Click here to switch to the map view.

The map label for this gene is yisK [H]

Identifier: 158424507

GI number: 158424507

Start: 3285416

End: 3286282

Strand: Direct

Name: yisK [H]

Synonym: AZC_2883

Alternate gene names: 158424507

Gene position: 3285416-3286282 (Clockwise)

Preceding gene: 158424506

Following gene: 158424508

Centisome position: 61.18

GC content: 68.4

Gene sequence:

>867_bases
ATGTTCAAGGAAAAGGTTCGCCCGATGAAGTTCGCTTCCTTCACCCATGCCGGCCGCGCCAGCTATGGCCTCGTGACCGA
CGGCGGGATCGTCGATCTCGCCCGCCGTTTCCCGGAGGCCCCGACGCTGCGGTCCTTCATCGCCGGCGGACTGGAGCGCG
CCGCCGCCTTCACCGCCGCGCCCGCCGACGTCGCGCTGGACGACGTGGCCCTCGATCCGGTCATTCCCGATCCCGACAAG
ATCGTGTGCGTGGGCCTCAACTATCATGACCACGTGACGGAGACGGGCCGCACCGTCACGCCCAACCCCATGCTGTTCGC
CCGCTATCCCGGCAGCCAGGTGGGCTCCGGCGCGGCGCTCGTGAAGCCGCTGGAATCCGACGAGTTCGATTATGAGGGCG
AGCTCGCCGTCATCATCGGCAAGGGCGGCCGGCGCATCTCCGAGGCGGATGCGCTCTCCCACGTGGCCGGCTATGCCTGC
TACAACGATGCCAGCGTCCGCGACTGGCAGCGCCACACCTCGCAGTTCATGCCGGGCAAGACCTTCGCCGCCACGGGTGG
CTTCGGCCCCTGGATGGTGAGCGCGGACGAAATCCCGGACCCGACGCAGCTCAAGCTCACCACGCGCCTCAATGGCCAGC
AGGTGCAGCAGACGAGCGTCGATCTGATGATCACGCCCATCCCGACCCTCATCGCCTACACCTCCACCATCCTGCCGCTG
CTGCCCGGCGACGTGATCGTCTCCGGTACGCCGGGCGGTGTCGGCGCCCGCCGCACGCCGAAGCTGTTCATGAAGGACGG
CGACGTGGTGGAAGTGGAGGTGAGCGGCGTCGGCGTGCTGCGCAACCCGGTGGTCGCCGAGCGCTGA

Upstream 100 bases:

>100_bases
CGCCCTGGCCGACTGGCCGATGGTCTACCTGCCCCAACGCGCCGCCGCCTGATCCGGCCGGCACCGCCCGCCCGGCCCTC
TCCTGTTTCCCCCCAAGAAG

Downstream 100 bases:

>100_bases
GCCCCCGGAAGGTTCCTTGAAGACGTGACACCTGCCGTGGCTGGAACGCTGGCCACGGCAGGTGTGCATTGTGTACGATA
CAAAAAGAGACCGGGGGATC

Product: fumarylacetoacetate (FAA) hydrolase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MFKEKVRPMKFASFTHAGRASYGLVTDGGIVDLARRFPEAPTLRSFIAGGLERAAAFTAAPADVALDDVALDPVIPDPDK
IVCVGLNYHDHVTETGRTVTPNPMLFARYPGSQVGSGAALVKPLESDEFDYEGELAVIIGKGGRRISEADALSHVAGYAC
YNDASVRDWQRHTSQFMPGKTFAATGGFGPWMVSADEIPDPTQLKLTTRLNGQQVQQTSVDLMITPIPTLIAYTSTILPL
LPGDVIVSGTPGGVGARRTPKLFMKDGDVVEVEVSGVGVLRNPVVAER

Sequences:

>Translated_288_residues
MFKEKVRPMKFASFTHAGRASYGLVTDGGIVDLARRFPEAPTLRSFIAGGLERAAAFTAAPADVALDDVALDPVIPDPDK
IVCVGLNYHDHVTETGRTVTPNPMLFARYPGSQVGSGAALVKPLESDEFDYEGELAVIIGKGGRRISEADALSHVAGYAC
YNDASVRDWQRHTSQFMPGKTFAATGGFGPWMVSADEIPDPTQLKLTTRLNGQQVQQTSVDLMITPIPTLIAYTSTILPL
LPGDVIVSGTPGGVGARRTPKLFMKDGDVVEVEVSGVGVLRNPVVAER
>Mature_288_residues
MFKEKVRPMKFASFTHAGRASYGLVTDGGIVDLARRFPEAPTLRSFIAGGLERAAAFTAAPADVALDDVALDPVIPDPDK
IVCVGLNYHDHVTETGRTVTPNPMLFARYPGSQVGSGAALVKPLESDEFDYEGELAVIIGKGGRRISEADALSHVAGYAC
YNDASVRDWQRHTSQFMPGKTFAATGGFGPWMVSADEIPDPTQLKLTTRLNGQQVQQTSVDLMITPIPTLIAYTSTILPL
LPGDVIVSGTPGGVGARRTPKLFMKDGDVVEVEVSGVGVLRNPVVAER

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=291, Percent_Identity=39.1752577319588, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI40786394, Length=291, Percent_Identity=38.8316151202749, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI13654274, Length=201, Percent_Identity=35.3233830845771, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI215422413, Length=201, Percent_Identity=35.3233830845771, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI66348062, Length=203, Percent_Identity=34.9753694581281, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1787428, Length=180, Percent_Identity=33.8888888888889, Blast_Score=94, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17557057, Length=199, Percent_Identity=36.1809045226131, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324161, Length=236, Percent_Identity=24.5762711864407, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28572127, Length=222, Percent_Identity=39.1891891891892, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24663695, Length=296, Percent_Identity=30.4054054054054, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI28571789, Length=222, Percent_Identity=31.0810810810811, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 30739; Mature: 30739

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKEKVRPMKFASFTHAGRASYGLVTDGGIVDLARRFPEAPTLRSFIAGGLERAAAFTAA
CCCHHCCCCHHHHHCCCCCCCCCEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
PADVALDDVALDPVIPDPDKIVCVGLNYHDHVTETGRTVTPNPMLFARYPGSQVGSGAAL
CCCCEECCEECCCCCCCCCCEEEEECCCCCCHHCCCCEECCCCEEEEECCCCCCCCCCEE
VKPLESDEFDYEGELAVIIGKGGRRISEADALSHVAGYACYNDASVRDWQRHTSQFMPGK
EECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCC
TFAATGGFGPWMVSADEIPDPTQLKLTTRLNGQQVQQTSVDLMITPIPTLIAYTSTILPL
EEEECCCCCCEEEECCCCCCCCEEEEEEECCCCCHHHCCCCEEEECHHHHHHHHHHHHHH
LPGDVIVSGTPGGVGARRTPKLFMKDGDVVEVEVSGVGVLRNPVVAER
CCCCEEEECCCCCCCCCCCCEEEECCCCEEEEEECCCEEECCCCCCCC
>Mature Secondary Structure
MFKEKVRPMKFASFTHAGRASYGLVTDGGIVDLARRFPEAPTLRSFIAGGLERAAAFTAA
CCCHHCCCCHHHHHCCCCCCCCCEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
PADVALDDVALDPVIPDPDKIVCVGLNYHDHVTETGRTVTPNPMLFARYPGSQVGSGAAL
CCCCEECCEECCCCCCCCCCEEEEECCCCCCHHCCCCEECCCCEEEEECCCCCCCCCCEE
VKPLESDEFDYEGELAVIIGKGGRRISEADALSHVAGYACYNDASVRDWQRHTSQFMPGK
EECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCC
TFAATGGFGPWMVSADEIPDPTQLKLTTRLNGQQVQQTSVDLMITPIPTLIAYTSTILPL
EEEECCCCCCEEEECCCCCCCCEEEEEEECCCCCHHHCCCCEEEECHHHHHHHHHHHHHH
LPGDVIVSGTPGGVGARRTPKLFMKDGDVVEVEVSGVGVLRNPVVAER
CCCCEEEECCCCCCCCCCCCEEEECCCCEEEEEECCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]