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The map label for this gene is nuoF1 [H]

Identifier: 158423296

GI number: 158423296

Start: 1912887

End: 1914188

Strand: Direct

Name: nuoF1 [H]

Synonym: AZC_1672

Alternate gene names: 158423296

Gene position: 1912887-1914188 (Clockwise)

Preceding gene: 158423295

Following gene: 158423297

Centisome position: 35.62

GC content: 66.21

Gene sequence:

>1302_bases
ATGCTTCAGGACAAGGACCGCATCTTCACGAACATCTACGGCTACGAGGACAGTGGCCTCAAGGGTGCTCTGAAGCGCGG
CAACTGGGACGGCACCAAGGGCATCCTGGAGAAGGGCCGCGACTGGATCATCAATGAGATGAAGGCGTCGGGCCTGCGCG
GCCGGGGCGGCGCCGGCTTCTCCACGGGCATGAAGTGGTCCTTCATGCCCAAGCAGTCCGACGGGCGCCCGCACTATCTC
GTGGTCAATGCCGACGAGTCCGAGCCGGGCACCTGCAAGGACCGCGAGATCATGCGCAATGATCCGCACACCCTCATCGA
GGGATGCCTGATCGCGTCCTTCGCCATGGGGGCTCACGCCGCCTACATCTATGTGCGCGGCGAGTATGTGCGGGAGCGCG
AGCGTCTGGAGGCCGCCATCGACGAGGCCTATGACGCGGGCCTCATCGGCAAGAACAACATCCACGGTTATCCCTTCGAC
CTCTATGTGCACCATGGTGCCGGCGCCTACATCTGCGGCGAGGAAACGGCGCTGCTGGAGAGCCTTGAGGGCAAGAAGGG
CATGCCGCGGCTGAAGCCGCCGTTCCCGGCCAACATGGGCCTCTACGGCTGCCCGACGACGGTGAACAACGTCGAGTCCA
TCGCGGTGGCGCCGGAAATCCTGCGTCGCGGTGCCTCCTGGTTCTCGTCCATCGGCCGGGCGAACAACGTCGGCACGAAG
CTGTTCGGCATCCTCGGCCATGTGAACACGCCCTGCGTCGTGGAGGATGCCATGAGCATCACCTTCCGCGAGCTGGTGGA
GAAGCACGGCGGCGGCATCCGGGGCGGCTGGGACAACCTGCTCGCCATCATCCCCGGCGGCGCCTCCTGCCCGGTGGTTC
CGGCGGCGGCCTGCGAGGATCTGATCCTCGACTTCGACGGCCTGCGCGCGGTGAAGTCCTCCTTCGGCACCGCCGGCGTG
CTGGTGATGGACAAGTCGACGGACATCGTGCGCGCCATCGCCCGCATCTCCTACTTCTTCAAGCATGAGAGCTGCGGCCA
GTGCACGCCGTGCCGCGAGGGCACGGGCTGGATGTGGCGCGTGCTGAACCGCATGGCCGAGGGTCGCGCCCAGAAGCGCG
AGATCGACCAGTTGCTGGAAGTGACGACCCAGATCGAGGGTCACACCATCTGCGCGCTCGGCGATGCCGCCGCGTGGCCG
GTGCAGGGCCTCATCCGAAACTTCCGCCACGAGATCGAGAAGCGGATCGACCAGTATGCGGCGAACCCGCATCCCGATCC
GGTGCCGGTCGCGGCGGAGTAG

Upstream 100 bases:

>100_bases
GTCCCTGACGGATCCCTCGCTCTACAACCGCAAGCCGGCCGAGCCGGCGGCGGCCGCCGACGCGCCGAAGACCGGCGCCG
GCGATGCGGAGGCTTGAGCC

Downstream 100 bases:

>100_bases
GGGACATGAGGATCGAGCAGGAGAAGCATCGTCTCGCGGTCACCCGCAGCGACTTGTCCGGTTCGGTCTTCAACGACGTG
AACCTGTCCGGTTCGACATT

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLQDKDRIFTNIYGYEDSGLKGALKRGNWDGTKGILEKGRDWIINEMKASGLRGRGGAGFSTGMKWSFMPKQSDGRPHYL
VVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMGAHAAYIYVRGEYVRERERLEAAIDEAYDAGLIGKNNIHGYPFD
LYVHHGAGAYICGEETALLESLEGKKGMPRLKPPFPANMGLYGCPTTVNNVESIAVAPEILRRGASWFSSIGRANNVGTK
LFGILGHVNTPCVVEDAMSITFRELVEKHGGGIRGGWDNLLAIIPGGASCPVVPAAACEDLILDFDGLRAVKSSFGTAGV
LVMDKSTDIVRAIARISYFFKHESCGQCTPCREGTGWMWRVLNRMAEGRAQKREIDQLLEVTTQIEGHTICALGDAAAWP
VQGLIRNFRHEIEKRIDQYAANPHPDPVPVAAE

Sequences:

>Translated_433_residues
MLQDKDRIFTNIYGYEDSGLKGALKRGNWDGTKGILEKGRDWIINEMKASGLRGRGGAGFSTGMKWSFMPKQSDGRPHYL
VVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMGAHAAYIYVRGEYVRERERLEAAIDEAYDAGLIGKNNIHGYPFD
LYVHHGAGAYICGEETALLESLEGKKGMPRLKPPFPANMGLYGCPTTVNNVESIAVAPEILRRGASWFSSIGRANNVGTK
LFGILGHVNTPCVVEDAMSITFRELVEKHGGGIRGGWDNLLAIIPGGASCPVVPAAACEDLILDFDGLRAVKSSFGTAGV
LVMDKSTDIVRAIARISYFFKHESCGQCTPCREGTGWMWRVLNRMAEGRAQKREIDQLLEVTTQIEGHTICALGDAAAWP
VQGLIRNFRHEIEKRIDQYAANPHPDPVPVAAE
>Mature_433_residues
MLQDKDRIFTNIYGYEDSGLKGALKRGNWDGTKGILEKGRDWIINEMKASGLRGRGGAGFSTGMKWSFMPKQSDGRPHYL
VVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMGAHAAYIYVRGEYVRERERLEAAIDEAYDAGLIGKNNIHGYPFD
LYVHHGAGAYICGEETALLESLEGKKGMPRLKPPFPANMGLYGCPTTVNNVESIAVAPEILRRGASWFSSIGRANNVGTK
LFGILGHVNTPCVVEDAMSITFRELVEKHGGGIRGGWDNLLAIIPGGASCPVVPAAACEDLILDFDGLRAVKSSFGTAGV
LVMDKSTDIVRAIARISYFFKHESCGQCTPCREGTGWMWRVLNRMAEGRAQKREIDQLLEVTTQIEGHTICALGDAAAWP
VQGLIRNFRHEIEKRIDQYAANPHPDPVPVAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=65.3937947494033, Blast_Score=589, Evalue=1e-168,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=65.3937947494033, Blast_Score=588, Evalue=1e-168,
Organism=Escherichia coli, GI1788620, Length=386, Percent_Identity=44.8186528497409, Blast_Score=329, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17531727, Length=419, Percent_Identity=64.9164677804296, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI19920794, Length=420, Percent_Identity=67.8571428571429, Blast_Score=610, Evalue=1e-175,
Organism=Drosophila melanogaster, GI45550452, Length=421, Percent_Identity=63.895486935867, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24653819, Length=422, Percent_Identity=43.6018957345972, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24653817, Length=422, Percent_Identity=40.521327014218, Blast_Score=334, Evalue=6e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47428; Mature: 47428

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQDKDRIFTNIYGYEDSGLKGALKRGNWDGTKGILEKGRDWIINEMKASGLRGRGGAGF
CCCCHHHHHHEECCCCCCCCHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
STGMKWSFMPKQSDGRPHYLVVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMGAHA
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCE
AYIYVRGEYVRERERLEAAIDEAYDAGLIGKNNIHGYPFDLYVHHGAGAYICGEETALLE
EEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHHH
SLEGKKGMPRLKPPFPANMGLYGCPTTVNNVESIAVAPEILRRGASWFSSIGRANNVGTK
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LFGILGHVNTPCVVEDAMSITFRELVEKHGGGIRGGWDNLLAIIPGGASCPVVPAAACED
HHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
LILDFDGLRAVKSSFGTAGVLVMDKSTDIVRAIARISYFFKHESCGQCTPCREGTGWMWR
HHHCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VLNRMAEGRAQKREIDQLLEVTTQIEGHTICALGDAAAWPVQGLIRNFRHEIEKRIDQYA
HHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
ANPHPDPVPVAAE
CCCCCCCCCCCCC
>Mature Secondary Structure
MLQDKDRIFTNIYGYEDSGLKGALKRGNWDGTKGILEKGRDWIINEMKASGLRGRGGAGF
CCCCHHHHHHEECCCCCCCCHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
STGMKWSFMPKQSDGRPHYLVVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMGAHA
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCE
AYIYVRGEYVRERERLEAAIDEAYDAGLIGKNNIHGYPFDLYVHHGAGAYICGEETALLE
EEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHHH
SLEGKKGMPRLKPPFPANMGLYGCPTTVNNVESIAVAPEILRRGASWFSSIGRANNVGTK
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LFGILGHVNTPCVVEDAMSITFRELVEKHGGGIRGGWDNLLAIIPGGASCPVVPAAACED
HHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
LILDFDGLRAVKSSFGTAGVLVMDKSTDIVRAIARISYFFKHESCGQCTPCREGTGWMWR
HHHCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VLNRMAEGRAQKREIDQLLEVTTQIEGHTICALGDAAAWPVQGLIRNFRHEIEKRIDQYA
HHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
ANPHPDPVPVAAE
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]