Click here to switch to the map view.

The map label for this gene is Hgd [H]

Identifier: 159041663

GI number: 159041663

Start: 1154757

End: 1155644

Strand: Reverse

Name: Hgd [H]

Synonym: Cmaq_1097

Alternate gene names: 159041663

Gene position: 1155644-1154757 (Counterclockwise)

Preceding gene: 159041667

Following gene: 159041662

Centisome position: 55.62

GC content: 41.89

Gene sequence:

>888_bases
ATGGTTAATGTAGGGTTAATAGGGTTAGGTACAATGGGCTGGAGGATTGCCAAGAATCTTAAGGATGATGGATTATTAAT
AGGGGTGTTTAATAGGACTATGAGCAAGGCCATTAAGTTCGCTGAGGAGAATAAGGTTAATGTGTTCAATAACCCTGCTG
AATTAGCTAGGAACGTTGATGTAGTATTATCAATAGTGTCTGATGATGATGCCGTTAAATCCATTATGCTGGGTGAGAAC
GGTGTAATTAATGGGATTAAGCAAGGTTCCCTAGTGATTGAAATGTCAACAATATCACCCTCCACATCAATTGAGTTAGC
TAACAAGATTAAGGAGAAGGGTGGGTTAATGGTTGATGCACCAATCATAGGTACTTCAATACTCATTGAGAAGCGTGAGG
CTGTGGTACTTATTGGTGGTGAGAGGGAAGCTTACGAGAGGGCCTACGAGGTAGTTAAGCACTTTGCCCGCTATGTAGTT
CACGTTGGGCCAAATGGGTATGGACTCTACGCAAAGTTAATTAATAATGCCCTACTCGGCTCCTACGTAGCAGCATTAGC
CGAGGTGGTTAATTTAGGTGAAGCCATGGGGTTAAGCAGTAGTGTAATAATGGATGTTTTAACTAAACTGTCAAGTGCTA
GGTCACCAACCTCGGAACTTAAGGTACCTAAGATGATTAACAATGATTTCACCACTCAATTCGCCACTAAACACATGAGA
AAGGACCTCGACTTGGTTAATAAGGAGGCTAGCAGGTTAGGGGTCCCAGTACCAATGGCTGCATTGGCGCTTCAATTATA
TAGAATGAGCGAGGCAGATGGGTTAAGTGATGATGATTTCTCAGCAGTAATTAAGATACTTAAGAGACGTAACTCAACTC
AACGTTAA

Upstream 100 bases:

>100_bases
CTTAAACCTACTCAAGGCCTTGGATTTAAGGAAGTAAGCTAATGCTCTGAAGGGGTTAACGTGAGCGTTAAGTTTAACTT
TAATCAGGGTAAGTGGGCTT

Downstream 100 bases:

>100_bases
TAACGCATCAGGAGTCTTAGTGATGATTTAAACAGCTTCAATAATTAACCTTAATGAGACGCCTACGTAATGAGGAATAA
TATATTAATGGTGTAATACT

Product: NAD-binding 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MVNVGLIGLGTMGWRIAKNLKDDGLLIGVFNRTMSKAIKFAEENKVNVFNNPAELARNVDVVLSIVSDDDAVKSIMLGEN
GVINGIKQGSLVIEMSTISPSTSIELANKIKEKGGLMVDAPIIGTSILIEKREAVVLIGGEREAYERAYEVVKHFARYVV
HVGPNGYGLYAKLINNALLGSYVAALAEVVNLGEAMGLSSSVIMDVLTKLSSARSPTSELKVPKMINNDFTTQFATKHMR
KDLDLVNKEASRLGVPVPMAALALQLYRMSEADGLSDDDFSAVIKILKRRNSTQR

Sequences:

>Translated_295_residues
MVNVGLIGLGTMGWRIAKNLKDDGLLIGVFNRTMSKAIKFAEENKVNVFNNPAELARNVDVVLSIVSDDDAVKSIMLGEN
GVINGIKQGSLVIEMSTISPSTSIELANKIKEKGGLMVDAPIIGTSILIEKREAVVLIGGEREAYERAYEVVKHFARYVV
HVGPNGYGLYAKLINNALLGSYVAALAEVVNLGEAMGLSSSVIMDVLTKLSSARSPTSELKVPKMINNDFTTQFATKHMR
KDLDLVNKEASRLGVPVPMAALALQLYRMSEADGLSDDDFSAVIKILKRRNSTQR
>Mature_295_residues
MVNVGLIGLGTMGWRIAKNLKDDGLLIGVFNRTMSKAIKFAEENKVNVFNNPAELARNVDVVLSIVSDDDAVKSIMLGEN
GVINGIKQGSLVIEMSTISPSTSIELANKIKEKGGLMVDAPIIGTSILIEKREAVVLIGGEREAYERAYEVVKHFARYVV
HVGPNGYGLYAKLINNALLGSYVAALAEVVNLGEAMGLSSSVIMDVLTKLSSARSPTSELKVPKMINNDFTTQFATKHMR
KDLDLVNKEASRLGVPVPMAALALQLYRMSEADGLSDDDFSAVIKILKRRNSTQR

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=32.6241134751773, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI23308751, Length=296, Percent_Identity=31.7567567567568, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1790315, Length=288, Percent_Identity=29.1666666666667, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI145693186, Length=282, Percent_Identity=29.7872340425532, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789092, Length=287, Percent_Identity=30.6620209059233, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1786719, Length=291, Percent_Identity=26.8041237113402, Blast_Score=103, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17557316, Length=298, Percent_Identity=31.2080536912752, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=31.2056737588652, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24655230, Length=295, Percent_Identity=28.8135593220339, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19922568, Length=295, Percent_Identity=28.8135593220339, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 31996; Mature: 31996

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNVGLIGLGTMGWRIAKNLKDDGLLIGVFNRTMSKAIKFAEENKVNVFNNPAELARNVD
CCEEEEEEECHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEECCHHHHHCCHH
VVLSIVSDDDAVKSIMLGENGVINGIKQGSLVIEMSTISPSTSIELANKIKEKGGLMVDA
HEEEEECCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEEC
PIIGTSILIEKREAVVLIGGEREAYERAYEVVKHFARYVVHVGPNGYGLYAKLINNALLG
CHHCHHHEEECCCEEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHH
SYVAALAEVVNLGEAMGLSSSVIMDVLTKLSSARSPTSELKVPKMINNDFTTQFATKHMR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHCCCCHHHCCCHHHHHHHHHHH
KDLDLVNKEASRLGVPVPMAALALQLYRMSEADGLSDDDFSAVIKILKRRNSTQR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVNVGLIGLGTMGWRIAKNLKDDGLLIGVFNRTMSKAIKFAEENKVNVFNNPAELARNVD
CCEEEEEEECHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEECCHHHHHCCHH
VVLSIVSDDDAVKSIMLGENGVINGIKQGSLVIEMSTISPSTSIELANKIKEKGGLMVDA
HEEEEECCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEEC
PIIGTSILIEKREAVVLIGGEREAYERAYEVVKHFARYVVHVGPNGYGLYAKLINNALLG
CHHCHHHEEECCCEEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHH
SYVAALAEVVNLGEAMGLSSSVIMDVLTKLSSARSPTSELKVPKMINNDFTTQFATKHMR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHCCCCHHHCCCHHHHHHHHHHH
KDLDLVNKEASRLGVPVPMAALALQLYRMSEADGLSDDDFSAVIKILKRRNSTQR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA