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The map label for this gene is clpP

Identifier: 158423232

GI number: 158423232

Start: 1835038

End: 1835670

Strand: Direct

Name: clpP

Synonym: AZC_1608

Alternate gene names: 158423232

Gene position: 1835038-1835670 (Clockwise)

Preceding gene: 158423231

Following gene: 158423233

Centisome position: 34.17

GC content: 61.3

Gene sequence:

>633_bases
ATGCGTGATCCTGTCGATACTTATATGAACTACCTCGTCCCCATGGTGGTCGAGCAGACCAACCGCGGGGAGCGCGCGTA
CGACATTTATTCCCGTCTCCTGAAGGAGCGGATCATCTTCCTGACCGGTCCGGTGGAAGACGGGATGTCCACGCTGGCGG
TGGCGCAGTTGCTCTTTCTTGAGGCGGAAAACCCCAAGAAGGAAATCTCCATGTACATCAACTCGCCGGGCGGCGTGGTG
ACGTCGGGTCTTGCGATCTACGACACCATGCAGTTCATCCGCCCGGCGGTGTCCACGCTGTGCATCGGCCAGGCTGCCTC
CATGGGCTCCCTGCTGCTGACCGCCGGCGAGAAGGGCCTGCGGTTCGCGCTGCCGAATGCTCGAATCATGGTCCATCAGC
CGTCCGGCGGCTTCCAGGGCCAGGTCACGGACATCATGCTGCACGCGCAGGAGATCCTCAGCCTCAAGAAGCGGCTGAAT
GAAATCTATGTGAAGCATACGGGCCAGCCGATCGAGAAGATCGAGGACGCCCTCGAGCGCGACAACTTCATGACGGCGAA
CGCCGCTCAGGAGTTCGGGCTCATCGATACCGTCATCGACAAGCGTCCCTCGGACGAGCCGGCCAAGGCCTGA

Upstream 100 bases:

>100_bases
GAGCTCTACAAGGAGGAAGAGGAGAAGGCGGCCTGAGTTCAGGCCTCCTTCACCGCTGCCTGCGACGATTTGCGCGCATT
CTCCGCGCCGAGGACCAAAA

Downstream 100 bases:

>100_bases
TCCTTCGACGTTTTCAGGGGGCGGTGTGCGCAATGCTCTTGCGTGCACCGCCATATCGCGCTTGCATGGCCCCAATAGCC
GGCATTTGACCGGCTGCGTC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MRDPVDTYMNYLVPMVVEQTNRGERAYDIYSRLLKERIIFLTGPVEDGMSTLAVAQLLFLEAENPKKEISMYINSPGGVV
TSGLAIYDTMQFIRPAVSTLCIGQAASMGSLLLTAGEKGLRFALPNARIMVHQPSGGFQGQVTDIMLHAQEILSLKKRLN
EIYVKHTGQPIEKIEDALERDNFMTANAAQEFGLIDTVIDKRPSDEPAKA

Sequences:

>Translated_210_residues
MRDPVDTYMNYLVPMVVEQTNRGERAYDIYSRLLKERIIFLTGPVEDGMSTLAVAQLLFLEAENPKKEISMYINSPGGVV
TSGLAIYDTMQFIRPAVSTLCIGQAASMGSLLLTAGEKGLRFALPNARIMVHQPSGGFQGQVTDIMLHAQEILSLKKRLN
EIYVKHTGQPIEKIEDALERDNFMTANAAQEFGLIDTVIDKRPSDEPAKA
>Mature_210_residues
MRDPVDTYMNYLVPMVVEQTNRGERAYDIYSRLLKERIIFLTGPVEDGMSTLAVAQLLFLEAENPKKEISMYINSPGGVV
TSGLAIYDTMQFIRPAVSTLCIGQAASMGSLLLTAGEKGLRFALPNARIMVHQPSGGFQGQVTDIMLHAQEILSLKKRLN
EIYVKHTGQPIEKIEDALERDNFMTANAAQEFGLIDTVIDKRPSDEPAKA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=194, Percent_Identity=62.3711340206186, Blast_Score=263, Evalue=7e-71,
Organism=Escherichia coli, GI1786641, Length=201, Percent_Identity=64.6766169154229, Blast_Score=282, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=61.2903225806452, Blast_Score=244, Evalue=3e-65,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=61.9791666666667, Blast_Score=262, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_AZOC5 (A8HYF2)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001524524.1
- ProteinModelPortal:   A8HYF2
- SMR:   A8HYF2
- MEROPS:   S14.001
- GeneID:   5687842
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_1608
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- ProtClustDB:   CLSK2516786
- BioCyc:   ACAU438753:AZC_1608-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23264; Mature: 23264

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 107-107 ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDPVDTYMNYLVPMVVEQTNRGERAYDIYSRLLKERIIFLTGPVEDGMSTLAVAQLLFL
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHH
EAENPKKEISMYINSPGGVVTSGLAIYDTMQFIRPAVSTLCIGQAASMGSLLLTAGEKGL
CCCCCHHEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCHHCCCCEEEECCCCCC
RFALPNARIMVHQPSGGFQGQVTDIMLHAQEILSLKKRLNEIYVKHTGQPIEKIEDALER
EEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DNFMTANAAQEFGLIDTVIDKRPSDEPAKA
CCCEECHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MRDPVDTYMNYLVPMVVEQTNRGERAYDIYSRLLKERIIFLTGPVEDGMSTLAVAQLLFL
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHH
EAENPKKEISMYINSPGGVVTSGLAIYDTMQFIRPAVSTLCIGQAASMGSLLLTAGEKGL
CCCCCHHEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCHHCCCCEEEECCCCCC
RFALPNARIMVHQPSGGFQGQVTDIMLHAQEILSLKKRLNEIYVKHTGQPIEKIEDALER
EEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DNFMTANAAQEFGLIDTVIDKRPSDEPAKA
CCCEECHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA