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The map label for this gene is icd [H]

Identifier: 158423489

GI number: 158423489

Start: 2135132

End: 2136346

Strand: Reverse

Name: icd [H]

Synonym: AZC_1865

Alternate gene names: 158423489

Gene position: 2136346-2135132 (Counterclockwise)

Preceding gene: 158423492

Following gene: 158423486

Centisome position: 39.78

GC content: 61.73

Gene sequence:

>1215_bases
ATGGCGAAGATCAAGGTCGCAAATCCGGTCGTCGAGCTCGACGGCGATGAGATGACGCGGATCATCTGGCAGTATATCAA
GGACAAGCTGATCCACCCCTACCTTGATATCGACCTCGAGTATTATGACCTTTCGGTCGAGAACCGCGACGCGACCAACG
ATCAGGTCACGATCGACGCGGCGAACGCCATCAAGAAGCACGGCGTGGGCGTCAAGTGCGCCACGATTACTCCCGACGAA
GCCCGCGTGAAGGAATTCAACCTCAAGGAAATGTGGAAGTCGCCGAACGGCACCATCCGCAACATCCTCGGCGGCGTGAT
CTTCCGTGAGCCCATCATCTGCAAGAACGTGCCGCGCCTCGTGCCGGGCTGGACGCAGCCGATCGTGGTCGGCCGCCATG
CCTTCGGCGACCAGTATCGCGCCACCGACTTCAAGGTGCCCGGCAAGGGCACGCTGACCATCTCCTTCGTGGGCGAGGAC
GGCACGAAGATCGAGAAGGAAGTCTACAAGTTCCCGGGCGCTGGCGTTGCCCTGTCCATGTACAACCTGGACGAGTCGAT
CCGCGATTTCGCCCGCGCCTCGCTGAACTACGGCCTGATGCGGAACTATCCGGTCTATCTCTCCACGAAGAACACGATCC
TGAAGGCCTATGACGGCCGCTTCAAGGATATCTTCCAAGAGATCTACGACACCGAGTTCAAGGCCGAGTTCGAGAAGCGC
AAGCTGACCTACGAGCACCGCCTGATCGACGACATGGTCGCTTCCGCCCTCAAGTGGTCCGGCGGCTATGTGTGGGCCTG
CAAGAACTATGACGGCGACGTGCAGTCCGACATCGTGGCCCAGGGCTTCGGCTCGCTCGGCCTGATGACCTCCGTGCTGA
TGACTCCCGATGGCCAGACTGTCGAGGCTGAAGCCGCCCACGGCACGGTGACCCGCCACTATCGCGAGCACCAGAAGGGC
AAGGAGACTTCCACCAACTCCATCGCCTCCATCTTCGCCTGGACCCGTGGCCTCGCGCACCGCGCCAAGCTCGACGGCAA
TGACGAGCTGAAGCGCTTCGCCGATACGCTCGAGAAGGTCTGCGTCGATACGGTCGAGGCCGGCGACATGACCAAGGACC
TCGCCCTGCTGGTCGGCGCCGACCAGAAGTGGCTGTCCACCACGGGCTTCCTCGACAAGGTGTCCGAGAACCTCGCAAAG
GCCCTCGCGGCCTGA

Upstream 100 bases:

>100_bases
GCTCGGGCCGGCATCGGAGTATCACGCGCACACCGGCGCCTGGCTGCGTGGACCGGCGCTGAGGCCCCATTACGATACGA
ATCCGCGTGAGGTGTCACCC

Downstream 100 bases:

>100_bases
TGCCGCCGGGCGCCCTCACCGGCGCCCGGTCCTTTCCGGCGGCCCGCCTCGCTCGTCAGGAGCGGCGCGGGCCGTTGTCG
TCTCCGGGGCTGCCCATTTC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAKIKVANPVVELDGDEMTRIIWQYIKDKLIHPYLDIDLEYYDLSVENRDATNDQVTIDAANAIKKHGVGVKCATITPDE
ARVKEFNLKEMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIVVGRHAFGDQYRATDFKVPGKGTLTISFVGED
GTKIEKEVYKFPGAGVALSMYNLDESIRDFARASLNYGLMRNYPVYLSTKNTILKAYDGRFKDIFQEIYDTEFKAEFEKR
KLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGQTVEAEAAHGTVTRHYREHQKG
KETSTNSIASIFAWTRGLAHRAKLDGNDELKRFADTLEKVCVDTVEAGDMTKDLALLVGADQKWLSTTGFLDKVSENLAK
ALAA

Sequences:

>Translated_404_residues
MAKIKVANPVVELDGDEMTRIIWQYIKDKLIHPYLDIDLEYYDLSVENRDATNDQVTIDAANAIKKHGVGVKCATITPDE
ARVKEFNLKEMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIVVGRHAFGDQYRATDFKVPGKGTLTISFVGED
GTKIEKEVYKFPGAGVALSMYNLDESIRDFARASLNYGLMRNYPVYLSTKNTILKAYDGRFKDIFQEIYDTEFKAEFEKR
KLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGQTVEAEAAHGTVTRHYREHQKG
KETSTNSIASIFAWTRGLAHRAKLDGNDELKRFADTLEKVCVDTVEAGDMTKDLALLVGADQKWLSTTGFLDKVSENLAK
ALAA
>Mature_403_residues
AKIKVANPVVELDGDEMTRIIWQYIKDKLIHPYLDIDLEYYDLSVENRDATNDQVTIDAANAIKKHGVGVKCATITPDEA
RVKEFNLKEMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIVVGRHAFGDQYRATDFKVPGKGTLTISFVGEDG
TKIEKEVYKFPGAGVALSMYNLDESIRDFARASLNYGLMRNYPVYLSTKNTILKAYDGRFKDIFQEIYDTEFKAEFEKRK
LTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGQTVEAEAAHGTVTRHYREHQKGK
ETSTNSIASIFAWTRGLAHRAKLDGNDELKRFADTLEKVCVDTVEAGDMTKDLALLVGADQKWLSTTGFLDKVSENLAKA
LAA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=68.3823529411765, Blast_Score=592, Evalue=1e-169,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=67.3170731707317, Blast_Score=575, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=67.3218673218673, Blast_Score=581, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=68.407960199005, Blast_Score=571, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6320137, Length=410, Percent_Identity=62.9268292682927, Blast_Score=541, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6324319, Length=409, Percent_Identity=61.3691931540342, Blast_Score=541, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6323203, Length=409, Percent_Identity=62.3471882640587, Blast_Score=531, Evalue=1e-152,
Organism=Drosophila melanogaster, GI21356561, Length=409, Percent_Identity=65.5256723716381, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI221330987, Length=409, Percent_Identity=65.5256723716381, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI221330985, Length=409, Percent_Identity=65.5256723716381, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI28574947, Length=409, Percent_Identity=65.5256723716381, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24660849, Length=409, Percent_Identity=65.5256723716381, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24660856, Length=409, Percent_Identity=65.5256723716381, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI221330983, Length=409, Percent_Identity=65.5256723716381, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24660868, Length=409, Percent_Identity=65.5256723716381, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24660860, Length=409, Percent_Identity=65.5256723716381, Blast_Score=563, Evalue=1e-161,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45203; Mature: 45072

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVANPVVELDGDEMTRIIWQYIKDKLIHPYLDIDLEYYDLSVENRDATNDQVTIDA
CCEEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCEEEEEH
ANAIKKHGVGVKCATITPDEARVKEFNLKEMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHCCHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIVVGRHAFGDQYRATDFKVPGKGTLTISFVGEDGTKIEKEVYKFPGAGVALSM
CCCCCCCEEEECHHCCCCCCCCCEECCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEE
YNLDESIRDFARASLNYGLMRNYPVYLSTKNTILKAYDGRFKDIFQEIYDTEFKAEFEKR
ECCCHHHHHHHHHHHCCCHHCCCCEEEECCCCEEECCCCHHHHHHHHHHCCHHHHHHHHH
KLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGQT
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYREHQKGKETSTNSIASIFAWTRGLAHRAKLDGNDELKRFADTLEKV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CVDTVEAGDMTKDLALLVGADQKWLSTTGFLDKVSENLAKALAA
HHHHHCCCCCHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVANPVVELDGDEMTRIIWQYIKDKLIHPYLDIDLEYYDLSVENRDATNDQVTIDA
CEEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCEEEEEH
ANAIKKHGVGVKCATITPDEARVKEFNLKEMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHCCHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIVVGRHAFGDQYRATDFKVPGKGTLTISFVGEDGTKIEKEVYKFPGAGVALSM
CCCCCCCEEEECHHCCCCCCCCCEECCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEE
YNLDESIRDFARASLNYGLMRNYPVYLSTKNTILKAYDGRFKDIFQEIYDTEFKAEFEKR
ECCCHHHHHHHHHHHCCCHHCCCCEEEECCCCEEECCCCHHHHHHHHHHCCHHHHHHHHH
KLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGQT
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYREHQKGKETSTNSIASIFAWTRGLAHRAKLDGNDELKRFADTLEKV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CVDTVEAGDMTKDLALLVGADQKWLSTTGFLDKVSENLAKALAA
HHHHHCCCCCHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]