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The map label for this gene is hisG [H]

Identifier: 158424742

GI number: 158424742

Start: 3569955

End: 3570935

Strand: Direct

Name: hisG [H]

Synonym: AZC_3118

Alternate gene names: 158424742

Gene position: 3569955-3570935 (Clockwise)

Preceding gene: 158424741

Following gene: 158424744

Centisome position: 66.48

GC content: 69.22

Gene sequence:

>981_bases
ATGAGCGACACGCTGATCCTTGCCGTTCCCTCCAAGGGCCGCCTTCAGGAAAACGTCCACGCCTTCTTCGCCCGCGCGGG
GATGCCGCTGGTGCAGGCGCGCGGCGCACGCGAGTATCGCGGCGCGCTGGGCGGGGTGGACAATGTGGAGGTCGCCTATC
TCTCGGCCTCCGAGATCGCGGCGGCGCTGGCTTCCGGGGCCGTCCATGTGGGCGTCACTGGCGAAGACCTCGTGCGCGAG
AACATCCCGGATGCCGACAAGCGCGTGATGCTGCTGGAGAAGCTCGGCTTCGGCCACGCCAATGTGGTGGTGGCGGTGCC
GCAGGCCTGGATCGACGTGCGGTCCATGGAAGACCTCGACGATGTCGCCGGTCACTTCCACGCCCGCACCGGCCGGCGCA
TCCGGGTGGCCACCAAATATGTGAACCTCACTCGCAGCTTCTTCGCCCGTCACGGCATCGTGGACTATCGGATCGTGGAA
AGCGCGGGCGCGACCGAAGGCACGCCCGCCGCCGGCAGCGCCGAACTCATCGTGGACATCACCACCACCGGCGCGACACT
GGCCGCAAACGCCCTGAAGGTGGTGGACGACGGCGTGATGCTGCGCTCGGAGGCCAATCTCGTCGCCTCGCTGACCGCCC
CATGGGGCGAGGCGCAGCATGCGGCGGCCCGCGCCATGTTCGACCGCATGGCGGCCGAAAAGCGCGCCCGCACCATGCGC
GAGGTGCGCACCCGCTTCATCCAGTGCGATACGAACCTCGTGGACGAGGCTGTGAGCCGCTTCCGCTGCGTGGCGCCCTT
CGGCGGGCCGACCTCCTCGGGCATGCTCACGCTGCACTGCCCGCCGGACACGCTCCACGCCCTCTCCCTGTTCCTGCGCG
AGCGGGGAGCGAGCATGGTGACGGTGGGCCCGATCGAATACGTGTTCGCGGCCGAAAACCCGCTCTATGAGGCGCTTCAG
GCCCGGCTCGCCGGGGCCTGA

Upstream 100 bases:

>100_bases
GCTATGACCGCCTGATGAGCCGCCTCGGCGCCGAAACCGTGGTGCCGGCCGTTGGATTTGCCGCGTGGGTGGAACGTCTC
GCCCTGCTGGAGAGCCAGTC

Downstream 100 bases:

>100_bases
GCGCGACCGATCCGGTCTTCGCGGCGGCGGGCGTAGCCATTGAACGCCCGCCGGGCCGGCTCCTCAATGCGGCTGTACGT
GAAGGCCGCAAGCGCAATCA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSDTLILAVPSKGRLQENVHAFFARAGMPLVQARGAREYRGALGGVDNVEVAYLSASEIAAALASGAVHVGVTGEDLVRE
NIPDADKRVMLLEKLGFGHANVVVAVPQAWIDVRSMEDLDDVAGHFHARTGRRIRVATKYVNLTRSFFARHGIVDYRIVE
SAGATEGTPAAGSAELIVDITTTGATLAANALKVVDDGVMLRSEANLVASLTAPWGEAQHAAARAMFDRMAAEKRARTMR
EVRTRFIQCDTNLVDEAVSRFRCVAPFGGPTSSGMLTLHCPPDTLHALSLFLRERGASMVTVGPIEYVFAAENPLYEALQ
ARLAGA

Sequences:

>Translated_326_residues
MSDTLILAVPSKGRLQENVHAFFARAGMPLVQARGAREYRGALGGVDNVEVAYLSASEIAAALASGAVHVGVTGEDLVRE
NIPDADKRVMLLEKLGFGHANVVVAVPQAWIDVRSMEDLDDVAGHFHARTGRRIRVATKYVNLTRSFFARHGIVDYRIVE
SAGATEGTPAAGSAELIVDITTTGATLAANALKVVDDGVMLRSEANLVASLTAPWGEAQHAAARAMFDRMAAEKRARTMR
EVRTRFIQCDTNLVDEAVSRFRCVAPFGGPTSSGMLTLHCPPDTLHALSLFLRERGASMVTVGPIEYVFAAENPLYEALQ
ARLAGA
>Mature_325_residues
SDTLILAVPSKGRLQENVHAFFARAGMPLVQARGAREYRGALGGVDNVEVAYLSASEIAAALASGAVHVGVTGEDLVREN
IPDADKRVMLLEKLGFGHANVVVAVPQAWIDVRSMEDLDDVAGHFHARTGRRIRVATKYVNLTRSFFARHGIVDYRIVES
AGATEGTPAAGSAELIVDITTTGATLAANALKVVDDGVMLRSEANLVASLTAPWGEAQHAAARAMFDRMAAEKRARTMRE
VRTRFIQCDTNLVDEAVSRFRCVAPFGGPTSSGMLTLHCPPDTLHALSLFLRERGASMVTVGPIEYVFAAENPLYEALQA
RLAGA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 34925; Mature: 34794

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTLILAVPSKGRLQENVHAFFARAGMPLVQARGAREYRGALGGVDNVEVAYLSASEIA
CCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHCCCCCCEEEEEEHHHHH
AALASGAVHVGVTGEDLVRENIPDADKRVMLLEKLGFGHANVVVAVPQAWIDVRSMEDLD
HHHHCCCEEEECCHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
DVAGHFHARTGRRIRVATKYVNLTRSFFARHGIVDYRIVESAGATEGTPAAGSAELIVDI
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEE
TTTGATLAANALKVVDDGVMLRSEANLVASLTAPWGEAQHAAARAMFDRMAAEKRARTMR
ECCCCHHHHHHHHHHCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EVRTRFIQCDTNLVDEAVSRFRCVAPFGGPTSSGMLTLHCPPDTLHALSLFLRERGASMV
HHHHHHHHCCCHHHHHHHHHEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEE
TVGPIEYVFAAENPLYEALQARLAGA
EECCEEEEEECCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SDTLILAVPSKGRLQENVHAFFARAGMPLVQARGAREYRGALGGVDNVEVAYLSASEIA
CCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHCCCCCCEEEEEEHHHHH
AALASGAVHVGVTGEDLVRENIPDADKRVMLLEKLGFGHANVVVAVPQAWIDVRSMEDLD
HHHHCCCEEEECCHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
DVAGHFHARTGRRIRVATKYVNLTRSFFARHGIVDYRIVESAGATEGTPAAGSAELIVDI
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEE
TTTGATLAANALKVVDDGVMLRSEANLVASLTAPWGEAQHAAARAMFDRMAAEKRARTMR
ECCCCHHHHHHHHHHCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EVRTRFIQCDTNLVDEAVSRFRCVAPFGGPTSSGMLTLHCPPDTLHALSLFLRERGASMV
HHHHHHHHCCCHHHHHHHHHEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEE
TVGPIEYVFAAENPLYEALQARLAGA
EECCEEEEEECCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]