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The map label for this gene is hlyD [H]

Identifier: 158424292

GI number: 158424292

Start: 3026526

End: 3027803

Strand: Reverse

Name: hlyD [H]

Synonym: AZC_2668

Alternate gene names: 158424292

Gene position: 3027803-3026526 (Counterclockwise)

Preceding gene: 158424293

Following gene: 158424291

Centisome position: 56.39

GC content: 70.58

Gene sequence:

>1278_bases
ATGACCGCTTCCGTATCCCCGTCCGAGCCGGCTGTGACCGGCGTGTCTGATCCGTCCCCGTCCACCCGGTCTTCTTCCCC
GTGGCGCCGGCGCCTGCTGCTTGGTGCAGTGGTACTGGTCGCCATCGGTGCCGGGATCTATGTCGTGCCCTCGGCGCTCA
AGCCGGCAGGCGGTGCGGCGTCTGCCGCAGCCCCAGGAAGCCCGCCCCCCGTGCCCGTGGCGGTTGCGACCGTGGAGGCG
CGCGATACGCGCCTTTACGAGAGCTTCTCCGGCCGTCTGGAGGCGGTGGAGCGGGTGGAGGTGCGCTCGCGGGTGGCCGG
TGCCATCAAGGCTGTGCACTTCCGCGAGGGCGCACTGGTGAAGGCCGGCGACCTCCTCGTGACCATCGACCCCGAGCCCT
ATCAGGCCGCCCTCGATGAGGCGGACGCGCAGGTGGCCTCGGCAGAGGCCCAGCTGGAACTCGCGCGCAACGAGCTGGAG
CGCGGTGAGCGCCTGTTCACGAGCCGCACCCTGTCCCAGCGCGATCTCGACGAGCGTCTCAATACGCAGCGGGCGGCCCA
GGCCGCCCTGCGGGCGGCGGAGGCCCGGCGCACGGTGGCGCGGCTGAACCTTTCTTACACGCAGGTCCGCGCGCCGGTTG
CCGGCCGTGTCGGCAAGTCGGAGATCACGGTGGGCAATCTCATCGCTGCCGGCCCCGGCGCGCAGCTTCTGACTTCCCTT
GTCTCCGTCGATCCGATCTATGCCAGCTTCAACGCGGATGAGGCGACTGTCGCCCAGGCCCTCGCCGCGCTTGGCACAGG
CGCCGACGTGACCGAGCGGCTGGACCGCATTCCGGTGCGGATGACGGCGGGCGGCAATCCGCCGGTGACTGGCGTCATGC
AACTGGTGGACAATCAGGTCGATCCGCGCACCGGTACGGTCCGCGTGCGTGCCCGCTTCGCCAATCCGGACGGACATCTT
CTGCCGGGCCAGTTCGCCCGCCTCGAGATGGGCCAGCCGCAATCGGCGCCCGCCGTGCTCGTGAGCGAAAGGGCCGTGGG
CACCGATCAGGACAAGAAGTTCGTCTTCGTGGTGGACGCCGACAACAAGGCGGTATGGCGCGAGGTGACGCTCGGCGCGC
CGGTGGACGGCCTGCGCGTTGTCACGCGGGGCCTCTCCGCCGGAGAGCGGGTGGTGGTCAACGGCCTGCACCGCGTCCGC
CCCGGCGCTGCCGTGACACCTGAGACCGCACCCATGCAGGTGACTGAGGCGACAAGCCGCTCGGCTGCCGCCAACTGA

Upstream 100 bases:

>100_bases
CAGAGCGATGTTTACCCGCTTTTTCGAGACCACGGGTCGTGCCCGGCCGGTCGCCTCGCCGTCTGTTCCCTGAACCGCCC
CGCTTTCAGGATTACCCCCG

Downstream 100 bases:

>100_bases
GATCCTGATCCGGCGGGCCTTATCCGCCGGCACGGCTGAAGGTGCCGCCGACGCAGGCCGTATGGCTCCGGCCCGGCACC
GTTAACAGGTTTCCCACCCC

Product: secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTASVSPSEPAVTGVSDPSPSTRSSSPWRRRLLLGAVVLVAIGAGIYVVPSALKPAGGAASAAAPGSPPPVPVAVATVEA
RDTRLYESFSGRLEAVERVEVRSRVAGAIKAVHFREGALVKAGDLLVTIDPEPYQAALDEADAQVASAEAQLELARNELE
RGERLFTSRTLSQRDLDERLNTQRAAQAALRAAEARRTVARLNLSYTQVRAPVAGRVGKSEITVGNLIAAGPGAQLLTSL
VSVDPIYASFNADEATVAQALAALGTGADVTERLDRIPVRMTAGGNPPVTGVMQLVDNQVDPRTGTVRVRARFANPDGHL
LPGQFARLEMGQPQSAPAVLVSERAVGTDQDKKFVFVVDADNKAVWREVTLGAPVDGLRVVTRGLSAGERVVVNGLHRVR
PGAAVTPETAPMQVTEATSRSAAAN

Sequences:

>Translated_425_residues
MTASVSPSEPAVTGVSDPSPSTRSSSPWRRRLLLGAVVLVAIGAGIYVVPSALKPAGGAASAAAPGSPPPVPVAVATVEA
RDTRLYESFSGRLEAVERVEVRSRVAGAIKAVHFREGALVKAGDLLVTIDPEPYQAALDEADAQVASAEAQLELARNELE
RGERLFTSRTLSQRDLDERLNTQRAAQAALRAAEARRTVARLNLSYTQVRAPVAGRVGKSEITVGNLIAAGPGAQLLTSL
VSVDPIYASFNADEATVAQALAALGTGADVTERLDRIPVRMTAGGNPPVTGVMQLVDNQVDPRTGTVRVRARFANPDGHL
LPGQFARLEMGQPQSAPAVLVSERAVGTDQDKKFVFVVDADNKAVWREVTLGAPVDGLRVVTRGLSAGERVVVNGLHRVR
PGAAVTPETAPMQVTEATSRSAAAN
>Mature_424_residues
TASVSPSEPAVTGVSDPSPSTRSSSPWRRRLLLGAVVLVAIGAGIYVVPSALKPAGGAASAAAPGSPPPVPVAVATVEAR
DTRLYESFSGRLEAVERVEVRSRVAGAIKAVHFREGALVKAGDLLVTIDPEPYQAALDEADAQVASAEAQLELARNELER
GERLFTSRTLSQRDLDERLNTQRAAQAALRAAEARRTVARLNLSYTQVRAPVAGRVGKSEITVGNLIAAGPGAQLLTSLV
SVDPIYASFNADEATVAQALAALGTGADVTERLDRIPVRMTAGGNPPVTGVMQLVDNQVDPRTGTVRVRARFANPDGHLL
PGQFARLEMGQPQSAPAVLVSERAVGTDQDKKFVFVVDADNKAVWREVTLGAPVDGLRVVTRGLSAGERVVVNGLHRVRP
GAAVTPETAPMQVTEATSRSAAAN

Specific function: May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=363, Percent_Identity=35.8126721763085, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1786668, Length=354, Percent_Identity=33.8983050847458, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789929, Length=377, Percent_Identity=31.5649867374005, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789665, Length=321, Percent_Identity=33.0218068535826, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI87081796, Length=358, Percent_Identity=28.2122905027933, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87081951, Length=141, Percent_Identity=36.1702127659575, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789637, Length=143, Percent_Identity=34.2657342657343, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44478; Mature: 44347

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASVSPSEPAVTGVSDPSPSTRSSSPWRRRLLLGAVVLVAIGAGIYVVPSALKPAGGAA
CCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
SAAAPGSPPPVPVAVATVEARDTRLYESFSGRLEAVERVEVRSRVAGAIKAVHFREGALV
CCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEE
KAGDLLVTIDPEPYQAALDEADAQVASAEAQLELARNELERGERLFTSRTLSQRDLDERL
EECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTQRAAQAALRAAEARRTVARLNLSYTQVRAPVAGRVGKSEITVGNLIAAGPGAQLLTSL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHCCCCCCCEEECCEEECCCCHHHHHHH
VSVDPIYASFNADEATVAQALAALGTGADVTERLDRIPVRMTAGGNPPVTGVMQLVDNQV
HHCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCC
DPRTGTVRVRARFANPDGHLLPGQFARLEMGQPQSAPAVLVSERAVGTDQDKKFVFVVDA
CCCCCEEEEEEEEECCCCCCCCCCHHEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEEC
DNKAVWREVTLGAPVDGLRVVTRGLSAGERVVVNGLHRVRPGAAVTPETAPMQVTEATSR
CCCEEEEEEECCCCCHHHHHHHHCCCCCCEEEHHCHHHCCCCCCCCCCCCCEEEEHHHCC
SAAAN
CCCCC
>Mature Secondary Structure 
TASVSPSEPAVTGVSDPSPSTRSSSPWRRRLLLGAVVLVAIGAGIYVVPSALKPAGGAA
CCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
SAAAPGSPPPVPVAVATVEARDTRLYESFSGRLEAVERVEVRSRVAGAIKAVHFREGALV
CCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEE
KAGDLLVTIDPEPYQAALDEADAQVASAEAQLELARNELERGERLFTSRTLSQRDLDERL
EECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTQRAAQAALRAAEARRTVARLNLSYTQVRAPVAGRVGKSEITVGNLIAAGPGAQLLTSL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHCCCCCCCEEECCEEECCCCHHHHHHH
VSVDPIYASFNADEATVAQALAALGTGADVTERLDRIPVRMTAGGNPPVTGVMQLVDNQV
HHCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCC
DPRTGTVRVRARFANPDGHLLPGQFARLEMGQPQSAPAVLVSERAVGTDQDKKFVFVVDA
CCCCCEEEEEEEEECCCCCCCCCCHHEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEEC
DNKAVWREVTLGAPVDGLRVVTRGLSAGERVVVNGLHRVRPGAAVTPETAPMQVTEATSR
CCCEEEEEEECCCCCHHHHHHHHCCCCCCEEEHHCHHHCCCCCCCCCCCCCEEEEHHHCC
SAAAN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12271122 [H]