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The map label for this gene is lysR [H]

Identifier: 158425493

GI number: 158425493

Start: 4420111

End: 4421007

Strand: Reverse

Name: lysR [H]

Synonym: AZC_3869

Alternate gene names: 158425493

Gene position: 4421007-4420111 (Counterclockwise)

Preceding gene: 158425502

Following gene: 158425480

Centisome position: 82.33

GC content: 55.07

Gene sequence:

>897_bases
ATGCGTTTCAGTCATGTGGCCGCTTTCCGGGCAGTCATGCTTTCCGGCTCCATGACCATGGCAGCCCATGAGCTGAACAC
CAGCCAGCCCAATGTCAGTCGCCTGATCACTCAGCTCGAGAAAGACACGGGCTTGAAGCTCTTTTCGCGCATGGCGGGGC
GGCTCCAAGCGACACCCGAAGCACACGCCTTTTATCGCGATGTTGAGCGCGCCTATGTGGGGCTTGCTGACTTGGAACAA
TCCGCCCAAACCATCCGCAAGCTTGGCACGGGGCATTTGCGTGTGGGGGCCGTGCCATCGATGGGTCTCACCGTGCTGCC
CGGCATCATGCGCGACTTCGCAGCCGTTCATCCGGCGGTTCGAATTTCGGTCCACTTCGGAGATTCCGTCACGGTCGCAC
AATGGACGGCGTCGCGCTTCTGCGACATCGGCATCACATCTTACATTTCGGACGCGATCGGCGTCGAAGCGGATCTTGCC
CTGAAGATGGATGGCGTCTGCATCGTACCACCAAAGCACCGACTCGCCCGGCGCCGCACCCCACTTCAGCCCAAGGATCT
CGCCGGCGAACCGTTCATCTCACTCTCTCACGGCGACCGGCGACATATTGATTCGGTTTTCACAAGAGGTGGAGAAGACA
AACGCGACCTAGCCCATGAGTGCCAGTACGCGGCAGTGATTTGCAGTATGGTCGGTAATGGAATGGGATTGAGCATTGTT
AATCCTATTGTCGCTGATTTCTATAAACACACCGGCATATCCGTTCATGAATTTGAACCAAGCATTCAATTCATGTCATA
CATACTGACGCCATTGCGCTACGCGAAAAGCGAGCTAACTAGCGAATTTTCTGCCATGATTAAGAATCATATTTCAGATG
CGCTAGGTCTAATATGA

Upstream 100 bases:

>100_bases
TGCTCGTTCATGCCGGCAAATGAGAAGATCGCCCATAGGTATGCAAAAATGATATGATAACAGCTGACCAGCTTTAGCCC
GTGCGGACGAGGGGGAGAGG

Downstream 100 bases:

>100_bases
AATTAAATCGGAAATATAATATCTTTTTTGTCGCAGAATAATTTTATGATTTAAATCGATATACTACATGAGTGAACGCA
ATTTATATTTTCCGGCATCA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MRFSHVAAFRAVMLSGSMTMAAHELNTSQPNVSRLITQLEKDTGLKLFSRMAGRLQATPEAHAFYRDVERAYVGLADLEQ
SAQTIRKLGTGHLRVGAVPSMGLTVLPGIMRDFAAVHPAVRISVHFGDSVTVAQWTASRFCDIGITSYISDAIGVEADLA
LKMDGVCIVPPKHRLARRRTPLQPKDLAGEPFISLSHGDRRHIDSVFTRGGEDKRDLAHECQYAAVICSMVGNGMGLSIV
NPIVADFYKHTGISVHEFEPSIQFMSYILTPLRYAKSELTSEFSAMIKNHISDALGLI

Sequences:

>Translated_298_residues
MRFSHVAAFRAVMLSGSMTMAAHELNTSQPNVSRLITQLEKDTGLKLFSRMAGRLQATPEAHAFYRDVERAYVGLADLEQ
SAQTIRKLGTGHLRVGAVPSMGLTVLPGIMRDFAAVHPAVRISVHFGDSVTVAQWTASRFCDIGITSYISDAIGVEADLA
LKMDGVCIVPPKHRLARRRTPLQPKDLAGEPFISLSHGDRRHIDSVFTRGGEDKRDLAHECQYAAVICSMVGNGMGLSIV
NPIVADFYKHTGISVHEFEPSIQFMSYILTPLRYAKSELTSEFSAMIKNHISDALGLI
>Mature_298_residues
MRFSHVAAFRAVMLSGSMTMAAHELNTSQPNVSRLITQLEKDTGLKLFSRMAGRLQATPEAHAFYRDVERAYVGLADLEQ
SAQTIRKLGTGHLRVGAVPSMGLTVLPGIMRDFAAVHPAVRISVHFGDSVTVAQWTASRFCDIGITSYISDAIGVEADLA
LKMDGVCIVPPKHRLARRRTPLQPKDLAGEPFISLSHGDRRHIDSVFTRGGEDKRDLAHECQYAAVICSMVGNGMGLSIV
NPIVADFYKHTGISVHEFEPSIQFMSYILTPLRYAKSELTSEFSAMIKNHISDALGLI

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=290, Percent_Identity=35.1724137931034, Blast_Score=187, Evalue=7e-49,
Organism=Escherichia coli, GI1787530, Length=237, Percent_Identity=23.6286919831224, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788481, Length=242, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788296, Length=245, Percent_Identity=27.3469387755102, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32666; Mature: 32666

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFSHVAAFRAVMLSGSMTMAAHELNTSQPNVSRLITQLEKDTGLKLFSRMAGRLQATPE
CCCHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCH
AHAFYRDVERAYVGLADLEQSAQTIRKLGTGHLRVGAVPSMGLTVLPGIMRDFAAVHPAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHCCEE
RISVHFGDSVTVAQWTASRFCDIGITSYISDAIGVEADLALKMDGVCIVPPKHRLARRRT
EEEEEECCCEEEHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCEEEECCHHHHHHCCC
PLQPKDLAGEPFISLSHGDRRHIDSVFTRGGEDKRDLAHECQYAAVICSMVGNGMGLSIV
CCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
NPIVADFYKHTGISVHEFEPSIQFMSYILTPLRYAKSELTSEFSAMIKNHISDALGLI
HHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRFSHVAAFRAVMLSGSMTMAAHELNTSQPNVSRLITQLEKDTGLKLFSRMAGRLQATPE
CCCHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCH
AHAFYRDVERAYVGLADLEQSAQTIRKLGTGHLRVGAVPSMGLTVLPGIMRDFAAVHPAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHCCEE
RISVHFGDSVTVAQWTASRFCDIGITSYISDAIGVEADLALKMDGVCIVPPKHRLARRRT
EEEEEECCCEEEHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCEEEECCHHHHHHCCC
PLQPKDLAGEPFISLSHGDRRHIDSVFTRGGEDKRDLAHECQYAAVICSMVGNGMGLSIV
CCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
NPIVADFYKHTGISVHEFEPSIQFMSYILTPLRYAKSELTSEFSAMIKNHISDALGLI
HHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]