Click here to switch to the map view.

The map label for this gene is argE [H]

Identifier: 158423879

GI number: 158423879

Start: 2578401

End: 2579642

Strand: Reverse

Name: argE [H]

Synonym: AZC_2255

Alternate gene names: 158423879

Gene position: 2579642-2578401 (Counterclockwise)

Preceding gene: 158423883

Following gene: 158423872

Centisome position: 48.04

GC content: 66.26

Gene sequence:

>1242_bases
ATGCGGCAGAGTTGCGCTGGAGTCGCATCCGTCGCCCACGAGAACCTTCCCTTTAGAGAACCTTCCCGGAGTTTCCGCGC
GATGCCCAATCCCCAGACCCTCGACTGGCTGGCGCGCCTGATTTCGTTCGATACGACGAGCCGCAATTCCAACCTGCCGC
TGATCGAGGCGGTGGAAGAGTTCCTGACCGCCGAAGGCATCTTCTTCGAGCGCGTGGAGAACACGGAAGAAAAGAAGGCG
AGCCTCATCACCACACTCGGCCCGCGCGACGTGCCCGGCATTGTCCTGTCCGGCCACACCGACACCGTGCCGGTGGACGG
GCAGGAATGGACGTCGGATCCCTTCACCGTCACCGAGCGCGACGGCAAGCTCTATGGGCGCGGCACCTGCGACATGAAGG
GCTTCCTCGCCGTCTGCCTCGGCATGGTGGCGGAGATGAAGGCCCAGCCGCTCAAGAAGCCGATCCACTTCGCCATCTCC
TATGACGAGGAAGTGGGCTGCGTCGGCGTGCGCCCGCTGATCGAGCACATGGTGGCCAACGGCTACAAGCCGGAGGCCTG
CATCGTCGGCGAGCCCACCAGCATGCAGGTGGTGGTCGGGCACAAGGGCAAGAAGAGCTACGCCACGGTCATCACCGGCG
CCGGCGGCCATTCCTCCCGCGCGCCGGAACTGGTGAATGCCGTGGAGGCGGGCGGCCGCCTGGTGGCCAAGGTGGCCGAT
CTCAGCGATCGTCTGGCGGCGGAAGGCCGGCGGGACGACCTCTACGACATCCCCCACAGCACCGCCCACGTGGGCACCTT
CCATGGCGGCACCGCCCTCAACATCGTGCCGGAACTGGCGACGATCGACTGGGAAGTCCGGGCCCTGCCCGAGGACGACG
TGGAGGCGCTGACCGGCGAAATCATCGCTTATGCCACGGACACGCTGGAGCCGGGGATGAAGGCCAAGGCGCCCCACACC
GGCATCGAGTTCAAGCTGAAGAGCGCATTTCCGGGCCTCTCCACCTCGCCGGACGCGCCCGTGGCCGTGCTGGCGAAGCA
CTTCGCCGGCCGCAACGATCACGCCAAGGTCGCCTACGGCACGGAAGCTGGCCTGTTCGTGGAAATGGCCGGCATCCCGA
CCGTGGTGTGCGGCCCCGGCTCCATCGTCCAGGCGCACCAGCCGGATGAATATCTCGAGAAGAACCAGCTCGATGCCTGC
GAGGCCTTCATCCGCCGCGTGATCGCTTATTGCGCCGCCTGA

Upstream 100 bases:

>100_bases
ACAACCGTCTCCCGACATGGCAGGCGCTCCGCGCCCGCAATCCACCGCATCGCCCCGGACAAATGGGCTGCGCCGCTCCG
AAAGGGGGTATATGTGTGCA

Downstream 100 bases:

>100_bases
GCCTCTTGCTCTGACGCATCACATGAAGACGCCCCGAGCCGGATGGTTCGGGGCGTTCTCTTTTCAGATCAATAAATTGA
GGCGGATTTTTCAGGTCCGC

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MRQSCAGVASVAHENLPFREPSRSFRAMPNPQTLDWLARLISFDTTSRNSNLPLIEAVEEFLTAEGIFFERVENTEEKKA
SLITTLGPRDVPGIVLSGHTDTVPVDGQEWTSDPFTVTERDGKLYGRGTCDMKGFLAVCLGMVAEMKAQPLKKPIHFAIS
YDEEVGCVGVRPLIEHMVANGYKPEACIVGEPTSMQVVVGHKGKKSYATVITGAGGHSSRAPELVNAVEAGGRLVAKVAD
LSDRLAAEGRRDDLYDIPHSTAHVGTFHGGTALNIVPELATIDWEVRALPEDDVEALTGEIIAYATDTLEPGMKAKAPHT
GIEFKLKSAFPGLSTSPDAPVAVLAKHFAGRNDHAKVAYGTEAGLFVEMAGIPTVVCGPGSIVQAHQPDEYLEKNQLDAC
EAFIRRVIAYCAA

Sequences:

>Translated_413_residues
MRQSCAGVASVAHENLPFREPSRSFRAMPNPQTLDWLARLISFDTTSRNSNLPLIEAVEEFLTAEGIFFERVENTEEKKA
SLITTLGPRDVPGIVLSGHTDTVPVDGQEWTSDPFTVTERDGKLYGRGTCDMKGFLAVCLGMVAEMKAQPLKKPIHFAIS
YDEEVGCVGVRPLIEHMVANGYKPEACIVGEPTSMQVVVGHKGKKSYATVITGAGGHSSRAPELVNAVEAGGRLVAKVAD
LSDRLAAEGRRDDLYDIPHSTAHVGTFHGGTALNIVPELATIDWEVRALPEDDVEALTGEIIAYATDTLEPGMKAKAPHT
GIEFKLKSAFPGLSTSPDAPVAVLAKHFAGRNDHAKVAYGTEAGLFVEMAGIPTVVCGPGSIVQAHQPDEYLEKNQLDAC
EAFIRRVIAYCAA
>Mature_413_residues
MRQSCAGVASVAHENLPFREPSRSFRAMPNPQTLDWLARLISFDTTSRNSNLPLIEAVEEFLTAEGIFFERVENTEEKKA
SLITTLGPRDVPGIVLSGHTDTVPVDGQEWTSDPFTVTERDGKLYGRGTCDMKGFLAVCLGMVAEMKAQPLKKPIHFAIS
YDEEVGCVGVRPLIEHMVANGYKPEACIVGEPTSMQVVVGHKGKKSYATVITGAGGHSSRAPELVNAVEAGGRLVAKVAD
LSDRLAAEGRRDDLYDIPHSTAHVGTFHGGTALNIVPELATIDWEVRALPEDDVEALTGEIIAYATDTLEPGMKAKAPHT
GIEFKLKSAFPGLSTSPDAPVAVLAKHFAGRNDHAKVAYGTEAGLFVEMAGIPTVVCGPGSIVQAHQPDEYLEKNQLDAC
EAFIRRVIAYCAA

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=261, Percent_Identity=24.904214559387, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1790395, Length=333, Percent_Identity=36.3363363363363, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1788816, Length=335, Percent_Identity=26.2686567164179, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71982085, Length=387, Percent_Identity=25.8397932816537, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71982082, Length=377, Percent_Identity=25.7294429708223, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24649202, Length=344, Percent_Identity=25, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24649204, Length=344, Percent_Identity=25, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24649210, Length=339, Percent_Identity=23.598820058997, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356353, Length=330, Percent_Identity=23.6363636363636, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24649206, Length=328, Percent_Identity=22.5609756097561, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24649212, Length=397, Percent_Identity=22.6700251889169, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 44378; Mature: 44378

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQSCAGVASVAHENLPFREPSRSFRAMPNPQTLDWLARLISFDTTSRNSNLPLIEAVEE
CCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
FLTAEGIFFERVENTEEKKASLITTLGPRDVPGIVLSGHTDTVPVDGQEWTSDPFTVTER
HHHHCCCHHHHHCCCHHHHHHHHEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEC
DGKLYGRGTCDMKGFLAVCLGMVAEMKAQPLKKPIHFAISYDEEVGCVGVRPLIEHMVAN
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEHHHHHHHHHHC
GYKPEACIVGEPTSMQVVVGHKGKKSYATVITGAGGHSSRAPELVNAVEAGGRLVAKVAD
CCCCCEEEEECCCCEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCEEEHHHHH
LSDRLAAEGRRDDLYDIPHSTAHVGTFHGGTALNIVPELATIDWEVRALPEDDVEALTGE
HHHHHHCCCCCCCCCCCCCCCCEEEECCCCCEEEEECHHHCCCEEEEECCCHHHHHHHCC
IIAYATDTLEPGMKAKAPHTGIEFKLKSAFPGLSTSPDAPVAVLAKHFAGRNDHAKVAYG
EEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEC
TEAGLFVEMAGIPTVVCGPGSIVQAHQPDEYLEKNQLDACEAFIRRVIAYCAA
CCCCEEEEECCCCEEEECCCCEEECCCCHHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRQSCAGVASVAHENLPFREPSRSFRAMPNPQTLDWLARLISFDTTSRNSNLPLIEAVEE
CCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
FLTAEGIFFERVENTEEKKASLITTLGPRDVPGIVLSGHTDTVPVDGQEWTSDPFTVTER
HHHHCCCHHHHHCCCHHHHHHHHEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEC
DGKLYGRGTCDMKGFLAVCLGMVAEMKAQPLKKPIHFAISYDEEVGCVGVRPLIEHMVAN
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEHHHHHHHHHHC
GYKPEACIVGEPTSMQVVVGHKGKKSYATVITGAGGHSSRAPELVNAVEAGGRLVAKVAD
CCCCCEEEEECCCCEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCEEEHHHHH
LSDRLAAEGRRDDLYDIPHSTAHVGTFHGGTALNIVPELATIDWEVRALPEDDVEALTGE
HHHHHHCCCCCCCCCCCCCCCCEEEECCCCCEEEEECHHHCCCEEEEECCCHHHHHHHCC
IIAYATDTLEPGMKAKAPHTGIEFKLKSAFPGLSTSPDAPVAVLAKHFAGRNDHAKVAYG
EEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEC
TEAGLFVEMAGIPTVVCGPGSIVQAHQPDEYLEKNQLDACEAFIRRVIAYCAA
CCCCEEEEECCCCEEEECCCCEEECCCCHHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA