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The map label for this gene is cobW [H]

Identifier: 158425558

GI number: 158425558

Start: 4496572

End: 4497600

Strand: Direct

Name: cobW [H]

Synonym: AZC_3934

Alternate gene names: 158425558

Gene position: 4496572-4497600 (Clockwise)

Preceding gene: 158425557

Following gene: 158425559

Centisome position: 83.74

GC content: 69.48

Gene sequence:

>1029_bases
ATGACCTCGCTCATCCGCGTTCCCTGCACCATCGTCACCGGCTTCCTCGGTGCCGGAAAGACCACGCTCATCCGCCACCT
GCTGGAGAATGCCGGCGGCCGGAAGCTGGCCGTCATCGTCAACGAGTTCGGCGATGTGGGCATTGACGGCGAAATCCTCA
AAGGCTGCGGCATCGAGGCCTGCCCGGAGGACAATATCGTCGAGCTCTCCAACGGCTGCCTGTGCTGCACGGTGGCGGAC
GACTTCGTGCCCGCGCTGGACCAGATCCTCGCCCGCGAGGTGGACCACATCCTCATTGAGACCTCCGGCCTCGCGCTGCC
CAAGCCCCTCGTGCAGGCCTTCCAGTGGCCGGCCATCAAGAGCCGGGTGACGGTGGACGGCGTGGTGGCGGTGGTGGATG
GCCCGGCGCTGGCGGAAGGCCGCGTCGCCCATGACATGGACGCCCTCGACGCCCAGCGCGCCGCCGACGACAGCCTCGAC
CATGACGACCCGGTGGAAGAGGTGTTCCAGGACCAGATCGCCTGCGCCGATCTCGTCATCATCTCCAAATCCGACCTGCT
GGACGCCACCGCCGCCGAGACGGCTGGCGCGCGTGTCTCCGCCGCCCTCCCCCGTGCGGTGAGCGTGGTGCGCGCGGCCG
GCGGCAAGGTGGACCCGGGCGTGATGCTCGGCCTCGGCCTTGCGGTCGAGAACGAGATCGAGAACCGCAAGACCCATCAC
GATGACGAGCTCGATCACGACCACGACGATTTCGACAGCTTCGTCGTGGCGATCCCTGAGATCACCGATCCGGCGGCGCT
CGCCGCCCGCGTCACCGCCGCCGCCGAAGCCCCCGACGTGCTGCGCGTGAAGGGCTTTGCGGCGGTGGCCGGCAAGCCCC
TGCGCCTGCTGGTGCAGGGCGTCGGCCCGCGCGTGTCGCACCATTTCGACCGTCCTTGGAAGGCGGAGGAAGCCCGGCGC
GGCGCCCTCGTGGTGATTGGCCTCAAGGGCTTCGACCGCGCGGCGGTGGAGCGGGCGCTGCTCGGCTGA

Upstream 100 bases:

>100_bases
GCCGTGGCGGGGCCGGCCCGACGCGCTGAAGCGCGGCATGGTGGCCCGCATCCCGCCGCTGGCGCCGCCCGCCGCCTGAC
CTCATGTTTCCGGAGCTTTC

Downstream 100 bases:

>100_bases
TCCATGCACATCCTCGCCACCACATCGGCCAGCATCGAGGACCTCGCGGAGCCCGTGGATCTCCGCCTGCCTCCGGCCGA
GGTGGTGGCGCTGTCCTTCA

Product: cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MTSLIRVPCTIVTGFLGAGKTTLIRHLLENAGGRKLAVIVNEFGDVGIDGEILKGCGIEACPEDNIVELSNGCLCCTVAD
DFVPALDQILAREVDHILIETSGLALPKPLVQAFQWPAIKSRVTVDGVVAVVDGPALAEGRVAHDMDALDAQRAADDSLD
HDDPVEEVFQDQIACADLVIISKSDLLDATAAETAGARVSAALPRAVSVVRAAGGKVDPGVMLGLGLAVENEIENRKTHH
DDELDHDHDDFDSFVVAIPEITDPAALAARVTAAAEAPDVLRVKGFAAVAGKPLRLLVQGVGPRVSHHFDRPWKAEEARR
GALVVIGLKGFDRAAVERALLG

Sequences:

>Translated_342_residues
MTSLIRVPCTIVTGFLGAGKTTLIRHLLENAGGRKLAVIVNEFGDVGIDGEILKGCGIEACPEDNIVELSNGCLCCTVAD
DFVPALDQILAREVDHILIETSGLALPKPLVQAFQWPAIKSRVTVDGVVAVVDGPALAEGRVAHDMDALDAQRAADDSLD
HDDPVEEVFQDQIACADLVIISKSDLLDATAAETAGARVSAALPRAVSVVRAAGGKVDPGVMLGLGLAVENEIENRKTHH
DDELDHDHDDFDSFVVAIPEITDPAALAARVTAAAEAPDVLRVKGFAAVAGKPLRLLVQGVGPRVSHHFDRPWKAEEARR
GALVVIGLKGFDRAAVERALLG
>Mature_341_residues
TSLIRVPCTIVTGFLGAGKTTLIRHLLENAGGRKLAVIVNEFGDVGIDGEILKGCGIEACPEDNIVELSNGCLCCTVADD
FVPALDQILAREVDHILIETSGLALPKPLVQAFQWPAIKSRVTVDGVVAVVDGPALAEGRVAHDMDALDAQRAADDSLDH
DDPVEEVFQDQIACADLVIISKSDLLDATAAETAGARVSAALPRAVSVVRAAGGKVDPGVMLGLGLAVENEIENRKTHHD
DELDHDHDDFDSFVVAIPEITDPAALAARVTAAAEAPDVLRVKGFAAVAGKPLRLLVQGVGPRVSHHFDRPWKAEEARRG
ALVVIGLKGFDRAAVERALLG

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=361, Percent_Identity=24.6537396121884, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI126722884, Length=363, Percent_Identity=25.6198347107438, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI223941779, Length=353, Percent_Identity=24.929178470255, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI148727351, Length=362, Percent_Identity=25.414364640884, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI146231952, Length=364, Percent_Identity=25.5494505494505, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI119120938, Length=133, Percent_Identity=37.593984962406, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI223941776, Length=338, Percent_Identity=25.4437869822485, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI87082430, Length=334, Percent_Identity=31.1377245508982, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788499, Length=211, Percent_Identity=30.8056872037915, Blast_Score=88, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=199, Percent_Identity=34.1708542713568, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 36042; Mature: 35911

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLIRVPCTIVTGFLGAGKTTLIRHLLENAGGRKLAVIVNEFGDVGIDGEILKGCGIEA
CCCEEECCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHCCCCCC
CPEDNIVELSNGCLCCTVADDFVPALDQILAREVDHILIETSGLALPKPLVQAFQWPAIK
CCCCCEEEECCCEEEEEECHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHCCCCCC
SRVTVDGVVAVVDGPALAEGRVAHDMDALDAQRAADDSLDHDDPVEEVFQDQIACADLVI
CCEEECEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEE
ISKSDLLDATAAETAGARVSAALPRAVSVVRAAGGKVDPGVMLGLGLAVENEIENRKTHH
EECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHCCCCC
DDELDHDHDDFDSFVVAIPEITDPAALAARVTAAAEAPDVLRVKGFAAVAGKPLRLLVQG
CCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCHHHHCCCCHHHHHHC
VGPRVSHHFDRPWKAEEARRGALVVIGLKGFDRAAVERALLG
CCCHHHHCCCCCCCHHHHCCCCEEEEEECCCCHHHHHHHHCC
>Mature Secondary Structure 
TSLIRVPCTIVTGFLGAGKTTLIRHLLENAGGRKLAVIVNEFGDVGIDGEILKGCGIEA
CCEEECCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHCCCCCC
CPEDNIVELSNGCLCCTVADDFVPALDQILAREVDHILIETSGLALPKPLVQAFQWPAIK
CCCCCEEEECCCEEEEEECHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHCCCCCC
SRVTVDGVVAVVDGPALAEGRVAHDMDALDAQRAADDSLDHDDPVEEVFQDQIACADLVI
CCEEECEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEE
ISKSDLLDATAAETAGARVSAALPRAVSVVRAAGGKVDPGVMLGLGLAVENEIENRKTHH
EECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHCCCCC
DDELDHDHDDFDSFVVAIPEITDPAALAARVTAAAEAPDVLRVKGFAAVAGKPLRLLVQG
CCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCHHHHCCCCHHHHHHC
VGPRVSHHFDRPWKAEEARRGALVVIGLKGFDRAAVERALLG
CCCHHHHCCCCCCCHHHHCCCCEEEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]