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The map label for this gene is ilvA [H]

Identifier: 158422817

GI number: 158422817

Start: 1335006

End: 1336547

Strand: Direct

Name: ilvA [H]

Synonym: AZC_1193

Alternate gene names: 158422817

Gene position: 1335006-1336547 (Clockwise)

Preceding gene: 158422816

Following gene: 158422819

Centisome position: 24.86

GC content: 66.73

Gene sequence:

>1542_bases
GTGCAACGCAGTTCGGGCTCGACGTCAGTGGAAGATTACATCCGGAAGATTCTGGCCGCCCGCGTCTATGACGTCGCCAT
CGAAAGCCCGCTCGATCCCATGCGCCGCCTGTCCGGGCGGCTCGGCAGCCCGGTCTTCCTGAAGCGGGAAGATTTGCAGC
CGGTCTTCTCGTTCAAGCTGCGCGGTGCCTACAACAAGATGGTGGGGCTGGACGAGGAGGCGCGCGCCCATGGCGTCATC
TGCGCGTCCGCGGGCAATCACGCACAGGGCGTGGCGCTGGCGGCGAAGGCGCTCGGCGTCAAGGCGACCATCGTGATGCC
GCGCACGACGCCCGACATCAAGGTCCAGGCGGTCAACGCCAATGGCGGCGATGCCGTGCTTCATGGCGACACGTTCGACG
AGGCCTATGCCCACGCCAAGACGCTGGAGGCGCAGACCGGCGCCGTCTTCATCCATCCCTATGACGATCCGCAGGTGATC
GCGGGGCAGGGCACCATCGGCATGGAACTGATGCGCCAGCATCCCGATCCGCTGGAGGCCATCTTCGTCCAGATCGGCGG
CGGCGGCCTTGCGGCCGGTGTCGCGGCCTATGTGAAGTTCCTGCGGCCGGACGTGAAGGTCATCGGCGTCGAGCCGGAGG
ATGCCGCCAGCATGACGGCTGCACTCGCCGCGGACGAGCGGGTGAAGCTGAACCAGGTGGGCCTGTTTGCCGATGGCGTC
GCGGTGCGCCAGGCGGGCGAGGAGACCTTCCGGCTCTGCCGCCAGCTTCTCGACGGCATGATCACCGTCACAACCGACGA
AATCTGCGCCGCCATGAAGGACATCTTCGAGGACACGCGCGCCATTCCCGAGCCTTCCGGCGCCGTCAGCCTTGCGGGCC
TGAAGAAATATGTGGAGCAGCACGGCCCATCCCAGCGCGGCCTCATCGCCATCAACAGCGGCGCCAATCTCAATTTCGAC
CGCCTGCGCCACATCGCCGAGCGGGCGGAGCTGGGTGAGCGGCGCGAGGCGCTGTTCGCGGTGTCGATCCCGGAGAAGCC
GGGCAGCTACCGCCACTTCATCCGCGTGCTGGGCGCCCGCGCCATCACCGAGTTCAACTATCGCTACGCGCCGGCCGGCG
AGGCACAGATCTTCGTCGGCGTGCAGCTCACGGGCGGCGAGGCGGAGCGCAAGGCGGTGGCGGATCTGTTGCGCGCCGAG
GGCTATGGCGTCATCGACATGAGCGACAACGAAATGGCCAAGCTCCATGTGCGTTACATGGTGGGCGGCCGCACGCCGGA
CCTGCCGAACGAGATGGTCTACCGCTTCCAGTTTCCCGAGCGCCCCGGCGCCCTGCTGAAGTTCCTGGAGAGCATGGCCC
AGACCTGGAACATCACCATGTTCCATTACCGCAACCATGGCGCGGACTATGGCCGCGTGCTTGCGGGCATCGACGTGCCG
CCGCAGGAGCGGGCGGAGTTCGCCGAGCGGCTGACCGCCCTCGATTATCCCTGCTGGGACGAGACCGACAATCCCGCCTA
TCGCCTCTTCCTCGCCAACTGA

Upstream 100 bases:

>100_bases
AGGGGAGACATTGCTGTTCCGCTTGCCGAAAGCGGTGACGGGGCCGGCCGTTCTGCGCTATCAGCGCGCAGCAGCGGATG
GCGCAGGCCGTCCGCTGCCC

Downstream 100 bases:

>100_bases
GGCGAGGCAGAGCGCAGGTATCTGGCGGCATCAACCCAAAGAAAAACCCCGCCGGTGCGCCCGGCGGGGTTTTCTTGTTC
AGGCCGTCGCGGCGCGTGCA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MQRSSGSTSVEDYIRKILAARVYDVAIESPLDPMRRLSGRLGSPVFLKREDLQPVFSFKLRGAYNKMVGLDEEARAHGVI
CASAGNHAQGVALAAKALGVKATIVMPRTTPDIKVQAVNANGGDAVLHGDTFDEAYAHAKTLEAQTGAVFIHPYDDPQVI
AGQGTIGMELMRQHPDPLEAIFVQIGGGGLAAGVAAYVKFLRPDVKVIGVEPEDAASMTAALAADERVKLNQVGLFADGV
AVRQAGEETFRLCRQLLDGMITVTTDEICAAMKDIFEDTRAIPEPSGAVSLAGLKKYVEQHGPSQRGLIAINSGANLNFD
RLRHIAERAELGERREALFAVSIPEKPGSYRHFIRVLGARAITEFNYRYAPAGEAQIFVGVQLTGGEAERKAVADLLRAE
GYGVIDMSDNEMAKLHVRYMVGGRTPDLPNEMVYRFQFPERPGALLKFLESMAQTWNITMFHYRNHGADYGRVLAGIDVP
PQERAEFAERLTALDYPCWDETDNPAYRLFLAN

Sequences:

>Translated_513_residues
MQRSSGSTSVEDYIRKILAARVYDVAIESPLDPMRRLSGRLGSPVFLKREDLQPVFSFKLRGAYNKMVGLDEEARAHGVI
CASAGNHAQGVALAAKALGVKATIVMPRTTPDIKVQAVNANGGDAVLHGDTFDEAYAHAKTLEAQTGAVFIHPYDDPQVI
AGQGTIGMELMRQHPDPLEAIFVQIGGGGLAAGVAAYVKFLRPDVKVIGVEPEDAASMTAALAADERVKLNQVGLFADGV
AVRQAGEETFRLCRQLLDGMITVTTDEICAAMKDIFEDTRAIPEPSGAVSLAGLKKYVEQHGPSQRGLIAINSGANLNFD
RLRHIAERAELGERREALFAVSIPEKPGSYRHFIRVLGARAITEFNYRYAPAGEAQIFVGVQLTGGEAERKAVADLLRAE
GYGVIDMSDNEMAKLHVRYMVGGRTPDLPNEMVYRFQFPERPGALLKFLESMAQTWNITMFHYRNHGADYGRVLAGIDVP
PQERAEFAERLTALDYPCWDETDNPAYRLFLAN
>Mature_513_residues
MQRSSGSTSVEDYIRKILAARVYDVAIESPLDPMRRLSGRLGSPVFLKREDLQPVFSFKLRGAYNKMVGLDEEARAHGVI
CASAGNHAQGVALAAKALGVKATIVMPRTTPDIKVQAVNANGGDAVLHGDTFDEAYAHAKTLEAQTGAVFIHPYDDPQVI
AGQGTIGMELMRQHPDPLEAIFVQIGGGGLAAGVAAYVKFLRPDVKVIGVEPEDAASMTAALAADERVKLNQVGLFADGV
AVRQAGEETFRLCRQLLDGMITVTTDEICAAMKDIFEDTRAIPEPSGAVSLAGLKKYVEQHGPSQRGLIAINSGANLNFD
RLRHIAERAELGERREALFAVSIPEKPGSYRHFIRVLGARAITEFNYRYAPAGEAQIFVGVQLTGGEAERKAVADLLRAE
GYGVIDMSDNEMAKLHVRYMVGGRTPDLPNEMVYRFQFPERPGALLKFLESMAQTWNITMFHYRNHGADYGRVLAGIDVP
PQERAEFAERLTALDYPCWDETDNPAYRLFLAN

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=303, Percent_Identity=34.6534653465347, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI33469958, Length=318, Percent_Identity=30.188679245283, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI19923959, Length=318, Percent_Identity=28.3018867924528, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1790207, Length=511, Percent_Identity=56.5557729941292, Blast_Score=546, Evalue=1e-156,
Organism=Escherichia coli, GI1789505, Length=326, Percent_Identity=36.5030674846626, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71991565, Length=319, Percent_Identity=34.4827586206897, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17537387, Length=342, Percent_Identity=31.2865497076023, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17508781, Length=280, Percent_Identity=31.0714285714286, Blast_Score=127, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320930, Length=514, Percent_Identity=50.7782101167315, Blast_Score=494, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6322631, Length=301, Percent_Identity=36.2126245847176, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6319788, Length=244, Percent_Identity=25.4098360655738, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21355833, Length=327, Percent_Identity=32.7217125382263, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24645328, Length=254, Percent_Identity=30.7086614173228, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 56048; Mature: 56048

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRSSGSTSVEDYIRKILAARVYDVAIESPLDPMRRLSGRLGSPVFLKREDLQPVFSFKL
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCHHHHEEE
RGAYNKMVGLDEEARAHGVICASAGNHAQGVALAAKALGVKATIVMPRTTPDIKVQAVNA
CCCHHHHCCCCCHHHHCEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCEEEEEEEC
NGGDAVLHGDTFDEAYAHAKTLEAQTGAVFIHPYDDPQVIAGQGTIGMELMRQHPDPLEA
CCCCEEEECCCHHHHHHHHHHEECCCCEEEEEECCCCCEEECCCCHHHHHHHCCCCHHHE
IFVQIGGGGLAAGVAAYVKFLRPDVKVIGVEPEDAASMTAALAADERVKLNQVGLFADGV
EEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCEEEEECCEEECCH
AVRQAGEETFRLCRQLLDGMITVTTDEICAAMKDIFEDTRAIPEPSGAVSLAGLKKYVEQ
HHHHCCHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHH
HGPSQRGLIAINSGANLNFDRLRHIAERAELGERREALFAVSIPEKPGSYRHFIRVLGAR
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
AITEFNYRYAPAGEAQIFVGVQLTGGEAERKAVADLLRAEGYGVIDMSDNEMAKLHVRYM
HHHHCCCEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEE
VGGRTPDLPNEMVYRFQFPERPGALLKFLESMAQTWNITMFHYRNHGADYGRVLAGIDVP
ECCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCHHHEEECCCCC
PQERAEFAERLTALDYPCWDETDNPAYRLFLAN
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MQRSSGSTSVEDYIRKILAARVYDVAIESPLDPMRRLSGRLGSPVFLKREDLQPVFSFKL
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCHHHHEEE
RGAYNKMVGLDEEARAHGVICASAGNHAQGVALAAKALGVKATIVMPRTTPDIKVQAVNA
CCCHHHHCCCCCHHHHCEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCEEEEEEEC
NGGDAVLHGDTFDEAYAHAKTLEAQTGAVFIHPYDDPQVIAGQGTIGMELMRQHPDPLEA
CCCCEEEECCCHHHHHHHHHHEECCCCEEEEEECCCCCEEECCCCHHHHHHHCCCCHHHE
IFVQIGGGGLAAGVAAYVKFLRPDVKVIGVEPEDAASMTAALAADERVKLNQVGLFADGV
EEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCEEEEECCEEECCH
AVRQAGEETFRLCRQLLDGMITVTTDEICAAMKDIFEDTRAIPEPSGAVSLAGLKKYVEQ
HHHHCCHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHH
HGPSQRGLIAINSGANLNFDRLRHIAERAELGERREALFAVSIPEKPGSYRHFIRVLGAR
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
AITEFNYRYAPAGEAQIFVGVQLTGGEAERKAVADLLRAEGYGVIDMSDNEMAKLHVRYM
HHHHCCCEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEE
VGGRTPDLPNEMVYRFQFPERPGALLKFLESMAQTWNITMFHYRNHGADYGRVLAGIDVP
ECCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCHHHEEECCCCC
PQERAEFAERLTALDYPCWDETDNPAYRLFLAN
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA