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The map label for this gene is lpxA

Identifier: 158423328

GI number: 158423328

Start: 1951795

End: 1952610

Strand: Direct

Name: lpxA

Synonym: AZC_1704

Alternate gene names: 158423328

Gene position: 1951795-1952610 (Clockwise)

Preceding gene: 158423327

Following gene: 158423329

Centisome position: 36.35

GC content: 67.4

Gene sequence:

>816_bases
GTGAACGTGGCCCTGATCGACCCGACTGCCCGCGTTGCCGATGGCGCGTGGCTCGCCGATGATGTGGAAGTTGGACCCTA
CTGCATCGTCGGCCCCGATGTGACCCTTGAGGACGGCGTGCGCCTCCACGCGCACGTGAACGTGCAGGGCGTGACCACGC
TGGGCGCCCGCACGCAGGTCTATCCCTTCGCCTCGCTCGGCACGCCGCCGCAGTCGGTGCATTACAAGGGCGAGAAGACC
AGCCTCGTGGTTGGCACCGACTGCCAGATCCGCGAGCACGTGACCATGAACACGGGCACGGCGAGCGGCCGCGGCGTCAC
CCGCGTCGGCAACAACTGCATGCTCATGACGGCCGCCCATGTCGCCCACGACTGCCTGGTCGGAGACAACGTGATCTTCG
CCAACAATGCGACGCTCGGCGGCCATGTGGAGGTGGGCGACAACGTCTTCCTCGGCGGCCTCAGCGCGGTGCATCAGTTC
GTGCGCATCGGCGCGCAGGTGATGATCGGCGGTGTCACCGGCGTGCGCGAGGATGTCATCCCCTTCGGCTACGCCATCGG
CCAGAACGCCAATCTGGTTGGCCTCAATGTGGTGGGCATGAAGCGGCGCGGCTTCTCCAAGTCGGAACTGCACGCCGCCC
GTGCCGCCTATCGTGATCTCTTCTTCGGCGAAGGCACGTTTGCCGAGCGGCTCGCCGGCCTGCGGGAGCGGCAGGACGCC
TCACCCTTCATCAAGGCGCTGGTCTCCTTCGTGGATGCGGGCGGCAAGCGCGCCCTCTGCCATCCCTCGCGTGGGGTGGT
GGCGCAGGAGGACTGA

Upstream 100 bases:

>100_bases
GCCTCAACAAGCGCCGCAACATGTGGTGGTACCGCGGCGAAGCCCGGGTGGGCGGAGAAATCGTGGCGGAGGCGCGTGTT
GGCGCCATGATCGCCGAGGA

Downstream 100 bases:

>100_bases
CGCAGAATGACCGTGGCGCCCGCCATATCCCCTCCTGCTTTGCCCGGCGACGGGCCGGTAGGCATCGTGGCGGGCGGCGG
CGCCTTTCCGGCGGCGGTGG

Product: acyl-(acyl-carrier-protein)-UDP-N- acetylglucosamine O-acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MNVALIDPTARVADGAWLADDVEVGPYCIVGPDVTLEDGVRLHAHVNVQGVTTLGARTQVYPFASLGTPPQSVHYKGEKT
SLVVGTDCQIREHVTMNTGTASGRGVTRVGNNCMLMTAAHVAHDCLVGDNVIFANNATLGGHVEVGDNVFLGGLSAVHQF
VRIGAQVMIGGVTGVREDVIPFGYAIGQNANLVGLNVVGMKRRGFSKSELHAARAAYRDLFFGEGTFAERLAGLRERQDA
SPFIKALVSFVDAGGKRALCHPSRGVVAQED

Sequences:

>Translated_271_residues
MNVALIDPTARVADGAWLADDVEVGPYCIVGPDVTLEDGVRLHAHVNVQGVTTLGARTQVYPFASLGTPPQSVHYKGEKT
SLVVGTDCQIREHVTMNTGTASGRGVTRVGNNCMLMTAAHVAHDCLVGDNVIFANNATLGGHVEVGDNVFLGGLSAVHQF
VRIGAQVMIGGVTGVREDVIPFGYAIGQNANLVGLNVVGMKRRGFSKSELHAARAAYRDLFFGEGTFAERLAGLRERQDA
SPFIKALVSFVDAGGKRALCHPSRGVVAQED
>Mature_271_residues
MNVALIDPTARVADGAWLADDVEVGPYCIVGPDVTLEDGVRLHAHVNVQGVTTLGARTQVYPFASLGTPPQSVHYKGEKT
SLVVGTDCQIREHVTMNTGTASGRGVTRVGNNCMLMTAAHVAHDCLVGDNVIFANNATLGGHVEVGDNVFLGGLSAVHQF
VRIGAQVMIGGVTGVREDVIPFGYAIGQNANLVGLNVVGMKRRGFSKSELHAARAAYRDLFFGEGTFAERLAGLRERQDA
SPFIKALVSFVDAGGKRALCHPSRGVVAQED

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=247, Percent_Identity=44.5344129554656, Blast_Score=215, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_AZOC5 (A8I491)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001524620.1
- ProteinModelPortal:   A8I491
- SMR:   A8I491
- GeneID:   5689485
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_1704
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- BioCyc:   ACAU438753:AZC_1704-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28621; Mature: 28621

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVALIDPTARVADGAWLADDVEVGPYCIVGPDVTLEDGVRLHAHVNVQGVTTLGARTQV
CCEEEECCCHHHCCCCEEECCCCCCCEEEECCCCCCCCCEEEEEEEEEEEEEEECCCEEE
YPFASLGTPPQSVHYKGEKTSLVVGTDCQIREHVTMNTGTASGRGVTRVGNNCMLMTAAH
EEECCCCCCCHHEEECCCCEEEEEECCCEEEEEEEEECCCCCCCCEEEECCCEEEEEEHH
VAHDCLVGDNVIFANNATLGGHVEVGDNVFLGGLSAVHQFVRIGAQVMIGGVTGVREDVI
HHHHHEECCCEEEECCCCCCCEEEECCCEEECCHHHHHHHHHCCCEEEEECCCCCHHHHC
PFGYAIGQNANLVGLNVVGMKRRGFSKSELHAARAAYRDLFFGEGTFAERLAGLRERQDA
CCCEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
SPFIKALVSFVDAGGKRALCHPSRGVVAQED
CHHHHHHHHHHCCCCCEEEECCCCCCEECCC
>Mature Secondary Structure
MNVALIDPTARVADGAWLADDVEVGPYCIVGPDVTLEDGVRLHAHVNVQGVTTLGARTQV
CCEEEECCCHHHCCCCEEECCCCCCCEEEECCCCCCCCCEEEEEEEEEEEEEEECCCEEE
YPFASLGTPPQSVHYKGEKTSLVVGTDCQIREHVTMNTGTASGRGVTRVGNNCMLMTAAH
EEECCCCCCCHHEEECCCCEEEEEECCCEEEEEEEEECCCCCCCCEEEECCCEEEEEEHH
VAHDCLVGDNVIFANNATLGGHVEVGDNVFLGGLSAVHQFVRIGAQVMIGGVTGVREDVI
HHHHHEECCCEEEECCCCCCCEEEECCCEEECCHHHHHHHHHCCCEEEEECCCCCHHHHC
PFGYAIGQNANLVGLNVVGMKRRGFSKSELHAARAAYRDLFFGEGTFAERLAGLRERQDA
CCCEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
SPFIKALVSFVDAGGKRALCHPSRGVVAQED
CHHHHHHHHHHCCCCCEEEECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA