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The map label for this gene is xseA

Identifier: 158424009

GI number: 158424009

Start: 2710341

End: 2711954

Strand: Reverse

Name: xseA

Synonym: AZC_2385

Alternate gene names: 158424009

Gene position: 2711954-2710341 (Counterclockwise)

Preceding gene: 158424012

Following gene: 158424008

Centisome position: 50.5

GC content: 71.07

Gene sequence:

>1614_bases
GTGCCGTCTGATTCGATGACCGATCTGCCTGAAACCCGCGCCAATGCGCCGGAATGGACCGTCTCCGAACTCTCTTTCGC
CCTGCGGCGGACGGTGGAGGACGCCTATGGCCATGTCCGGGTGCGCGGAGAAATCTCTGGATATCGCGGGCCCCATTCCT
CGGGCCACGCCTATTTCAGCATCAAGGACGAGGGCGCGCGCCTCGATGCGGTGATCTGGAAATCCGCCTTCGCGCGCCTG
AAGCTCAGGCCCGAGGAAGGGCTGGAGGTGGTGGCGGTGGGCAAGCTCACCACCTATCCGGGCAAGTCCGGCTACCAGAT
CGTCATCGAGAGCCTCGAATTCGCCGGGGCCGGCGCCATCATGGCCATGCTGGAGGAGCGCAAGCGCCGTCTCGCCGCCG
AGGGCCTGTTCGATGCCGCCCGCAAGCAGGAACTTCCCTTCCTGCCGAAGGTGATCGGCGTCGTCACTTCGCCCACCGGC
GCCGTCATCCGCGACATTCTCCACCGGCTCTCCGACCGCTTTCCGCGTCAGGTGATCGTCTGGCCCGTGCGGGTGCAGGG
CGAGACTAGCGCGGCGGAGGTGGCCGAGGCTATCCGGGGCTTCAACGCCTTGCCCGAGGGCGGTCCCATCCCGCGGCCGG
ACGTGCTCATCGTGGCGCGCGGCGGCGGCTCGCTGGAGGATCTGCTCGGCTTCTCCGACGAGGCGGTGGTGCGCGCGGCG
GCCGAGAGCTTCATTCCGCTGGTCTCGGCGGTGGGCCACGAGACCGACGTGACGCTGATCGATTTTGCCGCCGACGTGCG
GGCGCCGACCCCCACCGCCGCCGCCGAGATGGTGGTGCCGGTGCGTGCCGACCTGCTCGCGGGCATAGACGCCTATGGCG
AGCGCCTTTCTGCGGCGCCCCGGCGCCTTCTGGAGCGCCGCCGGGCCGATTTCCGCGCGCTCGCCCGGCACCTGCCGACA
GCGGATGCTTTGCTTGCTGTCCCGCGTCAGCGGCTGGATGCCGCCGGCGAGCGGCTGCCGCGCGCGCTCAGGGCCAATGC
GGCGGCGCATCGGCTGGCCTTCGAGGCAGTGCGCACACGTCATTCCGCTTCCGCCTTCCGCCTGCGGCTCGCCCGCGCGC
AGGACCGCGTCGCGGCTTTGGGCGGGCGCCTCCAGTGGGGGCTGACGGGCCTCGTGTCCCGCCGCAGCGAGCGTCTTTCG
GCGATGACGGCGCGCTTCGGATCGGCACGGGCCGCCTCGTTGCGCGCCCATGTCCTCCATCTGTCCCGCTGCCGGGAGCG
CCTCTCTGTCCTCTCGACGCGAGCGCAACGGGCGGTGAGGCACGACTTGCGGGAGCGGACCAATCGTCTCGCCGCGATGG
AACAATTGCTGAAGGCCCTCTCCTATCGCGGGGTTCTGGCCCGCGGCTTCGCGCTGGTGCGCGATGCGCAGGGCGGCGCG
GTGCGGGCTGCCGGCGCGGTCGTGCCGGGCGCGCGACTGGAACTGGAATTCGCCGACGGGCGCTTGGGCGTCCAGGCGCT
GGGAGAGGGGGCTCCTGTCGAGCCGCCGCAGGCTGCGCGGCCCTCGAAGGGGGCCCGGACCAAGGCGGCGCAGCCGTCGC
TGTTCGACGATTGA

Upstream 100 bases:

>100_bases
GTTTCGGTTTGGCTATCGGGTCGAGAGGCCGTGAACAAGGGGTAGGGCATTGCGCCCGCCGCATATGAGATAGCGGCTAT
GCTTCTGCCTCGATTGTCTG

Downstream 100 bases:

>100_bases
CGCGCCGCCGCAGGGTGTTGCCCTTTCGGCCTCTCCCGAAAACCAGTATCTTTCGGGCAGGTCTGCCATGTCTGCTTCGT
TTCTGGGGTCTCTCTTCGCC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MPSDSMTDLPETRANAPEWTVSELSFALRRTVEDAYGHVRVRGEISGYRGPHSSGHAYFSIKDEGARLDAVIWKSAFARL
KLRPEEGLEVVAVGKLTTYPGKSGYQIVIESLEFAGAGAIMAMLEERKRRLAAEGLFDAARKQELPFLPKVIGVVTSPTG
AVIRDILHRLSDRFPRQVIVWPVRVQGETSAAEVAEAIRGFNALPEGGPIPRPDVLIVARGGGSLEDLLGFSDEAVVRAA
AESFIPLVSAVGHETDVTLIDFAADVRAPTPTAAAEMVVPVRADLLAGIDAYGERLSAAPRRLLERRRADFRALARHLPT
ADALLAVPRQRLDAAGERLPRALRANAAAHRLAFEAVRTRHSASAFRLRLARAQDRVAALGGRLQWGLTGLVSRRSERLS
AMTARFGSARAASLRAHVLHLSRCRERLSVLSTRAQRAVRHDLRERTNRLAAMEQLLKALSYRGVLARGFALVRDAQGGA
VRAAGAVVPGARLELEFADGRLGVQALGEGAPVEPPQAARPSKGARTKAAQPSLFDD

Sequences:

>Translated_537_residues
MPSDSMTDLPETRANAPEWTVSELSFALRRTVEDAYGHVRVRGEISGYRGPHSSGHAYFSIKDEGARLDAVIWKSAFARL
KLRPEEGLEVVAVGKLTTYPGKSGYQIVIESLEFAGAGAIMAMLEERKRRLAAEGLFDAARKQELPFLPKVIGVVTSPTG
AVIRDILHRLSDRFPRQVIVWPVRVQGETSAAEVAEAIRGFNALPEGGPIPRPDVLIVARGGGSLEDLLGFSDEAVVRAA
AESFIPLVSAVGHETDVTLIDFAADVRAPTPTAAAEMVVPVRADLLAGIDAYGERLSAAPRRLLERRRADFRALARHLPT
ADALLAVPRQRLDAAGERLPRALRANAAAHRLAFEAVRTRHSASAFRLRLARAQDRVAALGGRLQWGLTGLVSRRSERLS
AMTARFGSARAASLRAHVLHLSRCRERLSVLSTRAQRAVRHDLRERTNRLAAMEQLLKALSYRGVLARGFALVRDAQGGA
VRAAGAVVPGARLELEFADGRLGVQALGEGAPVEPPQAARPSKGARTKAAQPSLFDD
>Mature_536_residues
PSDSMTDLPETRANAPEWTVSELSFALRRTVEDAYGHVRVRGEISGYRGPHSSGHAYFSIKDEGARLDAVIWKSAFARLK
LRPEEGLEVVAVGKLTTYPGKSGYQIVIESLEFAGAGAIMAMLEERKRRLAAEGLFDAARKQELPFLPKVIGVVTSPTGA
VIRDILHRLSDRFPRQVIVWPVRVQGETSAAEVAEAIRGFNALPEGGPIPRPDVLIVARGGGSLEDLLGFSDEAVVRAAA
ESFIPLVSAVGHETDVTLIDFAADVRAPTPTAAAEMVVPVRADLLAGIDAYGERLSAAPRRLLERRRADFRALARHLPTA
DALLAVPRQRLDAAGERLPRALRANAAAHRLAFEAVRTRHSASAFRLRLARAQDRVAALGGRLQWGLTGLVSRRSERLSA
MTARFGSARAASLRAHVLHLSRCRERLSVLSTRAQRAVRHDLRERTNRLAAMEQLLKALSYRGVLARGFALVRDAQGGAV
RAAGAVVPGARLELEFADGRLGVQALGEGAPVEPPQAARPSKGARTKAAQPSLFDD

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=485, Percent_Identity=35.0515463917526, Blast_Score=239, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_AZOC5 (A8I6A9)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001525301.1
- GeneID:   5688611
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_2385
- HOGENOM:   HBG634411
- OMA:   LVWPVKV
- ProtClustDB:   PRK00286
- BioCyc:   ACAU438753:AZC_2385-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 58030; Mature: 57899

Theoretical pI: Translated: 11.08; Mature: 11.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSDSMTDLPETRANAPEWTVSELSFALRRTVEDAYGHVRVRGEISGYRGPHSSGHAYFS
CCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCEEEE
IKDEGARLDAVIWKSAFARLKLRPEEGLEVVAVGKLTTYPGKSGYQIVIESLEFAGAGAI
ECCCCCCHHHHHHHHHHHHEEECCCCCCEEEEECCEEECCCCCCHHHHHHHHHHCCCHHH
MAMLEERKRRLAAEGLFDAARKQELPFLPKVIGVVTSPTGAVIRDILHRLSDRFPRQVIV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEE
WPVRVQGETSAAEVAEAIRGFNALPEGGPIPRPDVLIVARGGGSLEDLLGFSDEAVVRAA
EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHH
AESFIPLVSAVGHETDVTLIDFAADVRAPTPTAAAEMVVPVRADLLAGIDAYGERLSAAP
HHHHHHHHHHCCCCCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRLLERRRADFRALARHLPTADALLAVPRQRLDAAGERLPRALRANAAAHRLAFEAVRTR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSASAFRLRLARAQDRVAALGGRLQWGLTGLVSRRSERLSAMTARFGSARAASLRAHVLH
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LSRCRERLSVLSTRAQRAVRHDLRERTNRLAAMEQLLKALSYRGVLARGFALVRDAQGGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHEECCCCCC
VRAAGAVVPGARLELEFADGRLGVQALGEGAPVEPPQAARPSKGARTKAAQPSLFDD
EEECCCCCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSDSMTDLPETRANAPEWTVSELSFALRRTVEDAYGHVRVRGEISGYRGPHSSGHAYFS
CCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCEEEE
IKDEGARLDAVIWKSAFARLKLRPEEGLEVVAVGKLTTYPGKSGYQIVIESLEFAGAGAI
ECCCCCCHHHHHHHHHHHHEEECCCCCCEEEEECCEEECCCCCCHHHHHHHHHHCCCHHH
MAMLEERKRRLAAEGLFDAARKQELPFLPKVIGVVTSPTGAVIRDILHRLSDRFPRQVIV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEE
WPVRVQGETSAAEVAEAIRGFNALPEGGPIPRPDVLIVARGGGSLEDLLGFSDEAVVRAA
EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHH
AESFIPLVSAVGHETDVTLIDFAADVRAPTPTAAAEMVVPVRADLLAGIDAYGERLSAAP
HHHHHHHHHHCCCCCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRLLERRRADFRALARHLPTADALLAVPRQRLDAAGERLPRALRANAAAHRLAFEAVRTR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSASAFRLRLARAQDRVAALGGRLQWGLTGLVSRRSERLSAMTARFGSARAASLRAHVLH
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LSRCRERLSVLSTRAQRAVRHDLRERTNRLAAMEQLLKALSYRGVLARGFALVRDAQGGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHEECCCCCC
VRAAGAVVPGARLELEFADGRLGVQALGEGAPVEPPQAARPSKGARTKAAQPSLFDD
EEECCCCCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA