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The map label for this gene is ubiA [H]

Identifier: 159041103

GI number: 159041103

Start: 553361

End: 554221

Strand: Reverse

Name: ubiA [H]

Synonym: Cmaq_0520

Alternate gene names: 159041103

Gene position: 554221-553361 (Counterclockwise)

Preceding gene: 159041104

Following gene: 159041101

Centisome position: 26.68

GC content: 42.86

Gene sequence:

>861_bases
ATGAGTGTTAGACGTATGATTAACGAGTACCTGAAGCTAATGAAACCCCACGTAATATGGCTACTGGTGCTCTCGGCATT
AGTTGGTTACATTGCTGCTGCAGGCCCATTGGTGAACCCCATTAAGTTAATTGAATTAACTGTGGTGGGTTTCCTATCCA
CGGGTGGTTCAGCAGCCTTCAACATGTATTATGAGAGAGATATCGATAGCCTAATGGTTAGGACAATGAAGCGTCCAATA
CCCAGTGGTAAAGTGACTCCATTAAACGCCTTAACGTTCTCAATAGCCGTAAGCCTCAGCGGCTTTACCTTATCTTACCT
TTGGCTTGGATCATGGGTAACCTTAATGATTGCACTAGGTTGGTTCTTCTACGCAGTTCTATACACCATAATGCTTAAGA
GGAGGACATGGTTAAACATAGTGATCGGCGGCTTCGCGGGGAATGCCGCATTACTCTCAGGGTGGATTATGGCTAAGCCC
ATTGACCTGGAGTCTATATTACTATCAATGGTGATATATGTTTGGATCCCAGCCCATATTTGGTCACTAGCCTACTACGC
TAGGGATGATTACAAGAGGGTTAACGTACCCATGCTACCCACCATGGTTAATGAGAAGGCAAGCGTAAGAATAATATCCA
TACTTAACCTAGTATCTATAATATACATGCTGGTGCTTTACCAATTATACATGGCTAAGTTAATAGGCTATATCCTAGTT
ATACCGGCTACACTTGCAGGAATCATAGTAACCATTAAGGCCCTTATTAAGCCGAGTAATGAATCCTTCAGGACAATGTT
CAAGGCCACGAGCCCAATCCTACTACTATTCCTACTAGCCGTAATAATATCAAGGATTTGA

Upstream 100 bases:

>100_bases
GAGTTCCTGGAGTACATTAGGCCATTTAGGCTTAATAAATTCCTCACATGAGTAATCTAATTCACCTATTTCAATCGAGT
AAGGTATTTTAATAACCCGC

Downstream 100 bases:

>100_bases
GGAAACGTGGATTTTAAAAAATGAATTTAAACTCAGTAACCCTCAGTAGCGTACTTATCAAGGAGTCTAATTCTCTTAGC
TGGATGCGGGTGATCTGAGA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MSVRRMINEYLKLMKPHVIWLLVLSALVGYIAAAGPLVNPIKLIELTVVGFLSTGGSAAFNMYYERDIDSLMVRTMKRPI
PSGKVTPLNALTFSIAVSLSGFTLSYLWLGSWVTLMIALGWFFYAVLYTIMLKRRTWLNIVIGGFAGNAALLSGWIMAKP
IDLESILLSMVIYVWIPAHIWSLAYYARDDYKRVNVPMLPTMVNEKASVRIISILNLVSIIYMLVLYQLYMAKLIGYILV
IPATLAGIIVTIKALIKPSNESFRTMFKATSPILLLFLLAVIISRI

Sequences:

>Translated_286_residues
MSVRRMINEYLKLMKPHVIWLLVLSALVGYIAAAGPLVNPIKLIELTVVGFLSTGGSAAFNMYYERDIDSLMVRTMKRPI
PSGKVTPLNALTFSIAVSLSGFTLSYLWLGSWVTLMIALGWFFYAVLYTIMLKRRTWLNIVIGGFAGNAALLSGWIMAKP
IDLESILLSMVIYVWIPAHIWSLAYYARDDYKRVNVPMLPTMVNEKASVRIISILNLVSIIYMLVLYQLYMAKLIGYILV
IPATLAGIIVTIKALIKPSNESFRTMFKATSPILLLFLLAVIISRI
>Mature_285_residues
SVRRMINEYLKLMKPHVIWLLVLSALVGYIAAAGPLVNPIKLIELTVVGFLSTGGSAAFNMYYERDIDSLMVRTMKRPIP
SGKVTPLNALTFSIAVSLSGFTLSYLWLGSWVTLMIALGWFFYAVLYTIMLKRRTWLNIVIGGFAGNAALLSGWIMAKPI
DLESILLSMVIYVWIPAHIWSLAYYARDDYKRVNVPMLPTMVNEKASVRIISILNLVSIIYMLVLYQLYMAKLIGYILVI
PATLAGIIVTIKALIKPSNESFRTMFKATSPILLLFLLAVIISRI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=190, Percent_Identity=29.4736842105263, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786631, Length=202, Percent_Identity=28.2178217821782, Blast_Score=85, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71998235, Length=225, Percent_Identity=27.1111111111111, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325085, Length=212, Percent_Identity=31.6037735849057, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19921064, Length=196, Percent_Identity=30.1020408163265, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32077; Mature: 31946

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRRMINEYLKLMKPHVIWLLVLSALVGYIAAAGPLVNPIKLIELTVVGFLSTGGSAAF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHH
NMYYERDIDSLMVRTMKRPIPSGKVTPLNALTFSIAVSLSGFTLSYLWLGSWVTLMIALG
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHH
WFFYAVLYTIMLKRRTWLNIVIGGFAGNAALLSGWIMAKPIDLESILLSMVIYVWIPAHI
HHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
WSLAYYARDDYKRVNVPMLPTMVNEKASVRIISILNLVSIIYMLVLYQLYMAKLIGYILV
HHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPATLAGIIVTIKALIKPSNESFRTMFKATSPILLLFLLAVIISRI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVRRMINEYLKLMKPHVIWLLVLSALVGYIAAAGPLVNPIKLIELTVVGFLSTGGSAAF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHH
NMYYERDIDSLMVRTMKRPIPSGKVTPLNALTFSIAVSLSGFTLSYLWLGSWVTLMIALG
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHH
WFFYAVLYTIMLKRRTWLNIVIGGFAGNAALLSGWIMAKPIDLESILLSMVIYVWIPAHI
HHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
WSLAYYARDDYKRVNVPMLPTMVNEKASVRIISILNLVSIIYMLVLYQLYMAKLIGYILV
HHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPATLAGIIVTIKALIKPSNESFRTMFKATSPILLLFLLAVIISRI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA