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The map label for this gene is edd [H]

Identifier: 158424048

GI number: 158424048

Start: 2752773

End: 2754614

Strand: Reverse

Name: edd [H]

Synonym: AZC_2424

Alternate gene names: 158424048

Gene position: 2754614-2752773 (Counterclockwise)

Preceding gene: 158424049

Following gene: 158424047

Centisome position: 51.3

GC content: 69.49

Gene sequence:

>1842_bases
ATGGCCATCCAAGCCACCCTCAACGCCCGCGTCGGCGAGGTGACGGAACGTATCGTCCAACGCAGCAGCGGTCCCCGCCA
GCGCTATCTCGACCGTATCGCCGCCGCCGGGGCCGAGGGGCCGCGCCGTCGGGCGCTCGGCTGCGCCAACCAGGCACACG
GCTTTGCCGCCTGCGGTCCGGCCGACAAGGCAGAGCTTCGCGCGGGTGATGGCGCGAACCTCGCCATCGTCACCGCCTAT
AACGACATGCTGAGCGCCCATCAGCCCTATGAGCGCTATCCTGACCTCATCCGCGCGGCCGCCCGTGAGGCCGGCGGCGT
GGCGCAGGTGGCGGGCGGCGTGCCGGCCATGTGCGATGGCATCACGCAGGGCGAGGCGGGCATGGAGCTTTCGCTCTTCT
CCCGCGAGGTGATCGCCCTCTCCACCGCCGTCGCCCTGTCGCACCAGACCTATGATTCCGCCGTCTTCCTTGGCATCTGC
GACAAGATTGTGCCCGGCCTGGTCATCGGCGCGCTCTCCTTCGGCCATCTGCCCACCGTCTTCCTGCCGAGCGGCCCCAT
GACCTCGGGCCTGCCCAATGACGAGAAGACGCGGGTGCGCCAGCTCTTCGCCGAGGGCAAGGTGGGGCGCGATGCGCTGC
TGGAGGCCGAGTCCCAGTCCTATCACGGTCCGGGCACCTGCACCTTCTACGGCACCGCCAACACCAACCAGATGATGATG
GAGATCATGGGCGTGCACCTGCCCGGCGCCTCCTTCATCAATCCCAACACCCCCTTGCGCGATGCCGTGACCCGCGAGGG
CGTGAAGCGGGCGCTGGCCATCACCGCGCTCGGGAACCACTACACCCCGCTCGGCCGCATTCTGGATGAGCGCGCCTTTG
TGAACGCGGTGGTCGGTCTGCACGCCACCGGCGGCTCCACCAATCACACGCTGCACCTCGTCGCCATGGCGGCGGCGGCG
GGCATCACGCTGACCTGGGACGATTTCTCCGATCTCGCCGAGGTGGTGCCGCTGCTCGCCCGCGTCTATCCGAACGGCAA
GGCGGACGTGAACCATTTCCACGCCGCCGGCGGCATGGGCTTCGTGATCCGCGAACTGCTCTCCGAAGGCCTGCTGCACG
AGAATGTGGAGACCGTCTGGGGCACGGGTCTCTCCGGGTACACTTCGGAGCCGGCGCTGAACGAGGCCGGCCAGCTCACC
TGGACCGACGGCGCCACCGCCACGGGCGACGAGGCGGTGCTGCGGCCCGTGGCCAAGCCCTTCCAGCCCACCGGCGGCCT
CAAGGTGCTCGACGGCAATCTCGGCCGGGCGGTGAGCAAGACCTCCGCCGTCGCGCCCGAGCGCCACGTCATCGAGGCGC
CCGCCCGCGTCTTCCACTCGCAGGAGGAGCTTCAGGCCGCCTTCAAGGCCGGCAGCCTCACGGGTGATTTCGTGGCGGTG
GTGCGCTTCCAGGGGCCGAAGGCCAACGGCATGCCGGAACTGCACAAGCTGATGCCGCCGCTCGGCGTGCTGCAGGATCG
CGGGCAGAAGGTGGCGCTCGTCACTGACGGGCGCATGTCGGGCGCCTCCGGCAAGGTGCCGTCCGCCATCCATGTAACGC
CGGAAGCCGCCAATGGCGGCGCCATCGCCAAGATCAAGGATGGCGACATCGTCCGCTTCGATGGCGTGAACGGCCATCTG
ACCGTGCTGGTGGACGAGGCCGAATGGGCCGCCCGTCCGCTCGCTGAGCAGGACCTTTCCGGTTCGCATGTGGGCGTGGG
GCGCGAACTGTTCGCCCCGCTCCGTGCCGCCGTCGGCAGCGCCGAGCACGGCGCCACCATCTTCGACCGCACGGCGGCCT
GA

Upstream 100 bases:

>100_bases
ACCGCGTTGCGGTCCCATCTGGCTGGATCGCGCTCTAGCGGAGCGCCGCCCCGGTGATTAGGTTCGCCGGGACGGATCGC
TCAAGCCAGGAGGCACCCCC

Downstream 100 bases:

>100_bases
CCGGCCTTTTGCACGTGGGCTGCGGTGTCCGCATCGCTGCCCGCGTGGCATGGTTTGGTGGCCTGCGGGGCCGTCGTCGT
GGAGAAACGTATGCGTGCTG

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MAIQATLNARVGEVTERIVQRSSGPRQRYLDRIAAAGAEGPRRRALGCANQAHGFAACGPADKAELRAGDGANLAIVTAY
NDMLSAHQPYERYPDLIRAAAREAGGVAQVAGGVPAMCDGITQGEAGMELSLFSREVIALSTAVALSHQTYDSAVFLGIC
DKIVPGLVIGALSFGHLPTVFLPSGPMTSGLPNDEKTRVRQLFAEGKVGRDALLEAESQSYHGPGTCTFYGTANTNQMMM
EIMGVHLPGASFINPNTPLRDAVTREGVKRALAITALGNHYTPLGRILDERAFVNAVVGLHATGGSTNHTLHLVAMAAAA
GITLTWDDFSDLAEVVPLLARVYPNGKADVNHFHAAGGMGFVIRELLSEGLLHENVETVWGTGLSGYTSEPALNEAGQLT
WTDGATATGDEAVLRPVAKPFQPTGGLKVLDGNLGRAVSKTSAVAPERHVIEAPARVFHSQEELQAAFKAGSLTGDFVAV
VRFQGPKANGMPELHKLMPPLGVLQDRGQKVALVTDGRMSGASGKVPSAIHVTPEAANGGAIAKIKDGDIVRFDGVNGHL
TVLVDEAEWAARPLAEQDLSGSHVGVGRELFAPLRAAVGSAEHGATIFDRTAA

Sequences:

>Translated_613_residues
MAIQATLNARVGEVTERIVQRSSGPRQRYLDRIAAAGAEGPRRRALGCANQAHGFAACGPADKAELRAGDGANLAIVTAY
NDMLSAHQPYERYPDLIRAAAREAGGVAQVAGGVPAMCDGITQGEAGMELSLFSREVIALSTAVALSHQTYDSAVFLGIC
DKIVPGLVIGALSFGHLPTVFLPSGPMTSGLPNDEKTRVRQLFAEGKVGRDALLEAESQSYHGPGTCTFYGTANTNQMMM
EIMGVHLPGASFINPNTPLRDAVTREGVKRALAITALGNHYTPLGRILDERAFVNAVVGLHATGGSTNHTLHLVAMAAAA
GITLTWDDFSDLAEVVPLLARVYPNGKADVNHFHAAGGMGFVIRELLSEGLLHENVETVWGTGLSGYTSEPALNEAGQLT
WTDGATATGDEAVLRPVAKPFQPTGGLKVLDGNLGRAVSKTSAVAPERHVIEAPARVFHSQEELQAAFKAGSLTGDFVAV
VRFQGPKANGMPELHKLMPPLGVLQDRGQKVALVTDGRMSGASGKVPSAIHVTPEAANGGAIAKIKDGDIVRFDGVNGHL
TVLVDEAEWAARPLAEQDLSGSHVGVGRELFAPLRAAVGSAEHGATIFDRTAA
>Mature_612_residues
AIQATLNARVGEVTERIVQRSSGPRQRYLDRIAAAGAEGPRRRALGCANQAHGFAACGPADKAELRAGDGANLAIVTAYN
DMLSAHQPYERYPDLIRAAAREAGGVAQVAGGVPAMCDGITQGEAGMELSLFSREVIALSTAVALSHQTYDSAVFLGICD
KIVPGLVIGALSFGHLPTVFLPSGPMTSGLPNDEKTRVRQLFAEGKVGRDALLEAESQSYHGPGTCTFYGTANTNQMMME
IMGVHLPGASFINPNTPLRDAVTREGVKRALAITALGNHYTPLGRILDERAFVNAVVGLHATGGSTNHTLHLVAMAAAAG
ITLTWDDFSDLAEVVPLLARVYPNGKADVNHFHAAGGMGFVIRELLSEGLLHENVETVWGTGLSGYTSEPALNEAGQLTW
TDGATATGDEAVLRPVAKPFQPTGGLKVLDGNLGRAVSKTSAVAPERHVIEAPARVFHSQEELQAAFKAGSLTGDFVAVV
RFQGPKANGMPELHKLMPPLGVLQDRGQKVALVTDGRMSGASGKVPSAIHVTPEAANGGAIAKIKDGDIVRFDGVNGHLT
VLVDEAEWAARPLAEQDLSGSHVGVGRELFAPLRAAVGSAEHGATIFDRTAA

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=63.4551495016611, Blast_Score=776, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=549, Percent_Identity=30.2367941712204, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI2367371, Length=512, Percent_Identity=29.4921875, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786464, Length=514, Percent_Identity=29.7665369649805, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322476, Length=494, Percent_Identity=31.7813765182186, Blast_Score=192, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64184; Mature: 64052

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQATLNARVGEVTERIVQRSSGPRQRYLDRIAAAGAEGPRRRALGCANQAHGFAACGP
CEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCEECCC
ADKAELRAGDGANLAIVTAYNDMLSAHQPYERYPDLIRAAAREAGGVAQVAGGVPAMCDG
CCHHHCCCCCCCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHCC
ITQGEAGMELSLFSREVIALSTAVALSHQTYDSAVFLGICDKIVPGLVIGALSFGHLPTV
CCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCEE
FLPSGPMTSGLPNDEKTRVRQLFAEGKVGRDALLEAESQSYHGPGTCTFYGTANTNQMMM
EECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCEEEEEEECCCCHHHHH
EIMGVHLPGASFINPNTPLRDAVTREGVKRALAITALGNHYTPLGRILDERAFVNAVVGL
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHEE
HATGGSTNHTLHLVAMAAAAGITLTWDDFSDLAEVVPLLARVYPNGKADVNHFHAAGGMG
EECCCCCCCEEEEEEEHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHH
FVIRELLSEGLLHENVETVWGTGLSGYTSEPALNEAGQLTWTDGATATGDEAVLRPVAKP
HHHHHHHHHCHHHCCCHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCC
FQPTGGLKVLDGNLGRAVSKTSAVAPERHVIEAPARVFHSQEELQAAFKAGSLTGDFVAV
CCCCCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEE
VRFQGPKANGMPELHKLMPPLGVLQDRGQKVALVTDGRMSGASGKVPSAIHVTPEAANGG
EEECCCCCCCCHHHHHHCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCC
AIAKIKDGDIVRFDGVNGHLTVLVDEAEWAARPLAEQDLSGSHVGVGRELFAPLRAAVGS
EEEEECCCCEEEECCCCCEEEEEEECCHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHCC
AEHGATIFDRTAA
CCCCCEECCCCCC
>Mature Secondary Structure 
AIQATLNARVGEVTERIVQRSSGPRQRYLDRIAAAGAEGPRRRALGCANQAHGFAACGP
EEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCEECCC
ADKAELRAGDGANLAIVTAYNDMLSAHQPYERYPDLIRAAAREAGGVAQVAGGVPAMCDG
CCHHHCCCCCCCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHCC
ITQGEAGMELSLFSREVIALSTAVALSHQTYDSAVFLGICDKIVPGLVIGALSFGHLPTV
CCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCEE
FLPSGPMTSGLPNDEKTRVRQLFAEGKVGRDALLEAESQSYHGPGTCTFYGTANTNQMMM
EECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCEEEEEEECCCCHHHHH
EIMGVHLPGASFINPNTPLRDAVTREGVKRALAITALGNHYTPLGRILDERAFVNAVVGL
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHEE
HATGGSTNHTLHLVAMAAAAGITLTWDDFSDLAEVVPLLARVYPNGKADVNHFHAAGGMG
EECCCCCCCEEEEEEEHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHH
FVIRELLSEGLLHENVETVWGTGLSGYTSEPALNEAGQLTWTDGATATGDEAVLRPVAKP
HHHHHHHHHCHHHCCCHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCC
FQPTGGLKVLDGNLGRAVSKTSAVAPERHVIEAPARVFHSQEELQAAFKAGSLTGDFVAV
CCCCCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEE
VRFQGPKANGMPELHKLMPPLGVLQDRGQKVALVTDGRMSGASGKVPSAIHVTPEAANGG
EEECCCCCCCCHHHHHHCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCC
AIAKIKDGDIVRFDGVNGHLTVLVDEAEWAARPLAEQDLSGSHVGVGRELFAPLRAAVGS
EEEEECCCCEEEECCCCCEEEEEEECCHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHCC
AEHGATIFDRTAA
CCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]