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The map label for this gene is lysR [H]

Identifier: 158423429

GI number: 158423429

Start: 2065836

End: 2066798

Strand: Reverse

Name: lysR [H]

Synonym: AZC_1805

Alternate gene names: 158423429

Gene position: 2066798-2065836 (Counterclockwise)

Preceding gene: 158423431

Following gene: 158423428

Centisome position: 38.49

GC content: 65.94

Gene sequence:

>963_bases
ATGAATATCCGTTTCCTGGAAACCTTTGTGTGGGTCGCCCGGCTGCGGAGCTTCTCCAGCGCGGCGGACAAGCTGTGCAC
GACCCAGGCGGCTGTTTCCAACCGCATCGCGACCCTCGAACGCGATCTCGGCGTGCGGCTGTTCGAGCGTGACCTGCGCA
ATGTGAGCCTGACCCCGCAGGGCGAGCGGGCGCTGGCGCAGGCGGAAACCATCGTTCGCCTGACCGAAGAATTGCGGCTC
GGGGTCAGCGAGGCCAGCAGCCTCCGCGGGCGCATCGCCATCGGCACCATCGATTCCATCGTCTATGCGTGGCTGCCCAA
GCTGATCGAAGCCGTGAAGGCCACCTATCCGGACGTGGACATCGACCTCACGGTGGATAACAGCCTCACGGTCTCCCGCC
TGCTGCTGGACCGGCAGGTGAATCTGGCGCTGATCGCCGGGCCCGTACTGGCGGCCGAGTGCAGCAATATCGACCTGTGC
ACCTATCAGTGCCACTGGTTTGCCGCGCCACACCTCGGCCTGCACGGGCGCCGCCTCTCGCTCGTGGACATCGTGGCGAA
CCCCATCTTCGCCTTCTCAAAGGGCTCGCAACCCCACCAGAACGTGCTGCGCCTGATGGAGTCCGCCGGCCTCGATGCAA
ACCTCAATCTGGTGCGCATCCTCAATTCCAACTCACTCGCCACCATCACCCGCCTCGCCCGCGACGGCATGGGCGTCGCC
GTCCTGCCGACTGAGGTGGCCCGCGAGATGGTGGAACGGGGCGAACTGATGCAGCTCGACGTGGACGCGGACCTGCCGCC
CCTGCACCTCCACGCCGTCTATCGCGAGGAGCCGGGCAGCACCCTGCCGGCATTGATCGCCCGGATGGCGGCGCAAGTGG
CGAAGGCGGAAGACGCGGCCACGCTCACGCCATCGGCCAATGCGCGCCGCAACCAGATCCGCATTGCATCGCACACAAAA
TAG

Upstream 100 bases:

>100_bases
TGGGGGACCGGCAGCGCATCGCTTGCATTGCAGTTCGGTCCCCCAGAGCCCATCATCGGCGCCTGTCTGTTCCGCCACTG
GCCGGAGACCGCGCACGCCG

Downstream 100 bases:

>100_bases
GCACGCGCCGCCCGTGCCGCTGTCATAAGCATTTCTTGTAAGCGCCGACAATTATTTCGCGTTTGTCGGACGTGGTTTGG
TCTGGTCTGCTCCCGTCACC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MNIRFLETFVWVARLRSFSSAADKLCTTQAAVSNRIATLERDLGVRLFERDLRNVSLTPQGERALAQAETIVRLTEELRL
GVSEASSLRGRIAIGTIDSIVYAWLPKLIEAVKATYPDVDIDLTVDNSLTVSRLLLDRQVNLALIAGPVLAAECSNIDLC
TYQCHWFAAPHLGLHGRRLSLVDIVANPIFAFSKGSQPHQNVLRLMESAGLDANLNLVRILNSNSLATITRLARDGMGVA
VLPTEVAREMVERGELMQLDVDADLPPLHLHAVYREEPGSTLPALIARMAAQVAKAEDAATLTPSANARRNQIRIASHTK

Sequences:

>Translated_320_residues
MNIRFLETFVWVARLRSFSSAADKLCTTQAAVSNRIATLERDLGVRLFERDLRNVSLTPQGERALAQAETIVRLTEELRL
GVSEASSLRGRIAIGTIDSIVYAWLPKLIEAVKATYPDVDIDLTVDNSLTVSRLLLDRQVNLALIAGPVLAAECSNIDLC
TYQCHWFAAPHLGLHGRRLSLVDIVANPIFAFSKGSQPHQNVLRLMESAGLDANLNLVRILNSNSLATITRLARDGMGVA
VLPTEVAREMVERGELMQLDVDADLPPLHLHAVYREEPGSTLPALIARMAAQVAKAEDAATLTPSANARRNQIRIASHTK
>Mature_320_residues
MNIRFLETFVWVARLRSFSSAADKLCTTQAAVSNRIATLERDLGVRLFERDLRNVSLTPQGERALAQAETIVRLTEELRL
GVSEASSLRGRIAIGTIDSIVYAWLPKLIEAVKATYPDVDIDLTVDNSLTVSRLLLDRQVNLALIAGPVLAAECSNIDLC
TYQCHWFAAPHLGLHGRRLSLVDIVANPIFAFSKGSQPHQNVLRLMESAGLDANLNLVRILNSNSLATITRLARDGMGVA
VLPTEVAREMVERGELMQLDVDADLPPLHLHAVYREEPGSTLPALIARMAAQVAKAEDAATLTPSANARRNQIRIASHTK

Specific function: Regulates expression of the cell division protein ftsW, and is essential for cell viability during stationary phase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=276, Percent_Identity=28.9855072463768, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788626, Length=248, Percent_Identity=29.4354838709677, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1788297, Length=252, Percent_Identity=29.3650793650794, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI145693105, Length=117, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790399, Length=290, Percent_Identity=25.8620689655172, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788481, Length=265, Percent_Identity=27.9245283018868, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI48994962, Length=146, Percent_Identity=32.8767123287671, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788748, Length=258, Percent_Identity=26.7441860465116, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787128, Length=133, Percent_Identity=33.8345864661654, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1790208, Length=149, Percent_Identity=30.2013422818792, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1788887, Length=159, Percent_Identity=30.8176100628931, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693193, Length=285, Percent_Identity=27.3684210526316, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082132, Length=281, Percent_Identity=22.7758007117438, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787806, Length=149, Percent_Identity=28.8590604026846, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789173, Length=117, Percent_Identity=35.042735042735, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI157672245, Length=255, Percent_Identity=25.0980392156863, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790262, Length=255, Percent_Identity=23.921568627451, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081978, Length=271, Percent_Identity=26.1992619926199, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1786713, Length=73, Percent_Identity=46.5753424657534, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1789204, Length=148, Percent_Identity=31.7567567567568, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35054; Mature: 35054

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIRFLETFVWVARLRSFSSAADKLCTTQAAVSNRIATLERDLGVRLFERDLRNVSLTPQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GERALAQAETIVRLTEELRLGVSEASSLRGRIAIGTIDSIVYAWLPKLIEAVKATYPDVD
CHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCE
IDLTVDNSLTVSRLLLDRQVNLALIAGPVLAAECSNIDLCTYQCHWFAAPHLGLHGRRLS
EEEEECCCHHHHHHHHHCCCCEEEEECCHHHHCCCCCEEEEEEEEEEECCCCCCCCCEEH
LVDIVANPIFAFSKGSQPHQNVLRLMESAGLDANLNLVRILNSNSLATITRLARDGMGVA
HHHHHHCCHHEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCCCCEE
VLPTEVAREMVERGELMQLDVDADLPPLHLHAVYREEPGSTLPALIARMAAQVAKAEDAA
EECHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCE
TLTPSANARRNQIRIASHTK
EECCCCCCCCCEEEEECCCC
>Mature Secondary Structure
MNIRFLETFVWVARLRSFSSAADKLCTTQAAVSNRIATLERDLGVRLFERDLRNVSLTPQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GERALAQAETIVRLTEELRLGVSEASSLRGRIAIGTIDSIVYAWLPKLIEAVKATYPDVD
CHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCE
IDLTVDNSLTVSRLLLDRQVNLALIAGPVLAAECSNIDLCTYQCHWFAAPHLGLHGRRLS
EEEEECCCHHHHHHHHHCCCCEEEEECCHHHHCCCCCEEEEEEEEEEECCCCCCCCCEEH
LVDIVANPIFAFSKGSQPHQNVLRLMESAGLDANLNLVRILNSNSLATITRLARDGMGVA
HHHHHHCCHHEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCCCCEE
VLPTEVAREMVERGELMQLDVDADLPPLHLHAVYREEPGSTLPALIARMAAQVAKAEDAA
EECHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCE
TLTPSANARRNQIRIASHTK
EECCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA