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The map label for this gene is idnD [H]

Identifier: 158424237

GI number: 158424237

Start: 2947645

End: 2948682

Strand: Reverse

Name: idnD [H]

Synonym: AZC_2613

Alternate gene names: 158424237

Gene position: 2948682-2947645 (Counterclockwise)

Preceding gene: 158424244

Following gene: 158424236

Centisome position: 54.91

GC content: 68.88

Gene sequence:

>1038_bases
ATGCGCGCCGCCGTGCTTCATGCCGCCAAGGATCTGAGGGTCGAGGAGATTGATGAGCGCCCGCTCGCTGACGACGAGGT
GCGCCTGCGCTTCGCCGCCGGCGGCATCTGCGGCTCGGACCTCTCCTATTATTTCAAGGGCCGCGTCGGGGATTTCGACG
TGCGCCAGCCGCTCGTGCTGGGCCACGAGGTGTCCGGCGAGGTGGCGGCGGTCGGACCGCGCGTCGAGACGCTTAAGCCG
GGCGACCGCGTGGCCGTGGACCCGAGCCGGCCATGCCTCACCTGCGACTATTGCCGCATGGGGCGCTCCAACCTCTGCCG
CAACATGCGCTTCTTCGGCAGCGCGGCGATCTATCCGCACGTGCAGGGCGCCTTCAGCGAGACCTTCATCGCCCGCGCCG
ACCAGTGCGTGAAGGTGCCCGACAGCATGTCCATGCGGGTGGCCGCCTGCGCCGAGCCGCTGGCCGTTTCCGTCCACGCC
TGCCGGCGCGGCGGCGAGATCGCAGGGCGCAAGGTCCTGATCGCCGGGGCAGGGCCCATCGGCATCCTCTCGGCCCTCGT
CATGCGCCGCATGGGCGCGGCCGAGATCGCCATCACGGACCTCGTGGAGGCGCCGCTCGCCATCGCCCGCGAAGCGGGGG
TGGATGAGACCATCTGCGTCGGCACCGATCCGGAGAAGCTCACCCGTTATGAGGCGGACAAGGGCTATTTCGACATCGCG
CTCGAGGCGACTGGCTCGCCGCAGGCGCTCGCGTCGCTGTTCAAGGTGGTGCGGCCGGGCGGTCGCGTCATCCAGGTGGG
CATGATGCCGCCCGGTACCATTCCCGTGCCGGCCAACATGCTGATGGCCCGCGAGATCGATTTCGTCGGTGCCTTCCGCT
TCCACACCGAGTTCAAGACCGCCGTGGACTATCTGGCGCGCGGCCTCATCGACGTATCCCCCATCCTCTCGGCCCAGATG
CCCATGAGTGATGCCGACGCCGCCTTCGCCATGGCCGCCGACCGCAACCGGGCGATCAAGGTCCATCTCACCTTCTGA

Upstream 100 bases:

>100_bases
ATCCGGCGGCCTGCTTTTTTGCTTGTGCTCCAGATAGAGCATGTTATCGGTAACAAAACAAGAGGCCCCTCGCATGCGGG
CCTCGCACCGGGGAGTGACC

Downstream 100 bases:

>100_bases
CCGCGCGCATAACGAACAAAGGAAACGCTCATGTATACCCGCTGCGCCATCTTCGAGGGCCAGATCACGCCAGGCCGTGA
GGACGAGTTCTTCAAGGCGG

Product: zinc-binding dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MRAAVLHAAKDLRVEEIDERPLADDEVRLRFAAGGICGSDLSYYFKGRVGDFDVRQPLVLGHEVSGEVAAVGPRVETLKP
GDRVAVDPSRPCLTCDYCRMGRSNLCRNMRFFGSAAIYPHVQGAFSETFIARADQCVKVPDSMSMRVAACAEPLAVSVHA
CRRGGEIAGRKVLIAGAGPIGILSALVMRRMGAAEIAITDLVEAPLAIAREAGVDETICVGTDPEKLTRYEADKGYFDIA
LEATGSPQALASLFKVVRPGGRVIQVGMMPPGTIPVPANMLMAREIDFVGAFRFHTEFKTAVDYLARGLIDVSPILSAQM
PMSDADAAFAMAADRNRAIKVHLTF

Sequences:

>Translated_345_residues
MRAAVLHAAKDLRVEEIDERPLADDEVRLRFAAGGICGSDLSYYFKGRVGDFDVRQPLVLGHEVSGEVAAVGPRVETLKP
GDRVAVDPSRPCLTCDYCRMGRSNLCRNMRFFGSAAIYPHVQGAFSETFIARADQCVKVPDSMSMRVAACAEPLAVSVHA
CRRGGEIAGRKVLIAGAGPIGILSALVMRRMGAAEIAITDLVEAPLAIAREAGVDETICVGTDPEKLTRYEADKGYFDIA
LEATGSPQALASLFKVVRPGGRVIQVGMMPPGTIPVPANMLMAREIDFVGAFRFHTEFKTAVDYLARGLIDVSPILSAQM
PMSDADAAFAMAADRNRAIKVHLTF
>Mature_345_residues
MRAAVLHAAKDLRVEEIDERPLADDEVRLRFAAGGICGSDLSYYFKGRVGDFDVRQPLVLGHEVSGEVAAVGPRVETLKP
GDRVAVDPSRPCLTCDYCRMGRSNLCRNMRFFGSAAIYPHVQGAFSETFIARADQCVKVPDSMSMRVAACAEPLAVSVHA
CRRGGEIAGRKVLIAGAGPIGILSALVMRRMGAAEIAITDLVEAPLAIAREAGVDETICVGTDPEKLTRYEADKGYFDIA
LEATGSPQALASLFKVVRPGGRVIQVGMMPPGTIPVPANMLMAREIDFVGAFRFHTEFKTAVDYLARGLIDVSPILSAQM
PMSDADAAFAMAADRNRAIKVHLTF

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=328, Percent_Identity=37.8048780487805, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4501933, Length=377, Percent_Identity=25.4641909814324, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI71565152, Length=380, Percent_Identity=21.5789473684211, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4501929, Length=377, Percent_Identity=25.4641909814324, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI71565154, Length=283, Percent_Identity=25.7950530035336, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI71743840, Length=236, Percent_Identity=27.5423728813559, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI262073058, Length=236, Percent_Identity=27.5423728813559, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790718, Length=322, Percent_Identity=40.6832298136646, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1788073, Length=321, Percent_Identity=32.0872274143302, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790045, Length=330, Percent_Identity=30.3030303030303, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1787863, Length=348, Percent_Identity=27.0114942528736, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788407, Length=303, Percent_Identity=27.7227722772277, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI226510992, Length=353, Percent_Identity=28.328611898017, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87081918, Length=330, Percent_Identity=30.3030303030303, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788075, Length=339, Percent_Identity=26.5486725663717, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082125, Length=355, Percent_Identity=26.7605633802817, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786825, Length=221, Percent_Identity=28.0542986425339, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786552, Length=358, Percent_Identity=25.6983240223464, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=331, Percent_Identity=35.6495468277946, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17562878, Length=331, Percent_Identity=37.4622356495468, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI71988145, Length=308, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=314, Percent_Identity=25.796178343949, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=291, Percent_Identity=26.4604810996564, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=293, Percent_Identity=26.6211604095563, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562582, Length=164, Percent_Identity=28.0487804878049, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=346, Percent_Identity=31.7919075144509, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319955, Length=346, Percent_Identity=31.5028901734104, Blast_Score=179, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6323099, Length=311, Percent_Identity=32.7974276527331, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6319258, Length=383, Percent_Identity=27.6762402088773, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6319257, Length=379, Percent_Identity=26.6490765171504, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319621, Length=329, Percent_Identity=27.9635258358663, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=299, Percent_Identity=26.7558528428094, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=298, Percent_Identity=26.1744966442953, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=359, Percent_Identity=24.7910863509749, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=313, Percent_Identity=23.961661341853, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=290, Percent_Identity=26.551724137931, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319949, Length=268, Percent_Identity=26.1194029850746, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17737897, Length=330, Percent_Identity=40, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI17137530, Length=330, Percent_Identity=37.8787878787879, Blast_Score=212, Evalue=2e-55,
Organism=Drosophila melanogaster, GI45550770, Length=315, Percent_Identity=25.3968253968254, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45551930, Length=315, Percent_Identity=25.3968253968254, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI221457811, Length=315, Percent_Identity=25.3968253968254, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17737895, Length=357, Percent_Identity=24.3697478991597, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 37086; Mature: 37086

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAVLHAAKDLRVEEIDERPLADDEVRLRFAAGGICGSDLSYYFKGRVGDFDVRQPLVL
CCCHHHHHHHHCCHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCCCCCCCCEEE
GHEVSGEVAAVGPRVETLKPGDRVAVDPSRPCLTCDYCRMGRSNLCRNMRFFGSAAIYPH
CCCCCCCEEEECCCCEEECCCCEEEECCCCCCEECHHHHCCHHHHHHHHHHHCCEEECCC
VQGAFSETFIARADQCVKVPDSMSMRVAACAEPLAVSVHACRRGGEIAGRKVLIAGAGPI
CCCHHHHHHHHHCHHHEECCCCCCEEHHHHCCCHHEEHHHHHCCCCCCCCEEEEECCCHH
GILSALVMRRMGAAEIAITDLVEAPLAIAREAGVDETICVGTDPEKLTRYEADKGYFDIA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCCEEEEE
LEATGSPQALASLFKVVRPGGRVIQVGMMPPGTIPVPANMLMAREIDFVGAFRFHTEFKT
EECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCEEEEEEHHHHHH
AVDYLARGLIDVSPILSAQMPMSDADAAFAMAADRNRAIKVHLTF
HHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEEEC
>Mature Secondary Structure
MRAAVLHAAKDLRVEEIDERPLADDEVRLRFAAGGICGSDLSYYFKGRVGDFDVRQPLVL
CCCHHHHHHHHCCHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCCCCCCCCEEE
GHEVSGEVAAVGPRVETLKPGDRVAVDPSRPCLTCDYCRMGRSNLCRNMRFFGSAAIYPH
CCCCCCCEEEECCCCEEECCCCEEEECCCCCCEECHHHHCCHHHHHHHHHHHCCEEECCC
VQGAFSETFIARADQCVKVPDSMSMRVAACAEPLAVSVHACRRGGEIAGRKVLIAGAGPI
CCCHHHHHHHHHCHHHEECCCCCCEEHHHHCCCHHEEHHHHHCCCCCCCCEEEEECCCHH
GILSALVMRRMGAAEIAITDLVEAPLAIAREAGVDETICVGTDPEKLTRYEADKGYFDIA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCCEEEEE
LEATGSPQALASLFKVVRPGGRVIQVGMMPPGTIPVPANMLMAREIDFVGAFRFHTEFKT
EECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCEEEEEEHHHHHH
AVDYLARGLIDVSPILSAQMPMSDADAAFAMAADRNRAIKVHLTF
HHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]