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The map label for this gene is hisD [H]

Identifier: 158424773

GI number: 158424773

Start: 3602688

End: 3603980

Strand: Reverse

Name: hisD [H]

Synonym: AZC_3149

Alternate gene names: 158424773

Gene position: 3603980-3602688 (Counterclockwise)

Preceding gene: 158424774

Following gene: 158424772

Centisome position: 67.12

GC content: 69.37

Gene sequence:

>1293_bases
ATGCCGATCCGCCTCGACGCCAAGTCCACCGCTTTCCCCGACGCCTTCGCCACCTTCCTCGCCAGCAAGCGGGAAGCGTC
AACCGATGTTGCGGTGGCTGTCGCCGACATCATCGCCGGCGTGCGGGCGCGCGGGGATGCGGCCCTGATCGATTATTCGC
GCACCTTCGACCGGGTCGAGCTGGAAGGCCGCATCCGCGTGACCGAGGCGGAGATCGAGGCGGCGCTCGCCGAGGTGCCG
CAGGACACCTTCGAGGCGCTGAAGTTTGCGAAGGCCCGCATCGAGGCACACCACGCCCGCCAGCTTCCGGCGGACGAGCG
CTATACGGATGCAGTCGGGGTCGAGCTCGGCCAGCGCTGGACGCCGGTGGATGCGGTGGGTCTTTATGTGCCCGGCGGCA
CGGCGGCCTATCCCTCGTCCGTGCTCATGAATGCGGTGCCGGCGAAGGTCGCGGGCGTGCCGCGTGTCGCCATGGTGGTG
CCTTCGCCCGATGGCGTCATCGCGCCGCTGGTGCTCGCCGCTGCACGTCTTGCCGGCGTGGACGAGGTCTATCGCGTGGG
CGGGGCACAGGCGGTGGCCGCGCTCGCCTATGGCACCGAGACGATCGCTCCGGTGGACAAGATCGTCGGCCCGGGCAACG
CCTATGTGGCGGCGGCCAAGCGGCAGGTGTTCGGCAAGGTCGGTATCGACATGATCGCCGGCCCCTCCGAGGTGCTGATC
CTCGCCGACGGCAACGCCAATGCCGCCTGGATCGCCGCGGACCTGCTGGCGCAGGCCGAGCATGATGCCGCCGCCCAGTC
CATCCTCGTCACCGATTCCCCCGTGCTCGCCGATGCGGTCACCCGCGCGGTCGAGGCGCAGCTCACCACGCTGCCCCGCC
GCGAGATCGCGGAAGCCTCCTGGCGCGACCACGGGGCCATCATCCTGGTCGGCAGCATGGACGAGGCGCTGCCGCTGGTG
GACCGCGTTGCCCCCGAGCATCTGGAAATCCATGCGGACGATGCCGATGCGCTTGCCGACCGCATCCGTCATGCGGGTGC
GATCTTCGTGGGCGCCTATACGCCGGAGGCCATCGGCGACTATGTGGGCGGCACCAATCATGTGCTGCCCACCGCCCGTT
CGGCCCGCTTCTCTTCCGGGCTCGGCGTCTATGACTTCCTCAAGCGCACCTCCATCCTGAAGTGCAGCCCGGCCTCGCTG
AACGTGATCGGGCCGGCCGCGGTGCGCCTTGCCGAAGTGGAACGGCTCGATGCCCACGGCCGCTCTATCCTCATCCGCAC
CAATGCCGGCTGA

Upstream 100 bases:

>100_bases
GCGTGAAGCGCCGCCGGGCCGCTCCGGGGGCGTTTCGAGCGCCGGCGGATCCGGATGGAGCGACAGCTCCGGCCCGTGTC
TCCGGCCCCGGGAACCAGAG

Downstream 100 bases:

>100_bases
GGCCCGTTGAGTTCCGACCAGGTGACAGAGGGCCGCCGCGTCCACCCGGGCGCGCGCTGATCGAACCGGATGCGTGAGAC
GCCATGAGCCAGACCCCGCC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MPIRLDAKSTAFPDAFATFLASKREASTDVAVAVADIIAGVRARGDAALIDYSRTFDRVELEGRIRVTEAEIEAALAEVP
QDTFEALKFAKARIEAHHARQLPADERYTDAVGVELGQRWTPVDAVGLYVPGGTAAYPSSVLMNAVPAKVAGVPRVAMVV
PSPDGVIAPLVLAAARLAGVDEVYRVGGAQAVAALAYGTETIAPVDKIVGPGNAYVAAAKRQVFGKVGIDMIAGPSEVLI
LADGNANAAWIAADLLAQAEHDAAAQSILVTDSPVLADAVTRAVEAQLTTLPRREIAEASWRDHGAIILVGSMDEALPLV
DRVAPEHLEIHADDADALADRIRHAGAIFVGAYTPEAIGDYVGGTNHVLPTARSARFSSGLGVYDFLKRTSILKCSPASL
NVIGPAAVRLAEVERLDAHGRSILIRTNAG

Sequences:

>Translated_430_residues
MPIRLDAKSTAFPDAFATFLASKREASTDVAVAVADIIAGVRARGDAALIDYSRTFDRVELEGRIRVTEAEIEAALAEVP
QDTFEALKFAKARIEAHHARQLPADERYTDAVGVELGQRWTPVDAVGLYVPGGTAAYPSSVLMNAVPAKVAGVPRVAMVV
PSPDGVIAPLVLAAARLAGVDEVYRVGGAQAVAALAYGTETIAPVDKIVGPGNAYVAAAKRQVFGKVGIDMIAGPSEVLI
LADGNANAAWIAADLLAQAEHDAAAQSILVTDSPVLADAVTRAVEAQLTTLPRREIAEASWRDHGAIILVGSMDEALPLV
DRVAPEHLEIHADDADALADRIRHAGAIFVGAYTPEAIGDYVGGTNHVLPTARSARFSSGLGVYDFLKRTSILKCSPASL
NVIGPAAVRLAEVERLDAHGRSILIRTNAG
>Mature_429_residues
PIRLDAKSTAFPDAFATFLASKREASTDVAVAVADIIAGVRARGDAALIDYSRTFDRVELEGRIRVTEAEIEAALAEVPQ
DTFEALKFAKARIEAHHARQLPADERYTDAVGVELGQRWTPVDAVGLYVPGGTAAYPSSVLMNAVPAKVAGVPRVAMVVP
SPDGVIAPLVLAAARLAGVDEVYRVGGAQAVAALAYGTETIAPVDKIVGPGNAYVAAAKRQVFGKVGIDMIAGPSEVLIL
ADGNANAAWIAADLLAQAEHDAAAQSILVTDSPVLADAVTRAVEAQLTTLPRREIAEASWRDHGAIILVGSMDEALPLVD
RVAPEHLEIHADDADALADRIRHAGAIFVGAYTPEAIGDYVGGTNHVLPTARSARFSSGLGVYDFLKRTSILKCSPASLN
VIGPAAVRLAEVERLDAHGRSILIRTNAG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=408, Percent_Identity=42.6470588235294, Blast_Score=293, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6319819, Length=434, Percent_Identity=38.2488479262673, Blast_Score=263, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45016; Mature: 44884

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRLDAKSTAFPDAFATFLASKREASTDVAVAVADIIAGVRARGDAALIDYSRTFDRVE
CCEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEE
LEGRIRVTEAEIEAALAEVPQDTFEALKFAKARIEAHHARQLPADERYTDAVGVELGQRW
ECCEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
TPVDAVGLYVPGGTAAYPSSVLMNAVPAKVAGVPRVAMVVPSPDGVIAPLVLAAARLAGV
CCCCEEEEEECCCCCCCCHHHHHHHCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCH
DEVYRVGGAQAVAALAYGTETIAPVDKIVGPGNAYVAAAKRQVFGKVGIDMIAGPSEVLI
HHHHHCCCHHHHHHHHHCCCHHCCHHHHCCCCCCEEHHHHHHHHHHCCCCEECCCCEEEE
LADGNANAAWIAADLLAQAEHDAAAQSILVTDSPVLADAVTRAVEAQLTTLPRREIAEAS
EECCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHCC
WRDHGAIILVGSMDEALPLVDRVAPEHLEIHADDADALADRIRHAGAIFVGAYTPEAIGD
CCCCCEEEEEECCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCEEEEECCCHHHHHH
YVGGTNHVLPTARSARFSSGLGVYDFLKRTSILKCSPASLNVIGPAAVRLAEVERLDAHG
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEECCCCCEEECHHHHHHHHHHHHCCCC
RSILIRTNAG
CEEEEEECCC
>Mature Secondary Structure 
PIRLDAKSTAFPDAFATFLASKREASTDVAVAVADIIAGVRARGDAALIDYSRTFDRVE
CEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEE
LEGRIRVTEAEIEAALAEVPQDTFEALKFAKARIEAHHARQLPADERYTDAVGVELGQRW
ECCEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
TPVDAVGLYVPGGTAAYPSSVLMNAVPAKVAGVPRVAMVVPSPDGVIAPLVLAAARLAGV
CCCCEEEEEECCCCCCCCHHHHHHHCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCH
DEVYRVGGAQAVAALAYGTETIAPVDKIVGPGNAYVAAAKRQVFGKVGIDMIAGPSEVLI
HHHHHCCCHHHHHHHHHCCCHHCCHHHHCCCCCCEEHHHHHHHHHHCCCCEECCCCEEEE
LADGNANAAWIAADLLAQAEHDAAAQSILVTDSPVLADAVTRAVEAQLTTLPRREIAEAS
EECCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHCC
WRDHGAIILVGSMDEALPLVDRVAPEHLEIHADDADALADRIRHAGAIFVGAYTPEAIGD
CCCCCEEEEEECCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCEEEEECCCHHHHHH
YVGGTNHVLPTARSARFSSGLGVYDFLKRTSILKCSPASLNVIGPAAVRLAEVERLDAHG
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEECCCCCEEECHHHHHHHHHHHHCCCC
RSILIRTNAG
CEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]