Click here to switch to the map view.

The map label for this gene is htrA [H]

Identifier: 159040629

GI number: 159040629

Start: 52162

End: 53085

Strand: Reverse

Name: htrA [H]

Synonym: Cmaq_0037

Alternate gene names: 159040629

Gene position: 53085-52162 (Counterclockwise)

Preceding gene: 159040630

Following gene: 159040628

Centisome position: 2.56

GC content: 41.13

Gene sequence:

>924_bases
ATGTCAACTAATATTAAGGAACTAATCCCAAGCATAGTTAATAAGGTTAGTTCATCAATAGTTGCCATTGTGACTGCTGG
AGCGGTGGTGGATGAGTGGCTTAATGTAGTACCAGTTAGGGGTTTTGGGACAGGTTTTGCAGTGGATAAGCATTACGTAG
CCACGGCATCTCACGTGGTTTCTCAACTCGGTGAAGTCACCGTGGTTACAAGTGATGGTGACTTATTTGAATCAGAGTTA
GTTGGTGTGGATCCCGAGGTTGATACAGCAGTCCTTAGGGTTGAGGGTGAGCTTAACCCAATTAAACTGGGTGACTCTGA
TAAGTTAATGGTTGGTGAACCAGTAATTGCAATAGGTTATCCACTGGGTTTAATGAATCAACCCACCGCAACATTCGGCA
TAGTATCAGCCTTAGGTAGGACAATAAGGGCTGGTGAAGTAATGCTTGAGGGTTTAATTCAAACTGATGCGGCAATAAAC
CCAGGTAACTCAGGTGGACCATTAGTAAACCTGGATGGGGAGGTAGTGGGCATAAACACAGCTATAATAGCTGGAGCCCA
GAACATAGGCTTCGCTGTACCGATTAACTTAGCTAAATTATCAATAAGTGAATTAATAAGTAGGGGTGTTGTTGAGAAGC
CTAAGATAGGGATTTACGGTATTGATATTAATAAGATACTTGCAAGGCAGTATAAGTTACCGGTGGATAGAGGAGTATTA
GTGGTTTCTATTCAACCCTATTCACCTGCAGATGAGGCTGGTTTAAGGAGGGGTGATGTCATAACAAGTATAGATGATAT
TGAGTTATCATCAATAGTTAGGCTTAAGACATACCTATACAATAGGTATATTGAAGGTAAGAGGGAGTTTAAGCTAAGGG
TTGTTAGAGGTAGGAAATCAATGACGATTAATGTTTCACTTTAA

Upstream 100 bases:

>100_bases
AATCTCAAGATGAGTACATTAATTAGATTAAAGGAAGTATTAATTAAGTGATTTGGATGTTGAAATCAAGCTTTATAAGC
AGTGGTTAGAATGCGTTAAC

Downstream 100 bases:

>100_bases
ATACGCTACACGGCACTTAAGCTGGAAAAGTTTAATAAAGAAGAAGTTGAATAATTAGAGCATGCCTAATCAGGAGACTA
CTAAGGATTACCTAGAGGCC

Product: peptidase S1 and S6 chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSTNIKELIPSIVNKVSSSIVAIVTAGAVVDEWLNVVPVRGFGTGFAVDKHYVATASHVVSQLGEVTVVTSDGDLFESEL
VGVDPEVDTAVLRVEGELNPIKLGDSDKLMVGEPVIAIGYPLGLMNQPTATFGIVSALGRTIRAGEVMLEGLIQTDAAIN
PGNSGGPLVNLDGEVVGINTAIIAGAQNIGFAVPINLAKLSISELISRGVVEKPKIGIYGIDINKILARQYKLPVDRGVL
VVSIQPYSPADEAGLRRGDVITSIDDIELSSIVRLKTYLYNRYIEGKREFKLRVVRGRKSMTINVSL

Sequences:

>Translated_307_residues
MSTNIKELIPSIVNKVSSSIVAIVTAGAVVDEWLNVVPVRGFGTGFAVDKHYVATASHVVSQLGEVTVVTSDGDLFESEL
VGVDPEVDTAVLRVEGELNPIKLGDSDKLMVGEPVIAIGYPLGLMNQPTATFGIVSALGRTIRAGEVMLEGLIQTDAAIN
PGNSGGPLVNLDGEVVGINTAIIAGAQNIGFAVPINLAKLSISELISRGVVEKPKIGIYGIDINKILARQYKLPVDRGVL
VVSIQPYSPADEAGLRRGDVITSIDDIELSSIVRLKTYLYNRYIEGKREFKLRVVRGRKSMTINVSL
>Mature_306_residues
STNIKELIPSIVNKVSSSIVAIVTAGAVVDEWLNVVPVRGFGTGFAVDKHYVATASHVVSQLGEVTVVTSDGDLFESELV
GVDPEVDTAVLRVEGELNPIKLGDSDKLMVGEPVIAIGYPLGLMNQPTATFGIVSALGRTIRAGEVMLEGLIQTDAAINP
GNSGGPLVNLDGEVVGINTAIIAGAQNIGFAVPINLAKLSISELISRGVVEKPKIGIYGIDINKILARQYKLPVDRGVLV
VSIQPYSPADEAGLRRGDVITSIDDIELSSIVRLKTYLYNRYIEGKREFKLRVVRGRKSMTINVSL

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=251, Percent_Identity=39.0438247011952, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI7019477, Length=286, Percent_Identity=34.965034965035, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI24308541, Length=275, Percent_Identity=33.0909090909091, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI22129776, Length=245, Percent_Identity=36.3265306122449, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI1786356, Length=265, Percent_Identity=42.6415094339623, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1789629, Length=277, Percent_Identity=40.072202166065, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1789630, Length=304, Percent_Identity=33.2236842105263, Blast_Score=121, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24646839, Length=288, Percent_Identity=31.9444444444444, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 32687; Mature: 32556

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNIKELIPSIVNKVSSSIVAIVTAGAVVDEWLNVVPVRGFGTGFAVDKHYVATASHVV
CCCCHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHEEEECCCCCCCEECCHHHHHHHHHH
SQLGEVTVVTSDGDLFESELVGVDPEVDTAVLRVEGELNPIKLGDSDKLMVGEPVIAIGY
HHCCCEEEEECCCCCHHHHHCCCCCCCCEEEEEEECCCCEEEECCCCCEEECCCEEEEEC
PLGLMNQPTATFGIVSALGRTIRAGEVMLEGLIQTDAAINPGNSGGPLVNLDGEVVGINT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEEEE
AIIAGAQNIGFAVPINLAKLSISELISRGVVEKPKIGIYGIDINKILARQYKLPVDRGVL
EEEECCCCCCEEEECHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCEE
VVSIQPYSPADEAGLRRGDVITSIDDIELSSIVRLKTYLYNRYIEGKREFKLRVVRGRKS
EEEECCCCCCHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCE
MTINVSL
EEEEEEC
>Mature Secondary Structure 
STNIKELIPSIVNKVSSSIVAIVTAGAVVDEWLNVVPVRGFGTGFAVDKHYVATASHVV
CCCHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHEEEECCCCCCCEECCHHHHHHHHHH
SQLGEVTVVTSDGDLFESELVGVDPEVDTAVLRVEGELNPIKLGDSDKLMVGEPVIAIGY
HHCCCEEEEECCCCCHHHHHCCCCCCCCEEEEEEECCCCEEEECCCCCEEECCCEEEEEC
PLGLMNQPTATFGIVSALGRTIRAGEVMLEGLIQTDAAINPGNSGGPLVNLDGEVVGINT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEEEE
AIIAGAQNIGFAVPINLAKLSISELISRGVVEKPKIGIYGIDINKILARQYKLPVDRGVL
EEEECCCCCCEEEECHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCEE
VVSIQPYSPADEAGLRRGDVITSIDDIELSSIVRLKTYLYNRYIEGKREFKLRVVRGRKS
EEEECCCCCCHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCE
MTINVSL
EEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]