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The map label for this gene is czcD [H]

Identifier: 158425081

GI number: 158425081

Start: 3973325

End: 3974365

Strand: Reverse

Name: czcD [H]

Synonym: AZC_3457

Alternate gene names: 158425081

Gene position: 3974365-3973325 (Counterclockwise)

Preceding gene: 158425082

Following gene: 158425066

Centisome position: 74.01

GC content: 69.74

Gene sequence:

>1041_bases
ATGGGCAGCGAGCACGATCATTCGCACGATGCGGCCGAGACGACGCGGCACGCCGGCCATAATCACGCTGGGCACGACCA
TGGTGAAGGGGGGCATGCGGGCCACGCGCACGCTGCCGAGGGGCATGGCGGCCACTCCCACGGCAGTCATGCGGGCCACA
GCCATGCGGTGCCCAGTTCCCTGCGGGCCTTCGCCATCGGCGCGTCGGCCAATTTCGCCTTCGTGGTGGTGGAGGCGCTG
TTCGGTTACTGGTCGGGCTCGCTCTCGCTGCTGGCCGATGCCGGCCACAATCTCTCCGACGTGCTCGGCCTGCTGCTCGC
CTGGGCCGCCGCCTGGGCGGCGCAGCGCGTGCCGACGGAGCGCCGCACCTTCGGCTATGGCCGCACGTCCATCCTCGCCG
CCCTGACCAATGCCATCATCCTGCTGCTCGGCACCGGCGGCATCGTGGTGGAGGCGGTGAGCCGCCTGTCCGATCCCGAG
CCGGTCCAGACCGGCGTGGTCATGGTGGTGGCGCTCATCGGCATCGGCGTGAACTTCGGCACCGCGCTGCTCTTCATGGC
CGGGCGCAAGGGCGATCTGAACGTGCGCGGCGCCTTCGTCCACCTCATCGCGGACGCGGCCATCTCGCTGGGCGTGGTGA
TCGCCGCAGGGGTGATCGCTGTGACCGGCTGGCTCTGGCTCGATCCGGCGGTGAGCCTCGTGATCGCCGTCGCCATCATC
GCCGGCACCTGGAGCCTGTTCCGGGACAGCGTCGATCTGGTGCTGGACGCGGTGCCGCGCCATGTGGACCGGGCGGCGGT
GGAGACCTATCTGGCGGGTCTGCCCGGCGTCACGGAGGTGCATGACCTCCACATCTGGGGCCTCTCCACCACCGAAGTCG
CCCTCATGGTGCACCTCGTCCGCACGACGCCTGCGCCAGACGATACCTTTCTGGCCGAAGTGACGGGCGAGATGAAGCGT
CGCTTCGGCATCGGCCACGTCACCATTCAGTTGGAGGCCGGACCCCACCCTTGCGCGCTGGCGCCCGCCCACGTGGTGTG
A

Upstream 100 bases:

>100_bases
CGCGACGGGGCCGGTGCCTCGGCGGGGAACATTCCCCGATCGCTCGGCCTTGACGCCGGGCCTCATCGGCGCGGTAAAGG
CGTGAGGGCGGGAGAGAGCC

Downstream 100 bases:

>100_bases
GCGGAGCACCCGCAGGCGAAACTCAGTTGTGTGACGACGCGGGAAGGCCCTCCAGCGCCTCGCGGGCGATGGGCAGGAGG
CTGGGGTGCTCGGCCAGAAG

Product: cation efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MGSEHDHSHDAAETTRHAGHNHAGHDHGEGGHAGHAHAAEGHGGHSHGSHAGHSHAVPSSLRAFAIGASANFAFVVVEAL
FGYWSGSLSLLADAGHNLSDVLGLLLAWAAAWAAQRVPTERRTFGYGRTSILAALTNAIILLLGTGGIVVEAVSRLSDPE
PVQTGVVMVVALIGIGVNFGTALLFMAGRKGDLNVRGAFVHLIADAAISLGVVIAAGVIAVTGWLWLDPAVSLVIAVAII
AGTWSLFRDSVDLVLDAVPRHVDRAAVETYLAGLPGVTEVHDLHIWGLSTTEVALMVHLVRTTPAPDDTFLAEVTGEMKR
RFGIGHVTIQLEAGPHPCALAPAHVV

Sequences:

>Translated_346_residues
MGSEHDHSHDAAETTRHAGHNHAGHDHGEGGHAGHAHAAEGHGGHSHGSHAGHSHAVPSSLRAFAIGASANFAFVVVEAL
FGYWSGSLSLLADAGHNLSDVLGLLLAWAAAWAAQRVPTERRTFGYGRTSILAALTNAIILLLGTGGIVVEAVSRLSDPE
PVQTGVVMVVALIGIGVNFGTALLFMAGRKGDLNVRGAFVHLIADAAISLGVVIAAGVIAVTGWLWLDPAVSLVIAVAII
AGTWSLFRDSVDLVLDAVPRHVDRAAVETYLAGLPGVTEVHDLHIWGLSTTEVALMVHLVRTTPAPDDTFLAEVTGEMKR
RFGIGHVTIQLEAGPHPCALAPAHVV
>Mature_345_residues
GSEHDHSHDAAETTRHAGHNHAGHDHGEGGHAGHAHAAEGHGGHSHGSHAGHSHAVPSSLRAFAIGASANFAFVVVEALF
GYWSGSLSLLADAGHNLSDVLGLLLAWAAAWAAQRVPTERRTFGYGRTSILAALTNAIILLLGTGGIVVEAVSRLSDPEP
VQTGVVMVVALIGIGVNFGTALLFMAGRKGDLNVRGAFVHLIADAAISLGVVIAAGVIAVTGWLWLDPAVSLVIAVAIIA
GTWSLFRDSVDLVLDAVPRHVDRAAVETYLAGLPGVTEVHDLHIWGLSTTEVALMVHLVRTTPAPDDTFLAEVTGEMKRR
FGIGHVTIQLEAGPHPCALAPAHVV

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=304, Percent_Identity=27.6315789473684, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI289803013, Length=272, Percent_Identity=27.9411764705882, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI289803009, Length=272, Percent_Identity=27.9411764705882, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI289803007, Length=272, Percent_Identity=27.9411764705882, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI289803003, Length=272, Percent_Identity=27.9411764705882, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI64762489, Length=272, Percent_Identity=27.9411764705882, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI21361112, Length=298, Percent_Identity=28.1879194630872, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI21359890, Length=301, Percent_Identity=26.2458471760797, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI20070323, Length=309, Percent_Identity=27.5080906148867, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI14210520, Length=216, Percent_Identity=27.7777777777778, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI52351208, Length=152, Percent_Identity=27.6315789473684, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1786966, Length=274, Percent_Identity=36.8613138686131, Blast_Score=141, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17555794, Length=332, Percent_Identity=31.3253012048193, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17555796, Length=278, Percent_Identity=33.0935251798561, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI193210990, Length=352, Percent_Identity=28.9772727272727, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI32564488, Length=290, Percent_Identity=28.9655172413793, Blast_Score=104, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323899, Length=114, Percent_Identity=38.5964912280702, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324892, Length=147, Percent_Identity=31.9727891156463, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320411, Length=165, Percent_Identity=34.5454545454545, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583858, Length=355, Percent_Identity=25.3521126760563, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24585900, Length=155, Percent_Identity=34.1935483870968, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24585898, Length=155, Percent_Identity=34.1935483870968, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24585896, Length=155, Percent_Identity=34.1935483870968, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19921672, Length=155, Percent_Identity=34.1935483870968, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574430, Length=151, Percent_Identity=32.4503311258278, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24584409, Length=151, Percent_Identity=32.4503311258278, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24656728, Length=146, Percent_Identity=35.6164383561644, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24656724, Length=146, Percent_Identity=35.6164383561644, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24656720, Length=146, Percent_Identity=35.6164383561644, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24656715, Length=146, Percent_Identity=35.6164383561644, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21357035, Length=146, Percent_Identity=35.6164383561644, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24645863, Length=149, Percent_Identity=28.8590604026846, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35928; Mature: 35797

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSEHDHSHDAAETTRHAGHNHAGHDHGEGGHAGHAHAAEGHGGHSHGSHAGHSHAVPSS
CCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LRAFAIGASANFAFVVVEALFGYWSGSLSLLADAGHNLSDVLGLLLAWAAAWAAQRVPTE
HHEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCH
RRTFGYGRTSILAALTNAIILLLGTGGIVVEAVSRLSDPEPVQTGVVMVVALIGIGVNFG
HHHCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHH
TALLFMAGRKGDLNVRGAFVHLIADAAISLGVVIAAGVIAVTGWLWLDPAVSLVIAVAII
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGTWSLFRDSVDLVLDAVPRHVDRAAVETYLAGLPGVTEVHDLHIWGLSTTEVALMVHLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHH
RTTPAPDDTFLAEVTGEMKRRFGIGHVTIQLEAGPHPCALAPAHVV
HCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GSEHDHSHDAAETTRHAGHNHAGHDHGEGGHAGHAHAAEGHGGHSHGSHAGHSHAVPSS
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LRAFAIGASANFAFVVVEALFGYWSGSLSLLADAGHNLSDVLGLLLAWAAAWAAQRVPTE
HHEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCH
RRTFGYGRTSILAALTNAIILLLGTGGIVVEAVSRLSDPEPVQTGVVMVVALIGIGVNFG
HHHCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHH
TALLFMAGRKGDLNVRGAFVHLIADAAISLGVVIAAGVIAVTGWLWLDPAVSLVIAVAII
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGTWSLFRDSVDLVLDAVPRHVDRAAVETYLAGLPGVTEVHDLHIWGLSTTEVALMVHLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHH
RTTPAPDDTFLAEVTGEMKRRFGIGHVTIQLEAGPHPCALAPAHVV
HCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]