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The map label for this gene is lldD [H]

Identifier: 158423891

GI number: 158423891

Start: 2591558

End: 2592706

Strand: Reverse

Name: lldD [H]

Synonym: AZC_2267

Alternate gene names: 158423891

Gene position: 2592706-2591558 (Counterclockwise)

Preceding gene: 158423892

Following gene: 158423888

Centisome position: 48.28

GC content: 68.58

Gene sequence:

>1149_bases
GTGGCGCCCGTCACCAATATTGCCGATCTGCGCGACATCGCGCGCCGCCGCATTCCGCGTGCCATGTTCGAATATGCCCA
GCGCGGCTCCTATGACGAGCGCACGCTCGCCGCCAATTATGCCGAACTCGATGCGCTCCGCCTGCGCCAGCGTGTGATGG
TGGACGTCTCGAAGCGCAATGTTGCGACCACCTTCCTGGGACAGGACGTCACCATCCCGGTGGGCATCGCGCCCACTGGC
CTCACCGGGCTGTTTCATGCCGATGGCGAGATCCTCGGCGCGCGGGCCGCGCAGGCCTTCGGCGTGCCCTTCACGCTCAG
CACCATGTCCATCTGCTCCATCGAGGATGTGGCGGGGGCGGTGGACAAGCCTTTCTGGTTCCAGCTCTATGTGATGCGGG
ACCGGGCCTTCACCCAGTCGCTGGTGGAGCGGGCGCGCGCCGCCGGCTGCCCGGTGCTGGTGCTGACGCTGGATCTCGCC
GCCCACGGCCAGCGCCATCGCGACATCAAGAACGGCCTCAGCGTGCCGCCGCGCCTCACCCTCGCCAATGCGCTCGACAT
CGCCACCAAGCCCGGCTGGGCGCTGAACGTGTTGCGCGGCCAGCGCCGCAGCTTCGGCAATCTTCAGGGCTGGATGCCGG
CGGGCAAGAATCTCAACGCCATGGCCCAGTGGGTGGCGCAGCAGTTCGACCCCTCTCTGAGCTGGAAGGATGTCGCATGG
ATCCGGAGCCTGTGGCCCGGCAAGCTGGTCCTGAAGGGCATCCTTGATCCCGAGGACGCCCGCATCGCCGCCGACCATGG
CGCGGATGCCATCGTCGTGTCGAACCATGGCGGACGCCAGCTTGACAGCGCTCCCGCCAGCATCAGCGTGCTGCCGGAGA
TCGCCTCGGCGGTGGGCTCGCGCACGGAAATCCTGCTCGATGGCGGTATCCGCACCGGGCAGGACGTGCTGAAGGCGCTG
GCGCTCGGCGCGCGGGGCTGCCTGATCGGCCGCTCCTGGCTTTATGGCCTCGCGGCAGGAGGGCAGGGGGGCGTGACGCA
GGTGCTTGAAATCCTGCGCAAGGAACTCGACACCAGCATGGCCCTCGCCGGCCTCACGGACGTGCGCAGCGTCACTCCCG
CCGCGCTCCACACGCCGCGCCGGGTCTGA

Upstream 100 bases:

>100_bases
GCGGCAGCGCCGGCGCTTCCGTTGCCGGCTCGCCGGGTCTAAGAGCTTCGACGCGCGCGCCATCCGGTGCGCGCGTTTTG
CGTTCCGATGAGGCTTTGCC

Downstream 100 bases:

>100_bases
GCCGCCTTTAGGCCGCGGCCTTGCGCCAACCGGCGGCGAGCAGGCCGGCCCCCATCAACAACCCGCCCCCGGCGCGATTG
ACGGCGCGCCGGGCGGTAAC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MAPVTNIADLRDIARRRIPRAMFEYAQRGSYDERTLAANYAELDALRLRQRVMVDVSKRNVATTFLGQDVTIPVGIAPTG
LTGLFHADGEILGARAAQAFGVPFTLSTMSICSIEDVAGAVDKPFWFQLYVMRDRAFTQSLVERARAAGCPVLVLTLDLA
AHGQRHRDIKNGLSVPPRLTLANALDIATKPGWALNVLRGQRRSFGNLQGWMPAGKNLNAMAQWVAQQFDPSLSWKDVAW
IRSLWPGKLVLKGILDPEDARIAADHGADAIVVSNHGGRQLDSAPASISVLPEIASAVGSRTEILLDGGIRTGQDVLKAL
ALGARGCLIGRSWLYGLAAGGQGGVTQVLEILRKELDTSMALAGLTDVRSVTPAALHTPRRV

Sequences:

>Translated_382_residues
MAPVTNIADLRDIARRRIPRAMFEYAQRGSYDERTLAANYAELDALRLRQRVMVDVSKRNVATTFLGQDVTIPVGIAPTG
LTGLFHADGEILGARAAQAFGVPFTLSTMSICSIEDVAGAVDKPFWFQLYVMRDRAFTQSLVERARAAGCPVLVLTLDLA
AHGQRHRDIKNGLSVPPRLTLANALDIATKPGWALNVLRGQRRSFGNLQGWMPAGKNLNAMAQWVAQQFDPSLSWKDVAW
IRSLWPGKLVLKGILDPEDARIAADHGADAIVVSNHGGRQLDSAPASISVLPEIASAVGSRTEILLDGGIRTGQDVLKAL
ALGARGCLIGRSWLYGLAAGGQGGVTQVLEILRKELDTSMALAGLTDVRSVTPAALHTPRRV
>Mature_381_residues
APVTNIADLRDIARRRIPRAMFEYAQRGSYDERTLAANYAELDALRLRQRVMVDVSKRNVATTFLGQDVTIPVGIAPTGL
TGLFHADGEILGARAAQAFGVPFTLSTMSICSIEDVAGAVDKPFWFQLYVMRDRAFTQSLVERARAAGCPVLVLTLDLAA
HGQRHRDIKNGLSVPPRLTLANALDIATKPGWALNVLRGQRRSFGNLQGWMPAGKNLNAMAQWVAQQFDPSLSWKDVAWI
RSLWPGKLVLKGILDPEDARIAADHGADAIVVSNHGGRQLDSAPASISVLPEIASAVGSRTEILLDGGIRTGQDVLKALA
LGARGCLIGRSWLYGLAAGGQGGVTQVLEILRKELDTSMALAGLTDVRSVTPAALHTPRRV

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=366, Percent_Identity=39.0710382513661, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI54234014, Length=367, Percent_Identity=38.6920980926431, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI7705393, Length=367, Percent_Identity=38.6920980926431, Blast_Score=244, Evalue=9e-65,
Organism=Escherichia coli, GI1790033, Length=374, Percent_Identity=44.9197860962567, Blast_Score=337, Evalue=7e-94,
Organism=Caenorhabditis elegans, GI193208036, Length=368, Percent_Identity=36.6847826086957, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI32566217, Length=287, Percent_Identity=34.1463414634146, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6323587, Length=390, Percent_Identity=33.5897435897436, Blast_Score=192, Evalue=7e-50,
Organism=Drosophila melanogaster, GI78707188, Length=369, Percent_Identity=39.8373983739837, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI281363140, Length=369, Percent_Identity=39.8373983739837, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI78707190, Length=369, Percent_Identity=39.8373983739837, Blast_Score=268, Evalue=6e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41151; Mature: 41020

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPVTNIADLRDIARRRIPRAMFEYAQRGSYDERTLAANYAELDALRLRQRVMVDVSKRN
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
VATTFLGQDVTIPVGIAPTGLTGLFHADGEILGARAAQAFGVPFTLSTMSICSIEDVAGA
EEEEECCCCCEEEECCCCCCCCEEEECCCCCHHHHHHHHCCCCEEECHHHHHHHHHHHHC
VDKPFWFQLYVMRDRAFTQSLVERARAAGCPVLVLTLDLAAHGQRHRDIKNGLSVPPRLT
CCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCHHHHHHHCCCCCCCCEE
LANALDIATKPGWALNVLRGQRRSFGNLQGWMPAGKNLNAMAQWVAQQFDPSLSWKDVAW
HHHHHHHCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
IRSLWPGKLVLKGILDPEDARIAADHGADAIVVSNHGGRQLDSAPASISVLPEIASAVGS
HHHCCCCHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCC
RTEILLDGGIRTGQDVLKALALGARGCLIGRSWLYGLAAGGQGGVTQVLEILRKELDTSM
CEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
ALAGLTDVRSVTPAALHTPRRV
HHHHHHHHHHCCHHHHCCCCCC
>Mature Secondary Structure 
APVTNIADLRDIARRRIPRAMFEYAQRGSYDERTLAANYAELDALRLRQRVMVDVSKRN
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
VATTFLGQDVTIPVGIAPTGLTGLFHADGEILGARAAQAFGVPFTLSTMSICSIEDVAGA
EEEEECCCCCEEEECCCCCCCCEEEECCCCCHHHHHHHHCCCCEEECHHHHHHHHHHHHC
VDKPFWFQLYVMRDRAFTQSLVERARAAGCPVLVLTLDLAAHGQRHRDIKNGLSVPPRLT
CCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCHHHHHHHCCCCCCCCEE
LANALDIATKPGWALNVLRGQRRSFGNLQGWMPAGKNLNAMAQWVAQQFDPSLSWKDVAW
HHHHHHHCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
IRSLWPGKLVLKGILDPEDARIAADHGADAIVVSNHGGRQLDSAPASISVLPEIASAVGS
HHHCCCCHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCC
RTEILLDGGIRTGQDVLKALALGARGCLIGRSWLYGLAAGGQGGVTQVLEILRKELDTSM
CEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
ALAGLTDVRSVTPAALHTPRRV
HHHHHHHHHHCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA