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The map label for this gene is cobB

Identifier: 159041025

GI number: 159041025

Start: 477235

End: 478008

Strand: Reverse

Name: cobB

Synonym: Cmaq_0442

Alternate gene names: 159041025

Gene position: 478008-477235 (Counterclockwise)

Preceding gene: 159041027

Following gene: 159041023

Centisome position: 23.01

GC content: 45.87

Gene sequence:

>774_bases
ATGGGTAATGGGGAATGCTTAGAAGGTGGTAGGAAGGCTGCAGTGATACTTACTAGCAGTAGACATGCGATAGCATTCAC
TGGCGCTGGTATAAGTACTGAAAGCGGTATACCAGACTTCAGGGGTCCTCAGGGTCTTTGGAGGAGGTTTGACCCAGCAT
TAGCATCCATTGATTACCTAAACACCGATCCCAAGGGCTTCTGGGAATTCTACATTGAGAGGTTCCGTGTACTTAATAAT
GCGAGACCCAATAAGGCTCACCTAGCGTTAGCTGAATTGGAGAAGCTAGGTATTATTAAGTACGTGATAACTCAGAACAT
TGATAATCTTCATCAATCAGCGGGATCAATCAATGTAATCGAGCTTCACGGTAACTACACAACCGTGTACTGCATGAGAT
GTAAGACCCAGTACCCGTTTACATTAGCCTTAAGAAAGTATGAGGAGGGTGAGAATCCTCCAAGGTGCCCAAAATGCGGT
GGAATCCTTAGACCCAATGTGGTTCTCTTCGGTGAACCAGTTAATGAGATTAATAGGGCTCTTGAGATAGCTGCCTTAAG
TGACGTAGCCCTGGTGGTTGGTTCATCATTAACGGTGTATCCTGCAGCCTACGTACCCCTCGTGGTTAAGGAGCATGGTG
GTAGATTAATAATCATTAACCTGGAACCCACTGATTACGATGACTACGCGGACGTGGTGCTGCATTGCAGTGCCTCGGAG
GCATTAGACCTAGTACTTAATGAGGTTAAAGGCATTATGGCGGCAGGTAATTAA

Upstream 100 bases:

>100_bases
TTAAAAGTGGGCTTAACCATGAGTTTTAGGTTAATTATAACGTATTAAAGTATTACCTAGCAATGAAATACTTAAATCAA
GGTAATCACCACTCATAATT

Downstream 100 bases:

>100_bases
TCCATGTTAGGGGACTTGGTTTAATTTGAGTTAGTTAAGGCATACTGAATCATCAGTAGGTTTGCTTAACGTACTTGCTT
TCCAGGTAATTAAGTAGGTG

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MGNGECLEGGRKAAVILTSSRHAIAFTGAGISTESGIPDFRGPQGLWRRFDPALASIDYLNTDPKGFWEFYIERFRVLNN
ARPNKAHLALAELEKLGIIKYVITQNIDNLHQSAGSINVIELHGNYTTVYCMRCKTQYPFTLALRKYEEGENPPRCPKCG
GILRPNVVLFGEPVNEINRALEIAALSDVALVVGSSLTVYPAAYVPLVVKEHGGRLIIINLEPTDYDDYADVVLHCSASE
ALDLVLNEVKGIMAAGN

Sequences:

>Translated_257_residues
MGNGECLEGGRKAAVILTSSRHAIAFTGAGISTESGIPDFRGPQGLWRRFDPALASIDYLNTDPKGFWEFYIERFRVLNN
ARPNKAHLALAELEKLGIIKYVITQNIDNLHQSAGSINVIELHGNYTTVYCMRCKTQYPFTLALRKYEEGENPPRCPKCG
GILRPNVVLFGEPVNEINRALEIAALSDVALVVGSSLTVYPAAYVPLVVKEHGGRLIIINLEPTDYDDYADVVLHCSASE
ALDLVLNEVKGIMAAGN
>Mature_256_residues
GNGECLEGGRKAAVILTSSRHAIAFTGAGISTESGIPDFRGPQGLWRRFDPALASIDYLNTDPKGFWEFYIERFRVLNNA
RPNKAHLALAELEKLGIIKYVITQNIDNLHQSAGSINVIELHGNYTTVYCMRCKTQYPFTLALRKYEEGENPPRCPKCGG
ILRPNVVLFGEPVNEINRALEIAALSDVALVVGSSLTVYPAAYVPLVVKEHGGRLIIINLEPTDYDDYADVVLHCSASEA
LDLVLNEVKGIMAAGN

Specific function: Modulates the activity of chromatin proteins, thereby having an effect on transcription

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain

Homologues:

Organism=Homo sapiens, GI300797577, Length=248, Percent_Identity=32.6612903225806, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI13787215, Length=256, Percent_Identity=36.71875, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI6912664, Length=256, Percent_Identity=36.71875, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI300795542, Length=248, Percent_Identity=35.8870967741936, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI6912662, Length=262, Percent_Identity=33.969465648855, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI300797597, Length=243, Percent_Identity=32.9218106995885, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI7657575, Length=227, Percent_Identity=34.8017621145374, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI7706712, Length=260, Percent_Identity=29.2307692307692, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI63054862, Length=204, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI6912660, Length=212, Percent_Identity=32.0754716981132, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI13775602, Length=197, Percent_Identity=31.9796954314721, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI13775600, Length=197, Percent_Identity=31.9796954314721, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI300797705, Length=191, Percent_Identity=31.413612565445, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI215982798, Length=177, Percent_Identity=33.8983050847458, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI308199517, Length=239, Percent_Identity=36.4016736401674, Blast_Score=120, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17541892, Length=217, Percent_Identity=32.258064516129, Blast_Score=113, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71990482, Length=272, Percent_Identity=29.0441176470588, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71990487, Length=274, Percent_Identity=28.8321167883212, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17567771, Length=274, Percent_Identity=29.1970802919708, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17505510, Length=221, Percent_Identity=28.9592760180996, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325242, Length=244, Percent_Identity=31.5573770491803, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6324599, Length=283, Percent_Identity=26.8551236749117, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320163, Length=263, Percent_Identity=24.7148288973384, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320397, Length=251, Percent_Identity=27.8884462151394, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324504, Length=245, Percent_Identity=25.7142857142857, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24645650, Length=255, Percent_Identity=30.5882352941176, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17137536, Length=226, Percent_Identity=31.4159292035398, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28571445, Length=260, Percent_Identity=31.5384615384615, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24648389, Length=195, Percent_Identity=31.2820512820513, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24650933, Length=254, Percent_Identity=28.3464566929134, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NPD_CALMQ (A8MBU4)

Other databases:

- EMBL:   CP000852
- RefSeq:   YP_001540277.1
- ProteinModelPortal:   A8MBU4
- SMR:   A8MBU4
- GeneID:   5709925
- GenomeReviews:   CP000852_GR
- KEGG:   cma:Cmaq_0442
- HOGENOM:   HBG641281
- OMA:   SSYTIAF
- ProtClustDB:   PRK00481
- BioCyc:   CMAQ397948:CMAQ_0442-MONOMER
- GO:   GO:0005737
- GO:   GO:0006350
- HAMAP:   MF_01121
- InterPro:   IPR003000
- PANTHER:   PTHR11085

Pfam domain/function: PF02146 SIR2

EC number: 3.5.1.- [C]

Molecular weight: Translated: 28162; Mature: 28030

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50305 SIRTUIN

Important sites: ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNGECLEGGRKAAVILTSSRHAIAFTGAGISTESGIPDFRGPQGLWRRFDPALASIDYL
CCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHCHHHHEEECC
NTDPKGFWEFYIERFRVLNNARPNKAHLALAELEKLGIIKYVITQNIDNLHQSAGSINVI
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEE
ELHGNYTTVYCMRCKTQYPFTLALRKYEEGENPPRCPKCGGILRPNVVLFGEPVNEINRA
EEECCEEEEEEEEECCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHH
LEIAALSDVALVVGSSLTVYPAAYVPLVVKEHGGRLIIINLEPTDYDDYADVVLHCSASE
HHHHHHHHHHHHHCCCEEEECHHEEEEEEEECCCEEEEEEECCCCCCCCEEEEEECCCHH
ALDLVLNEVKGIMAAGN
HHHHHHHHHHHHEECCC
>Mature Secondary Structure 
GNGECLEGGRKAAVILTSSRHAIAFTGAGISTESGIPDFRGPQGLWRRFDPALASIDYL
CCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHCHHHHEEECC
NTDPKGFWEFYIERFRVLNNARPNKAHLALAELEKLGIIKYVITQNIDNLHQSAGSINVI
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEE
ELHGNYTTVYCMRCKTQYPFTLALRKYEEGENPPRCPKCGGILRPNVVLFGEPVNEINRA
EEECCEEEEEEEEECCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHH
LEIAALSDVALVVGSSLTVYPAAYVPLVVKEHGGRLIIINLEPTDYDDYADVVLHCSASE
HHHHHHHHHHHHHCCCEEEECHHEEEEEEEECCCEEEEEEECCCCCCCCEEEEEECCCHH
ALDLVLNEVKGIMAAGN
HHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA