Click here to switch to the map view.

The map label for this gene is rmlA1 [C]

Identifier: 159041568

GI number: 159041568

Start: 1052402

End: 1053115

Strand: Reverse

Name: rmlA1 [C]

Synonym: Cmaq_0999

Alternate gene names: 159041568

Gene position: 1053115-1052402 (Counterclockwise)

Preceding gene: 159041569

Following gene: 159041567

Centisome position: 50.69

GC content: 43.14

Gene sequence:

>714_bases
ATGGCAATGTTCGCCGTAATCCTTGCGGGTGGATTTGGGAAGAGGCTTAGACCACTTACTGATGATAGACCCAAGCCCCT
TGTTGAGGTTGCTGGTAGGCCAATACTGGCATGGCAGATAGATTGGTTAAGGGAACAGGGGGTTACTGATATTATTTTAG
CCGTCGGTTACCTGGGTGGTAAGATATTTGACTACATTGGGGATGGTTCACAATTCGGTGTTAGGGTTTACTACAGTGTT
GAAAGGGAACCGCTTGGAACCGGTGGCGCTGTTAGGAATGCGTTAAAGTACATTAATGATGATGGCTTCATTGTTGTTAA
CGGTGATGTAATAACCAACTTAAGGATAGGTAAACTCATGGATTCCCTTCAAAGGGGTGTTATTGGGGCCATTGCATTAA
CACCACTTAAGAGCCCATACGGTATAGTTCAGGTTGATGAGGATGGCTTCATATTAAACTTCCAGGAGAAACCCCAGTTA
CCTTACTTAATTAATGCAGGTGTGTACGCTTTAAGAACGTCAATAAGGGATTACTTACCGGAGAAGGGTGATATTGAGGT
TTACACATTCCCTAGGTTGGCTAAGGATAAGAAACTCATAGGTATTACGTACAATGACGTCTACTGGAAGTCCATAGATA
CCCTTAAGGATCTTGAGGAGGCTGATAAGGCGATTAACGAGCAAGGTGTCTTTAATAATAAGGTTAAGGGTTAA

Upstream 100 bases:

>100_bases
CTTATGAAGTAATTTTACTAGCCTCATGTTAAATAAGCCACAGTCCTAGTACTTAACCATGTGGTAATTGTTAATAACCC
TCACTGATGCAGTAAACTTA

Downstream 100 bases:

>100_bases
TCACCGCAGTGATTCGGTAAGGGATTAAAAGCGATTATTGGTGAATTAATGTGCCTAATGTTGAGGATATTGTTAAGGAG
GCCCTTAGGATCGTTACCCC

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MAMFAVILAGGFGKRLRPLTDDRPKPLVEVAGRPILAWQIDWLREQGVTDIILAVGYLGGKIFDYIGDGSQFGVRVYYSV
EREPLGTGGAVRNALKYINDDGFIVVNGDVITNLRIGKLMDSLQRGVIGAIALTPLKSPYGIVQVDEDGFILNFQEKPQL
PYLINAGVYALRTSIRDYLPEKGDIEVYTFPRLAKDKKLIGITYNDVYWKSIDTLKDLEEADKAINEQGVFNNKVKG

Sequences:

>Translated_237_residues
MAMFAVILAGGFGKRLRPLTDDRPKPLVEVAGRPILAWQIDWLREQGVTDIILAVGYLGGKIFDYIGDGSQFGVRVYYSV
EREPLGTGGAVRNALKYINDDGFIVVNGDVITNLRIGKLMDSLQRGVIGAIALTPLKSPYGIVQVDEDGFILNFQEKPQL
PYLINAGVYALRTSIRDYLPEKGDIEVYTFPRLAKDKKLIGITYNDVYWKSIDTLKDLEEADKAINEQGVFNNKVKG
>Mature_236_residues
AMFAVILAGGFGKRLRPLTDDRPKPLVEVAGRPILAWQIDWLREQGVTDIILAVGYLGGKIFDYIGDGSQFGVRVYYSVE
REPLGTGGAVRNALKYINDDGFIVVNGDVITNLRIGKLMDSLQRGVIGAIALTPLKSPYGIVQVDEDGFILNFQEKPQLP
YLINAGVYALRTSIRDYLPEKGDIEVYTFPRLAKDKKLIGITYNDVYWKSIDTLKDLEEADKAINEQGVFNNKVKG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=226, Percent_Identity=36.7256637168142, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI11761619, Length=226, Percent_Identity=36.7256637168142, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI31881779, Length=181, Percent_Identity=30.939226519337, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI45447090, Length=181, Percent_Identity=30.939226519337, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1788351, Length=161, Percent_Identity=29.8136645962733, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=226, Percent_Identity=38.0530973451327, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17509979, Length=243, Percent_Identity=30.0411522633745, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17509981, Length=227, Percent_Identity=29.0748898678414, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=227, Percent_Identity=37.4449339207048, Blast_Score=115, Evalue=8e-27,
Organism=Drosophila melanogaster, GI21355443, Length=223, Percent_Identity=37.219730941704, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24644084, Length=223, Percent_Identity=37.219730941704, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24653912, Length=191, Percent_Identity=31.413612565445, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 26346; Mature: 26215

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMFAVILAGGFGKRLRPLTDDRPKPLVEVAGRPILAWQIDWLREQGVTDIILAVGYLGG
CHHEEEEECCCCCCCCCCCCCCCCCCHHHHCCCEEEEEEEHHHHHCCHHHHHHHHHHHCC
KIFDYIGDGSQFGVRVYYSVEREPLGTGGAVRNALKYINDDGFIVVNGDVITNLRIGKLM
HHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCEEECCHHHHHH
DSLQRGVIGAIALTPLKSPYGIVQVDEDGFILNFQEKPQLPYLINAGVYALRTSIRDYLP
HHHHHCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCCCCEEECCCHHHHHHHHHHHCC
EKGDIEVYTFPRLAKDKKLIGITYNDVYWKSIDTLKDLEEADKAINEQGVFNNKVKG
CCCCEEEEECCCCCCCCEEEEEEECCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AMFAVILAGGFGKRLRPLTDDRPKPLVEVAGRPILAWQIDWLREQGVTDIILAVGYLGG
HHEEEEECCCCCCCCCCCCCCCCCCHHHHCCCEEEEEEEHHHHHCCHHHHHHHHHHHCC
KIFDYIGDGSQFGVRVYYSVEREPLGTGGAVRNALKYINDDGFIVVNGDVITNLRIGKLM
HHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCEEECCHHHHHH
DSLQRGVIGAIALTPLKSPYGIVQVDEDGFILNFQEKPQLPYLINAGVYALRTSIRDYLP
HHHHHCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCCCCEEECCCHHHHHHHHHHHCC
EKGDIEVYTFPRLAKDKKLIGITYNDVYWKSIDTLKDLEEADKAINEQGVFNNKVKG
CCCCEEEEECCCCCCCCEEEEEEECCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA