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The map label for this gene is ccdA [H]

Identifier: 158424573

GI number: 158424573

Start: 3370988

End: 3371809

Strand: Reverse

Name: ccdA [H]

Synonym: AZC_2949

Alternate gene names: 158424573

Gene position: 3371809-3370988 (Counterclockwise)

Preceding gene: 158424576

Following gene: 158424565

Centisome position: 62.79

GC content: 70.07

Gene sequence:

>822_bases
ATGGGGCGCGGGGCTTGCCGCTGGCGCGCGATGGGGCCAAGACACGGGAGCCCGCCCGTGCGGAGGCGGGGCGTAGCACC
CAAGGGTCCGATGGCCGACGTTTCGCTGCCCGCCGCCTTCCTTGCCGGCCTTGCCAGCTTTCTCTCCCCCTGCGTGCTGC
CGCTGGTGCCGCCCTATCTGTGCTACATCGGCGGCGCGACCCTCGACGACCTCACCAATGCCGAGCCGCTGCGTCAGGTC
GCCCGCCGGGCCTTCTATGGGGCGGTGCTGTTCGTCTCCGGCTTCACCGTTGTGTTCGTGCTGCTGGGAGCGGGGGCATC
CGCCATCGGCAATGTGCTGCGCGCCCATCTCGACACGCTCTCGCTCATTGCCGGCATCGCCATCATCCTGATGGGCCTCA
ACTTCCTCGGCGTGTTCCGCATCGCCTTTCTGTCGCGCACCGCGCGCGCCCATGTGGCGGAGCCGACGGGCGTATGGGGC
GCCTTCGTGATGGGCCTTGCCTTCGCCTTCGGCTGGACCCCCTGCCTCGGCCCGGTGCTCGGGGCCATCCTCGCGGTCGC
GGGCTCGGAGGCGACGGTGACGAAGGGGGCAGCGCTGCTCGCGGTCTATTCCGCCGGCCTCGGTGTGCCCTTCCTGCTGG
CGGCGCTCGCCGTGCGGCCCTTCCTCAAGAGCCTCACCCACATGCGGCGCTTCCTGCCGGTGGTGGAGAAGGTGATGGGC
GGCGTGCTGGTGCTCACGGGCATCGCCTTCCTGTCCGGCGGCATCGCCAGCATGAGCTACTGGCTGCTCGAAACCTTCCC
CATCCTCAGCACGCTCGGCTGA

Upstream 100 bases:

>100_bases
CCGGGCACGTCGGTGAGGAGATTGCGCATGGCGGCACCGGGGAATCAGGACAGGACGGCAGGGTAGGGCGGGAGGGCGCG
GCTTCACAACGCGGGGAGGC

Downstream 100 bases:

>100_bases
GGATCTCGATCAGGAACTGGCGTCCCGCAGGCGCGGGTTGGGCGCCTTGGCCGCGTTGCGCGCGCCGAGCGCTGCGTCGA
TGCGGGCGAGCGTCAGCTGG

Product: cytochrome c biogenesis protein

Products: DsbDoxidized; DsbGreduced [C]

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MGRGACRWRAMGPRHGSPPVRRRGVAPKGPMADVSLPAAFLAGLASFLSPCVLPLVPPYLCYIGGATLDDLTNAEPLRQV
ARRAFYGAVLFVSGFTVVFVLLGAGASAIGNVLRAHLDTLSLIAGIAIILMGLNFLGVFRIAFLSRTARAHVAEPTGVWG
AFVMGLAFAFGWTPCLGPVLGAILAVAGSEATVTKGAALLAVYSAGLGVPFLLAALAVRPFLKSLTHMRRFLPVVEKVMG
GVLVLTGIAFLSGGIASMSYWLLETFPILSTLG

Sequences:

>Translated_273_residues
MGRGACRWRAMGPRHGSPPVRRRGVAPKGPMADVSLPAAFLAGLASFLSPCVLPLVPPYLCYIGGATLDDLTNAEPLRQV
ARRAFYGAVLFVSGFTVVFVLLGAGASAIGNVLRAHLDTLSLIAGIAIILMGLNFLGVFRIAFLSRTARAHVAEPTGVWG
AFVMGLAFAFGWTPCLGPVLGAILAVAGSEATVTKGAALLAVYSAGLGVPFLLAALAVRPFLKSLTHMRRFLPVVEKVMG
GVLVLTGIAFLSGGIASMSYWLLETFPILSTLG
>Mature_272_residues
GRGACRWRAMGPRHGSPPVRRRGVAPKGPMADVSLPAAFLAGLASFLSPCVLPLVPPYLCYIGGATLDDLTNAEPLRQVA
RRAFYGAVLFVSGFTVVFVLLGAGASAIGNVLRAHLDTLSLIAGIAIILMGLNFLGVFRIAFLSRTARAHVAEPTGVWGA
FVMGLAFAFGWTPCLGPVLGAILAVAGSEATVTKGAALLAVYSAGLGVPFLLAALAVRPFLKSLTHMRRFLPVVEKVMGG
VLVLTGIAFLSGGIASMSYWLLETFPILSTLG

Specific function: Cytochrome c oxidase activity is partially restored by mutations in bdbC or bdbD that are defective in the synthesis of disulfide bond containing proteins. The same mutations abrogate the need for CcdA in sporulation [H]

COG id: COG0785

COG function: function code O; Cytochrome c biogenesis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DsbD family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834 [H]

Pfam domain/function: PF02683 DsbD [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 28420; Mature: 28289

Theoretical pI: Translated: 10.91; Mature: 10.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GRGACRWRAMGPRHGSPPVRRRGVAPKGPMADVSLPAAFLAGLASFLSPCVLPLVPPYL
CCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
CYIGGATLDDLTNAEPLRQVARRAFYGAVLFVSGFTVVFVLLGAGASAIGNVLRAHLDTL
HHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SLIAGIAIILMGLNFLGVFRIAFLSRTARAHVAEPTGVWGAFVMGLAFAFGWTPCLGPVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
GAILAVAGSEATVTKGAALLAVYSAGLGVPFLLAALAVRPFLKSLTHMRRFLPVVEKVMG
HHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVLVLTGIAFLSGGIASMSYWLLETFPILSTLG
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DsbGoxidized; DsbDreduced/thiol:disulfide reductase [C]

Specific reaction: DsbDreduced/thiol:disulfide reductase + DsbCoxidized = DsbDoxidized + DsbCreduced DsbGoxidized + DsbDreduced/thiol:disulfide reductase = DsbGreduced + DsbDoxidized [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969507; 9068642; 9384377; 10781554; 11844773 [H]