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The map label for this gene is expE1 [H]

Identifier: 158424950

GI number: 158424950

Start: 3851722

End: 3852381

Strand: Reverse

Name: expE1 [H]

Synonym: AZC_3326

Alternate gene names: 158424950

Gene position: 3852381-3851722 (Counterclockwise)

Preceding gene: 158424951

Following gene: 158424949

Centisome position: 71.74

GC content: 65.61

Gene sequence:

>660_bases
ATGGCAACCATCGAAGGAAGCGCATTCGACGATACGCTTCTCGGAAGCCGGTTCCACGACGTGATCTTCGCTCATGGTGG
CGACGACACGGTGCTCGCCGGCGATGGGCATGACCTCGTGTTTGGTGAACACGGCGCGGATACCCTCTACGGCGATGCCG
GAGACGACTCGTTGTTCGGAAACTCAGGAGACGACGCCCTGTTCGGCGGCGCCGGCCACGATTTCCTCTCCGGCGGCTCC
GGCTCGGATTATCTCTCCGGCGGCGAGGGCAACGATACGCTTCTCGGCGGCGCTGGCGACGATGCCCTGGTCGGTGGCGC
GGGGGATGATTTCCTCTCCGGCGGTGCGGGCGACGACATCCTGCACGGCGGCGCGGGCAACGACCTGCTGCAAGGCGGCG
CGGGCAGCGACCTGTTCGTCTTCACCGGCGGCGGCGGCAACGACGTGGTGCTGGACTTCAAGGCCGGCACCGATCTTCTC
GAAATCTCGAAGGGGATCAACGGCACGGATATCACGAGCGCCGACGACGTGGCGGCGCGGGCCACGGAGGTGGGCGGCCA
TACGGTCATCGATCTCGGCAACGGCGACACCGTCACGCTGCATGGCGTGAGCCTGGAAGACGTTCAGGATCACCCGAACA
CCTACTTCCTCGTGCACTGA

Upstream 100 bases:

>100_bases
GGCCTGTGAATTCGCCTCTGCAACTTGAGCCAGACACGCTTTCGCCTGACGGCCAGTGCCGGTCCGGGATCGGGCGTGCT
TTGGAGTGACGGAGACAGCC

Downstream 100 bases:

>100_bases
TGCTCCGGCGTGGGGCGCACCGCTCCGCGCCGCTTGCCAAGACACCGCCGGGTCTTCCCCCGCCCGCGGTTTCCTGCTGC
CCGCGAGCCCGTCTCGCGGG

Product: calcium binding protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MATIEGSAFDDTLLGSRFHDVIFAHGGDDTVLAGDGHDLVFGEHGADTLYGDAGDDSLFGNSGDDALFGGAGHDFLSGGS
GSDYLSGGEGNDTLLGGAGDDALVGGAGDDFLSGGAGDDILHGGAGNDLLQGGAGSDLFVFTGGGGNDVVLDFKAGTDLL
EISKGINGTDITSADDVAARATEVGGHTVIDLGNGDTVTLHGVSLEDVQDHPNTYFLVH

Sequences:

>Translated_219_residues
MATIEGSAFDDTLLGSRFHDVIFAHGGDDTVLAGDGHDLVFGEHGADTLYGDAGDDSLFGNSGDDALFGGAGHDFLSGGS
GSDYLSGGEGNDTLLGGAGDDALVGGAGDDFLSGGAGDDILHGGAGNDLLQGGAGSDLFVFTGGGGNDVVLDFKAGTDLL
EISKGINGTDITSADDVAARATEVGGHTVIDLGNGDTVTLHGVSLEDVQDHPNTYFLVH
>Mature_218_residues
ATIEGSAFDDTLLGSRFHDVIFAHGGDDTVLAGDGHDLVFGEHGADTLYGDAGDDSLFGNSGDDALFGGAGHDFLSGGSG
SDYLSGGEGNDTLLGGAGDDALVGGAGDDFLSGGAGDDILHGGAGNDLLQGGAGSDLFVFTGGGGNDVVLDFKAGTDLLE
ISKGINGTDITSADDVAARATEVGGHTVIDLGNGDTVTLHGVSLEDVQDHPNTYFLVH

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 21717; Mature: 21586

Theoretical pI: Translated: 3.68; Mature: 3.68

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIEGSAFDDTLLGSRFHDVIFAHGGDDTVLAGDGHDLVFGEHGADTLYGDAGDDSLFG
CCCCCCCCCCCHHHCCCEEEEEEEECCCCEEEECCCCEEEEECCCCCCEECCCCCCCCCC
NSGDDALFGGAGHDFLSGGSGSDYLSGGEGNDTLLGGAGDDALVGGAGDDFLSGGAGDDI
CCCCCCEECCCCCHHCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCHHHCCCCCCCE
LHGGAGNDLLQGGAGSDLFVFTGGGGNDVVLDFKAGTDLLEISKGINGTDITSADDVAAR
EECCCCCHHHCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHCCCCCCCCCCCCHHHHH
ATEVGGHTVIDLGNGDTVTLHGVSLEDVQDHPNTYFLVH
HEECCCEEEEECCCCCEEEEECCCHHHHHCCCCEEEEEC
>Mature Secondary Structure 
ATIEGSAFDDTLLGSRFHDVIFAHGGDDTVLAGDGHDLVFGEHGADTLYGDAGDDSLFG
CCCCCCCCCCHHHCCCEEEEEEEECCCCEEEECCCCEEEEECCCCCCEECCCCCCCCCC
NSGDDALFGGAGHDFLSGGSGSDYLSGGEGNDTLLGGAGDDALVGGAGDDFLSGGAGDDI
CCCCCCEECCCCCHHCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCHHHCCCCCCCE
LHGGAGNDLLQGGAGSDLFVFTGGGGNDVVLDFKAGTDLLEISKGINGTDITSADDVAAR
EECCCCCHHHCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHCCCCCCCCCCCCHHHHH
ATEVGGHTVIDLGNGDTVTLHGVSLEDVQDHPNTYFLVH
HEECCCEEEEECCCCCEEEEECCCHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]