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The map label for this gene is fumC [H]

Identifier: 158424190

GI number: 158424190

Start: 2891728

End: 2893119

Strand: Reverse

Name: fumC [H]

Synonym: AZC_2566

Alternate gene names: 158424190

Gene position: 2893119-2891728 (Counterclockwise)

Preceding gene: 158424198

Following gene: 158424189

Centisome position: 53.88

GC content: 66.38

Gene sequence:

>1392_bases
ATGAGTGCCACCCGCGTCGAAACTGACACTTTCGGCCCCATCGAGGTGCCGGCGGACCGTTATTGGGGCGCGCAGGCGCA
GCGATCCTACGGCAATTTCAAGATCGGCTGGGAACGCCAGCCGCTTCCGGTCGTCCGCGCTCTCGGCATCGTGAAGCGCG
CCGCCGCCGAGGCCAACCGTGACCTCGGCAAGCTGGACGGCAAGATCGCCGACGCCATCGTCGCGGCCGCCCAGGAAGTG
ATCGACGGCAAGCTCGACGACCATTTCCCGCTGGTGGTCTGGCAGACCGGCTCGGGCACCCAGTCCAACATGAACGCGAA
CGAGGTCATCTCGAACCGCGCCATCGAGATGCTGGGCGGCGAGAAGGGCTCCAAGAAGCCCGTGCACCCGAACGACCACG
TCAACATGAGCCAGTCGTCCAACGACACCTATCCGACGGCGATGCATGTCGCCTGCTCGGAAGAGATCGTGCACCGGCTG
CTTCCCGCCCTGAAGACGCTGCACGGCGCCCTCGACGCCAAGGCGAAGCAGTGGGCCTCGATCATCAAGATCGGCCGCAC
GCACACGCAGGACGCCACCCCGCTGACGCTCGGCCAGGAATTCTCCGGCTATGCCAAGCAGGTGGAAAACGGCATCGCCC
GCATCGAATCCACCCTCCCGGCGCTGATGCAGCTCGCCCAGGGCGGCACGGCGGTCGGTACCGGCCTCAATGCGCCGGTG
GGCTTTGCCGAGAAGGTGGCCGAGAAGATCGCCGCCATCACCGGCCTGCCCTTCACCACCGCTCCGAACAAGTTCGAGGC
GCTCGCCGCCCATGACGCCATGGTGTTCTCGCACGGCGCCATCAACACGGTGGCGGCCTCGCTGTTCAAGATCGCCAACG
ACATCCGCTTCCTCGGCTCTGGCCCGCGTTCCGGCCTCGGCGAACTGGCCCTGCCGGAGAACGAGCCCGGCTCGTCCATC
ATGCCGGGCAAGGTGAACCCGACCCAGTGCGAGGCGCTGACGCAGGTTTGCGTGCAGGTGTTCGGCAACAATGCCGCGCT
CACCTTCGCCGGCAGCCAGGGCCATTTCGAGCTGAACGTGTTCAACCCGGTGATGGCCTACAACTTCCTGCAGTCGGTGC
GCCTGATCGCGGATGCGGCGGTGAGCTTCACCGAGCACTGCGTGGTCGGCATCGAGCCGCGCGAGGACAACATCAAGGCC
GGCCTCGAGCGCTCCCTGATGCTGGTCACCGCGCTGGCACCGAAGATCGGCTATGACGCGGCCGCCAAGATCGCCAAGAC
CGCCCACAAGAACGGCACCACGCTGCGCGAGGAAGCGGTCGGCGGCGGCTATGTGACGAACGAGGAGTTCGACGCGGTCG
TCCGTCCGGAGAACATGATCTCTCCCGGCTGA

Upstream 100 bases:

>100_bases
ACCTCCCTGCAATTATTTTGATCGCGCCCGGCGCTCACGGACTTCTGATGACGTGTGCTAGAAGCCTGGCCGCTGGACAG
TCCAAGGAGAGTACCGGACC

Downstream 100 bases:

>100_bases
TCCGTTTCAGGCCGATTGCGTTCATGGGGGTGCGGCGCCGGTCGCCGCACCCCTTTTTCGTCTCATGCTCCGGAAGCGCG
TCATGGCCAGCCTGCCCGAC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSATRVETDTFGPIEVPADRYWGAQAQRSYGNFKIGWERQPLPVVRALGIVKRAAAEANRDLGKLDGKIADAIVAAAQEV
IDGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGEKGSKKPVHPNDHVNMSQSSNDTYPTAMHVACSEEIVHRL
LPALKTLHGALDAKAKQWASIIKIGRTHTQDATPLTLGQEFSGYAKQVENGIARIESTLPALMQLAQGGTAVGTGLNAPV
GFAEKVAEKIAAITGLPFTTAPNKFEALAAHDAMVFSHGAINTVAASLFKIANDIRFLGSGPRSGLGELALPENEPGSSI
MPGKVNPTQCEALTQVCVQVFGNNAALTFAGSQGHFELNVFNPVMAYNFLQSVRLIADAAVSFTEHCVVGIEPREDNIKA
GLERSLMLVTALAPKIGYDAAAKIAKTAHKNGTTLREEAVGGGYVTNEEFDAVVRPENMISPG

Sequences:

>Translated_463_residues
MSATRVETDTFGPIEVPADRYWGAQAQRSYGNFKIGWERQPLPVVRALGIVKRAAAEANRDLGKLDGKIADAIVAAAQEV
IDGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGEKGSKKPVHPNDHVNMSQSSNDTYPTAMHVACSEEIVHRL
LPALKTLHGALDAKAKQWASIIKIGRTHTQDATPLTLGQEFSGYAKQVENGIARIESTLPALMQLAQGGTAVGTGLNAPV
GFAEKVAEKIAAITGLPFTTAPNKFEALAAHDAMVFSHGAINTVAASLFKIANDIRFLGSGPRSGLGELALPENEPGSSI
MPGKVNPTQCEALTQVCVQVFGNNAALTFAGSQGHFELNVFNPVMAYNFLQSVRLIADAAVSFTEHCVVGIEPREDNIKA
GLERSLMLVTALAPKIGYDAAAKIAKTAHKNGTTLREEAVGGGYVTNEEFDAVVRPENMISPG
>Mature_462_residues
SATRVETDTFGPIEVPADRYWGAQAQRSYGNFKIGWERQPLPVVRALGIVKRAAAEANRDLGKLDGKIADAIVAAAQEVI
DGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGEKGSKKPVHPNDHVNMSQSSNDTYPTAMHVACSEEIVHRLL
PALKTLHGALDAKAKQWASIIKIGRTHTQDATPLTLGQEFSGYAKQVENGIARIESTLPALMQLAQGGTAVGTGLNAPVG
FAEKVAEKIAAITGLPFTTAPNKFEALAAHDAMVFSHGAINTVAASLFKIANDIRFLGSGPRSGLGELALPENEPGSSIM
PGKVNPTQCEALTQVCVQVFGNNAALTFAGSQGHFELNVFNPVMAYNFLQSVRLIADAAVSFTEHCVVGIEPREDNIKAG
LERSLMLVTALAPKIGYDAAAKIAKTAHKNGTTLREEAVGGGYVTNEEFDAVVRPENMISPG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=69.3478260869565, Blast_Score=636, Evalue=0.0,
Organism=Homo sapiens, GI266458395, Length=67, Percent_Identity=55.2238805970149, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=58.695652173913, Blast_Score=553, Evalue=1e-159,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=38.8286334056399, Blast_Score=338, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI17553882, Length=464, Percent_Identity=70.0431034482759, Blast_Score=661, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=69.7247706422018, Blast_Score=465, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=68.0345572354212, Blast_Score=628, Evalue=0.0,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=66.1605206073753, Blast_Score=626, Evalue=1e-180,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=66.1605206073753, Blast_Score=626, Evalue=1e-179,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=62.1212121212121, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=61.3390928725702, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=52.9157667386609, Blast_Score=507, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49199; Mature: 49068

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATRVETDTFGPIEVPADRYWGAQAQRSYGNFKIGWERQPLPVVRALGIVKRAAAEANR
CCCCCCCCCCCCCCCCCCHHHCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHC
DLGKLDGKIADAIVAAAQEVIDGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
EKGSKKPVHPNDHVNMSQSSNDTYPTAMHVACSEEIVHRLLPALKTLHGALDAKAKQWAS
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHTQDATPLTLGQEFSGYAKQVENGIARIESTLPALMQLAQGGTAVGTGLNAPV
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
GFAEKVAEKIAAITGLPFTTAPNKFEALAAHDAMVFSHGAINTVAASLFKIANDIRFLGS
CHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GPRSGLGELALPENEPGSSIMPGKVNPTQCEALTQVCVQVFGNNAALTFAGSQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEE
FNPVMAYNFLQSVRLIADAAVSFTEHCVVGIEPREDNIKAGLERSLMLVTALAPKIGYDA
CCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
AAKIAKTAHKNGTTLREEAVGGGYVTNEEFDAVVRPENMISPG
HHHHHHHHCCCCCCHHHHHCCCCCEECCCCCEEECCCCCCCCC
>Mature Secondary Structure 
SATRVETDTFGPIEVPADRYWGAQAQRSYGNFKIGWERQPLPVVRALGIVKRAAAEANR
CCCCCCCCCCCCCCCCCHHHCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHC
DLGKLDGKIADAIVAAAQEVIDGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
EKGSKKPVHPNDHVNMSQSSNDTYPTAMHVACSEEIVHRLLPALKTLHGALDAKAKQWAS
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHTQDATPLTLGQEFSGYAKQVENGIARIESTLPALMQLAQGGTAVGTGLNAPV
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
GFAEKVAEKIAAITGLPFTTAPNKFEALAAHDAMVFSHGAINTVAASLFKIANDIRFLGS
CHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GPRSGLGELALPENEPGSSIMPGKVNPTQCEALTQVCVQVFGNNAALTFAGSQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEE
FNPVMAYNFLQSVRLIADAAVSFTEHCVVGIEPREDNIKAGLERSLMLVTALAPKIGYDA
CCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
AAKIAKTAHKNGTTLREEAVGGGYVTNEEFDAVVRPENMISPG
HHHHHHHHCCCCCCHHHHHCCCCCEECCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]