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The map label for this gene is hmgA [H]

Identifier: 159040995

GI number: 159040995

Start: 446894

End: 448126

Strand: Reverse

Name: hmgA [H]

Synonym: Cmaq_0412

Alternate gene names: 159040995

Gene position: 448126-446894 (Counterclockwise)

Preceding gene: 159040997

Following gene: 159040994

Centisome position: 21.57

GC content: 47.85

Gene sequence:

>1233_bases
ATGGAGCTTGAGGATGTGGTTAAAATGCTTGAGGAGGGTAAGGTTAAGATGCATGAGCTTGAGGGCCTGCTCAAGGATCC
TAACGCAGCCACTAGGGCTAGGAGGCTGTTCCTTGAGAGGAGGCTTGGTATTAAGCTTAATGCCATAGGTTCAACGGTAA
TTGACTTTAACCAGGTTTATGGTAGGAATACTGAGAACACCATTGGGGCTGTTCAAGTACCATTAGGCGTAGCTGGTCCG
CTTTTAGTTAAGGGGGTTTATGCTAATGGCTTATACTACGTACCCTTAGCCACAACTGAGGGTGCCTTGGTGGCTTCTGT
GAATAGGGGGGCTAAGGTTATTACTGAGAATGGTGGAGCCAGGAGTATTGTTGTTAAGGATGGTATGGCTAGGGCACCCT
TATTCAGATTACCCACAGCCACTGATGCTGTGGATTTCATTAATTGGATTAACACTAATATTGATAAGATTAGGGAGGTT
GCTGAGTCCAGTAGTAGGCATTTAAGGCTTAAGGAGATTCAACCATTCATAAATGGTAACAATGCATGGCTTAGATTAGT
CTTCAGTACTGGGGACGCCATGGGTATGAACATGGTTACCATAGCCTCTGAGAGAGTTGCGCAGTGGATTGAGGGTAATT
ACCCTAAGGCCAAGTTAATTACCGTTAGCGGTAACATGTGTGTTGATAAGAAGCCCAATGCAGTCAACTTCCTACTGGGT
AGGGGGAAGACGGTTATCAGTGAGGCCACTGTATCAAGGAGGTACCTAATGGAGCGCTTCAACATAACCCCGGAGGAGGT
TGTTAATGTTAATGTTAGGAAGAATCTACTTGGCTCAGCCTACGCCCACTCCTACGGCTTCAACGCCCACTTCGCAAACA
TAGTGGCGGCAATGTTCATAGCCACAGGTCAGGATGTGGCCCAGGTTGTTGAATCAAGCATGGGTATTACTTGGGCTGAG
GTTGATGATAATGGTGACTTATACGTTTCAGTAACGCTACCAAGCCTAGAGGTGGGTACTGTTGGTGGCGGTACTGGTTT
ACCAACCCAGAGGGAGGCATTGCAGATGCTTGGGGTGCAGGGGGGTGGTGATCCACCTGGCTCCAATGCATTAAAGCTTG
CTGAAATAATAGCCGCAGCGGTGCTTGCTGGTGAACTTAACTTACTCATTGCCCAGCATAGGAGGGAGTTGGGTAAGGCT
CATGAGAGGCTTGGTAGGGCTGGACGCACCTAA

Upstream 100 bases:

>100_bases
ATCTACGTTTACTTAGCTAACTTAAGAATAGGCTCGTATGAAACTCTCCTCAAGATGGGAGGGGTCATAAAGTTTAATAA
TTGAGTCTAGGTTTAAGGGC

Downstream 100 bases:

>100_bases
TGCAGTTAAGTTAGTTACATGGTTTCAGGTACCGGTAATATTAGTGTATTCTATTTTTAATACCGTGTAGTAAAATTTAA
TTGCATGCATTAGTAACCCC

Product: 3-hydroxy-3-methylglutaryl coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MELEDVVKMLEEGKVKMHELEGLLKDPNAATRARRLFLERRLGIKLNAIGSTVIDFNQVYGRNTENTIGAVQVPLGVAGP
LLVKGVYANGLYYVPLATTEGALVASVNRGAKVITENGGARSIVVKDGMARAPLFRLPTATDAVDFINWINTNIDKIREV
AESSSRHLRLKEIQPFINGNNAWLRLVFSTGDAMGMNMVTIASERVAQWIEGNYPKAKLITVSGNMCVDKKPNAVNFLLG
RGKTVISEATVSRRYLMERFNITPEEVVNVNVRKNLLGSAYAHSYGFNAHFANIVAAMFIATGQDVAQVVESSMGITWAE
VDDNGDLYVSVTLPSLEVGTVGGGTGLPTQREALQMLGVQGGGDPPGSNALKLAEIIAAAVLAGELNLLIAQHRRELGKA
HERLGRAGRT

Sequences:

>Translated_410_residues
MELEDVVKMLEEGKVKMHELEGLLKDPNAATRARRLFLERRLGIKLNAIGSTVIDFNQVYGRNTENTIGAVQVPLGVAGP
LLVKGVYANGLYYVPLATTEGALVASVNRGAKVITENGGARSIVVKDGMARAPLFRLPTATDAVDFINWINTNIDKIREV
AESSSRHLRLKEIQPFINGNNAWLRLVFSTGDAMGMNMVTIASERVAQWIEGNYPKAKLITVSGNMCVDKKPNAVNFLLG
RGKTVISEATVSRRYLMERFNITPEEVVNVNVRKNLLGSAYAHSYGFNAHFANIVAAMFIATGQDVAQVVESSMGITWAE
VDDNGDLYVSVTLPSLEVGTVGGGTGLPTQREALQMLGVQGGGDPPGSNALKLAEIIAAAVLAGELNLLIAQHRRELGKA
HERLGRAGRT
>Mature_410_residues
MELEDVVKMLEEGKVKMHELEGLLKDPNAATRARRLFLERRLGIKLNAIGSTVIDFNQVYGRNTENTIGAVQVPLGVAGP
LLVKGVYANGLYYVPLATTEGALVASVNRGAKVITENGGARSIVVKDGMARAPLFRLPTATDAVDFINWINTNIDKIREV
AESSSRHLRLKEIQPFINGNNAWLRLVFSTGDAMGMNMVTIASERVAQWIEGNYPKAKLITVSGNMCVDKKPNAVNFLLG
RGKTVISEATVSRRYLMERFNITPEEVVNVNVRKNLLGSAYAHSYGFNAHFANIVAAMFIATGQDVAQVVESSMGITWAE
VDDNGDLYVSVTLPSLEVGTVGGGTGLPTQREALQMLGVQGGGDPPGSNALKLAEIIAAAVLAGELNLLIAQHRRELGKA
HERLGRAGRT

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=405, Percent_Identity=42.2222222222222, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI196049380, Length=290, Percent_Identity=46.551724137931, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI25144592, Length=407, Percent_Identity=44.2260442260442, Blast_Score=312, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6323483, Length=426, Percent_Identity=40.6103286384976, Blast_Score=279, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6323565, Length=412, Percent_Identity=41.504854368932, Blast_Score=278, Evalue=1e-75,
Organism=Drosophila melanogaster, GI281362379, Length=418, Percent_Identity=43.3014354066986, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI45553469, Length=418, Percent_Identity=43.3014354066986, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24649399, Length=418, Percent_Identity=43.3014354066986, Blast_Score=290, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 44248; Mature: 44248

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS00318 HMG_COA_REDUCTASE_2 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELEDVVKMLEEGKVKMHELEGLLKDPNAATRARRLFLERRLGIKLNAIGSTVIDFNQVY
CCHHHHHHHHHCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECCCHHEEHHHHH
GRNTENTIGAVQVPLGVAGPLLVKGVYANGLYYVPLATTEGALVASVNRGAKVITENGGA
CCCCCCCCEEEEECCCCCCHHHHEEEECCCEEEEEEECCCCCEEEECCCCCEEEECCCCE
RSIVVKDGMARAPLFRLPTATDAVDFINWINTNIDKIREVAESSSRHLRLKEIQPFINGN
EEEEEECCCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHCHHCCEEHHHCCCEECCC
NAWLRLVFSTGDAMGMNMVTIASERVAQWIEGNYPKAKLITVSGNMCVDKKPNAVNFLLG
CEEEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCCCEEEEEEECCEEECCCCCEEEEEEC
RGKTVISEATVSRRYLMERFNITPEEVVNVNVRKNLLGSAYAHSYGFNAHFANIVAAMFI
CCCHHHHHHHHHHHHHHHHHCCCHHHHEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ATGQDVAQVVESSMGITWAEVDDNGDLYVSVTLPSLEVGTVGGGTGLPTQREALQMLGVQ
HCCHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCEEEECCCCCCCCCCHHHHHHHHCCC
GGGDPPGSNALKLAEIIAAAVLAGELNLLIAQHRRELGKAHERLGRAGRT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MELEDVVKMLEEGKVKMHELEGLLKDPNAATRARRLFLERRLGIKLNAIGSTVIDFNQVY
CCHHHHHHHHHCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECCCHHEEHHHHH
GRNTENTIGAVQVPLGVAGPLLVKGVYANGLYYVPLATTEGALVASVNRGAKVITENGGA
CCCCCCCCEEEEECCCCCCHHHHEEEECCCEEEEEEECCCCCEEEECCCCCEEEECCCCE
RSIVVKDGMARAPLFRLPTATDAVDFINWINTNIDKIREVAESSSRHLRLKEIQPFINGN
EEEEEECCCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHCHHCCEEHHHCCCEECCC
NAWLRLVFSTGDAMGMNMVTIASERVAQWIEGNYPKAKLITVSGNMCVDKKPNAVNFLLG
CEEEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCCCEEEEEEECCEEECCCCCEEEEEEC
RGKTVISEATVSRRYLMERFNITPEEVVNVNVRKNLLGSAYAHSYGFNAHFANIVAAMFI
CCCHHHHHHHHHHHHHHHHHCCCHHHHEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ATGQDVAQVVESSMGITWAEVDDNGDLYVSVTLPSLEVGTVGGGTGLPTQREALQMLGVQ
HCCHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCEEEECCCCCCCCCCHHHHHHHHCCC
GGGDPPGSNALKLAEIIAAAVLAGELNLLIAQHRRELGKAHERLGRAGRT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171410; 10701121; 11427726 [H]