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The map label for this gene is ghrA [H]

Identifier: 158424983

GI number: 158424983

Start: 3888080

End: 3889045

Strand: Direct

Name: ghrA [H]

Synonym: AZC_3359

Alternate gene names: 158424983

Gene position: 3888080-3889045 (Clockwise)

Preceding gene: 158424982

Following gene: 158424984

Centisome position: 72.41

GC content: 68.84

Gene sequence:

>966_bases
ATGCACGGCAGCCACGCCCCGGCACGCAGGATCATCGCGGTGAAGTCCGGAGGCGAGGCCGCCATCCCGGATTGGCAAGC
CTGCTTCGCCGAACTTGCGCCGCACCTCGAGGTGCGCTGGTGGGATGATCCACAGGTGGCGCCGGAGGACGTGGATTATG
TGATCGTCTGGCAGCCGGAGCCGGGGCGGCTCGCCGCCTACCCCAACCTGCGCCTCATCCTGTCCAGTGCCGCCGGCACG
GACCACATCACGAGCGATCCGTCCTGGCCGCGCCACCTGCCGATCGTGCGGGCGGTGACACCGGAAGCCTCCCAGCGCAT
GGCGGAATTCATCGTCATGTCCACGCTCGCCCTGATGCGCGATCTCAAGCGCGCCATCACCGGCCAACACCAGCGCGTGT
GGGACAATTTCGAGGTGGACCGCTGCGCGTGGGACATGCGGGTGGGCATCCTCGGCCTCGGCTCCATGGGCGCGGCCTCG
GCCCGCATGCTCCGGTCCGTCGGCTTCGGCGTCTCCGGCTGGTCGCGCAGCCAGAAGGCCATCGAGGGCATCACCTGCCA
TGCCGGACGGGAGGGGCTCGACGCCTTCCTGAAGGAGACGGACATCCTCGTCTGCCTGCTGCCCAACACGCCGGAGACCA
CCGGCCTCATCAATGCGGACCTGCTGGCCAAGCTGCCCGCCGGTGCCGGCCTCATCAATGCCGGCCGCGGCACCCACATG
GTGCTGGAGGACGTGCTCTCGGCCCTCGACAGTGGACAACTGAGCGGCGCCGTGCTCGACGTGTTCGAGGAGGAGCCGTT
GCTGGCGGACAATCCCGCCTGGACTCATCCCAAGGTCATCGTCACCCCGCACATCGGCTCCATCGCCTCGCGCCGGGCGC
GTGCCGCTTTCTACGCCGAGCAGATCCGCCGCTTCGAGGCCGGTGAGCCGATGGACGCGCTCTACGATCCGGTGGCTGGC
TACTGA

Upstream 100 bases:

>100_bases
GAAAGCGCGACCGGAGCGGCAGGAGTACCGGGTACCCGGGACTCCTGCCGCAGGAACGAGATGATCGGGTGCTGATCGCA
CCCTCGGAGACACAACGACC

Downstream 100 bases:

>100_bases
GCCGGCCTGCGGGCAAAGGTCCCCTTTCGCAACAACGCACCGCGACTGGGCATGCCCCACACCTTCCATTTGCCGCTACG
CACTCGACGAACGATCTCAA

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MHGSHAPARRIIAVKSGGEAAIPDWQACFAELAPHLEVRWWDDPQVAPEDVDYVIVWQPEPGRLAAYPNLRLILSSAAGT
DHITSDPSWPRHLPIVRAVTPEASQRMAEFIVMSTLALMRDLKRAITGQHQRVWDNFEVDRCAWDMRVGILGLGSMGAAS
ARMLRSVGFGVSGWSRSQKAIEGITCHAGREGLDAFLKETDILVCLLPNTPETTGLINADLLAKLPAGAGLINAGRGTHM
VLEDVLSALDSGQLSGAVLDVFEEEPLLADNPAWTHPKVIVTPHIGSIASRRARAAFYAEQIRRFEAGEPMDALYDPVAG
Y

Sequences:

>Translated_321_residues
MHGSHAPARRIIAVKSGGEAAIPDWQACFAELAPHLEVRWWDDPQVAPEDVDYVIVWQPEPGRLAAYPNLRLILSSAAGT
DHITSDPSWPRHLPIVRAVTPEASQRMAEFIVMSTLALMRDLKRAITGQHQRVWDNFEVDRCAWDMRVGILGLGSMGAAS
ARMLRSVGFGVSGWSRSQKAIEGITCHAGREGLDAFLKETDILVCLLPNTPETTGLINADLLAKLPAGAGLINAGRGTHM
VLEDVLSALDSGQLSGAVLDVFEEEPLLADNPAWTHPKVIVTPHIGSIASRRARAAFYAEQIRRFEAGEPMDALYDPVAG
Y
>Mature_321_residues
MHGSHAPARRIIAVKSGGEAAIPDWQACFAELAPHLEVRWWDDPQVAPEDVDYVIVWQPEPGRLAAYPNLRLILSSAAGT
DHITSDPSWPRHLPIVRAVTPEASQRMAEFIVMSTLALMRDLKRAITGQHQRVWDNFEVDRCAWDMRVGILGLGSMGAAS
ARMLRSVGFGVSGWSRSQKAIEGITCHAGREGLDAFLKETDILVCLLPNTPETTGLINADLLAKLPAGAGLINAGRGTHM
VLEDVLSALDSGQLSGAVLDVFEEEPLLADNPAWTHPKVIVTPHIGSIASRRARAAFYAEQIRRFEAGEPMDALYDPVAG
Y

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=257, Percent_Identity=30.7392996108949, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI23308577, Length=241, Percent_Identity=26.5560165975104, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87081824, Length=307, Percent_Identity=36.1563517915309, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI87082289, Length=239, Percent_Identity=30.1255230125523, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1789279, Length=215, Percent_Identity=29.3023255813954, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=262, Percent_Identity=26.7175572519084, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320925, Length=236, Percent_Identity=27.9661016949153, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=233, Percent_Identity=26.6094420600858, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322116, Length=200, Percent_Identity=29, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=247, Percent_Identity=27.1255060728745, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=143, Percent_Identity=34.2657342657343, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574286, Length=263, Percent_Identity=30.4182509505703, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24585514, Length=260, Percent_Identity=30.7692307692308, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574282, Length=260, Percent_Identity=30.7692307692308, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45552429, Length=260, Percent_Identity=31.1538461538462, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574284, Length=260, Percent_Identity=31.1538461538462, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45551003, Length=260, Percent_Identity=31.1538461538462, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI28571528, Length=170, Percent_Identity=32.3529411764706, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19921140, Length=253, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34922; Mature: 34922

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGSHAPARRIIAVKSGGEAAIPDWQACFAELAPHLEVRWWDDPQVAPEDVDYVIVWQPE
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEECC
PGRLAAYPNLRLILSSAAGTDHITSDPSWPRHLPIVRAVTPEASQRMAEFIVMSTLALMR
CCCEEECCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
DLKRAITGQHQRVWDNFEVDRCAWDMRVGILGLGSMGAASARMLRSVGFGVSGWSRSQKA
HHHHHHCCCHHHHHCCCCHHHHHHHHEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHH
IEGITCHAGREGLDAFLKETDILVCLLPNTPETTGLINADLLAKLPAGAGLINAGRGTHM
HCCEEECCCHHHHHHHHHCCCEEEEECCCCCCCCCEECHHHHHHCCCCCCEEECCCCHHH
VLEDVLSALDSGQLSGAVLDVFEEEPLLADNPAWTHPKVIVTPHIGSIASRRARAAFYAE
HHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
QIRRFEAGEPMDALYDPVAGY
HHHHHCCCCCHHHHHCCCCCC
>Mature Secondary Structure
MHGSHAPARRIIAVKSGGEAAIPDWQACFAELAPHLEVRWWDDPQVAPEDVDYVIVWQPE
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEECC
PGRLAAYPNLRLILSSAAGTDHITSDPSWPRHLPIVRAVTPEASQRMAEFIVMSTLALMR
CCCEEECCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
DLKRAITGQHQRVWDNFEVDRCAWDMRVGILGLGSMGAASARMLRSVGFGVSGWSRSQKA
HHHHHHCCCHHHHHCCCCHHHHHHHHEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHH
IEGITCHAGREGLDAFLKETDILVCLLPNTPETTGLINADLLAKLPAGAGLINAGRGTHM
HCCEEECCCHHHHHHHHHCCCEEEEECCCCCCCCCEECHHHHHHCCCCCCEEECCCCHHH
VLEDVLSALDSGQLSGAVLDVFEEEPLLADNPAWTHPKVIVTPHIGSIASRRARAAFYAE
HHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
QIRRFEAGEPMDALYDPVAGY
HHHHHCCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA