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The map label for this gene is hlyD [H]

Identifier: 158425535

GI number: 158425535

Start: 4469861

End: 4471165

Strand: Reverse

Name: hlyD [H]

Synonym: AZC_3911

Alternate gene names: 158425535

Gene position: 4471165-4469861 (Counterclockwise)

Preceding gene: 158425536

Following gene: 158425534

Centisome position: 83.27

GC content: 66.28

Gene sequence:

>1305_bases
TTGCAGGAAGCTGTGCTATCGACCGTTCCCGAAGGAATGGCTCGTCAGTTGCGGGAGGCGTCGTTCCGAGAAATTGACCG
CCCCTCGCGGCGCTCTGTTGGAGCTCCCTTGATGTTTGTGTTGCCCCGCCTTCCGCTCAAGGCTCTCGGTGCAGTCTCCC
TTCTTTCGCTTGCCGCCTGTGGCCAGCCGCAGCAGCAGCAGGGTGGCCCGCCGCCGCCTCCGGCCGTGACGGTCGCCAAG
CCGCAGCCCAGGACGATCACCGACTATGATGAGTATGTCGGCCGTTTCGTGGCGATGGATGAGGTGAACGTGCACGCCCG
CGTGTCCGGCTATCTCTCGGAGATCCAGTTCACCGACGGCCAGCTGGTGAAGAAGGGCGATCCGCTGTTCACGCTCGACC
AGCGCCCGTTCAAGATCGCGCTCGATCAGGCGAAGGCGAACCTCGCCCAGGCGCAGGCCAATCTCGATTATGCGCAGACC
GACCTTGAGCGCGCCAAGACGCTGCTCCAGGACCGCAATTCGACGGCCATCTCCAAGCAGACCTTCGACCAGCGCACCCA
GACCGAGCGGACCGCCGCCGCCACGCTCCAGGCGCAGGAAGCTGCCGTGGCCTCGGCCCAGCTCGATCTCGAGTTCACGC
AGCTCACTGCACCCATCTCCGGCCGCATCGGCGACCGGCGCGTGTCGGTGGGCAACTATGTGATCGGCGCCAGTGCCGGC
ACGCCGACCCTGCTCGCGGTGATCGTGTCGCAGGATCCGATCCGCTTCGAGTTCACCTTCGATGAAGGCTCGCTGCTGCG
CTACAAGAACAGCGGCACGGGCGCCAACGACGGCGCGCCGGTGGACCTCAAGCTGCTGGACGAGAAGACCTTTGCCCATC
ACGGCAAGATGGACTTCCTGAACAACGTGGTGGACACCGCCACCGGCACCATCCGCGGCCGTGCCGTGTTCGCCAATCCG
GACGGCCTGTTCAAGCCGGGCATGTTCGCCCGCATCCGCGTGGCCGCCAGCAAGCCCTATGAGGCACTGACCGTTCCCGA
TACCGCCATCGGCACCGAGCAGGTGCGCAAGTTCGTCTATGTGGTCGGCCCCGAGAACACGATCGCCATGAAGTTCGTGG
AGCTTGGCCCGGTGGTGGACGGCCGCCGCGCGGTGAAGTCCGGCCTCACGGCGGACGATGTGGTGGTGGTGAACGGCCTG
ATGCGCGTGCGTCCGGGCGTCAAGGTGACGCCGCAGGAAGAAAAGCCCGCTGCTCCGGCTCCCGCCGGCGCCCAGAACGG
TAACGCCGCCGCCCCGGCGAAGTGA

Upstream 100 bases:

>100_bases
TGCGGCATTTCTGGGCAAGGGCTTCGTGCTGGGCCTGGCCGGCCGCCGCCGCACCTGAGACCGGCGTTCCGCATCTGATG
CGCCCGCGGGGCATTTTGCA

Downstream 100 bases:

>100_bases
GGAGCGATCCCCCATGCGCTTCTCTCATTTCTTCATTGACCGGCCGATCTTCGCCTTCGTCATCTCCATCGTGGTGATGC
TGCTGGGCGGTGTGTCCTAT

Product: secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MQEAVLSTVPEGMARQLREASFREIDRPSRRSVGAPLMFVLPRLPLKALGAVSLLSLAACGQPQQQQGGPPPPPAVTVAK
PQPRTITDYDEYVGRFVAMDEVNVHARVSGYLSEIQFTDGQLVKKGDPLFTLDQRPFKIALDQAKANLAQAQANLDYAQT
DLERAKTLLQDRNSTAISKQTFDQRTQTERTAAATLQAQEAAVASAQLDLEFTQLTAPISGRIGDRRVSVGNYVIGASAG
TPTLLAVIVSQDPIRFEFTFDEGSLLRYKNSGTGANDGAPVDLKLLDEKTFAHHGKMDFLNNVVDTATGTIRGRAVFANP
DGLFKPGMFARIRVAASKPYEALTVPDTAIGTEQVRKFVYVVGPENTIAMKFVELGPVVDGRRAVKSGLTADDVVVVNGL
MRVRPGVKVTPQEEKPAAPAPAGAQNGNAAAPAK

Sequences:

>Translated_434_residues
MQEAVLSTVPEGMARQLREASFREIDRPSRRSVGAPLMFVLPRLPLKALGAVSLLSLAACGQPQQQQGGPPPPPAVTVAK
PQPRTITDYDEYVGRFVAMDEVNVHARVSGYLSEIQFTDGQLVKKGDPLFTLDQRPFKIALDQAKANLAQAQANLDYAQT
DLERAKTLLQDRNSTAISKQTFDQRTQTERTAAATLQAQEAAVASAQLDLEFTQLTAPISGRIGDRRVSVGNYVIGASAG
TPTLLAVIVSQDPIRFEFTFDEGSLLRYKNSGTGANDGAPVDLKLLDEKTFAHHGKMDFLNNVVDTATGTIRGRAVFANP
DGLFKPGMFARIRVAASKPYEALTVPDTAIGTEQVRKFVYVVGPENTIAMKFVELGPVVDGRRAVKSGLTADDVVVVNGL
MRVRPGVKVTPQEEKPAAPAPAGAQNGNAAAPAK
>Mature_434_residues
MQEAVLSTVPEGMARQLREASFREIDRPSRRSVGAPLMFVLPRLPLKALGAVSLLSLAACGQPQQQQGGPPPPPAVTVAK
PQPRTITDYDEYVGRFVAMDEVNVHARVSGYLSEIQFTDGQLVKKGDPLFTLDQRPFKIALDQAKANLAQAQANLDYAQT
DLERAKTLLQDRNSTAISKQTFDQRTQTERTAAATLQAQEAAVASAQLDLEFTQLTAPISGRIGDRRVSVGNYVIGASAG
TPTLLAVIVSQDPIRFEFTFDEGSLLRYKNSGTGANDGAPVDLKLLDEKTFAHHGKMDFLNNVVDTATGTIRGRAVFANP
DGLFKPGMFARIRVAASKPYEALTVPDTAIGTEQVRKFVYVVGPENTIAMKFVELGPVVDGRRAVKSGLTADDVVVVNGL
MRVRPGVKVTPQEEKPAAPAPAGAQNGNAAAPAK

Specific function: May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=353, Percent_Identity=32.2946175637394, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1786668, Length=366, Percent_Identity=35.2459016393443, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789929, Length=386, Percent_Identity=29.0155440414508, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1789665, Length=390, Percent_Identity=30, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI87081951, Length=196, Percent_Identity=31.6326530612245, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789637, Length=145, Percent_Identity=32.4137931034483, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 46560; Mature: 46560

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEAVLSTVPEGMARQLREASFREIDRPSRRSVGAPLMFVLPRLPLKALGAVSLLSLAAC
CCCHHHHHCCHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHC
GQPQQQQGGPPPPPAVTVAKPQPRTITDYDEYVGRFVAMDEVNVHARVSGYLSEIQFTDG
CCCHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHEEEEECCCEEEEHHHHHHHEEECCC
QLVKKGDPLFTLDQRPFKIALDQAKANLAQAQANLDYAQTDLERAKTLLQDRNSTAISKQ
CEEECCCCEEEECCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHH
TFDQRTQTERTAAATLQAQEAAVASAQLDLEFTQLTAPISGRIGDRRVSVGNYVIGASAG
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCEEEEECCEEEECCCC
TPTLLAVIVSQDPIRFEFTFDEGSLLRYKNSGTGANDGAPVDLKLLDEKTFAHHGKMDFL
CCEEEEEEECCCCEEEEEEECCCCEEEEECCCCCCCCCCCEEEEEECCHHHHHCCCHHHH
NNVVDTATGTIRGRAVFANPDGLFKPGMFARIRVAASKPYEALTVPDTAIGTEQVRKFVY
HHHHHHCCCCEECCEEEECCCCCCCCCCEEEEEEECCCCCCEEECCCCCCCHHHHCEEEE
VVGPENTIAMKFVELGPVVDGRRAVKSGLTADDVVVVNGLMRVRPGVKVTPQEEKPAAPA
EECCCCEEEEEEEECCCCCCCHHHHHCCCCCCCCCEEHHHHHHCCCCEECCCCCCCCCCC
PAGAQNGNAAAPAK
CCCCCCCCCCCCCC
>Mature Secondary Structure
MQEAVLSTVPEGMARQLREASFREIDRPSRRSVGAPLMFVLPRLPLKALGAVSLLSLAAC
CCCHHHHHCCHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHC
GQPQQQQGGPPPPPAVTVAKPQPRTITDYDEYVGRFVAMDEVNVHARVSGYLSEIQFTDG
CCCHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHEEEEECCCEEEEHHHHHHHEEECCC
QLVKKGDPLFTLDQRPFKIALDQAKANLAQAQANLDYAQTDLERAKTLLQDRNSTAISKQ
CEEECCCCEEEECCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHH
TFDQRTQTERTAAATLQAQEAAVASAQLDLEFTQLTAPISGRIGDRRVSVGNYVIGASAG
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCEEEEECCEEEECCCC
TPTLLAVIVSQDPIRFEFTFDEGSLLRYKNSGTGANDGAPVDLKLLDEKTFAHHGKMDFL
CCEEEEEEECCCCEEEEEEECCCCEEEEECCCCCCCCCCCEEEEEECCHHHHHCCCHHHH
NNVVDTATGTIRGRAVFANPDGLFKPGMFARIRVAASKPYEALTVPDTAIGTEQVRKFVY
HHHHHHCCCCEECCEEEECCCCCCCCCCEEEEEEECCCCCCEEECCCCCCCHHHHCEEEE
VVGPENTIAMKFVELGPVVDGRRAVKSGLTADDVVVVNGLMRVRPGVKVTPQEEKPAAPA
EECCCCEEEEEEEECCCCCCCHHHHHCCCCCCCCCEEHHHHHHCCCCEECCCCCCCCCCC
PAGAQNGNAAAPAK
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12271122 [H]