCGCACCTTG
CGCATAATGACACGGCAAGC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MIIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFEREVNQAVLRGEADVAVHSLK
DMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNSIVGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGE
YDALIMAAAGLERLSINANVSEISPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHV
PLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRNARGLVARLLKYS

Sequences:

>Translated_305_residues
MIIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFEREVNQAVLRGEADVAVHSLK
DMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNSIVGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGE
YDALIMAAAGLERLSINANVSEISPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHV
PLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRNARGLVARLLKYS
>Mature_305_residues
MIIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFEREVNQAVLRGEADVAVHSLK
DMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNSIVGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGE
YDALIMAAAGLERLSINANVSEISPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHV
PLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRNARGLVARLLKYS

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI66933009, Length=285, Percent_Identity=36.140350877193, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI20149500, Length=288, Percent_Identity=37.5, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI48994974, Length=302, Percent_Identity=41.0596026490066, Blast_Score=209, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6319996, Length=312, Percent_Identity=29.4871794871795, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI20130425, Length=247, Percent_Identity=34.412955465587, Blast_Score=140, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_CALMQ (A8MDU3)

Other databases:

- EMBL:   CP000852
- RefSeq:   YP_001540939.1
- ProteinModelPortal:   A8MDU3
- SMR:   A8MDU3
- GeneID:   5710294
- GenomeReviews:   CP000852_GR
- KEGG:   cma:Cmaq_1121
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- ProtClustDB:   PRK00072
- BioCyc:   CMAQ397948:CMAQ_1121-MONOMER
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 33650; Mature: 33650

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFE
CEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCHHHHCCHHHHH
REVNQAVLRGEADVAVHSLKDMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNS
HHHHHHHHCCCHHHHHHHHHHCCHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHH
IVGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGEYDALIMAAAGLERLSINANV
HHCCHHHHHCCCEEEECCCCEEEECCCCHHHHHHCCCCCCCCEEEEECCCCEEEEECCCH
SEISPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHV
HHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC
PLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRNARGLVAR
CCCCEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLKYS
HHHCC
>Mature Secondary Structure
MIIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFE
CEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCHHHHCCHHHHH
REVNQAVLRGEADVAVHSLKDMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNS
HHHHHHHHCCCHHHHHHHHHHCCHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHH
IVGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGEYDALIMAAAGLERLSINANV
HHCCHHHHHCCCEEEECCCCEEEECCCCHHHHHHCCCCCCCCEEEEECCCCEEEEECCCH
SEISPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHV
HHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC
PLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRNARGLVAR
CCCCEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLKYS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA