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The map label for this gene is cvrA [H]

Identifier: 158423196

GI number: 158423196

Start: 1793336

End: 1795132

Strand: Direct

Name: cvrA [H]

Synonym: AZC_1572

Alternate gene names: 158423196

Gene position: 1793336-1795132 (Clockwise)

Preceding gene: 158423195

Following gene: 158423197

Centisome position: 33.4

GC content: 68.95

Gene sequence:

>1797_bases
ATGGGTACTGTTTTCCTCTCCGATCTGGTGCTGCTGGTAGGGTCGGCTCTGGTACTCCTCGGTACCGTTTCAAGCCTCCT
GGCAGCCCGCTTCGGCGCGCCCATCCTTCTCGTCTTCCTGTTGCTCGGAATTCTGGCCGGCGAGGCCGGGCCGGGACAGA
TACACTTCTCCGACTACTGGGCCACCTACATGGTGGGCTCGGCGGCCCTGGCCGTGATCCTGTTCGACGGCGGCCTCCGG
ATGCGCGCGTCCACCATGCGGGGCGCCGTGGTGCCGGCGGTCATCCTCTCCACGGTCGGCGTGATGCTGACCGCCGGGCT
GGTGGCGCTCGCCGCTTTGCCTCTGCTGGGTCTGCCACCGCTGGAGAGCCTGCTGGTGGGCGCCATCGTCGCCTCGACGG
ACGCCGCCGCCGTCCTGTTCCTCGTCCGCGCGCAAGGGTTGCGCCTCGGTCGCCGGGTGGGGGCGGTGATCGAGATCGAA
TCGGCCACCAATGATCCGGCGGCGGTCTTCCTCACCGTCACGCTGGTGGAGCTTCTGGCATCCGGCGCCGGCAATCCCGG
CTGGGCGCTTACCGTCGGTCTCGTCCAGCAGATGGTGCTCGGCGCGGCGCTAGGCGTGGCGGGCGGTTTCGGTCTCGCAT
TCGTGCTGAACCGGCTGGACCTGCCGGGCGGGCTTCATCCCGCGCTCGTGGTGGCGGCTGCGGTGCTGATCTATGCGGCC
ACCGCCATGCTGCACGGGTCCGGCTTCCTCGCCGTCTATCTGGCGGGTCTCGTGCTGGGCAACCGACCCGTGCGGGCCAT
CGCCTCCATCACCAGTTTCCATGACACGGTGACCTGGCTCTGCCAGATCGTGATGTTCGTGATGCTGGGGCTGCTGCTCT
CACCCTCACGCATGGTGCAATATCTGCCCCCGGCGCTGCTGATTGCCGCCTTCCTCGTGCTGGTGGGCCGGCCGGTGGCG
GTCTTCCTCTGTCTGTGGCCCTTCCGCTTCAACTGGCGGGAGAAGGCCTTCATCTCCTGGGCGGGTCTGCGCGGGGCGGT
GTCCATCTTCCTCGCCACCATTCCCATGCTGGCGCAGCTTCCCAATGCGGAGGCCTATTTCAACGTGGCCTTCGTGGTGG
TCCTGGTCTCGCTGATCCTGCACGGCTGGAGCCTCGTCTTTGCCGCCCGCCGGCTCGACGTGGCGCTGGCCGAGCCGGCG
CGCGAGGCTAAGCGGTTCGAGATCGACCTGCCGGGCCAGAGCGAGCACGAACTGGTCGCCTATCCGGTGACCGGCGATAC
GCTGGCCATCTCCTCCGGCCTGCTGCCGCTCTGGGCCCGGCTCGTCTTCGTGGTCCGGCGCGGGCAGGTGCTCTCGCCGC
AGGAGGCGGGTGTGCTGAAGAGCGGCGACTATGCCTATATTCTCGCCCCGCCCCGCAGGGTGCACAGGCTCGACCCCTTG
TTCATGCCGGAGGAGCGGGTGCCGAGCGAGACCGTGGCTGGCTTTCCCTTCTCCGGCGAGGTGATGGTGGGGGACGTGGC
CGATCTCTACGGCCTCTCCGTTCCGCAGGACGAGCGCGCCGTGAGCATCGCCGACACTTTCGCCGACCGCTCCGACGAGC
GTCCCTTGCCGGGCATGCGTTTTCCGCTGGGCAATGCGGCCATGGAGGCGCTGGAGGTGGAGGAAGGCCGCGTCACGCAG
GCCGCCCTGCGCTTCGAGACGCTCGGCGAGGAGGGCGACAGCCTGCTGACGCGCGTGCGCCGCCAGATCCGCCGCCGCGC
CGCGACGGCCGAAGAAGGCGCAAGCCCGGGACCGTGA

Upstream 100 bases:

>100_bases
CTAGATGAACCAGTTGTCAGGAATCATAGCTGGCAAGGTCCGATCCGGCTACTGGGAAACAGTGTCAAAACGGATCAGTG
CAGACGTTGGAAGGGAAAGG

Downstream 100 bases:

>100_bases
GCGGGGCTGCCGCCATGTTGACGTTTTCGGCGGGCCGTATGGCGCGCGTGCGCCGGTGTCACGCCGGCTTGAAAGGGAAG
TGAGATGGTGCGCCTGTTCA

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MGTVFLSDLVLLVGSALVLLGTVSSLLAARFGAPILLVFLLLGILAGEAGPGQIHFSDYWATYMVGSAALAVILFDGGLR
MRASTMRGAVVPAVILSTVGVMLTAGLVALAALPLLGLPPLESLLVGAIVASTDAAAVLFLVRAQGLRLGRRVGAVIEIE
SATNDPAAVFLTVTLVELLASGAGNPGWALTVGLVQQMVLGAALGVAGGFGLAFVLNRLDLPGGLHPALVVAAAVLIYAA
TAMLHGSGFLAVYLAGLVLGNRPVRAIASITSFHDTVTWLCQIVMFVMLGLLLSPSRMVQYLPPALLIAAFLVLVGRPVA
VFLCLWPFRFNWREKAFISWAGLRGAVSIFLATIPMLAQLPNAEAYFNVAFVVVLVSLILHGWSLVFAARRLDVALAEPA
REAKRFEIDLPGQSEHELVAYPVTGDTLAISSGLLPLWARLVFVVRRGQVLSPQEAGVLKSGDYAYILAPPRRVHRLDPL
FMPEERVPSETVAGFPFSGEVMVGDVADLYGLSVPQDERAVSIADTFADRSDERPLPGMRFPLGNAAMEALEVEEGRVTQ
AALRFETLGEEGDSLLTRVRRQIRRRAATAEEGASPGP

Sequences:

>Translated_598_residues
MGTVFLSDLVLLVGSALVLLGTVSSLLAARFGAPILLVFLLLGILAGEAGPGQIHFSDYWATYMVGSAALAVILFDGGLR
MRASTMRGAVVPAVILSTVGVMLTAGLVALAALPLLGLPPLESLLVGAIVASTDAAAVLFLVRAQGLRLGRRVGAVIEIE
SATNDPAAVFLTVTLVELLASGAGNPGWALTVGLVQQMVLGAALGVAGGFGLAFVLNRLDLPGGLHPALVVAAAVLIYAA
TAMLHGSGFLAVYLAGLVLGNRPVRAIASITSFHDTVTWLCQIVMFVMLGLLLSPSRMVQYLPPALLIAAFLVLVGRPVA
VFLCLWPFRFNWREKAFISWAGLRGAVSIFLATIPMLAQLPNAEAYFNVAFVVVLVSLILHGWSLVFAARRLDVALAEPA
REAKRFEIDLPGQSEHELVAYPVTGDTLAISSGLLPLWARLVFVVRRGQVLSPQEAGVLKSGDYAYILAPPRRVHRLDPL
FMPEERVPSETVAGFPFSGEVMVGDVADLYGLSVPQDERAVSIADTFADRSDERPLPGMRFPLGNAAMEALEVEEGRVTQ
AALRFETLGEEGDSLLTRVRRQIRRRAATAEEGASPGP
>Mature_597_residues
GTVFLSDLVLLVGSALVLLGTVSSLLAARFGAPILLVFLLLGILAGEAGPGQIHFSDYWATYMVGSAALAVILFDGGLRM
RASTMRGAVVPAVILSTVGVMLTAGLVALAALPLLGLPPLESLLVGAIVASTDAAAVLFLVRAQGLRLGRRVGAVIEIES
ATNDPAAVFLTVTLVELLASGAGNPGWALTVGLVQQMVLGAALGVAGGFGLAFVLNRLDLPGGLHPALVVAAAVLIYAAT
AMLHGSGFLAVYLAGLVLGNRPVRAIASITSFHDTVTWLCQIVMFVMLGLLLSPSRMVQYLPPALLIAAFLVLVGRPVAV
FLCLWPFRFNWREKAFISWAGLRGAVSIFLATIPMLAQLPNAEAYFNVAFVVVLVSLILHGWSLVFAARRLDVALAEPAR
EAKRFEIDLPGQSEHELVAYPVTGDTLAISSGLLPLWARLVFVVRRGQVLSPQEAGVLKSGDYAYILAPPRRVHRLDPLF
MPEERVPSETVAGFPFSGEVMVGDVADLYGLSVPQDERAVSIADTFADRSDERPLPGMRFPLGNAAMEALEVEEGRVTQA
ALRFETLGEEGDSLLTRVRRQIRRRAATAEEGASPGP

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=574, Percent_Identity=39.198606271777, Blast_Score=344, Evalue=9e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 63286; Mature: 63155

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTVFLSDLVLLVGSALVLLGTVSSLLAARFGAPILLVFLLLGILAGEAGPGQIHFSDYW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEEEEHHHH
ATYMVGSAALAVILFDGGLRMRASTMRGAVVPAVILSTVGVMLTAGLVALAALPLLGLPP
HHHHHHHHHEEEEEECCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LESLLVGAIVASTDAAAVLFLVRAQGLRLGRRVGAVIEIESATNDPAAVFLTVTLVELLA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHH
SGAGNPGWALTVGLVQQMVLGAALGVAGGFGLAFVLNRLDLPGGLHPALVVAAAVLIYAA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
TAMLHGSGFLAVYLAGLVLGNRPVRAIASITSFHDTVTWLCQIVMFVMLGLLLSPSRMVQ
HHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
YLPPALLIAAFLVLVGRPVAVFLCLWPFRFNWREKAFISWAGLRGAVSIFLATIPMLAQL
HCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHHC
PNAEAYFNVAFVVVLVSLILHGWSLVFAARRLDVALAEPAREAKRFEIDLPGQSEHELVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEEEECCCCCCCCEEE
YPVTGDTLAISSGLLPLWARLVFVVRRGQVLSPQEAGVLKSGDYAYILAPPRRVHRLDPL
EECCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEECCCHHHHHCCCC
FMPEERVPSETVAGFPFSGEVMVGDVADLYGLSVPQDERAVSIADTFADRSDERPLPGMR
CCCCCCCCCHHCCCCCCCCCEEECCHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
FPLGNAAMEALEVEEGRVTQAALRFETLGEEGDSLLTRVRRQIRRRAATAEEGASPGP
CCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHCCCCCCC
>Mature Secondary Structure 
GTVFLSDLVLLVGSALVLLGTVSSLLAARFGAPILLVFLLLGILAGEAGPGQIHFSDYW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEEEEHHHH
ATYMVGSAALAVILFDGGLRMRASTMRGAVVPAVILSTVGVMLTAGLVALAALPLLGLPP
HHHHHHHHHEEEEEECCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LESLLVGAIVASTDAAAVLFLVRAQGLRLGRRVGAVIEIESATNDPAAVFLTVTLVELLA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHH
SGAGNPGWALTVGLVQQMVLGAALGVAGGFGLAFVLNRLDLPGGLHPALVVAAAVLIYAA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
TAMLHGSGFLAVYLAGLVLGNRPVRAIASITSFHDTVTWLCQIVMFVMLGLLLSPSRMVQ
HHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
YLPPALLIAAFLVLVGRPVAVFLCLWPFRFNWREKAFISWAGLRGAVSIFLATIPMLAQL
HCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHHC
PNAEAYFNVAFVVVLVSLILHGWSLVFAARRLDVALAEPAREAKRFEIDLPGQSEHELVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEEEECCCCCCCCEEE
YPVTGDTLAISSGLLPLWARLVFVVRRGQVLSPQEAGVLKSGDYAYILAPPRRVHRLDPL
EECCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEECCCHHHHHCCCC
FMPEERVPSETVAGFPFSGEVMVGDVADLYGLSVPQDERAVSIADTFADRSDERPLPGMR
CCCCCCCCCHHCCCCCCCCCEEECCHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
FPLGNAAMEALEVEEGRVTQAALRFETLGEEGDSLLTRVRRQIRRRAATAEEGASPGP
CCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]