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The map label for this gene is ghrA [H]

Identifier: 158423662

GI number: 158423662

Start: 2350611

End: 2351540

Strand: Reverse

Name: ghrA [H]

Synonym: AZC_2038

Alternate gene names: 158423662

Gene position: 2351540-2350611 (Counterclockwise)

Preceding gene: 158423664

Following gene: 158423661

Centisome position: 43.79

GC content: 68.49

Gene sequence:

>930_bases
TTGGCCTTCCTGTTCAATTCCGATGCCGGGCGCGGGCGCATCTTCAAGGCGGCCTTCGCCAGCGCCCGCCCGGACATCCC
CTTCTTCCTTTCGCCCGCGGAGGCCGATCCGGCACGCGTGCGCTACATCATCTCCTGGACCGTCCCGCAGAACCTTGTCG
CCTATACGGGGTTGGAGGTGCTGTTCTGCGTCGGCGCGGGTGTTGACCACATGCCCATCGATACCCTGCCGCCACACGTG
AAGGTGGTACGCATGATGGAAGACGGCATCGTGCGCATGATGCAGGAATATGTGACGCTCGGCGTCCTCACCCTGCACCG
CGACATATTCGGGTATCGCGCGCAGCAGGCCCGCGCCGAATGGACGCCGCGTGCGGTCGTGCGGGCGCACGAGCGGAACG
TCGGCGTGCTCGGCCTCGGCATGCTCGGCAAGGCTGTGCTTTCGCGTCTTGCGCCCTTCGGCTTTCAACTCGCGGGCTGG
AGCCGCTCCGCCCACGACCTGCCCGGCGTCACCTGCTTTCACGGCCATGGGCCGGATGGGCTCGATGCCTTTCTCGCCCG
CACGGACATCCTCGTCTGCCTTCTGCCGTTGACCCACGAAACGCGCGGCTTTCTCAACGGCGAGCGCCTCCGCCGCCTGC
GGCCGGGAGCGGGCCTCGTGCATGTGGGGCGCGGGCCGCAGCTCGACGGCGCGGCCCTGCTTGCCGCACTCGAGGACGGG
CATGTGTCCGGGGCCGTTCTCGATGTCACCCATCCCGAGCCCCTGCCGGCAACCTCGCCGCTCTGGGCCCATCCGAACGT
GATGATTACTCCCCACATCGCCAGCGTGACGCGGCCGGACACGGCCGCCGAAGTGGTGCTGGAGAATATCCGCCGCCACG
AGGCGGGGCTCGATCCCATCGGCCTCGTGGACCGCGCGCGCGGCTACTGA

Upstream 100 bases:

>100_bases
TTTCGGCGGGATGTATCGTCCGCCCGCTGCCCTTTGATGGAATCTGCGGCGGGCAGCCGGGCACCCTCGGCGGGTCCAAC
GTCGGGCTCCGGAGCATGCC

Downstream 100 bases:

>100_bases
TCCCTCTCGAACCAGAAGGGCCCATCCATGTCCCTGCTCAAGACCATCGACACTGCTCCCACCTTCGAACCCGTGGAGAA
GAAGCCCGATGCGGACCGCC

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MAFLFNSDAGRGRIFKAAFASARPDIPFFLSPAEADPARVRYIISWTVPQNLVAYTGLEVLFCVGAGVDHMPIDTLPPHV
KVVRMMEDGIVRMMQEYVTLGVLTLHRDIFGYRAQQARAEWTPRAVVRAHERNVGVLGLGMLGKAVLSRLAPFGFQLAGW
SRSAHDLPGVTCFHGHGPDGLDAFLARTDILVCLLPLTHETRGFLNGERLRRLRPGAGLVHVGRGPQLDGAALLAALEDG
HVSGAVLDVTHPEPLPATSPLWAHPNVMITPHIASVTRPDTAAEVVLENIRRHEAGLDPIGLVDRARGY

Sequences:

>Translated_309_residues
MAFLFNSDAGRGRIFKAAFASARPDIPFFLSPAEADPARVRYIISWTVPQNLVAYTGLEVLFCVGAGVDHMPIDTLPPHV
KVVRMMEDGIVRMMQEYVTLGVLTLHRDIFGYRAQQARAEWTPRAVVRAHERNVGVLGLGMLGKAVLSRLAPFGFQLAGW
SRSAHDLPGVTCFHGHGPDGLDAFLARTDILVCLLPLTHETRGFLNGERLRRLRPGAGLVHVGRGPQLDGAALLAALEDG
HVSGAVLDVTHPEPLPATSPLWAHPNVMITPHIASVTRPDTAAEVVLENIRRHEAGLDPIGLVDRARGY
>Mature_308_residues
AFLFNSDAGRGRIFKAAFASARPDIPFFLSPAEADPARVRYIISWTVPQNLVAYTGLEVLFCVGAGVDHMPIDTLPPHVK
VVRMMEDGIVRMMQEYVTLGVLTLHRDIFGYRAQQARAEWTPRAVVRAHERNVGVLGLGMLGKAVLSRLAPFGFQLAGWS
RSAHDLPGVTCFHGHGPDGLDAFLARTDILVCLLPLTHETRGFLNGERLRRLRPGAGLVHVGRGPQLDGAALLAALEDGH
VSGAVLDVTHPEPLPATSPLWAHPNVMITPHIASVTRPDTAAEVVLENIRRHEAGLDPIGLVDRARGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=229, Percent_Identity=27.5109170305677, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI23308577, Length=227, Percent_Identity=27.7533039647577, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI145580578, Length=284, Percent_Identity=27.112676056338, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4557499, Length=284, Percent_Identity=27.112676056338, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI61743967, Length=254, Percent_Identity=27.9527559055118, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4557497, Length=254, Percent_Identity=27.9527559055118, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI145580575, Length=268, Percent_Identity=26.865671641791, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87081824, Length=274, Percent_Identity=40.5109489051095, Blast_Score=189, Evalue=1e-49,
Organism=Escherichia coli, GI87082289, Length=220, Percent_Identity=29.0909090909091, Blast_Score=96, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17532191, Length=241, Percent_Identity=26.5560165975104, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25147481, Length=254, Percent_Identity=27.1653543307087, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324055, Length=163, Percent_Identity=34.3558282208589, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28574286, Length=172, Percent_Identity=33.1395348837209, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571528, Length=143, Percent_Identity=34.2657342657343, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24585516, Length=175, Percent_Identity=30.8571428571429, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585514, Length=170, Percent_Identity=31.7647058823529, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28574282, Length=170, Percent_Identity=31.7647058823529, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45552429, Length=170, Percent_Identity=31.7647058823529, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28574284, Length=170, Percent_Identity=31.7647058823529, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45551003, Length=170, Percent_Identity=31.7647058823529, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921140, Length=225, Percent_Identity=28, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646446, Length=275, Percent_Identity=24, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24646448, Length=275, Percent_Identity=24, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24646452, Length=275, Percent_Identity=24, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24646450, Length=275, Percent_Identity=24, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33588; Mature: 33457

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFLFNSDAGRGRIFKAAFASARPDIPFFLSPAEADPARVRYIISWTVPQNLVAYTGLEV
CEEEECCCCCCCEEEHHHHHCCCCCCCEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHH
LFCVGAGVDHMPIDTLPPHVKVVRMMEDGIVRMMQEYVTLGVLTLHRDIFGYRAQQARAE
HHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WTPRAVVRAHERNVGVLGLGMLGKAVLSRLAPFGFQLAGWSRSAHDLPGVTCFHGHGPDG
CCCHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEECCCCCCH
LDAFLARTDILVCLLPLTHETRGFLNGERLRRLRPGAGLVHVGRGPQLDGAALLAALEDG
HHHHHHHHCEEEEEECCCCCHHCCCCHHHHHHCCCCCCEEEECCCCCCCHHHHEEECCCC
HVSGAVLDVTHPEPLPATSPLWAHPNVMITPHIASVTRPDTAAEVVLENIRRHEAGLDPI
CCCCEEEECCCCCCCCCCCCCCCCCCEEECCCHHCCCCCCHHHHHHHHHHHHHHCCCCCC
GLVDRARGY
CHHHHCCCC
>Mature Secondary Structure 
AFLFNSDAGRGRIFKAAFASARPDIPFFLSPAEADPARVRYIISWTVPQNLVAYTGLEV
EEEECCCCCCCEEEHHHHHCCCCCCCEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHH
LFCVGAGVDHMPIDTLPPHVKVVRMMEDGIVRMMQEYVTLGVLTLHRDIFGYRAQQARAE
HHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WTPRAVVRAHERNVGVLGLGMLGKAVLSRLAPFGFQLAGWSRSAHDLPGVTCFHGHGPDG
CCCHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEECCCCCCH
LDAFLARTDILVCLLPLTHETRGFLNGERLRRLRPGAGLVHVGRGPQLDGAALLAALEDG
HHHHHHHHCEEEEEECCCCCHHCCCCHHHHHHCCCCCCEEEECCCCCCCHHHHEEECCCC
HVSGAVLDVTHPEPLPATSPLWAHPNVMITPHIASVTRPDTAAEVVLENIRRHEAGLDPI
CCCCEEEECCCCCCCCCCCCCCCCCCEEECCCHHCCCCCCHHHHHHHHHHHHHHCCCCCC
GLVDRARGY
CHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA