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The map label for this gene is pyrC [H]

Identifier: 158423238

GI number: 158423238

Start: 1843917

End: 1845272

Strand: Reverse

Name: pyrC [H]

Synonym: AZC_1614

Alternate gene names: 158423238

Gene position: 1845272-1843917 (Counterclockwise)

Preceding gene: 158423241

Following gene: 158423236

Centisome position: 34.36

GC content: 69.1

Gene sequence:

>1356_bases
GTGGCCACGGGACGGCCGGGCCGCCGCCGGCGCGCGCCGAGCGGGGGCAGCGGGTATCCGCGCGCATTTCCGCGCTGCCG
CCATGGACGAAGCGAGGACGGACCAGCTAACACAGGCGCGCGCCCGCGCAGCCCCTTGCCGGGCAGCTGCGGGGCGGCGC
TGCCTTGGCGGCACAGCCGCCGATCGACATGCCGCAGCACGCCCGCCGCCGTCCTTACGGCATCGGCGGCCGGGCCTGCG
GACCGTGACGGCCAGGGCGCGCGAGACTGGACTTCAGCCCGAAGCATGGGGCTGTTTCGGAGGATGGGTGACGTGGCGAG
CTTGACGATCCGGCGGCCAGACGACTGGCATGTCCATTTCCGCGACGGTGCGGTGCTGAAGGAGGTTGTGCCCTTCACCG
CCCGGCAGTTCGGGCGAGCCATCGTGATGCCGAACCTGACGCCGCCGGTGGTGACGACCGCCATGGCCGCCGCCTATCGC
GAGCGCATCCGCGCCGCCATTCCCGCCGGCGTCGATTTCACGCCGCTGATGACCGTCTATCTCACCGACGGCACCGATCC
GAAGGATCTCATCGCCGGCCACAGCGACGGCGTGCTCACCGCCGCCAAGCTCTATCCGGCGCACGCCACCACCAACTCGG
CCCACGGCGTCTCCGAGATCGCCCGCATCGAGCAGGTACTGGCGGCGATGGAAGAGGCGGGCATGCCGCTGCTCGTCCAT
GGCGAGCTGCCACGCGAGCATATCGACATCTTCGACCGCGAGCGCGCGTTCATCGATGCGGTGCTGGAGCCCATGCTCGC
CAAGTTCCCGCGCCTCAAGGTGGTGATGGAGCACATCACCACGGCGGAGGGCGTTGCCCTCGTGCGCCGGCACCGGAGCC
ATGTGGGCGGCACCATCACGCCCCAGCACCTGCTCTATAACCGCAACGCGCTGTTCCAGGGTGGCGTGCGGCCGCACATG
TACTGCCTGCCGATCCTCAAGCGCGAGCAGCACCGGCTTGCGCTCCGTCAGGCGGCGACCAGCGGGGAAGCGAATTTCTT
CCTCGGCACCGACACCGCGCCGCATATGCGCCACCTGAAGGAAAATGCCTGCGGCTGCGCCGGCGTTTTCAGCGCGCCTG
TCGCGCTTCAAGCCTATCTGAAGGTGTTCGCCGAGGAAGGCGCGCTGGACAAGTTCGAGGCCTTCGCCTCCCTCAACGGC
CCGGCCTTCTACGGCCTCAAGCCCAATGAAGCGCGCATCACCATCACCGACACGCTCTCCCCCACCTGCGAGGCGGTGAA
CATCCCCGGCGAGGGCGAACTCATCCCCCTGTTCCATGGCGAACAGGTGCCGTGGTCGCAGATCGAGTCGGCCTGA

Upstream 100 bases:

>100_bases
GTGCACCTTATGGCCATGGGGCCGGCCGCGTCATGGCGACCACTGACCGCCATATAAGACGCCGCCGCGCCAGCGTAAAC
TCCGGACCGCGCGATAAGCT

Downstream 100 bases:

>100_bases
TCCCGATCGCAAGCCGGGCGCCTCGCGGGGCGTCCGGCTTGCGACGCCAGTTCGCCCGTCAGGTCAGCGCCTCGCCCCGG
CGCTCCGGCACCAGAAACAC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MATGRPGRRRRAPSGGSGYPRAFPRCRHGRSEDGPANTGARPRSPLPGSCGAALPWRHSRRSTCRSTPAAVLTASAAGPA
DRDGQGARDWTSARSMGLFRRMGDVASLTIRRPDDWHVHFRDGAVLKEVVPFTARQFGRAIVMPNLTPPVVTTAMAAAYR
ERIRAAIPAGVDFTPLMTVYLTDGTDPKDLIAGHSDGVLTAAKLYPAHATTNSAHGVSEIARIEQVLAAMEEAGMPLLVH
GELPREHIDIFDRERAFIDAVLEPMLAKFPRLKVVMEHITTAEGVALVRRHRSHVGGTITPQHLLYNRNALFQGGVRPHM
YCLPILKREQHRLALRQAATSGEANFFLGTDTAPHMRHLKENACGCAGVFSAPVALQAYLKVFAEEGALDKFEAFASLNG
PAFYGLKPNEARITITDTLSPTCEAVNIPGEGELIPLFHGEQVPWSQIESA

Sequences:

>Translated_451_residues
MATGRPGRRRRAPSGGSGYPRAFPRCRHGRSEDGPANTGARPRSPLPGSCGAALPWRHSRRSTCRSTPAAVLTASAAGPA
DRDGQGARDWTSARSMGLFRRMGDVASLTIRRPDDWHVHFRDGAVLKEVVPFTARQFGRAIVMPNLTPPVVTTAMAAAYR
ERIRAAIPAGVDFTPLMTVYLTDGTDPKDLIAGHSDGVLTAAKLYPAHATTNSAHGVSEIARIEQVLAAMEEAGMPLLVH
GELPREHIDIFDRERAFIDAVLEPMLAKFPRLKVVMEHITTAEGVALVRRHRSHVGGTITPQHLLYNRNALFQGGVRPHM
YCLPILKREQHRLALRQAATSGEANFFLGTDTAPHMRHLKENACGCAGVFSAPVALQAYLKVFAEEGALDKFEAFASLNG
PAFYGLKPNEARITITDTLSPTCEAVNIPGEGELIPLFHGEQVPWSQIESA
>Mature_450_residues
ATGRPGRRRRAPSGGSGYPRAFPRCRHGRSEDGPANTGARPRSPLPGSCGAALPWRHSRRSTCRSTPAAVLTASAAGPAD
RDGQGARDWTSARSMGLFRRMGDVASLTIRRPDDWHVHFRDGAVLKEVVPFTARQFGRAIVMPNLTPPVVTTAMAAAYRE
RIRAAIPAGVDFTPLMTVYLTDGTDPKDLIAGHSDGVLTAAKLYPAHATTNSAHGVSEIARIEQVLAAMEEAGMPLLVHG
ELPREHIDIFDRERAFIDAVLEPMLAKFPRLKVVMEHITTAEGVALVRRHRSHVGGTITPQHLLYNRNALFQGGVRPHMY
CLPILKREQHRLALRQAATSGEANFFLGTDTAPHMRHLKENACGCAGVFSAPVALQAYLKVFAEEGALDKFEAFASLNGP
AFYGLKPNEARITITDTLSPTCEAVNIPGEGELIPLFHGEQVPWSQIESA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=339, Percent_Identity=56.9321533923304, Blast_Score=394, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6323452, Length=355, Percent_Identity=30.9859154929577, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48955; Mature: 48823

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATGRPGRRRRAPSGGSGYPRAFPRCRHGRSEDGPANTGARPRSPLPGSCGAALPWRHSR
CCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
RSTCRSTPAAVLTASAAGPADRDGQGARDWTSARSMGLFRRMGDVASLTIRRPDDWHVHF
HHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHEEEEECCCCCEEEE
RDGAVLKEVVPFTARQFGRAIVMPNLTPPVVTTAMAAAYRERIRAAIPAGVDFTPLMTVY
ECCHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
LTDGTDPKDLIAGHSDGVLTAAKLYPAHATTNSAHGVSEIARIEQVLAAMEEAGMPLLVH
EECCCCHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEE
GELPREHIDIFDRERAFIDAVLEPMLAKFPRLKVVMEHITTAEGVALVRRHRSHVGGTIT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PQHLLYNRNALFQGGVRPHMYCLPILKREQHRLALRQAATSGEANFFLGTDTAPHMRHLK
HHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
ENACGCAGVFSAPVALQAYLKVFAEEGALDKFEAFASLNGPAFYGLKPNEARITITDTLS
HHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCCEEEEECCCC
PTCEAVNIPGEGELIPLFHGEQVPWSQIESA
CCCCEEECCCCCCEEEEECCCCCCHHHHCCC
>Mature Secondary Structure 
ATGRPGRRRRAPSGGSGYPRAFPRCRHGRSEDGPANTGARPRSPLPGSCGAALPWRHSR
CCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
RSTCRSTPAAVLTASAAGPADRDGQGARDWTSARSMGLFRRMGDVASLTIRRPDDWHVHF
HHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHEEEEECCCCCEEEE
RDGAVLKEVVPFTARQFGRAIVMPNLTPPVVTTAMAAAYRERIRAAIPAGVDFTPLMTVY
ECCHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
LTDGTDPKDLIAGHSDGVLTAAKLYPAHATTNSAHGVSEIARIEQVLAAMEEAGMPLLVH
EECCCCHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEE
GELPREHIDIFDRERAFIDAVLEPMLAKFPRLKVVMEHITTAEGVALVRRHRSHVGGTIT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PQHLLYNRNALFQGGVRPHMYCLPILKREQHRLALRQAATSGEANFFLGTDTAPHMRHLK
HHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
ENACGCAGVFSAPVALQAYLKVFAEEGALDKFEAFASLNGPAFYGLKPNEARITITDTLS
HHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCCEEEEECCCC
PTCEAVNIPGEGELIPLFHGEQVPWSQIESA
CCCCEEECCCCCCEEEEECCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA