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The map label for this gene is tdcB [H]

Identifier: 158423923

GI number: 158423923

Start: 2623622

End: 2624614

Strand: Reverse

Name: tdcB [H]

Synonym: AZC_2299

Alternate gene names: 158423923

Gene position: 2624614-2623622 (Counterclockwise)

Preceding gene: 158423924

Following gene: 158423921

Centisome position: 48.88

GC content: 70.29

Gene sequence:

>993_bases
ATGAACGCGCACGCTCGTCCGATTCCGACCGCCGCCGATGTGGATGCCGCCGCCGAACGCCTCAAGGGCGTGGCCGTCCG
CACCCCGCTCGTCTATTCGCCGCTGCTCAGCGACATGACGGGCGGCCGCATCTTCCTGAAGCCCGAGACGCTCCAGCGCA
CCGGTTCCTTCAAGTTCCGCGGCGCCTACAATCGCGCGGTGCAGATCCCGGAAGAGCGCCGCGCCGCCGGCGTGGTGGCA
TGCTCGTCGGGCAATCACGCGCAGGGCCTCGCCGCCGCCGCCAAGCTGCTCGGCATGCCCGCCGTCATCGTCATGCCCAA
CGACGCCCCCGCGCTGAAGCGCGAGCGCACCAAGGCCCTGGGCGCGCAGGTGGTCGGCTATGACCGCGTGACCGAGGATC
GCGACGCCATCGCCAATGCCATCGCCGCCGAGCGCGGCGCCGTCTTCGTGCCGCCCTATGACGATCCGGACGTGATCGCC
GGGCAGGGGACGGTGGGACGCGAGATCTGCGAGGATCTAGCGGCGCTCGGCCTTTCCCTCGATATCGTCTCGGCCAACGC
GTCCGGAGGCGGTCTCATGGCGGGCATCTCCCTGGCGGTGAAGGCGCGCTTCCCGGACGCTCTGCCGCTGACGGCGGAGC
CGGCGGACTTCGACGACCACGCCCGCTCCTACAAGTCCGGCATTCGCGAGCGCAATGCGAAGCCGGCGGGCTCCTTCTGC
GATGCGCTGCTGGCGCCGACGCCTGGTGAGATCACATTCGCGGTCAACAGCAAGCTCACGGGCGGCGCGGTCTCGGCGAC
CGACGCGGAGGTAGCGCGCGCCGTCGCCTTTGCCTTCCTGGAACTGAAGCTGGTGGTGGAGCCGGGCGGCGCAGTCGCGC
TGGCGGCCCTGCTGGAAGGCCGCATCCCCGCCAGGGACAAGACGGTCGCCATCGTCCTGTCCGGCGGCAATGTGGATCCG
GAGACCTTCGAGGCCTGCCTCAAGACGCTCTGA

Upstream 100 bases:

>100_bases
GTGCCCGCCAGTTCCTCGACAACGTGCTGATCGCGCACGACATCGGCCCGATCGCGCGGCGCTATCGCCTGCTGCGGCGG
CCTCGGATATTGTCGCGCGC

Downstream 100 bases:

>100_bases
AGGAACCTGCGGCACCCAACAAAAAGGCCCGGAATGATCCGTTCCGGGCCTTTGTCGTTCTGCGGGAGGCTTCGCTCAGC
GGGCGAAGCCCGGCGAGAAG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNAHARPIPTAADVDAAAERLKGVAVRTPLVYSPLLSDMTGGRIFLKPETLQRTGSFKFRGAYNRAVQIPEERRAAGVVA
CSSGNHAQGLAAAAKLLGMPAVIVMPNDAPALKRERTKALGAQVVGYDRVTEDRDAIANAIAAERGAVFVPPYDDPDVIA
GQGTVGREICEDLAALGLSLDIVSANASGGGLMAGISLAVKARFPDALPLTAEPADFDDHARSYKSGIRERNAKPAGSFC
DALLAPTPGEITFAVNSKLTGGAVSATDAEVARAVAFAFLELKLVVEPGGAVALAALLEGRIPARDKTVAIVLSGGNVDP
ETFEACLKTL

Sequences:

>Translated_330_residues
MNAHARPIPTAADVDAAAERLKGVAVRTPLVYSPLLSDMTGGRIFLKPETLQRTGSFKFRGAYNRAVQIPEERRAAGVVA
CSSGNHAQGLAAAAKLLGMPAVIVMPNDAPALKRERTKALGAQVVGYDRVTEDRDAIANAIAAERGAVFVPPYDDPDVIA
GQGTVGREICEDLAALGLSLDIVSANASGGGLMAGISLAVKARFPDALPLTAEPADFDDHARSYKSGIRERNAKPAGSFC
DALLAPTPGEITFAVNSKLTGGAVSATDAEVARAVAFAFLELKLVVEPGGAVALAALLEGRIPARDKTVAIVLSGGNVDP
ETFEACLKTL
>Mature_330_residues
MNAHARPIPTAADVDAAAERLKGVAVRTPLVYSPLLSDMTGGRIFLKPETLQRTGSFKFRGAYNRAVQIPEERRAAGVVA
CSSGNHAQGLAAAAKLLGMPAVIVMPNDAPALKRERTKALGAQVVGYDRVTEDRDAIANAIAAERGAVFVPPYDDPDVIA
GQGTVGREICEDLAALGLSLDIVSANASGGGLMAGISLAVKARFPDALPLTAEPADFDDHARSYKSGIRERNAKPAGSFC
DALLAPTPGEITFAVNSKLTGGAVSATDAEVARAVAFAFLELKLVVEPGGAVALAALLEGRIPARDKTVAIVLSGGNVDP
ETFEACLKTL

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=315, Percent_Identity=35.8730158730159, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI33469958, Length=149, Percent_Identity=36.9127516778523, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI19923959, Length=145, Percent_Identity=33.7931034482759, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=37.9421221864952, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790207, Length=294, Percent_Identity=31.2925170068027, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71991565, Length=311, Percent_Identity=35.6913183279743, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17508781, Length=325, Percent_Identity=27.6923076923077, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17537387, Length=319, Percent_Identity=33.5423197492163, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322631, Length=316, Percent_Identity=40.1898734177215, Blast_Score=213, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320930, Length=293, Percent_Identity=35.1535836177474, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6319788, Length=287, Percent_Identity=27.1777003484321, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355833, Length=322, Percent_Identity=33.8509316770186, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34136; Mature: 34136

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAHARPIPTAADVDAAAERLKGVAVRTPLVYSPLLSDMTGGRIFLKPETLQRTGSFKFR
CCCCCCCCCCCCCHHHHHHHHCCEEEECCHHHHHHHHCCCCCEEEECCHHHHHCCCEEEE
GAYNRAVQIPEERRAAGVVACSSGNHAQGLAAAAKLLGMPAVIVMPNDAPALKRERTKAL
CCCCCEEECCHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
GAQVVGYDRVTEDRDAIANAIAAERGAVFVPPYDDPDVIAGQGTVGREICEDLAALGLSL
HHHEECCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCEE
DIVSANASGGGLMAGISLAVKARFPDALPLTAEPADFDDHARSYKSGIRERNAKPAGSFC
EEEEECCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHH
DALLAPTPGEITFAVNSKLTGGAVSATDAEVARAVAFAFLELKLVVEPGGAVALAALLEG
HHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHC
RIPARDKTVAIVLSGGNVDPETFEACLKTL
CCCCCCCEEEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MNAHARPIPTAADVDAAAERLKGVAVRTPLVYSPLLSDMTGGRIFLKPETLQRTGSFKFR
CCCCCCCCCCCCCHHHHHHHHCCEEEECCHHHHHHHHCCCCCEEEECCHHHHHCCCEEEE
GAYNRAVQIPEERRAAGVVACSSGNHAQGLAAAAKLLGMPAVIVMPNDAPALKRERTKAL
CCCCCEEECCHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
GAQVVGYDRVTEDRDAIANAIAAERGAVFVPPYDDPDVIAGQGTVGREICEDLAALGLSL
HHHEECCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCEE
DIVSANASGGGLMAGISLAVKARFPDALPLTAEPADFDDHARSYKSGIRERNAKPAGSFC
EEEEECCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHH
DALLAPTPGEITFAVNSKLTGGAVSATDAEVARAVAFAFLELKLVVEPGGAVALAALLEG
HHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHC
RIPARDKTVAIVLSGGNVDPETFEACLKTL
CCCCCCCEEEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA