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The map label for this gene is garR [H]

Identifier: 158424234

GI number: 158424234

Start: 2945326

End: 2946174

Strand: Reverse

Name: garR [H]

Synonym: AZC_2610

Alternate gene names: 158424234

Gene position: 2946174-2945326 (Counterclockwise)

Preceding gene: 158424235

Following gene: 158424233

Centisome position: 54.87

GC content: 69.14

Gene sequence:

>849_bases
ATGGGCAGCGCCATCGCGACGCGCTTCCTGGAGCGCGGCCGCACCGTGCATCTGCGCGACATGGACCCGCAGAAGCTGGC
GCCGCTGGTCGCGCGCGGGGCGATCGCCGTGGAAAGCGTCGCGGCCCTGACGCAGGCGAGCGACGTTATCATCACCAGCC
TCAACACGGCGGAGATTGTCGAGGCGGTGCTGTTCGGGGCCGATGGCATCGCCGCGGCGGCAAAGCCTGGCCAACTCTTC
ATCGACATGTCGAGCATCGACCCCAAGGCGACTGCCACGCTCGCCGCGCGGCTGGAGCGGGAGACCGGCATGGCCTATGT
GGATGCGCCCTTGTCGGGCGGCGCGCCGGCCGCCCTGGCGGGGCGGCTCACGCTCATGATGGGCGGCAGCCCGGAGGCCG
TGGAGCGGGCCAAGGTGGTGCTGGCCGATGTGGCGGCGAATATGACCCATATGGGGCCGTACGGGGCAGGGCAGACCACC
AAGCTCATCAATCAGGTGCTGTGCGCCTGCAATTTCCTCGCGGTGGCGGAGGCGACCCGTCTCGCGCTCGATGGCGGGGT
GGATGCCGCGCGCATTCCGCAGGCGCTGGCCGGCGGACGCGCCGATTCGCGCATCCTCCAGGAGTTCATGGGCAAGATGG
CCGCCTTCGATCTGACCCCCACGGGCCGGATCGACAACATGCTGAAGGATCTGGAGGCGGTGCAGCGCTATGCCATGGCC
CTGCGCACGCCCATGCCGCTCACCGGCCTCGTCACCGAACTGCATCGTGTCATGGTGGCGGCTGGCATCGGTCCAGAGGA
CAGCGCGGCCTATATGAAGCTCTTCGACTTCGGCACCCGCGCCGCCTGA

Upstream 100 bases:

>100_bases
GGCTGATCGAGCGGGAGACCACCGCGCCGTCCCGCAAGCGCCGCAAGAATGGGAGGAAGTCCAGTTGAGAGAGACCATCG
GCATCATCGGCGTCGGCGTC

Downstream 100 bases:

>100_bases
TCGCATTTATGGAAAAGCTCCGACCTCAATCGGGCAGGGGCGCGCGCGGGGCCGGGGGGTGCTATATGCGCCGTGCGGCT
TTGGCCGCGCCTCCGTCCGC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MGSAIATRFLERGRTVHLRDMDPQKLAPLVARGAIAVESVAALTQASDVIITSLNTAEIVEAVLFGADGIAAAAKPGQLF
IDMSSIDPKATATLAARLERETGMAYVDAPLSGGAPAALAGRLTLMMGGSPEAVERAKVVLADVAANMTHMGPYGAGQTT
KLINQVLCACNFLAVAEATRLALDGGVDAARIPQALAGGRADSRILQEFMGKMAAFDLTPTGRIDNMLKDLEAVQRYAMA
LRTPMPLTGLVTELHRVMVAAGIGPEDSAAYMKLFDFGTRAA

Sequences:

>Translated_282_residues
MGSAIATRFLERGRTVHLRDMDPQKLAPLVARGAIAVESVAALTQASDVIITSLNTAEIVEAVLFGADGIAAAAKPGQLF
IDMSSIDPKATATLAARLERETGMAYVDAPLSGGAPAALAGRLTLMMGGSPEAVERAKVVLADVAANMTHMGPYGAGQTT
KLINQVLCACNFLAVAEATRLALDGGVDAARIPQALAGGRADSRILQEFMGKMAAFDLTPTGRIDNMLKDLEAVQRYAMA
LRTPMPLTGLVTELHRVMVAAGIGPEDSAAYMKLFDFGTRAA
>Mature_281_residues
GSAIATRFLERGRTVHLRDMDPQKLAPLVARGAIAVESVAALTQASDVIITSLNTAEIVEAVLFGADGIAAAAKPGQLFI
DMSSIDPKATATLAARLERETGMAYVDAPLSGGAPAALAGRLTLMMGGSPEAVERAKVVLADVAANMTHMGPYGAGQTTK
LINQVLCACNFLAVAEATRLALDGGVDAARIPQALAGGRADSRILQEFMGKMAAFDLTPTGRIDNMLKDLEAVQRYAMAL
RTPMPLTGLVTELHRVMVAAGIGPEDSAAYMKLFDFGTRAA

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=294, Percent_Identity=30.6122448979592, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI145693186, Length=278, Percent_Identity=34.8920863309352, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786719, Length=277, Percent_Identity=35.7400722021661, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1790315, Length=279, Percent_Identity=30.8243727598566, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1789092, Length=280, Percent_Identity=31.7857142857143, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17557316, Length=279, Percent_Identity=30.1075268817204, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24655230, Length=276, Percent_Identity=31.1594202898551, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19922568, Length=276, Percent_Identity=31.1594202898551, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=24.113475177305, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 29384; Mature: 29252

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSAIATRFLERGRTVHLRDMDPQKLAPLVARGAIAVESVAALTQASDVIITSLNTAEIV
CCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHH
EAVLFGADGIAAAAKPGQLFIDMSSIDPKATATLAARLERETGMAYVDAPLSGGAPAALA
HHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHH
GRLTLMMGGSPEAVERAKVVLADVAANMTHMGPYGAGQTTKLINQVLCACNFLAVAEATR
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LALDGGVDAARIPQALAGGRADSRILQEFMGKMAAFDLTPTGRIDNMLKDLEAVQRYAMA
HHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
LRTPMPLTGLVTELHRVMVAAGIGPEDSAAYMKLFDFGTRAA
HCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
GSAIATRFLERGRTVHLRDMDPQKLAPLVARGAIAVESVAALTQASDVIITSLNTAEIV
CHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHH
EAVLFGADGIAAAAKPGQLFIDMSSIDPKATATLAARLERETGMAYVDAPLSGGAPAALA
HHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHH
GRLTLMMGGSPEAVERAKVVLADVAANMTHMGPYGAGQTTKLINQVLCACNFLAVAEATR
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LALDGGVDAARIPQALAGGRADSRILQEFMGKMAAFDLTPTGRIDNMLKDLEAVQRYAMA
HHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
LRTPMPLTGLVTELHRVMVAAGIGPEDSAAYMKLFDFGTRAA
HCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]