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The map label for this gene is mmgC [H]

Identifier: 158425182

GI number: 158425182

Start: 4085185

End: 4086402

Strand: Direct

Name: mmgC [H]

Synonym: AZC_3558

Alternate gene names: 158425182

Gene position: 4085185-4086402 (Clockwise)

Preceding gene: 158425181

Following gene: 158425183

Centisome position: 76.08

GC content: 66.75

Gene sequence:

>1218_bases
ATGGGAGAACCTCAGAAGGCCGAGACGGCCACCAGCACGAAGGCGGCTTTCGACTGGGCCGATCCCTTCCGTTTCGAGGA
CCAGCTCACGGAAGAAGAGCGCCTTGTCCGCGACACCGCCCGTGATTATGCGCAGGAGAAGCTCCTGCCGCGCGTGACCA
GCGCCTATCTCGACGAGCGCTTCGACCGCGAGATCATGAGCGAGATGGGCGAACTCGGCCTGCTCGGCGTGACCATTCCG
GAGAATTACGGCGGCGCCGGCCTTGGCTATGTGTCCTACGGCCTTGCCGCCCGCGAGGTGGAGCGGGTCGATTCGGGCTA
TCGCTCGGCCATGAGCGTGCAGTCCTCGCTCGTCATGCACCCCATCTATGCCTATGGCGACGAGAGCCAGCGCAAGAAGT
ATCTGCCCAAGCTCGCCACCGGCGAGTGGGTCGGCTGCTTCGGCCTCACCGAGCCGGACGCCGGCTCCGATCCGGCCGGC
ATGCGCACCCGCGCCGAGAAGATTGACGGCGGCTACCGCCTGACCGGCGCCAAGATGTGGATCACCAACTCGCCCATCGC
CGACATCGCGGTGGTGTGGGCGAAGTCGGCGGCACATGGCGATGCCATCCGCGGCTTCATCGTCGAGCGCGGCATGAAGG
GCTTCTCCACCCCGAAGATCGAGAAGAAGCTCTCGCTGCGCGCCTCCATCACCGGCGAGATCGTGCTGGAAGGCGTCGAG
ATTCCGGAAGAGAACCTGCTGCCCAACGTCTCCGGCCTGAAGGGCCCGTTCGGCTGCCTCAACCGCGCCCGCTACGGCAT
CGGCTGGGGCGTGCTCGGCGCGGCGGAAGCCTGCCTCGAGGCCGCCCGCCAGTACACGCTGGACCGCAAGCAGTTCGGCC
GCCCGCTGGCGCAGACCCAGCTGGTGCAGAAGAAGCTGGCCGACATGTCCACGGACATCGCCTTCGGCCTGCAGGCCTGC
CTGCGCGCCGGCCGCCTGTTCGACGAAGGCCAGCTGGCGCCGGAGACCATCTCCTACATCAAGCGCAACAATTGCGGCAA
AGCCCTCGACATCGCCCGCGTCGCCCGCGACATGCATGGCGGCAACGGCATCTCGGCCGAGTTCCACGTGATCCGTCACG
CGGCCAACCTCGAGACGGTGAACACCTACGAGGGCACGCACGACATCCACGCGCTCATCATCGGCCGCGCCATCACCGGG
CTCCAGGCTTTCTTTTGA

Upstream 100 bases:

>100_bases
GTCCGTATGATCCTTCGCGTGAAATTCGGGCTTGCAGCGTCGCGCGCGGCAGCGCATCACACACGGCATCGCGGTATAGA
GCGGCAAGAAGGAGCGAGAG

Downstream 100 bases:

>100_bases
GAAAGCTATTCTCCTGAGACCCCCCTTCTTCCGGGAAGGATTCTCAGAGGCGCCTGCGTCACCTGACAAACACCGCCCCG
GCTTCCCGCGAAGCCGGGGC

Product: glutaryl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MGEPQKAETATSTKAAFDWADPFRFEDQLTEEERLVRDTARDYAQEKLLPRVTSAYLDERFDREIMSEMGELGLLGVTIP
ENYGGAGLGYVSYGLAAREVERVDSGYRSAMSVQSSLVMHPIYAYGDESQRKKYLPKLATGEWVGCFGLTEPDAGSDPAG
MRTRAEKIDGGYRLTGAKMWITNSPIADIAVVWAKSAAHGDAIRGFIVERGMKGFSTPKIEKKLSLRASITGEIVLEGVE
IPEENLLPNVSGLKGPFGCLNRARYGIGWGVLGAAEACLEAARQYTLDRKQFGRPLAQTQLVQKKLADMSTDIAFGLQAC
LRAGRLFDEGQLAPETISYIKRNNCGKALDIARVARDMHGGNGISAEFHVIRHAANLETVNTYEGTHDIHALIIGRAITG
LQAFF

Sequences:

>Translated_405_residues
MGEPQKAETATSTKAAFDWADPFRFEDQLTEEERLVRDTARDYAQEKLLPRVTSAYLDERFDREIMSEMGELGLLGVTIP
ENYGGAGLGYVSYGLAAREVERVDSGYRSAMSVQSSLVMHPIYAYGDESQRKKYLPKLATGEWVGCFGLTEPDAGSDPAG
MRTRAEKIDGGYRLTGAKMWITNSPIADIAVVWAKSAAHGDAIRGFIVERGMKGFSTPKIEKKLSLRASITGEIVLEGVE
IPEENLLPNVSGLKGPFGCLNRARYGIGWGVLGAAEACLEAARQYTLDRKQFGRPLAQTQLVQKKLADMSTDIAFGLQAC
LRAGRLFDEGQLAPETISYIKRNNCGKALDIARVARDMHGGNGISAEFHVIRHAANLETVNTYEGTHDIHALIIGRAITG
LQAFF
>Mature_404_residues
GEPQKAETATSTKAAFDWADPFRFEDQLTEEERLVRDTARDYAQEKLLPRVTSAYLDERFDREIMSEMGELGLLGVTIPE
NYGGAGLGYVSYGLAAREVERVDSGYRSAMSVQSSLVMHPIYAYGDESQRKKYLPKLATGEWVGCFGLTEPDAGSDPAGM
RTRAEKIDGGYRLTGAKMWITNSPIADIAVVWAKSAAHGDAIRGFIVERGMKGFSTPKIEKKLSLRASITGEIVLEGVEI
PEENLLPNVSGLKGPFGCLNRARYGIGWGVLGAAEACLEAARQYTLDRKQFGRPLAQTQLVQKKLADMSTDIAFGLQACL
RAGRLFDEGQLAPETISYIKRNNCGKALDIARVARDMHGGNGISAEFHVIRHAANLETVNTYEGTHDIHALIIGRAITGL
QAFF

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=401, Percent_Identity=66.0847880299252, Blast_Score=552, Evalue=1e-157,
Organism=Homo sapiens, GI7669494, Length=381, Percent_Identity=64.8293963254593, Blast_Score=513, Evalue=1e-146,
Organism=Homo sapiens, GI226958412, Length=380, Percent_Identity=34.7368421052632, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI226958414, Length=350, Percent_Identity=34.8571428571429, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=32.8840970350404, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=32.5396825396825, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=32.5396825396825, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=30.5630026809651, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI21361497, Length=392, Percent_Identity=32.1428571428571, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4557235, Length=418, Percent_Identity=31.8181818181818, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI76496475, Length=403, Percent_Identity=32.258064516129, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI4501857, Length=378, Percent_Identity=29.6296296296296, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI7656849, Length=380, Percent_Identity=29.7368421052632, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI48976061, Length=334, Percent_Identity=25.1497005988024, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI211971008, Length=334, Percent_Identity=25.1497005988024, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786223, Length=344, Percent_Identity=24.7093023255814, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=26.1096605744125, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=64.1752577319588, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=33.9522546419098, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17508101, Length=404, Percent_Identity=30.9405940594059, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=31.758530183727, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71985184, Length=379, Percent_Identity=32.1899736147757, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=30.1587301587302, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17506239, Length=380, Percent_Identity=29.7368421052632, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=29.1005291005291, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=280, Percent_Identity=34.6428571428571, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI71990804, Length=263, Percent_Identity=34.2205323193916, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=31.8681318681319, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=32.9004329004329, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17533517, Length=382, Percent_Identity=26.1780104712042, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17551932, Length=268, Percent_Identity=27.9850746268657, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17505929, Length=311, Percent_Identity=24.1157556270096, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19920834, Length=402, Percent_Identity=62.4378109452736, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=34.9081364829396, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI24666513, Length=381, Percent_Identity=32.0209973753281, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=34.1269841269841, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=32.0855614973262, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=30.952380952381, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI281363737, Length=405, Percent_Identity=32.0987654320988, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 44320; Mature: 44189

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEPQKAETATSTKAAFDWADPFRFEDQLTEEERLVRDTARDYAQEKLLPRVTSAYLDER
CCCCCCCHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDREIMSEMGELGLLGVTIPENYGGAGLGYVSYGLAAREVERVDSGYRSAMSVQSSLVMH
HHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PIYAYGDESQRKKYLPKLATGEWVGCFGLTEPDAGSDPAGMRTRAEKIDGGYRLTGAKMW
HHHHCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCEEEECEEEE
ITNSPIADIAVVWAKSAAHGDAIRGFIVERGMKGFSTPKIEKKLSLRASITGEIVLEGVE
EECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCC
IPEENLLPNVSGLKGPFGCLNRARYGIGWGVLGAAEACLEAARQYTLDRKQFGRPLAQTQ
CCHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHH
LVQKKLADMSTDIAFGLQACLRAGRLFDEGQLAPETISYIKRNNCGKALDIARVARDMHG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCC
GNGISAEFHVIRHAANLETVNTYEGTHDIHALIIGRAITGLQAFF
CCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GEPQKAETATSTKAAFDWADPFRFEDQLTEEERLVRDTARDYAQEKLLPRVTSAYLDER
CCCCCCHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDREIMSEMGELGLLGVTIPENYGGAGLGYVSYGLAAREVERVDSGYRSAMSVQSSLVMH
HHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PIYAYGDESQRKKYLPKLATGEWVGCFGLTEPDAGSDPAGMRTRAEKIDGGYRLTGAKMW
HHHHCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCEEEECEEEE
ITNSPIADIAVVWAKSAAHGDAIRGFIVERGMKGFSTPKIEKKLSLRASITGEIVLEGVE
EECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCC
IPEENLLPNVSGLKGPFGCLNRARYGIGWGVLGAAEACLEAARQYTLDRKQFGRPLAQTQ
CCHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHH
LVQKKLADMSTDIAFGLQACLRAGRLFDEGQLAPETISYIKRNNCGKALDIARVARDMHG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCC
GNGISAEFHVIRHAANLETVNTYEGTHDIHALIIGRAITGLQAFF
CCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]