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The map label for this gene is glxR [H]

Identifier: 158423516

GI number: 158423516

Start: 2168440

End: 2169345

Strand: Reverse

Name: glxR [H]

Synonym: AZC_1892

Alternate gene names: 158423516

Gene position: 2169345-2168440 (Counterclockwise)

Preceding gene: 158423517

Following gene: 158423503

Centisome position: 40.4

GC content: 68.65

Gene sequence:

>906_bases
ATGACGCTCCAACGGATCGGCTTTCTCGGCACCGGCATCATGGGCGGCCCGATGGCCCGCAATCTGGCGCGCGCCGGCTT
CGAGGTGACCGCATGGAACCGCTCTTCCGGCAAGGCGCGCGCCCTTGAAGCGGATGGCGTCAGGAGCGCGCCCACGGCCC
ATGAGGCCGTCCGGGCCGCAGAGGTCGTCATCTGCATGCTCAGCTCCGGCCCGGTCTGCGACGAGTTCCTGCTGGGCGCT
GACGGTATGATCTCCGCCATGGCGCCCGGCGCCACCCTCGTGGTGATGAGTTCCATCCCTGTCGAGACCGCCGAGGCGCA
GGCCCGTGCCGCCGCCGAACGTGGCCTCCTTTATGTGGATGCTCCGGTCTCCGGCGGCGAGAAAGGCGCCATCGCGGGCA
GTCTTGCCATCATGGCCGGCGGGCCGGCGGAAGCCGTGGCGCGGGTAACGCCCGTGCTGGCGGCCATGGGACGAGCCGTC
CATGTGGGGCCGGCCGGGACCGGCCAGTTGTGCAAGCTCATCAACCAGGGGATCGTGGCCTCAACCCTCGTCGCGATGGC
GGAAGCCATGACACTCGCCAGGCAAGGCGGCGCGGATCCTCTGAAGGTGCGGGAAGCGCTGCTCGGCGGCTTTGCCGATT
CAACTATCCTGAAGCAGCACGCCTTGCGGATGGCCACCGGCGACTTCGTGCCCGGCGGGCCAGCGAAATATCAGCTGAAG
GACACCCGCACCGCCCTCGCCCATGCGGCGCATCTGGGGCTATCCTTGCCCATGCTGTCGCTCACCGACAGCATGTTCGA
GGCACTGGTCGCCAACGGCGACGGCGATTTGGACCACAGCGCCGTGATCCGGGAAATCTGGCGCGCCAATCCGGCCGTGG
GCGCCGATCTGAGCGCGCCAGTCTGA

Upstream 100 bases:

>100_bases
ACTTCGCCCGCTTCAGGGACGGCTTTCCGGCCCTGATCGTGGCTGAACGGCCGGTGCGCTTCCTCGCCCGCGCCACAAGC
GGCGCCGGGAACTGAAGATC

Downstream 100 bases:

>100_bases
GCTGCCATCCAGGCAAGCGGTTCAAGCGAAGCCTTGGCCTTCACTTCTGGGGCCGGAGGCGGGTGCCGGCGCGCTCCGGT
TAGGTGCGCGCGTTGGCGAT

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTLQRIGFLGTGIMGGPMARNLARAGFEVTAWNRSSGKARALEADGVRSAPTAHEAVRAAEVVICMLSSGPVCDEFLLGA
DGMISAMAPGATLVVMSSIPVETAEAQARAAAERGLLYVDAPVSGGEKGAIAGSLAIMAGGPAEAVARVTPVLAAMGRAV
HVGPAGTGQLCKLINQGIVASTLVAMAEAMTLARQGGADPLKVREALLGGFADSTILKQHALRMATGDFVPGGPAKYQLK
DTRTALAHAAHLGLSLPMLSLTDSMFEALVANGDGDLDHSAVIREIWRANPAVGADLSAPV

Sequences:

>Translated_301_residues
MTLQRIGFLGTGIMGGPMARNLARAGFEVTAWNRSSGKARALEADGVRSAPTAHEAVRAAEVVICMLSSGPVCDEFLLGA
DGMISAMAPGATLVVMSSIPVETAEAQARAAAERGLLYVDAPVSGGEKGAIAGSLAIMAGGPAEAVARVTPVLAAMGRAV
HVGPAGTGQLCKLINQGIVASTLVAMAEAMTLARQGGADPLKVREALLGGFADSTILKQHALRMATGDFVPGGPAKYQLK
DTRTALAHAAHLGLSLPMLSLTDSMFEALVANGDGDLDHSAVIREIWRANPAVGADLSAPV
>Mature_300_residues
TLQRIGFLGTGIMGGPMARNLARAGFEVTAWNRSSGKARALEADGVRSAPTAHEAVRAAEVVICMLSSGPVCDEFLLGAD
GMISAMAPGATLVVMSSIPVETAEAQARAAAERGLLYVDAPVSGGEKGAIAGSLAIMAGGPAEAVARVTPVLAAMGRAVH
VGPAGTGQLCKLINQGIVASTLVAMAEAMTLARQGGADPLKVREALLGGFADSTILKQHALRMATGDFVPGGPAKYQLKD
TRTALAHAAHLGLSLPMLSLTDSMFEALVANGDGDLDHSAVIREIWRANPAVGADLSAPV

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=284, Percent_Identity=29.5774647887324, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI23308751, Length=196, Percent_Identity=31.1224489795918, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1786719, Length=282, Percent_Identity=42.5531914893617, Blast_Score=197, Evalue=6e-52,
Organism=Escherichia coli, GI145693186, Length=279, Percent_Identity=37.9928315412186, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1790315, Length=285, Percent_Identity=30.1754385964912, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1789092, Length=284, Percent_Identity=27.4647887323944, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788341, Length=215, Percent_Identity=27.4418604651163, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=200, Percent_Identity=33.5, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28574115, Length=287, Percent_Identity=27.8745644599303, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=27.891156462585, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=27.891156462585, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30569; Mature: 30438

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQRIGFLGTGIMGGPMARNLARAGFEVTAWNRSSGKARALEADGVRSAPTAHEAVRAA
CCHHHHHHHHCCCCCCHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHH
EVVICMLSSGPVCDEFLLGADGMISAMAPGATLVVMSSIPVETAEAQARAAAERGLLYVD
HHHEEEECCCCCHHHHHHCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEE
APVSGGEKGAIAGSLAIMAGGPAEAVARVTPVLAAMGRAVHVGPAGTGQLCKLINQGIVA
CCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCHHH
STLVAMAEAMTLARQGGADPLKVREALLGGFADSTILKQHALRMATGDFVPGGPAKYQLK
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEH
DTRTALAHAAHLGLSLPMLSLTDSMFEALVANGDGDLDHSAVIREIWRANPAVGADLSAP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
V
C
>Mature Secondary Structure 
TLQRIGFLGTGIMGGPMARNLARAGFEVTAWNRSSGKARALEADGVRSAPTAHEAVRAA
CHHHHHHHHCCCCCCHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHH
EVVICMLSSGPVCDEFLLGADGMISAMAPGATLVVMSSIPVETAEAQARAAAERGLLYVD
HHHEEEECCCCCHHHHHHCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEE
APVSGGEKGAIAGSLAIMAGGPAEAVARVTPVLAAMGRAVHVGPAGTGQLCKLINQGIVA
CCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCHHH
STLVAMAEAMTLARQGGADPLKVREALLGGFADSTILKQHALRMATGDFVPGGPAKYQLK
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEH
DTRTALAHAAHLGLSLPMLSLTDSMFEALVANGDGDLDHSAVIREIWRANPAVGADLSAP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]