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The map label for this gene is trpC

Identifier: 158423829

GI number: 158423829

Start: 2519438

End: 2520229

Strand: Reverse

Name: trpC

Synonym: AZC_2205

Alternate gene names: 158423829

Gene position: 2520229-2519438 (Counterclockwise)

Preceding gene: 158423830

Following gene: 158423828

Centisome position: 46.93

GC content: 67.93

Gene sequence:

>792_bases
ATGAGCGACATTCTTTCCCGCATCGAGACCTACAAGCGCGCCGAGATCGAAGCCGCCCGCGCCGCGCGTCCGCAGGCCGA
GACCGAGGCGGCCGCCCGCGCCGCTGATCCCGTGCGCCCCTTCGCCAAGGCGCTGGAGGCGAAGATCGCCGCCGGCCAGA
CGGCTCTGATCGCCGAGATCAAGAAGGCAAGCCCTTCCAAGGGCCTCATCCGTCCGGATTTCGATCCGCCGGTGCTGGCC
CGCGCCTATGAGGACGGGGGCGCGGCCTGCCTCTCCATCCTGACCGACGGCCCTTCTTTCCAGGGCGCGCCGGAATATCT
CATCGCCGCCCGCGCGCAGGTAAGCCTGCCGGTGCTGCGCAAGGACTTCCTGTTCGACACCTATCAGGTGGCGGAAGCCC
GCGCGTGGGGCGCCGACTGCATCCTCGTCATCATGGCCGCCGTGGATGACGCGCTCGCCCGCGACCTTGTGGAGGCGGCG
ACCGATTTCGGCATGGATTCGATCATCGAGGTGCATGACGAAGCCGAGCTCGACCGGGCGCTGGCTCTGCCCTCAAAGCT
CATCGGCATTAACAACCGCAACCTGCGCACCTTCGAGACGACGCTCGCCACCTCCGGCCGCCTCGCCCCGCGCGTGCCGA
AGGACCGCATCGTCATCGGCGAGAGCGGCATCTTCACGCATGCGGACGTGAAGCTGCTCCGGCAGGTGGGCATCGCCAGC
ATTCTCGTGGGCGAAAGCCTGATGCGGCAGGAGGATGTCACCTCCGCCACCCGCACGCTGCTGAACGGCTGA

Upstream 100 bases:

>100_bases
GAGTGGACATGGCCAAGGCCAGCATCGATAGCGGCGCCGCCAAGGCGAAGCTTGATCAACTTGCCCGCGCCACGCAGGCG
CTCGCCCCGCAGGTGGACGC

Downstream 100 bases:

>100_bases
CTTCCGGCGCGGAACGGCCGGGGGCATACTGGCCCCGAGGCCGCCGCAAGATGCGGCCCCTGGGAGATGCGCATGAAGAC
GATGGGAATTCTGGCCGCTG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSDILSRIETYKRAEIEAARAARPQAETEAAARAADPVRPFAKALEAKIAAGQTALIAEIKKASPSKGLIRPDFDPPVLA
RAYEDGGAACLSILTDGPSFQGAPEYLIAARAQVSLPVLRKDFLFDTYQVAEARAWGADCILVIMAAVDDALARDLVEAA
TDFGMDSIIEVHDEAELDRALALPSKLIGINNRNLRTFETTLATSGRLAPRVPKDRIVIGESGIFTHADVKLLRQVGIAS
ILVGESLMRQEDVTSATRTLLNG

Sequences:

>Translated_263_residues
MSDILSRIETYKRAEIEAARAARPQAETEAAARAADPVRPFAKALEAKIAAGQTALIAEIKKASPSKGLIRPDFDPPVLA
RAYEDGGAACLSILTDGPSFQGAPEYLIAARAQVSLPVLRKDFLFDTYQVAEARAWGADCILVIMAAVDDALARDLVEAA
TDFGMDSIIEVHDEAELDRALALPSKLIGINNRNLRTFETTLATSGRLAPRVPKDRIVIGESGIFTHADVKLLRQVGIAS
ILVGESLMRQEDVTSATRTLLNG
>Mature_262_residues
SDILSRIETYKRAEIEAARAARPQAETEAAARAADPVRPFAKALEAKIAAGQTALIAEIKKASPSKGLIRPDFDPPVLAR
AYEDGGAACLSILTDGPSFQGAPEYLIAARAQVSLPVLRKDFLFDTYQVAEARAWGADCILVIMAAVDDALARDLVEAAT
DFGMDSIIEVHDEAELDRALALPSKLIGINNRNLRTFETTLATSGRLAPRVPKDRIVIGESGIFTHADVKLLRQVGIASI
LVGESLMRQEDVTSATRTLLNG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=263, Percent_Identity=36.8821292775665, Blast_Score=160, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322638, Length=234, Percent_Identity=35.042735042735, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_AZOC5 (A8I836)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001525121.1
- ProteinModelPortal:   A8I836
- SMR:   A8I836
- GeneID:   5689545
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_2205
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- ProtClustDB:   PRK00278
- BioCyc:   ACAU438753:AZC_2205-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28223; Mature: 28091

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILSRIETYKRAEIEAARAARPQAETEAAARAADPVRPFAKALEAKIAAGQTALIAEI
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHH
KKASPSKGLIRPDFDPPVLARAYEDGGAACLSILTDGPSFQGAPEYLIAARAQVSLPVLR
HHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
KDFLFDTYQVAEARAWGADCILVIMAAVDDALARDLVEAATDFGMDSIIEVHDEAELDRA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LALPSKLIGINNRNLRTFETTLATSGRLAPRVPKDRIVIGESGIFTHADVKLLRQVGIAS
HHCHHHHHCCCCCCCEEHHHHHHCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
ILVGESLMRQEDVTSATRTLLNG
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDILSRIETYKRAEIEAARAARPQAETEAAARAADPVRPFAKALEAKIAAGQTALIAEI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHH
KKASPSKGLIRPDFDPPVLARAYEDGGAACLSILTDGPSFQGAPEYLIAARAQVSLPVLR
HHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
KDFLFDTYQVAEARAWGADCILVIMAAVDDALARDLVEAATDFGMDSIIEVHDEAELDRA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LALPSKLIGINNRNLRTFETTLATSGRLAPRVPKDRIVIGESGIFTHADVKLLRQVGIAS
HHCHHHHHCCCCCCCEEHHHHHHCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
ILVGESLMRQEDVTSATRTLLNG
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA