Click here to switch to the map view.

The map label for this gene is apt [H]

Identifier: 158425120

GI number: 158425120

Start: 4014033

End: 4014758

Strand: Reverse

Name: apt [H]

Synonym: AZC_3496

Alternate gene names: 158425120

Gene position: 4014758-4014033 (Counterclockwise)

Preceding gene: 158425123

Following gene: 158425118

Centisome position: 74.77

GC content: 67.36

Gene sequence:

>726_bases
GTGCGCGGCTGCGGGCCGCATCCCAGTCATAGGCAGGCTACGGCCCGCCGCGCATGGCGGATCATCCCCTCACGGGGGCT
TGAAGGCTTTGTCGGGTCCTCAAACGATGCTAGGTGCGAGGCATCGGGCGCCGCAGCGCGGACGCCAGCTTCCCCTTGCC
GAACGGCTATTCCGCGAGTTCCTCTGATGTCGCCTCTTCCCGATCTGGCCTCGGTCGTCCGGACCATCCCCGATTATCCC
AAGCCCGGCGTCATGTTCCGGGACATCACGACCCTGCTCGGCAATCCGCAGGCTTTCCGCCGCACGGTGGACGAACTGGT
TCAGCCCTGGGCCGGCGCGAAGATCGACAAGGTGGCGGGCATCGAGGCGCGCGGCTTCATCGTCGGCGGTGCGGTGGCGC
ACCAGCTCTCCGCCGGCTTCGTGCCGATCCGCAAGAAGGGCAAGCTGCCCCACCAGACCGTGCGCATGGCCTATGCGCTG
GAATACGGGCAGGACGAGATGGAGATGCACGTGGATGCCGTGCATCCGGGCGAACGGGTGATCCTCGTGGACGATCTCAT
CGCCACCGGCGGCACAGCGGAAGGGGCGGTGAAACTGCTGCGCCAGATCGGCGCGCAGGTGGAGGCCGCCTGCTTCATCG
TGGACCTGCCGGATCTCGGCGGTGCCGAGAAGCTGAGGGCCATGGGCGTGCCGGTGCGCACCATCATGAGCTTTTCGGGC
CACTGA

Upstream 100 bases:

>100_bases
GCGGCAAAGGCGGGGGCGGCCGCAACGGCGAGCGGCAGAGAGAGGCTTGCGAGCGCGAACGTGCGGCGGGAGAGGGGCAT
GCGGTTCTCCTGATCCATCG

Downstream 100 bases:

>100_bases
GCCCGGAACCCAAACGCAAACGGGCGGCCGCAGGGCCGCCCGTATCATTTCAGGCGGAACACCGCCTCACATGTTGGGAT
AGTTCGGCCCGCCGCCGCCC

Product: adenine phosphoribosyl transferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MRGCGPHPSHRQATARRAWRIIPSRGLEGFVGSSNDARCEASGAAARTPASPCRTAIPRVPLMSPLPDLASVVRTIPDYP
KPGVMFRDITTLLGNPQAFRRTVDELVQPWAGAKIDKVAGIEARGFIVGGAVAHQLSAGFVPIRKKGKLPHQTVRMAYAL
EYGQDEMEMHVDAVHPGERVILVDDLIATGGTAEGAVKLLRQIGAQVEAACFIVDLPDLGGAEKLRAMGVPVRTIMSFSG
H

Sequences:

>Translated_241_residues
MRGCGPHPSHRQATARRAWRIIPSRGLEGFVGSSNDARCEASGAAARTPASPCRTAIPRVPLMSPLPDLASVVRTIPDYP
KPGVMFRDITTLLGNPQAFRRTVDELVQPWAGAKIDKVAGIEARGFIVGGAVAHQLSAGFVPIRKKGKLPHQTVRMAYAL
EYGQDEMEMHVDAVHPGERVILVDDLIATGGTAEGAVKLLRQIGAQVEAACFIVDLPDLGGAEKLRAMGVPVRTIMSFSG
H
>Mature_241_residues
MRGCGPHPSHRQATARRAWRIIPSRGLEGFVGSSNDARCEASGAAARTPASPCRTAIPRVPLMSPLPDLASVVRTIPDYP
KPGVMFRDITTLLGNPQAFRRTVDELVQPWAGAKIDKVAGIEARGFIVGGAVAHQLSAGFVPIRKKGKLPHQTVRMAYAL
EYGQDEMEMHVDAVHPGERVILVDDLIATGGTAEGAVKLLRQIGAQVEAACFIVDLPDLGGAEKLRAMGVPVRTIMSFSG
H

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=42.9411764705882, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=47.1074380165289, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI1786675, Length=176, Percent_Identity=50, Blast_Score=194, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17509087, Length=179, Percent_Identity=41.8994413407821, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=174, Percent_Identity=37.3563218390805, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=37.5722543352601, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17136334, Length=170, Percent_Identity=35.2941176470588, Blast_Score=110, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 25756; Mature: 25756

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGCGPHPSHRQATARRAWRIIPSRGLEGFVGSSNDARCEASGAAARTPASPCRTAIPRV
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCC
PLMSPLPDLASVVRTIPDYPKPGVMFRDITTLLGNPQAFRRTVDELVQPWAGAKIDKVAG
CCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHCC
IEARGFIVGGAVAHQLSAGFVPIRKKGKLPHQTVRMAYALEYGQDEMEMHVDAVHPGERV
CCCCCEEECHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHEEEEEECCCCEE
ILVDDLIATGGTAEGAVKLLRQIGAQVEAACFIVDLPDLGGAEKLRAMGVPVRTIMSFSG
EEEECHHHCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHCCCCHHHHHHCCC
H
C
>Mature Secondary Structure
MRGCGPHPSHRQATARRAWRIIPSRGLEGFVGSSNDARCEASGAAARTPASPCRTAIPRV
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCC
PLMSPLPDLASVVRTIPDYPKPGVMFRDITTLLGNPQAFRRTVDELVQPWAGAKIDKVAG
CCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHCC
IEARGFIVGGAVAHQLSAGFVPIRKKGKLPHQTVRMAYALEYGQDEMEMHVDAVHPGERV
CCCCCEEECHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHEEEEEECCCCEE
ILVDDLIATGGTAEGAVKLLRQIGAQVEAACFIVDLPDLGGAEKLRAMGVPVRTIMSFSG
EEEECHHHCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHCCCCHHHHHHCCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA