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The map label for this gene is trpF

Identifier: 158422641

GI number: 158422641

Start: 1142316

End: 1143002

Strand: Direct

Name: trpF

Synonym: AZC_1017

Alternate gene names: 158422641

Gene position: 1142316-1143002 (Clockwise)

Preceding gene: 158422640

Following gene: 158422642

Centisome position: 21.27

GC content: 70.16

Gene sequence:

>687_bases
ATGGCCATCGAGGTGAAGATCTGCGGGCTCAGCACCGCCGAGACGCTGGAGGCCGCGCTTGCGGCCGGCGCCGACCTCGT
GGGTTTCGTCCACTTTCCGAAGAGCCCCCGCCACGTTCCGCTCGAAGCCGCGCCCGCCCTCTCGAGGGCGGTGGCCGGTC
GCGCGGCCAAGGTGCTGCTGCTGGTGGACCCGGACGATGCCACGCTGGCTGCGGCCGTGGCCGCCTTCCAGCCCGACATC
ATCCAGCTGCATGGCAAGGAGAGCCCCGAGCGCGTCGCCGCCATCCGCGCCCGCACGGGCCGGCCGGTGATGAAGGCGCT
GCCGGTCAGCGGACCCGCTGATCTTGCCGTCGTGCCCGCCTATGCAGCGGTGGCCGACCGTCTTCTCTTCGATGCCAAGC
CCGCTCCCGACGACACGCTGCCGGGCGGCAACGGGCGGGTGTTCGACTGGACCCTGCTCGCCGGCCTTGACCCTGGGCGC
CCGGTCATGCTTTCCGGTGGTCTGGATGCCGGCAATGTGTCGCAAGCCCTGTCCGTGGTCCGCCTCGATGGCGTGGACGT
ATCGTCAGGGGTTGAAACGGCCCCCGGCCTGAAATCGCCGGAAAAGATCCTGGCCTTCGTCCGTGCGGTGAAGGCTGCCG
AGGCGGCATCGCGGCCGTCGCGCCTGAAGAAAGTCGAAGCTCCGTGA

Upstream 100 bases:

>100_bases
GGGAGCTATCTTTGGCGCTTCCGCAAGGCGGGTCAGTTCACCCATATCCCGACCTGATGGGGCGCCGCGCGCGGCGCGGA
CCGGAAAGGCAGACGGGACG

Downstream 100 bases:

>100_bases
ACGCGCTCAATTCCTATCGCACCGGCCCCGACGAGAACGGCCATTTCGGCATCCATGGCGGACGTTTCGTCGCCGAGACC
CTGATGCCGAACATTCTCGA

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MAIEVKICGLSTAETLEAALAAGADLVGFVHFPKSPRHVPLEAAPALSRAVAGRAAKVLLLVDPDDATLAAAVAAFQPDI
IQLHGKESPERVAAIRARTGRPVMKALPVSGPADLAVVPAYAAVADRLLFDAKPAPDDTLPGGNGRVFDWTLLAGLDPGR
PVMLSGGLDAGNVSQALSVVRLDGVDVSSGVETAPGLKSPEKILAFVRAVKAAEAASRPSRLKKVEAP

Sequences:

>Translated_228_residues
MAIEVKICGLSTAETLEAALAAGADLVGFVHFPKSPRHVPLEAAPALSRAVAGRAAKVLLLVDPDDATLAAAVAAFQPDI
IQLHGKESPERVAAIRARTGRPVMKALPVSGPADLAVVPAYAAVADRLLFDAKPAPDDTLPGGNGRVFDWTLLAGLDPGR
PVMLSGGLDAGNVSQALSVVRLDGVDVSSGVETAPGLKSPEKILAFVRAVKAAEAASRPSRLKKVEAP
>Mature_227_residues
AIEVKICGLSTAETLEAALAAGADLVGFVHFPKSPRHVPLEAAPALSRAVAGRAAKVLLLVDPDDATLAAAVAAFQPDII
QLHGKESPERVAAIRARTGRPVMKALPVSGPADLAVVPAYAAVADRLLFDAKPAPDDTLPGGNGRVFDWTLLAGLDPGRP
VMLSGGLDAGNVSQALSVVRLDGVDVSSGVETAPGLKSPEKILAFVRAVKAAEAASRPSRLKKVEAP

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=211, Percent_Identity=30.3317535545024, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320210, Length=225, Percent_Identity=33.7777777777778, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_AZOC5 (A8HQ40)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001523933.1
- ProteinModelPortal:   A8HQ40
- SMR:   A8HQ40
- GeneID:   5691457
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_1017
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- ProtClustDB:   PRK01222
- BioCyc:   ACAU438753:AZC_1017-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 23350; Mature: 23219

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEVKICGLSTAETLEAALAAGADLVGFVHFPKSPRHVPLEAAPALSRAVAGRAAKVLL
CEEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEE
LVDPDDATLAAAVAAFQPDIIQLHGKESPERVAAIRARTGRPVMKALPVSGPADLAVVPA
EECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCHHHHCCCCCCCCEEEHHH
YAAVADRLLFDAKPAPDDTLPGGNGRVFDWTLLAGLDPGRPVMLSGGLDAGNVSQALSVV
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHH
RLDGVDVSSGVETAPGLKSPEKILAFVRAVKAAEAASRPSRLKKVEAP
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCC
>Mature Secondary Structure 
AIEVKICGLSTAETLEAALAAGADLVGFVHFPKSPRHVPLEAAPALSRAVAGRAAKVLL
EEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEE
LVDPDDATLAAAVAAFQPDIIQLHGKESPERVAAIRARTGRPVMKALPVSGPADLAVVPA
EECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCHHHHCCCCCCCCEEEHHH
YAAVADRLLFDAKPAPDDTLPGGNGRVFDWTLLAGLDPGRPVMLSGGLDAGNVSQALSVV
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHH
RLDGVDVSSGVETAPGLKSPEKILAFVRAVKAAEAASRPSRLKKVEAP
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA