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The map label for this gene is ttuE [H]

Identifier: 158423029

GI number: 158423029

Start: 1599668

End: 1601095

Strand: Direct

Name: ttuE [H]

Synonym: AZC_1405

Alternate gene names: 158423029

Gene position: 1599668-1601095 (Clockwise)

Preceding gene: 158423028

Following gene: 158423030

Centisome position: 29.79

GC content: 67.93

Gene sequence:

>1428_bases
ATGCATCGCAATCGTCGCGCCAAGATCGTCGCAACCGTGGGGCCGGCGAGCTCCGATCCTGCGGTGCTGAAGGCCCTGTA
TCTCGCCGGCGTCGATACCTTCCGGATGAATTTCAGCCACGGCAGCCGTGAGAACCATGCGGCGGTGCATGCTTCGATCC
GCGCCCTCGAAATCGAGATGGGGCGCCCCATCGGCATTCTTCAGGACCTTCAGGGGCCGAAGATCCGCGTCGGCACCATC
AAGGACGGCCGCATCACCGTGCAGGCGGGCGAGAAGATCCGTTTCGTGCTTCACGGCGCGGACGGCGACCGCGATGCCAT
TCCGCTGCCCCATCCGGAAATCTTCGCCGCCATCGCGCCCCGGCAGGACCTGCTCATCGACGACGGCCGGGTGCGCGTGC
GGGTGCAGGGCGTGGGCGATGATTTCATCGACGCCGAAGTGGTCATCGGCGGCGTCATCTCCAACCGCAAGGGCGTGAAC
CTGCCCGGCACGATCCTTGACCTCTCCCCGCTCACCGCGAAGGACCGCGAGGACCTGGAATTCGGTCTCTCGCTCGGCGT
GGACTGGGTGGCGCTCTCCTTCGTGCAGCGGGCCTCCGACGTGATCGAGGCGCGCGGCATCATCGGCGACCGCGCCGGCA
TCATGTCCAAGATCGAGAAGCCCTCGGCACTGGAGCATATCGAGGACATCGTCCGCATGTCGGATGCGGTGATGGTGGCG
CGCGGCGATCTCGGCGTCGAAATCCCGCATGAGGAAGTGCCCGGCCGCCAGAAGGAACTGGTGCGCGCCTGCCGCCTTGC
GGCGAAGCCCGTGATCGTGGCGACGCAGATGCTCGAATCCATGGTCAACGCCCCGACGCCCACCCGCGCGGAGGCCTCCG
ACGTCGCCACCGCCATCTATGACGGGGCGGATGCGGTGATGCTCTCGGCGGAATCCGCAACCGGCAGCTATCCGGTCGAG
GCCGTGACCATGATGGACCGCATCATCTCGGCCACCGAGCGCCACAAGCTCTATCGCTCCTTCATCTCTGCCTCCGCGCT
CGATCCCGAGCAGTCGCCGCCCCACGCGGTGGCTGCCGCCGGGGCCGGCCTTGCGGAGACCATCGGGGCGAAGGCCATCG
TCGGCTATACGTCGAGCGGCACCACGGTGGCCCGCATCGCGCGCCAGCGGCCCGCGCTGCCCATCGTGGCACTGACGCCC
AATCTCGCCGTGGCCCGCCGGGCCTCCCTCATGTGGGGCGTGCACAGCGTGCCGTCCCAGGACGTGACCACCTATGAGGA
AATGGTGGCGACGGCCCGCAAGGCGCTGGTGGACGAGAATTTCGGCGGGCCCGGTGATCTCGCGGTCGTGGTGGCGGGCA
TTCCCTTTGCCCAGTCCGGCACCACAAACAACCTGCGCGTCTTCTCCCTCGGCGGCTCCGCGCGCTGA

Upstream 100 bases:

>100_bases
GCGGCATGCCCAACCGCCCGACGCTGGCCCGTCACCCGCAAACGTCAACATCGGGCCATCATCCCAGCCTGAGGAGCGGC
CTTAAGGGCCGGAGACGCCA

Downstream 100 bases:

>100_bases
CCGCCCGACAGCCTGGCCACCCCGTGGCCGGGCTGTCTTTTCGACCCCGTTTGTGTCGTTGACCTCGCTCCGTCCGGCCC
GCATGACCCCGCCATCGGGA

Product: pyruvate kinase

Products: NA

Alternate protein names: PK [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MHRNRRAKIVATVGPASSDPAVLKALYLAGVDTFRMNFSHGSRENHAAVHASIRALEIEMGRPIGILQDLQGPKIRVGTI
KDGRITVQAGEKIRFVLHGADGDRDAIPLPHPEIFAAIAPRQDLLIDDGRVRVRVQGVGDDFIDAEVVIGGVISNRKGVN
LPGTILDLSPLTAKDREDLEFGLSLGVDWVALSFVQRASDVIEARGIIGDRAGIMSKIEKPSALEHIEDIVRMSDAVMVA
RGDLGVEIPHEEVPGRQKELVRACRLAAKPVIVATQMLESMVNAPTPTRAEASDVATAIYDGADAVMLSAESATGSYPVE
AVTMMDRIISATERHKLYRSFISASALDPEQSPPHAVAAAGAGLAETIGAKAIVGYTSSGTTVARIARQRPALPIVALTP
NLAVARRASLMWGVHSVPSQDVTTYEEMVATARKALVDENFGGPGDLAVVVAGIPFAQSGTTNNLRVFSLGGSAR

Sequences:

>Translated_475_residues
MHRNRRAKIVATVGPASSDPAVLKALYLAGVDTFRMNFSHGSRENHAAVHASIRALEIEMGRPIGILQDLQGPKIRVGTI
KDGRITVQAGEKIRFVLHGADGDRDAIPLPHPEIFAAIAPRQDLLIDDGRVRVRVQGVGDDFIDAEVVIGGVISNRKGVN
LPGTILDLSPLTAKDREDLEFGLSLGVDWVALSFVQRASDVIEARGIIGDRAGIMSKIEKPSALEHIEDIVRMSDAVMVA
RGDLGVEIPHEEVPGRQKELVRACRLAAKPVIVATQMLESMVNAPTPTRAEASDVATAIYDGADAVMLSAESATGSYPVE
AVTMMDRIISATERHKLYRSFISASALDPEQSPPHAVAAAGAGLAETIGAKAIVGYTSSGTTVARIARQRPALPIVALTP
NLAVARRASLMWGVHSVPSQDVTTYEEMVATARKALVDENFGGPGDLAVVVAGIPFAQSGTTNNLRVFSLGGSAR
>Mature_475_residues
MHRNRRAKIVATVGPASSDPAVLKALYLAGVDTFRMNFSHGSRENHAAVHASIRALEIEMGRPIGILQDLQGPKIRVGTI
KDGRITVQAGEKIRFVLHGADGDRDAIPLPHPEIFAAIAPRQDLLIDDGRVRVRVQGVGDDFIDAEVVIGGVISNRKGVN
LPGTILDLSPLTAKDREDLEFGLSLGVDWVALSFVQRASDVIEARGIIGDRAGIMSKIEKPSALEHIEDIVRMSDAVMVA
RGDLGVEIPHEEVPGRQKELVRACRLAAKPVIVATQMLESMVNAPTPTRAEASDVATAIYDGADAVMLSAESATGSYPVE
AVTMMDRIISATERHKLYRSFISASALDPEQSPPHAVAAAGAGLAETIGAKAIVGYTSSGTTVARIARQRPALPIVALTP
NLAVARRASLMWGVHSVPSQDVTTYEEMVATARKALVDENFGGPGDLAVVVAGIPFAQSGTTNNLRVFSLGGSAR

Specific function: Glycolysis; final step. [C]

COG id: COG0469

COG function: function code G; Pyruvate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyruvate kinase family [H]

Homologues:

Organism=Homo sapiens, GI33286422, Length=488, Percent_Identity=37.0901639344262, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI33286420, Length=488, Percent_Identity=37.0901639344262, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI33286418, Length=486, Percent_Identity=37.8600823045267, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI32967597, Length=492, Percent_Identity=38.4146341463415, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI10835121, Length=492, Percent_Identity=38.4146341463415, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI310128732, Length=287, Percent_Identity=36.9337979094077, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI310128730, Length=287, Percent_Identity=36.9337979094077, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI310128736, Length=230, Percent_Identity=34.7826086956522, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI310128734, Length=230, Percent_Identity=34.7826086956522, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI310128738, Length=206, Percent_Identity=34.4660194174757, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1788160, Length=478, Percent_Identity=38.2845188284519, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1787965, Length=472, Percent_Identity=36.0169491525424, Blast_Score=274, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI17544584, Length=488, Percent_Identity=35.4508196721311, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI71984413, Length=489, Percent_Identity=37.8323108384458, Blast_Score=268, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI71984406, Length=489, Percent_Identity=37.8323108384458, Blast_Score=268, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17506829, Length=489, Percent_Identity=37.8323108384458, Blast_Score=268, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17506831, Length=489, Percent_Identity=37.8323108384458, Blast_Score=267, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6319279, Length=421, Percent_Identity=39.9049881235154, Blast_Score=265, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6324923, Length=486, Percent_Identity=37.2427983539095, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24648964, Length=495, Percent_Identity=36.5656565656566, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI28571814, Length=495, Percent_Identity=36.5656565656566, Blast_Score=278, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24648966, Length=401, Percent_Identity=39.6508728179551, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24581235, Length=488, Percent_Identity=32.3770491803279, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24646914, Length=265, Percent_Identity=38.8679245283019, Blast_Score=165, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001697
- InterPro:   IPR015813
- InterPro:   IPR011037
- InterPro:   IPR015794
- InterPro:   IPR018209
- InterPro:   IPR015793
- InterPro:   IPR015795
- InterPro:   IPR015806 [H]

Pfam domain/function: PF00224 PK; PF02887 PK_C [H]

EC number: =2.7.1.40 [H]

Molecular weight: Translated: 50386; Mature: 50386

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00110 PYRUVATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRNRRAKIVATVGPASSDPAVLKALYLAGVDTFRMNFSHGSRENHAAVHASIRALEIEM
CCCCCCEEEEEEECCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCHHEEEEEEEEEEEC
GRPIGILQDLQGPKIRVGTIKDGRITVQAGEKIRFVLHGADGDRDAIPLPHPEIFAAIAP
CCCCCHHHCCCCCEEEEEEECCCEEEEEECCEEEEEEECCCCCCCCCCCCCHHHHEEECC
RQDLLIDDGRVRVRVQGVGDDFIDAEVVIGGVISNRKGVNLPGTILDLSPLTAKDREDLE
CCCEEEECCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCEEECCCCCCCCCHHHH
FGLSLGVDWVALSFVQRASDVIEARGIIGDRAGIMSKIEKPSALEHIEDIVRMSDAVMVA
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCEEEEE
RGDLGVEIPHEEVPGRQKELVRACRLAAKPVIVATQMLESMVNAPTPTRAEASDVATAIY
ECCCCCCCCHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHC
DGADAVMLSAESATGSYPVEAVTMMDRIISATERHKLYRSFISASALDPEQSPPHAVAAA
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHC
GAGLAETIGAKAIVGYTSSGTTVARIARQRPALPIVALTPNLAVARRASLMWGVHSVPSQ
CCCHHHHCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCC
DVTTYEEMVATARKALVDENFGGPGDLAVVVAGIPFAQSGTTNNLRVFSLGGSAR
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MHRNRRAKIVATVGPASSDPAVLKALYLAGVDTFRMNFSHGSRENHAAVHASIRALEIEM
CCCCCCEEEEEEECCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCHHEEEEEEEEEEEC
GRPIGILQDLQGPKIRVGTIKDGRITVQAGEKIRFVLHGADGDRDAIPLPHPEIFAAIAP
CCCCCHHHCCCCCEEEEEEECCCEEEEEECCEEEEEEECCCCCCCCCCCCCHHHHEEECC
RQDLLIDDGRVRVRVQGVGDDFIDAEVVIGGVISNRKGVNLPGTILDLSPLTAKDREDLE
CCCEEEECCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCEEECCCCCCCCCHHHH
FGLSLGVDWVALSFVQRASDVIEARGIIGDRAGIMSKIEKPSALEHIEDIVRMSDAVMVA
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCEEEEE
RGDLGVEIPHEEVPGRQKELVRACRLAAKPVIVATQMLESMVNAPTPTRAEASDVATAIY
ECCCCCCCCHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHC
DGADAVMLSAESATGSYPVEAVTMMDRIISATERHKLYRSFISASALDPEQSPPHAVAAA
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHC
GAGLAETIGAKAIVGYTSSGTTVARIARQRPALPIVALTPNLAVARRASLMWGVHSVPSQ
CCCHHHHCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCC
DVTTYEEMVATARKALVDENFGGPGDLAVVVAGIPFAQSGTTNNLRVFSLGGSAR
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592429 [H]