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The map label for this gene is yfeW [C]

Identifier: 158423913

GI number: 158423913

Start: 2612432

End: 2614009

Strand: Direct

Name: yfeW [C]

Synonym: AZC_2289

Alternate gene names: 158423913

Gene position: 2612432-2614009 (Clockwise)

Preceding gene: 158423910

Following gene: 158423914

Centisome position: 48.65

GC content: 66.29

Gene sequence:

>1578_bases
ATGTCCTGCCAAACGACCCATCGCCTTTCTCGTCTTTGCAACCGCGCTTGCCACTGCCGGTCTCGCGATGGCCGCGCCAA
CCACCTCCCGTGGATTGATCTCGGTCGATCAGGTGGCGGAGATGCTGGAGAAGGCTCCAACGGATCGCACCGCGCAGCAG
GTTCTCACCGCCTATCTGGCCGGCGTTGGCGAAGCCGCAAGTGCGGTCGTGACCATGGGAAATGCCGCCTGCCAGAAGCC
GTTGAGCCTGAACGCGGCGAACGCTGGCCAAGCCCTCAAGGGTACAGCCTCCGATCGCGGTGCAGAAACACCTGCGACGC
CGTTGATTGTCAGCGATATGCTTCATCGCGCCGGGTGCCGGCGCCAGTGAGCCGTCCCGCCCGCCGGATCGCTGACCTCG
ATTGGCAGCGCAACCGGGCCGGGGCCGTGATTCGGCAGGCGCGCCTGATCCTCGCGCTGGTCGGGCTCATGAGCCTGGCG
GGGGGCTCATCCGCCCATTCCGCCGACTTTGGCCCCGTTCAATGCACCGTTCGGGCCAGCTATATCGGCGCGCCGATGCA
TCCCGCAGTCGCCATCACGACGATGGCCCCGGTGCCCGAGCAGGCGCTGCCGTCGGGCATCAGCCGTCGTCTCGACGGCA
TTTACAAGCGGATCGAAGAATTCACGGTCGCATCGGCGCTGACGGCAGCGGTCGCCGTTCCGGGAAAGGGCCTGTGGCAG
AAGACCCATGCGCCGGCGGATGCGCCGCGCCTGTTCTGGGCGAGTGCCGGGAAGACCTTTACGGCGGTCGTTGTCCTGCA
ACTCGCCGAAGAGGGGAAACTGTCGCTCGATGACCCGGTTTCGCGATGGATCGCAGGTGTGCCGAGCGGCGAGATCGCGA
CGCTCCGTGATCTGCTCGCCCACACCAGCGGCTTGTTCAGCGCCAATGAGGATGTCGGGGCCCACGCCGATCCCCGCTAT
CGCGATCCGGCAACCAACCTTGAGATCGTGCGCCGTCACGGAGCTCTGTTCTGCCCCGGCGCAAACTGGCGCTATTCCAA
CACGGGATACGATCTGCTCGGGGAAGTCGTCCGCAAGGCCGATCACCGTTCCATTGATGAGGCGATCACGGCGCGGATCA
TCACGCCATTGGGGCTCTCCTCGCTGCGTGCGCTCGTGCCGGGCGGCGGATCGGAAGGCGTTGCGCCACTTGTGACGGCG
CGCGAACAGGCCATCGATCCAAGCTGGGCTGGCGCTGCCGGTCCCGTCGTCGGCGATGCCGCCGATATGGCCCGCTTCTG
GGCGGCCCTGCTCGGCGGACGACTGCTTCCGAAACGGACGGTGCGCGCGATGGCTCAAGCGCTATACCCCATGTACGAAA
AGGGCACCTATTCCGGGCTCGGAATCATGGTGTTCGACGTGAACGACGGTGCCCGTTCGATTCGATGGATCGGGCACGCG
GGCGGAACACCCGGCGCCAGCGCCATCGTCGCGTTCTCGCCCGCGGACAACGCGATCGTTGCCGTCGCCCTCACCGGCGA
CAGCGCGACCGTGCCGGCGGCCAACATGCTTCTGAAGGCCCTTGCAGGACCAGAATGA

Upstream 100 bases:

>100_bases
CTCTGCCCGCCGGGTCAACATGGGAAAAAAATTATCGTTTGCCAATAATTTTTTGTCGTGAGACAGATTTCCCGTCTTCA
GGGAGTCGCCCCATGCCCCA

Downstream 100 bases:

>100_bases
GGCGCCGCGAGGGTGCCCCGCCTGCCGGCTCGGACGGCCGGCCGCCTGCGGAAAGGGAAAGGGCCGGAGTGCCTGTCAGC
ACTCCGGCCCTTTTATCAGA

Product: beta-lactamase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSCQTTHRLSRLCNRACHCRSRDGRANHLPWIDLGRSGGGDAGEGSNGSHRAAGSHRLSGRRWRSRKCGRDHGKCRLPEA
VEPERGERWPSPQGYSLRSRCRNTCDAVDCQRYASSRRVPAPVSRPARRIADLDWQRNRAGAVIRQARLILALVGLMSLA
GGSSAHSADFGPVQCTVRASYIGAPMHPAVAITTMAPVPEQALPSGISRRLDGIYKRIEEFTVASALTAAVAVPGKGLWQ
KTHAPADAPRLFWASAGKTFTAVVVLQLAEEGKLSLDDPVSRWIAGVPSGEIATLRDLLAHTSGLFSANEDVGAHADPRY
RDPATNLEIVRRHGALFCPGANWRYSNTGYDLLGEVVRKADHRSIDEAITARIITPLGLSSLRALVPGGGSEGVAPLVTA
REQAIDPSWAGAAGPVVGDAADMARFWAALLGGRLLPKRTVRAMAQALYPMYEKGTYSGLGIMVFDVNDGARSIRWIGHA
GGTPGASAIVAFSPADNAIVAVALTGDSATVPAANMLLKALAGPE

Sequences:

>Translated_525_residues
MSCQTTHRLSRLCNRACHCRSRDGRANHLPWIDLGRSGGGDAGEGSNGSHRAAGSHRLSGRRWRSRKCGRDHGKCRLPEA
VEPERGERWPSPQGYSLRSRCRNTCDAVDCQRYASSRRVPAPVSRPARRIADLDWQRNRAGAVIRQARLILALVGLMSLA
GGSSAHSADFGPVQCTVRASYIGAPMHPAVAITTMAPVPEQALPSGISRRLDGIYKRIEEFTVASALTAAVAVPGKGLWQ
KTHAPADAPRLFWASAGKTFTAVVVLQLAEEGKLSLDDPVSRWIAGVPSGEIATLRDLLAHTSGLFSANEDVGAHADPRY
RDPATNLEIVRRHGALFCPGANWRYSNTGYDLLGEVVRKADHRSIDEAITARIITPLGLSSLRALVPGGGSEGVAPLVTA
REQAIDPSWAGAAGPVVGDAADMARFWAALLGGRLLPKRTVRAMAQALYPMYEKGTYSGLGIMVFDVNDGARSIRWIGHA
GGTPGASAIVAFSPADNAIVAVALTGDSATVPAANMLLKALAGPE
>Mature_524_residues
SCQTTHRLSRLCNRACHCRSRDGRANHLPWIDLGRSGGGDAGEGSNGSHRAAGSHRLSGRRWRSRKCGRDHGKCRLPEAV
EPERGERWPSPQGYSLRSRCRNTCDAVDCQRYASSRRVPAPVSRPARRIADLDWQRNRAGAVIRQARLILALVGLMSLAG
GSSAHSADFGPVQCTVRASYIGAPMHPAVAITTMAPVPEQALPSGISRRLDGIYKRIEEFTVASALTAAVAVPGKGLWQK
THAPADAPRLFWASAGKTFTAVVVLQLAEEGKLSLDDPVSRWIAGVPSGEIATLRDLLAHTSGLFSANEDVGAHADPRYR
DPATNLEIVRRHGALFCPGANWRYSNTGYDLLGEVVRKADHRSIDEAITARIITPLGLSSLRALVPGGGSEGVAPLVTAR
EQAIDPSWAGAAGPVVGDAADMARFWAALLGGRLLPKRTVRAMAQALYPMYEKGTYSGLGIMVFDVNDGARSIRWIGHAG
GTPGASAIVAFSPADNAIVAVALTGDSATVPAANMLLKALAGPE

Specific function: Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e., a D-alanyl-D-alanine- terminated peptide), it becomes im

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

Organism=Caenorhabditis elegans, GI115533026, Length=338, Percent_Identity=22.4852071005917, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 55805; Mature: 55674

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCQTTHRLSRLCNRACHCRSRDGRANHLPWIDLGRSGGGDAGEGSNGSHRAAGSHRLSG
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
RRWRSRKCGRDHGKCRLPEAVEPERGERWPSPQGYSLRSRCRNTCDAVDCQRYASSRRVP
CHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
APVSRPARRIADLDWQRNRAGAVIRQARLILALVGLMSLAGGSSAHSADFGPVQCTVRAS
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEH
YIGAPMHPAVAITTMAPVPEQALPSGISRRLDGIYKRIEEFTVASALTAAVAVPGKGLWQ
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
KTHAPADAPRLFWASAGKTFTAVVVLQLAEEGKLSLDDPVSRWIAGVPSGEIATLRDLLA
HCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHH
HTSGLFSANEDVGAHADPRYRDPATNLEIVRRHGALFCPGANWRYSNTGYDLLGEVVRKA
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHH
DHRSIDEAITARIITPLGLSSLRALVPGGGSEGVAPLVTAREQAIDPSWAGAAGPVVGDA
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCH
ADMARFWAALLGGRLLPKRTVRAMAQALYPMYEKGTYSGLGIMVFDVNDGARSIRWIGHA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECC
GGTPGASAIVAFSPADNAIVAVALTGDSATVPAANMLLKALAGPE
CCCCCCCEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SCQTTHRLSRLCNRACHCRSRDGRANHLPWIDLGRSGGGDAGEGSNGSHRAAGSHRLSG
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
RRWRSRKCGRDHGKCRLPEAVEPERGERWPSPQGYSLRSRCRNTCDAVDCQRYASSRRVP
CHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
APVSRPARRIADLDWQRNRAGAVIRQARLILALVGLMSLAGGSSAHSADFGPVQCTVRAS
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEH
YIGAPMHPAVAITTMAPVPEQALPSGISRRLDGIYKRIEEFTVASALTAAVAVPGKGLWQ
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
KTHAPADAPRLFWASAGKTFTAVVVLQLAEEGKLSLDDPVSRWIAGVPSGEIATLRDLLA
HCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHH
HTSGLFSANEDVGAHADPRYRDPATNLEIVRRHGALFCPGANWRYSNTGYDLLGEVVRKA
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHH
DHRSIDEAITARIITPLGLSSLRALVPGGGSEGVAPLVTAREQAIDPSWAGAAGPVVGDA
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCH
ADMARFWAALLGGRLLPKRTVRAMAQALYPMYEKGTYSGLGIMVFDVNDGARSIRWIGHA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECC
GGTPGASAIVAFSPADNAIVAVALTGDSATVPAANMLLKALAGPE
CCCCCCCEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3830154; 7925404; 3030739; 2175384; 2386365; 3997832; 7490745 [H]