Click here to switch to the map view.

The map label for this gene is ilvD [H]

Identifier: 158425376

GI number: 158425376

Start: 4304065

End: 4305879

Strand: Reverse

Name: ilvD [H]

Synonym: AZC_3752

Alternate gene names: 158425376

Gene position: 4305879-4304065 (Counterclockwise)

Preceding gene: 158425377

Following gene: 158425375

Centisome position: 80.19

GC content: 66.72

Gene sequence:

>1815_bases
ATGGTCGGTCAAGGGGATCAGCCGGAAAATCACGGCCGCAAGCTGCGCTCGCAGCTCTGGTTCGACAATCCGGACAATCC
GGGCATGACCGCGCTCTATCTCGAGCGGTATCTGAACTTCGGCCTGACCCGCGAGGAGCTCCAGTCCGGCAAGCCGATCA
TCGGCATCGCCCAGACCGGCTCCGACCTCTCTCCCTGCAACCGCCATCACCTCGACCTTGCCAAGCGCGTGCGCGAGGGC
ATCGCGGCGGCGGGCGGCATTCCCTTTGAATTTCCGGTCCATCCCATCCAGGAAACCGGCAAGCGGCCCACAGCCGCCCT
CGACCGGAACCTTGCCTATCTCGGCCTTGTCGAGGTGCTCTACGGCTATCCGCTCGACGGCGTCGTGCTGACCACCGGCT
GCGACAAGACGACACCCGCCTGCATCATGGCGGCGGCCACCGTGAACATCCCCGCCATCGTGCTCTCCGGCGGCCCCATG
CTGAACGGCTGGTGGAACGGCGAGCGCACCGGCTCCGGCACCGTGGTGTGGAAGGCCCGCGCCCAGCATGCGGCGGGCGA
GATCGACTACGACACCTTCATGGAGATCGTGGCGTCCTCCGCCCCCTCCGTCGGCCATTGCAACACCATGGGCACGGCCT
CCACCATGAACGGCCTTGCCGAGGCGCTGGGCATGTCGCTGCCGGGCTGCGCGGCCATTCCCGCCCCCTATCGCGAGCGC
GGTCAGATTTCCTATGAGACCGGCAAGCGCATCGTGGACATGGTGTGGGAGGATCTGAAGCCTTCCGATATCCTGACCCG
TGAAGCGTTCGAGAACGCCATCCGCGTCAATTCGGCCATCGGCGGCTCCACGAACGCCCCCATCCATCTCAATGCCATCG
CCCGCCACGTGGGCGTGTCGCTGACCGTCGATGACTGGCAGGCGGTGGGCCACAAGATCCCGCTGCTCGTGAACCTTCAA
CCGGCGGGCGAATATCTAGGCGAGGAATTCCACCGCGCCGGCGGCATTCCCGCCGTGGTGGCCGAACTGATCCAGGCCGG
CCAGATCCATGAGGGCGCGCTCACGGTGAACGGCCGCAGCATCGGCGAGAACTGCCGCGGCAAGTTCTCCTGGGATCGCG
ACGTGATCCGCGCCTATGACGCGCCCATGAAGGCGGACGCCGGCTTCATCGTGCTGCGCGGCAATCTGTTCGAGAACGCC
ATCATGAAGACCTCGGTGATCTCCGAGGAGTTCCGCGCCCGCTTCCTGTCCGATCCGAAGGACCCCAACGCCTTCGAGGG
ACCGGCCGTGGTGTTCGAGGGGCCGGAGGACTACCACCACCGCATCGATGATCCGGCGCTGGGCATCGACGAGCACACGC
TGCTCTTCATCCGCGGCACCGGGCCCATCGGTTATCCCGGTGGCGCCGAGGTGGTGAACATGCAGCCGCCGGCCGCCCTC
ATCAAGCGCGGGGTCAATGCGCTGCCCTGCATCGGCGATGGCCGCCAGTCGGGCACGTCTGGTTCGCCCTCCATCCTCAA
CGCCTCGCCGGAAGCGGCGGCGGGCGGCGGCCTCGCCCTGCTGAAGACCGGCGACCGGGTGCGCATCGACCTGGAGAAGG
GCACCGCGGACATCCTGATTTCGGATGAGGAACTGGCGCAGCGCCGGGCCGCCCTTGAGGCCAATGGCGGCTTCCCCATT
CCGCAGAGCCAAACTCCCTGGCAGGAGATCCAGCGCTCCATGGTCGCCCAGTTCGATGAGGGCATGGTTCTGAAGCCGGC
CGTGAAGTATCAGCGGGTGGCGCAGACGATGGGCGTTCCGCGCGACAACCACTAG

Upstream 100 bases:

>100_bases
CTCTCCAGCCTGATTGATTTCGCGGCCCGCGAGGCGCATAAAGCGGCGATCAAATCGTTTCAAATGCCGCCGCAAGACGC
GCTTCGCCTGGGAGAAAACC

Downstream 100 bases:

>100_bases
GGTCCTGCCATGACTGGGGAAGCCGCCGCCGAGGATCAGGTTCTGGGGGCGCCCGTCAGCGGTCCGCCCGCGCGCCGCCC
GGCGCGCGTGGCGCTGGAAG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MVGQGDQPENHGRKLRSQLWFDNPDNPGMTALYLERYLNFGLTREELQSGKPIIGIAQTGSDLSPCNRHHLDLAKRVREG
IAAAGGIPFEFPVHPIQETGKRPTAALDRNLAYLGLVEVLYGYPLDGVVLTTGCDKTTPACIMAAATVNIPAIVLSGGPM
LNGWWNGERTGSGTVVWKARAQHAAGEIDYDTFMEIVASSAPSVGHCNTMGTASTMNGLAEALGMSLPGCAAIPAPYRER
GQISYETGKRIVDMVWEDLKPSDILTREAFENAIRVNSAIGGSTNAPIHLNAIARHVGVSLTVDDWQAVGHKIPLLVNLQ
PAGEYLGEEFHRAGGIPAVVAELIQAGQIHEGALTVNGRSIGENCRGKFSWDRDVIRAYDAPMKADAGFIVLRGNLFENA
IMKTSVISEEFRARFLSDPKDPNAFEGPAVVFEGPEDYHHRIDDPALGIDEHTLLFIRGTGPIGYPGGAEVVNMQPPAAL
IKRGVNALPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRIDLEKGTADILISDEELAQRRAALEANGGFPI
PQSQTPWQEIQRSMVAQFDEGMVLKPAVKYQRVAQTMGVPRDNH

Sequences:

>Translated_604_residues
MVGQGDQPENHGRKLRSQLWFDNPDNPGMTALYLERYLNFGLTREELQSGKPIIGIAQTGSDLSPCNRHHLDLAKRVREG
IAAAGGIPFEFPVHPIQETGKRPTAALDRNLAYLGLVEVLYGYPLDGVVLTTGCDKTTPACIMAAATVNIPAIVLSGGPM
LNGWWNGERTGSGTVVWKARAQHAAGEIDYDTFMEIVASSAPSVGHCNTMGTASTMNGLAEALGMSLPGCAAIPAPYRER
GQISYETGKRIVDMVWEDLKPSDILTREAFENAIRVNSAIGGSTNAPIHLNAIARHVGVSLTVDDWQAVGHKIPLLVNLQ
PAGEYLGEEFHRAGGIPAVVAELIQAGQIHEGALTVNGRSIGENCRGKFSWDRDVIRAYDAPMKADAGFIVLRGNLFENA
IMKTSVISEEFRARFLSDPKDPNAFEGPAVVFEGPEDYHHRIDDPALGIDEHTLLFIRGTGPIGYPGGAEVVNMQPPAAL
IKRGVNALPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRIDLEKGTADILISDEELAQRRAALEANGGFPI
PQSQTPWQEIQRSMVAQFDEGMVLKPAVKYQRVAQTMGVPRDNH
>Mature_604_residues
MVGQGDQPENHGRKLRSQLWFDNPDNPGMTALYLERYLNFGLTREELQSGKPIIGIAQTGSDLSPCNRHHLDLAKRVREG
IAAAGGIPFEFPVHPIQETGKRPTAALDRNLAYLGLVEVLYGYPLDGVVLTTGCDKTTPACIMAAATVNIPAIVLSGGPM
LNGWWNGERTGSGTVVWKARAQHAAGEIDYDTFMEIVASSAPSVGHCNTMGTASTMNGLAEALGMSLPGCAAIPAPYRER
GQISYETGKRIVDMVWEDLKPSDILTREAFENAIRVNSAIGGSTNAPIHLNAIARHVGVSLTVDDWQAVGHKIPLLVNLQ
PAGEYLGEEFHRAGGIPAVVAELIQAGQIHEGALTVNGRSIGENCRGKFSWDRDVIRAYDAPMKADAGFIVLRGNLFENA
IMKTSVISEEFRARFLSDPKDPNAFEGPAVVFEGPEDYHHRIDDPALGIDEHTLLFIRGTGPIGYPGGAEVVNMQPPAAL
IKRGVNALPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRIDLEKGTADILISDEELAQRRAALEANGGFPI
PQSQTPWQEIQRSMVAQFDEGMVLKPAVKYQRVAQTMGVPRDNH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=565, Percent_Identity=30.9734513274336, Blast_Score=223, Evalue=4e-59,
Organism=Escherichia coli, GI1788157, Length=443, Percent_Identity=30.4740406320542, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI2367371, Length=541, Percent_Identity=28.6506469500924, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1786464, Length=555, Percent_Identity=27.027027027027, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6322476, Length=525, Percent_Identity=29.9047619047619, Blast_Score=217, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 64806; Mature: 64806

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGQGDQPENHGRKLRSQLWFDNPDNPGMTALYLERYLNFGLTREELQSGKPIIGIAQTG
CCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCC
SDLSPCNRHHLDLAKRVREGIAAAGGIPFEFPVHPIQETGKRPTAALDRNLAYLGLVEVL
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHHCCHHHHHHHHHH
YGYPLDGVVLTTGCDKTTPACIMAAATVNIPAIVLSGGPMLNGWWNGERTGSGTVVWKAR
HCCCCCCEEEECCCCCCCCHHEEEEHHCCCCEEEEECCCEECCEECCCCCCCCEEEEEEC
AQHAAGEIDYDTFMEIVASSAPSVGHCNTMGTASTMNGLAEALGMSLPGCAAIPAPYRER
HHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHC
GQISYETGKRIVDMVWEDLKPSDILTREAFENAIRVNSAIGGSTNAPIHLNAIARHVGVS
CCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCE
LTVDDWQAVGHKIPLLVNLQPAGEYLGEEFHRAGGIPAVVAELIQAGQIHEGALTVNGRS
EEEHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCC
IGENCRGKFSWDRDVIRAYDAPMKADAGFIVLRGNLFENAIMKTSVISEEFRARFLSDPK
CCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
DPNAFEGPAVVFEGPEDYHHRIDDPALGIDEHTLLFIRGTGPIGYPGGAEVVNMQPPAAL
CCCCCCCCEEEECCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCHHH
IKRGVNALPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRIDLEKGTADILI
HHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCEEEEEEECCCEEEEE
SDEELAQRRAALEANGGFPIPQSQTPWQEIQRSMVAQFDEGMVLKPAVKYQRVAQTMGVP
CHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCC
RDNH
CCCC
>Mature Secondary Structure
MVGQGDQPENHGRKLRSQLWFDNPDNPGMTALYLERYLNFGLTREELQSGKPIIGIAQTG
CCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCC
SDLSPCNRHHLDLAKRVREGIAAAGGIPFEFPVHPIQETGKRPTAALDRNLAYLGLVEVL
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHHCCHHHHHHHHHH
YGYPLDGVVLTTGCDKTTPACIMAAATVNIPAIVLSGGPMLNGWWNGERTGSGTVVWKAR
HCCCCCCEEEECCCCCCCCHHEEEEHHCCCCEEEEECCCEECCEECCCCCCCCEEEEEEC
AQHAAGEIDYDTFMEIVASSAPSVGHCNTMGTASTMNGLAEALGMSLPGCAAIPAPYRER
HHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHC
GQISYETGKRIVDMVWEDLKPSDILTREAFENAIRVNSAIGGSTNAPIHLNAIARHVGVS
CCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCE
LTVDDWQAVGHKIPLLVNLQPAGEYLGEEFHRAGGIPAVVAELIQAGQIHEGALTVNGRS
EEEHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCC
IGENCRGKFSWDRDVIRAYDAPMKADAGFIVLRGNLFENAIMKTSVISEEFRARFLSDPK
CCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
DPNAFEGPAVVFEGPEDYHHRIDDPALGIDEHTLLFIRGTGPIGYPGGAEVVNMQPPAAL
CCCCCCCCEEEECCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCHHH
IKRGVNALPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRIDLEKGTADILI
HHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCEEEEEEECCCEEEEE
SDEELAQRRAALEANGGFPIPQSQTPWQEIQRSMVAQFDEGMVLKPAVKYQRVAQTMGVP
CHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCC
RDNH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]