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The map label for this gene is fumC [H]

Identifier: 159041501

GI number: 159041501

Start: 976981

End: 978306

Strand: Reverse

Name: fumC [H]

Synonym: Cmaq_0931

Alternate gene names: 159041501

Gene position: 978306-976981 (Counterclockwise)

Preceding gene: 159041505

Following gene: 159041500

Centisome position: 47.09

GC content: 42.99

Gene sequence:

>1326_bases
ATGAAGTACACTGAGGCGGCGACAAGACTTTTCATGGCCACTGGGACAAAGTTTCCTCGCCAAGTAATATGGGCCATGGG
TTTAGTGAAGTACGCATCAGCGAAGGTTAACACTGAATTAGGCTTGCTTAGTGGTGATATTGGGCATGCGATAATGGAGG
CATCTAAGGAAGTTATGGATGGTAGGTTTGATGATGAAGTAACAGTGGATGTATTCCAAACAGGCTCCGGCACGGGATTA
AACATGAATATTAACGAAGTAATCGCGGAAAGAGCCGGTGAAATTTCAGGGAAGAGAATTCACCCTAATGATCACGTGAA
TTTAGGGCAATCATCAAACGATACCGTATCCACGGCCATTAGGATAGCGGCTGTGCACTCCTCCATGTTACTCCTCATAC
CGGCCCTTAATAAATTAATTACATCATTAGGTGAGAAGTCGTCATTATTTAATACCGTAATCAAGGCTGGTAGGACTCAT
TTAAGGGATGCATTACCCATAACCCTAGGGCAGGAATTAAGTGGTTACCTTGATGCATTCTCCCACGACTTAAAGATCAT
TGAATCCACCCTGGATTACGTTAAGGAATTACCCATAGGTGGAACAGCAGTGGGTACTGGGTTAAATACCCACCCGGAAT
TTCAGGGAAGGGTAATAAAGGAGATTAATGAAATCACATCCCTTGATTTTAAACCCGCGAATAAGTTCAGGGGATTAAAA
CTCCTAACTGATATACTTAACTTGAGCGGTGCATTAAGGGCAACAGCCATTGACTTATACAGGTTGGGACAGGATATAAG
GTTAATGTTCTCAGGCCCCATGACTGGGTTAAATGAGATTGATTTACCAACACAAGGGGAAGTGGCTGGAAGCAGTATTA
TGCCGGGTAAAACTAACCCAGTAACCGTGGAGGCAACCTTACTGGCAGTGGCTCAAGTGGTAGGGTTAGATCACGCTAAT
CAATTTGCATCAATGCTTGGGGAATTTGAATTAGCCATGGGGGTGCCTTTAATGGGTTATAACATAGTGCTTCAAGTCCA
CTTGCTCTCTGAGGCGTTAAGTAAGTTTACTAACCTTGTGATTGATGGAATGGTTCCCAACACAGATAGGATGAGGAGAT
ACGCAGAAAGTAGCCCATCATTAATAACAGTGATTTCACCAGTAATTGGGTACGATAAAGCCGCTGAAATAGGTAGGAGA
TTAACGCATGGGTTATCAATAAGGGAGGCATTAAGGGAATTAGGGTACACTGATGAGCAGATTAATGAAATCCTTAACCT
AGAGAAGTTAACTAAACCTGGCTTTCCATTAAGTCATGAATCCTGA

Upstream 100 bases:

>100_bases
AATAAAACTACCCTACTCCTCAGTAGGGGAATTATTACAGGGTGTCGTTTCCCAGTTGCCGATACTGTAAGGAATAAATG
CCCTGAAATTAAGCAACACT

Downstream 100 bases:

>100_bases
AAACCACATTCTTTAAGTTTCTAGAATACTCTAAAAGGGTAATGTGGGTTCTTTTAACATGACTGGGATTACTTAAATAC
GCTAACCTAGGGGTTTTAAT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKYTEAATRLFMATGTKFPRQVIWAMGLVKYASAKVNTELGLLSGDIGHAIMEASKEVMDGRFDDEVTVDVFQTGSGTGL
NMNINEVIAERAGEISGKRIHPNDHVNLGQSSNDTVSTAIRIAAVHSSMLLLIPALNKLITSLGEKSSLFNTVIKAGRTH
LRDALPITLGQELSGYLDAFSHDLKIIESTLDYVKELPIGGTAVGTGLNTHPEFQGRVIKEINEITSLDFKPANKFRGLK
LLTDILNLSGALRATAIDLYRLGQDIRLMFSGPMTGLNEIDLPTQGEVAGSSIMPGKTNPVTVEATLLAVAQVVGLDHAN
QFASMLGEFELAMGVPLMGYNIVLQVHLLSEALSKFTNLVIDGMVPNTDRMRRYAESSPSLITVISPVIGYDKAAEIGRR
LTHGLSIREALRELGYTDEQINEILNLEKLTKPGFPLSHES

Sequences:

>Translated_441_residues
MKYTEAATRLFMATGTKFPRQVIWAMGLVKYASAKVNTELGLLSGDIGHAIMEASKEVMDGRFDDEVTVDVFQTGSGTGL
NMNINEVIAERAGEISGKRIHPNDHVNLGQSSNDTVSTAIRIAAVHSSMLLLIPALNKLITSLGEKSSLFNTVIKAGRTH
LRDALPITLGQELSGYLDAFSHDLKIIESTLDYVKELPIGGTAVGTGLNTHPEFQGRVIKEINEITSLDFKPANKFRGLK
LLTDILNLSGALRATAIDLYRLGQDIRLMFSGPMTGLNEIDLPTQGEVAGSSIMPGKTNPVTVEATLLAVAQVVGLDHAN
QFASMLGEFELAMGVPLMGYNIVLQVHLLSEALSKFTNLVIDGMVPNTDRMRRYAESSPSLITVISPVIGYDKAAEIGRR
LTHGLSIREALRELGYTDEQINEILNLEKLTKPGFPLSHES
>Mature_441_residues
MKYTEAATRLFMATGTKFPRQVIWAMGLVKYASAKVNTELGLLSGDIGHAIMEASKEVMDGRFDDEVTVDVFQTGSGTGL
NMNINEVIAERAGEISGKRIHPNDHVNLGQSSNDTVSTAIRIAAVHSSMLLLIPALNKLITSLGEKSSLFNTVIKAGRTH
LRDALPITLGQELSGYLDAFSHDLKIIESTLDYVKELPIGGTAVGTGLNTHPEFQGRVIKEINEITSLDFKPANKFRGLK
LLTDILNLSGALRATAIDLYRLGQDIRLMFSGPMTGLNEIDLPTQGEVAGSSIMPGKTNPVTVEATLLAVAQVVGLDHAN
QFASMLGEFELAMGVPLMGYNIVLQVHLLSEALSKFTNLVIDGMVPNTDRMRRYAESSPSLITVISPVIGYDKAAEIGRR
LTHGLSIREALRELGYTDEQINEILNLEKLTKPGFPLSHES

Specific function: May function as an auxiliary aerobic enzyme in the citric acid cycle [H]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=426, Percent_Identity=42.7230046948357, Blast_Score=299, Evalue=4e-81,
Organism=Escherichia coli, GI1787896, Length=404, Percent_Identity=43.5643564356436, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI87082375, Length=427, Percent_Identity=34.6604215456674, Blast_Score=239, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17553882, Length=426, Percent_Identity=42.018779342723, Blast_Score=305, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI32565146, Length=329, Percent_Identity=39.8176291793313, Blast_Score=222, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6324993, Length=425, Percent_Identity=40.2352941176471, Blast_Score=295, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24640179, Length=427, Percent_Identity=40.9836065573771, Blast_Score=294, Evalue=9e-80,
Organism=Drosophila melanogaster, GI24640177, Length=427, Percent_Identity=40.9836065573771, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24662684, Length=427, Percent_Identity=40.0468384074941, Blast_Score=289, Evalue=3e-78,
Organism=Drosophila melanogaster, GI78710009, Length=429, Percent_Identity=40.5594405594406, Blast_Score=288, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24583245, Length=427, Percent_Identity=35.5971896955504, Blast_Score=258, Evalue=8e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 47826; Mature: 47826

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYTEAATRLFMATGTKFPRQVIWAMGLVKYASAKVNTELGLLSGDIGHAIMEASKEVMD
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHC
GRFDDEVTVDVFQTGSGTGLNMNINEVIAERAGEISGKRIHPNDHVNLGQSSNDTVSTAI
CCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHH
RIAAVHSSMLLLIPALNKLITSLGEKSSLFNTVIKAGRTHLRDALPITLGQELSGYLDAF
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHH
SHDLKIIESTLDYVKELPIGGTAVGTGLNTHPEFQGRVIKEINEITSLDFKPANKFRGLK
HHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
LLTDILNLSGALRATAIDLYRLGQDIRLMFSGPMTGLNEIDLPTQGEVAGSSIMPGKTNP
HHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VTVEATLLAVAQVVGLDHANQFASMLGEFELAMGVPLMGYNIVLQVHLLSEALSKFTNLV
EEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHE
IDGMVPNTDRMRRYAESSPSLITVISPVIGYDKAAEIGRRLTHGLSIREALRELGYTDEQ
ECCCCCCHHHHHHHHHCCCCEEEEHHHHHCCHHHHHHHHHHHHCHHHHHHHHHCCCCHHH
INEILNLEKLTKPGFPLSHES
HHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKYTEAATRLFMATGTKFPRQVIWAMGLVKYASAKVNTELGLLSGDIGHAIMEASKEVMD
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHC
GRFDDEVTVDVFQTGSGTGLNMNINEVIAERAGEISGKRIHPNDHVNLGQSSNDTVSTAI
CCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHH
RIAAVHSSMLLLIPALNKLITSLGEKSSLFNTVIKAGRTHLRDALPITLGQELSGYLDAF
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHH
SHDLKIIESTLDYVKELPIGGTAVGTGLNTHPEFQGRVIKEINEITSLDFKPANKFRGLK
HHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
LLTDILNLSGALRATAIDLYRLGQDIRLMFSGPMTGLNEIDLPTQGEVAGSSIMPGKTNP
HHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VTVEATLLAVAQVVGLDHANQFASMLGEFELAMGVPLMGYNIVLQVHLLSEALSKFTNLV
EEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHE
IDGMVPNTDRMRRYAESSPSLITVISPVIGYDKAAEIGRRLTHGLSIREALRELGYTDEQ
ECCCCCCHHHHHHHHHCCCCEEEEHHHHHCCHHHHHHHHHHHHCHHHHHHHHHCCCCHHH
INEILNLEKLTKPGFPLSHES
HHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8276121; 8119400; 11427726; 2124611 [H]