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The map label for this gene is ahpC [C]

Identifier: 158422974

GI number: 158422974

Start: 1520785

End: 1521357

Strand: Direct

Name: ahpC [C]

Synonym: AZC_1350

Alternate gene names: 158422974

Gene position: 1520785-1521357 (Clockwise)

Preceding gene: 158422973

Following gene: 158422975

Centisome position: 28.32

GC content: 64.92

Gene sequence:

>573_bases
ATGCGGGTGTCAATGCGCCGCCTCGACCGGAGCCGGAGCATTGTCGCGACAAGGAGCGGCACAATGACAGAGCAGTCCGT
CCCCCCAACCGGGGCCTTACCGGCTGGCGTGCAGGCGCCAGATTTCACCCTTTCCGCGACGCCGGACCAGACCTTGTCCC
TCTCCGAGATGAGGGGCCACCCGGTCATTCTCGCCTTCTATCCGGCGGACTGGAGCCCGGTCTGCGGCGATGAGATGAGC
CTGCTCAACGCGGTTCTGCCGGAGTTCCATCGTCTGGGCGCTCAACTCGTCGGCATTTCCGCGGATGGTGTCTGGTGCCA
TGCGGCCTTTGCGGCCGAACGCAAGCTGCATTTCCCGCTGCTGGCCGACTTCGAGCCGAAGGGCGAGGTCGCCCGACGCT
ATGGCGTGTATCGTGTACAGGACGGCGTTGCAGACCGCGCGCTGTTCGTGATCGATGCCGAGGGTGTCATCCGCTGGTCC
TACGTGTCGCCGCTCGGCATCAATCCTGGCGCGGACGGAATTCTCGAGGCGCTGGAGAAGCTGAGCGTTCGCACGGAAGG
AGCGGTGTCATGA

Upstream 100 bases:

>100_bases
CGCAGATCGAAAGCGGAGCGGATCTGCTTCGCCCGTCCAAACCTAGGTATGGCCGCGATACGCCAAGAGCCAATTCACCG
CCGCCGGCATCGCTTCGACA

Downstream 100 bases:

>100_bases
GCCGGCCCATCCCCTCGCTGGCGGCCGACGACCATATTCTCGGCACTCCCAGCTTCTCCGTCACGCTGGTCGAATATGGC
GATTACCAATGCCCCTATTG

Product: AhpC/TSA family protein

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MRVSMRRLDRSRSIVATRSGTMTEQSVPPTGALPAGVQAPDFTLSATPDQTLSLSEMRGHPVILAFYPADWSPVCGDEMS
LLNAVLPEFHRLGAQLVGISADGVWCHAAFAAERKLHFPLLADFEPKGEVARRYGVYRVQDGVADRALFVIDAEGVIRWS
YVSPLGINPGADGILEALEKLSVRTEGAVS

Sequences:

>Translated_190_residues
MRVSMRRLDRSRSIVATRSGTMTEQSVPPTGALPAGVQAPDFTLSATPDQTLSLSEMRGHPVILAFYPADWSPVCGDEMS
LLNAVLPEFHRLGAQLVGISADGVWCHAAFAAERKLHFPLLADFEPKGEVARRYGVYRVQDGVADRALFVIDAEGVIRWS
YVSPLGINPGADGILEALEKLSVRTEGAVS
>Mature_190_residues
MRVSMRRLDRSRSIVATRSGTMTEQSVPPTGALPAGVQAPDFTLSATPDQTLSLSEMRGHPVILAFYPADWSPVCGDEMS
LLNAVLPEFHRLGAQLVGISADGVWCHAAFAAERKLHFPLLADFEPKGEVARRYGVYRVQDGVADRALFVIDAEGVIRWS
YVSPLGINPGADGILEALEKLSVRTEGAVS

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=161, Percent_Identity=32.2981366459627, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI32455266, Length=161, Percent_Identity=32.2981366459627, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI32455264, Length=161, Percent_Identity=32.2981366459627, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI32189392, Length=167, Percent_Identity=32.3353293413174, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI32483377, Length=163, Percent_Identity=31.2883435582822, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI5802974, Length=168, Percent_Identity=31.547619047619, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786822, Length=132, Percent_Identity=28.030303030303, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554494, Length=186, Percent_Identity=29.5698924731183, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193204376, Length=165, Percent_Identity=29.6969696969697, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32565831, Length=165, Percent_Identity=29.6969696969697, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=152, Percent_Identity=33.5526315789474, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320661, Length=152, Percent_Identity=32.2368421052632, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357347, Length=158, Percent_Identity=36.7088607594937, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17738015, Length=172, Percent_Identity=29.0697674418605, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24656348, Length=162, Percent_Identity=31.4814814814815, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17864676, Length=162, Percent_Identity=31.4814814814815, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24581278, Length=172, Percent_Identity=27.906976744186, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17157991, Length=137, Percent_Identity=30.6569343065693, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24641739, Length=137, Percent_Identity=30.6569343065693, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20534; Mature: 20534

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVSMRRLDRSRSIVATRSGTMTEQSVPPTGALPAGVQAPDFTLSATPDQTLSLSEMRGH
CCCHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEHHHHCCC
PVILAFYPADWSPVCGDEMSLLNAVLPEFHRLGAQLVGISADGVWCHAAFAAERKLHFPL
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEHHHCCEECCCE
LADFEPKGEVARRYGVYRVQDGVADRALFVIDAEGVIRWSYVSPLGINPGADGILEALEK
EECCCCCHHHHHHCCCEEECCCCCCEEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHH
LSVRTEGAVS
HHCCCCCCCC
>Mature Secondary Structure
MRVSMRRLDRSRSIVATRSGTMTEQSVPPTGALPAGVQAPDFTLSATPDQTLSLSEMRGH
CCCHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEHHHHCCC
PVILAFYPADWSPVCGDEMSLLNAVLPEFHRLGAQLVGISADGVWCHAAFAAERKLHFPL
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEHHHCCEECCCE
LADFEPKGEVARRYGVYRVQDGVADRALFVIDAEGVIRWSYVSPLGINPGADGILEALEK
EECCCCCHHHHHHCCCEEECCCCCCEEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHH
LSVRTEGAVS
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]