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The map label for this gene is hlyD [H]

Identifier: 158424930

GI number: 158424930

Start: 3825069

End: 3826532

Strand: Reverse

Name: hlyD [H]

Synonym: AZC_3306

Alternate gene names: 158424930

Gene position: 3826532-3825069 (Counterclockwise)

Preceding gene: 158424933

Following gene: 158424929

Centisome position: 71.26

GC content: 67.62

Gene sequence:

>1464_bases
ATGAACGGGTCGGCGGCTTGTCAATGCGAGCGGCCGGAAAATACGGCGCGGCGGCACTTTGTGACTGTGGCCAGCGAGCG
TGAGCGGGGCAGGGGCCGGATCCGGGCAGCTTTTCGCCAGGGAGGGGTGTCGTCAGGGCGTTACTCTGGTATGGCGGTCT
CATGGACAGGTCCGGGGGCGCTGCTTACACTCGCGCCGGGTGAAGGTCGGGGGTCGATTATGACGGTTTGGGCGTGGGTT
GCTGGCGTGCGCGGTGCGGCGTTCGAGGGGCGGTCCGTCAAGGTCGTGGCGCCGGCTCTGGCGGCGCTGGCGCTGGCCGG
CTGCAATGAGCAGAATACCTATGTCGCCCCGCCGCCGCCCACCGTCACGGTCGCCCCGGCGCCCGAGCAGTCGGTGGTGC
GCTATCTGGAGCTGACTGGCAACACGGCCTCCATCAATACGGTGGACCTGAACGCCCGCGTGCAGGGCTTCCTCACCAGC
ATCAACTACAAGGACGGCGCGATGGCGAAGAAGGGCGACCTGCTCTTCGTCATCGAACAGGATCAGTACAAGGCCGACGT
GGCGCAGGCCCAGGCGACGCTCGCCGCCAAGCAGGCCGCCCAGGTTCAGGCGGAAGCCGAGTTCAACCGGCAGAACCAGC
TCGCCAAGCAGGACTTCGCCTCGCAGGCCACCCTCGATCAGGCGCGCGCCAAGCGCGACGGGGCGGTGGCGGACGTTCAG
AACGCGCAGGCCAGCCTCGACCTCGCCAAGATCAACCTCGGCTATACGGAGGTGCGCGCGCCCTTCGACGGCGTCGTGAC
CGCCCACCTTCAGGATGTCGGCGCGCTGGTCGGCTACGGCAGCCCCACCAAGCTCGCCACCATCGTCGAGATCAACCCCA
TCTACGTCTGGTTCTCGCTCTCGGAGACGCAGGTCCTGCGCATCAAGGACGCCCTGGCCCAGCAGGGCAAGACCCTGCGC
AGCATCGAGGGGCAGCTTGCCGATATTCCGGTGGAGATCGGCCTCCAGACCGAGCAGGGCTATCCCCACGTTGGCCACCT
CGACTATGTGGCCCCGCAGGTGGACGCCAATACCGGCACGCTCACCGTGCGCGGCATCTTCGACAACAAGGATCTCTCCC
TGCTGCCGGGTCTCTTCGCCCGCGTCCGCCTGCCGCTCGGGGCCTCCACCGACATGGTTCTGGTGGCGGACGCCGCCATC
GGCACCAACCAGAGCGGCAGCTATGTGCTGACCGTCGGGTCCGACGGCATCGTGAAGCAGCAGACCGTGCAGCTCGGCCA
GATGCAGGCGGAAGGCCTGCGCGCCATCACCTCGGGCCTCGCCAAGGGTGACCAGGTGGTGGTGAACGGCCTCCAGCGCG
CCGTCCCCGGCTCGAAGGTCACGGTCGAGAAGGGGCAGATGGTGAACGAGAGCGCCAAGCCCAAGCCGCCGATCGATCCG
TCCAAGCCTGCGCCCAAGAACTGA

Upstream 100 bases:

>100_bases
CAGCAAGTCCGCTGCGTTTCGGCGCCGGGCTGCGGCGATTAGGCCACACCCCGGCCGAAAAACGCCGCTGCGAACCGCCT
GACGCGCCGCGGGGAGACTT

Downstream 100 bases:

>100_bases
CCTCCGGTCCCTCGAACACAGGCAGCGACCATGATCTCGCGCTTTTTCATCGAGCGGCCGGTTCTCGCGAACGTCCTGGC
GCTCTTTTTCGTCCTGATCG

Product: secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MNGSAACQCERPENTARRHFVTVASERERGRGRIRAAFRQGGVSSGRYSGMAVSWTGPGALLTLAPGEGRGSIMTVWAWV
AGVRGAAFEGRSVKVVAPALAALALAGCNEQNTYVAPPPPTVTVAPAPEQSVVRYLELTGNTASINTVDLNARVQGFLTS
INYKDGAMAKKGDLLFVIEQDQYKADVAQAQATLAAKQAAQVQAEAEFNRQNQLAKQDFASQATLDQARAKRDGAVADVQ
NAQASLDLAKINLGYTEVRAPFDGVVTAHLQDVGALVGYGSPTKLATIVEINPIYVWFSLSETQVLRIKDALAQQGKTLR
SIEGQLADIPVEIGLQTEQGYPHVGHLDYVAPQVDANTGTLTVRGIFDNKDLSLLPGLFARVRLPLGASTDMVLVADAAI
GTNQSGSYVLTVGSDGIVKQQTVQLGQMQAEGLRAITSGLAKGDQVVVNGLQRAVPGSKVTVEKGQMVNESAKPKPPIDP
SKPAPKN

Sequences:

>Translated_487_residues
MNGSAACQCERPENTARRHFVTVASERERGRGRIRAAFRQGGVSSGRYSGMAVSWTGPGALLTLAPGEGRGSIMTVWAWV
AGVRGAAFEGRSVKVVAPALAALALAGCNEQNTYVAPPPPTVTVAPAPEQSVVRYLELTGNTASINTVDLNARVQGFLTS
INYKDGAMAKKGDLLFVIEQDQYKADVAQAQATLAAKQAAQVQAEAEFNRQNQLAKQDFASQATLDQARAKRDGAVADVQ
NAQASLDLAKINLGYTEVRAPFDGVVTAHLQDVGALVGYGSPTKLATIVEINPIYVWFSLSETQVLRIKDALAQQGKTLR
SIEGQLADIPVEIGLQTEQGYPHVGHLDYVAPQVDANTGTLTVRGIFDNKDLSLLPGLFARVRLPLGASTDMVLVADAAI
GTNQSGSYVLTVGSDGIVKQQTVQLGQMQAEGLRAITSGLAKGDQVVVNGLQRAVPGSKVTVEKGQMVNESAKPKPPIDP
SKPAPKN
>Mature_487_residues
MNGSAACQCERPENTARRHFVTVASERERGRGRIRAAFRQGGVSSGRYSGMAVSWTGPGALLTLAPGEGRGSIMTVWAWV
AGVRGAAFEGRSVKVVAPALAALALAGCNEQNTYVAPPPPTVTVAPAPEQSVVRYLELTGNTASINTVDLNARVQGFLTS
INYKDGAMAKKGDLLFVIEQDQYKADVAQAQATLAAKQAAQVQAEAEFNRQNQLAKQDFASQATLDQARAKRDGAVADVQ
NAQASLDLAKINLGYTEVRAPFDGVVTAHLQDVGALVGYGSPTKLATIVEINPIYVWFSLSETQVLRIKDALAQQGKTLR
SIEGQLADIPVEIGLQTEQGYPHVGHLDYVAPQVDANTGTLTVRGIFDNKDLSLLPGLFARVRLPLGASTDMVLVADAAI
GTNQSGSYVLTVGSDGIVKQQTVQLGQMQAEGLRAITSGLAKGDQVVVNGLQRAVPGSKVTVEKGQMVNESAKPKPPIDP
SKPAPKN

Specific function: May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=391, Percent_Identity=29.923273657289, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI87082036, Length=351, Percent_Identity=30.7692307692308, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789665, Length=365, Percent_Identity=32.6027397260274, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1786668, Length=386, Percent_Identity=33.419689119171, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI87081796, Length=237, Percent_Identity=32.0675105485232, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789637, Length=152, Percent_Identity=34.2105263157895, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081951, Length=163, Percent_Identity=33.1288343558282, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790519, Length=276, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 51420; Mature: 51420

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGSAACQCERPENTARRHFVTVASERERGRGRIRAAFRQGGVSSGRYSGMAVSWTGPGA
CCCCCCEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCE
LLTLAPGEGRGSIMTVWAWVAGVRGAAFEGRSVKVVAPALAALALAGCNEQNTYVAPPPP
EEEECCCCCCCCEEEHHHHHHCCCCCEECCCEEEEEHHHHHHHHHHCCCCCCCEECCCCC
TVTVAPAPEQSVVRYLELTGNTASINTVDLNARVQGFLTSINYKDGAMAKKGDLLFVIEQ
EEEECCCCHHHHHHEEEECCCCEEEEEEEECCEEEEEEEEECCCCCCCCCCCCEEEEEEC
DQYKADVAQAQATLAAKQAAQVQAEAEFNRQNQLAKQDFASQATLDQARAKRDGAVADVQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC
NAQASLDLAKINLGYTEVRAPFDGVVTAHLQDVGALVGYGSPTKLATIVEINPIYVWFSL
CCCCEEEEEEEECCHHHCCCCCCCEEEHHHHHHHHHHCCCCCCCEEEEEEECEEEEEEEE
SETQVLRIKDALAQQGKTLRSIEGQLADIPVEIGLQTEQGYPHVGHLDYVAPQVDANTGT
CCCEEEHHHHHHHHCCCHHHHHCCCEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCE
LTVRGIFDNKDLSLLPGLFARVRLPLGASTDMVLVADAAIGTNQSGSYVLTVGSDGIVKQ
EEEEEEECCCCCHHHHCHHHHEEECCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCHH
QTVQLGQMQAEGLRAITSGLAKGDQVVVNGLQRAVPGSKVTVEKGQMVNESAKPKPPIDP
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCC
SKPAPKN
CCCCCCC
>Mature Secondary Structure
MNGSAACQCERPENTARRHFVTVASERERGRGRIRAAFRQGGVSSGRYSGMAVSWTGPGA
CCCCCCEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCE
LLTLAPGEGRGSIMTVWAWVAGVRGAAFEGRSVKVVAPALAALALAGCNEQNTYVAPPPP
EEEECCCCCCCCEEEHHHHHHCCCCCEECCCEEEEEHHHHHHHHHHCCCCCCCEECCCCC
TVTVAPAPEQSVVRYLELTGNTASINTVDLNARVQGFLTSINYKDGAMAKKGDLLFVIEQ
EEEECCCCHHHHHHEEEECCCCEEEEEEEECCEEEEEEEEECCCCCCCCCCCCEEEEEEC
DQYKADVAQAQATLAAKQAAQVQAEAEFNRQNQLAKQDFASQATLDQARAKRDGAVADVQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC
NAQASLDLAKINLGYTEVRAPFDGVVTAHLQDVGALVGYGSPTKLATIVEINPIYVWFSL
CCCCEEEEEEEECCHHHCCCCCCCEEEHHHHHHHHHHCCCCCCCEEEEEEECEEEEEEEE
SETQVLRIKDALAQQGKTLRSIEGQLADIPVEIGLQTEQGYPHVGHLDYVAPQVDANTGT
CCCEEEHHHHHHHHCCCHHHHHCCCEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCE
LTVRGIFDNKDLSLLPGLFARVRLPLGASTDMVLVADAAIGTNQSGSYVLTVGSDGIVKQ
EEEEEEECCCCCHHHHCHHHHEEECCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCHH
QTVQLGQMQAEGLRAITSGLAKGDQVVVNGLQRAVPGSKVTVEKGQMVNESAKPKPPIDP
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCC
SKPAPKN
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12271122 [H]