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The map label for this gene is serA [H]

Identifier: 158422609

GI number: 158422609

Start: 1099670

End: 1101256

Strand: Direct

Name: serA [H]

Synonym: AZC_0985

Alternate gene names: 158422609

Gene position: 1099670-1101256 (Clockwise)

Preceding gene: 158422608

Following gene: 158422610

Centisome position: 20.48

GC content: 65.78

Gene sequence:

>1587_bases
ATGGCCCCTCGCGTTCTCATTTCCGACAAGCTGTCCGATGCCGCCGTTCAGATCTTCAAGGATCGCGGCGTGGAGGTGGA
TTTCCGCCCCGATCTCGGCAAGGACAAGGATAAGCTCGCCGAAGTCATTGGCGATTATGACGGCCTCGCCATCCGCTCGG
CGACCAAGGTCACGCCGAAGATCCTGGAGAAGGCCTCCCGCCTCAAGGTGATCGGCCGCGCCGGCATCGGCGTCGACAAT
GTGGACATTCCCGCCGCCACCGCCCGTGGCGTCATCGTGATGAACACGCCCTTCGGCAATTCCATCACCACCGCCGAGCA
CGCCATCGCCATGATGTTCGCGCTCGCCCGTCAGATCCCGCAGGCGGATGCGTCCACGCAGGCCGGCAAGTGGGAGAAGA
ACCGCTTCATGGGCGTGGAGCTCACGGCCAAGACGCTAGGCATCATCGGCTGCGGCAACATCGGCTCTATCGTCGCCGAG
CGCGGCATCGGGCTGAAGATGAAGGTCATCGCCTTCGATCCCTTCCTCTCGCCGGAGCGGGCTCTGGCGCTGGGCGTGGA
GAAGGTGGAACTGGACGAGCTGCTCGCCCGCGCCGACGTCATCACTTTGCACACGCCGCTCACCGAGAAGACGAAGAACG
TCCTCTCGGCCGAGAACATCGCGCGCGCCAAACCGGGCGTGCGCATCATCAATTGCGCGCGCGGCGGCCTCGTGGACGAG
GTGGCCCTGCGCGCCGCCCTCGACAGCGGCCATGTGGCGGGCGCGGCCTTCGATGTCTTCTCCGTGGAGCCGGCGGAGAC
CAATGTGCTGTTCGGCCATCCCAATGTGGTGTGCACGCCGCATCTCGGCGCCGCCACCACTGAGGCGCAGGAGAATGTGG
CCCTCCAGGTGGCTGAGCAGATGAGCGATTATCTGCTGGCGGGGGCCATCTCCAATGCGGTGAACTTCCCCTCCATCACG
GCGGAGGAGGCTCCCCGCCTCAAGCCCTTCATTGCGTTGGCGGAAAAGCTCGGCTCCTTCGCCGGGCAGCTCACCGACAC
GGACATCAAGACCGTGCGCATCACCTATGAGGGCGCCGTTGCGGAGCAGAAGGTGAAGGCGCTCACCAGCGCCGCCATCG
CCGGCCTGCTGCGCCCCGTGCTGGCGGATGTGAACGTGGTGTCCGCGCCCTCGGTCGCCAAGGAACGGGGCATCGTCATC
GAGGAGACCACCCGCGACGCGGTGGGCGACTATGACAGTCTCGTCACCTTGTCCGTGGTGGCGGATGATTTCGAGCGCCA
CGTGGCCGGCACGGTCTTCGCGGATGGCCAGCCGCGCATCGTGGACATCAAGGGCATCAAGGTGGATGCCGGCTTCGCGC
CCAACATGCTCTATGTCACCAATGAGGATAAGCCGGGCTTCATCGGCCGGTTCGCGAGCCTTCTGGGCGATGCGGGCGTG
AACATCGCCACCTTCGCGCTCGGCCGCGACCATCCCGGCGGAGACGCCATCGCCCTTGTGGAGGTAGATGGCCCCGTGCC
GGCGGACGTGCTCGGCAAAGTGAGCGCGCTGCCCCATGTCCGGCAGGTGAAACAGCTCCGCTTCTGA

Upstream 100 bases:

>100_bases
AGCCCTTTCGGCATCGGCCGGCCCAGACCTTCTGCCATAACGCCCCGCCGGCCGCTTTGAGCGCGGCGGGGCCGGTCCCC
CTTGCATCCGGAGCCGCATC

Downstream 100 bases:

>100_bases
AACCTCCCCGGCGCTTGGGGGTTGTCTCCGGGCGCCGGGCGGTAGCACCTTGCACCGCCTTTTCGGCGCCGACGCCTTAC
AACAAGCGTTGGCGCAACAT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MAPRVLISDKLSDAAVQIFKDRGVEVDFRPDLGKDKDKLAEVIGDYDGLAIRSATKVTPKILEKASRLKVIGRAGIGVDN
VDIPAATARGVIVMNTPFGNSITTAEHAIAMMFALARQIPQADASTQAGKWEKNRFMGVELTAKTLGIIGCGNIGSIVAE
RGIGLKMKVIAFDPFLSPERALALGVEKVELDELLARADVITLHTPLTEKTKNVLSAENIARAKPGVRIINCARGGLVDE
VALRAALDSGHVAGAAFDVFSVEPAETNVLFGHPNVVCTPHLGAATTEAQENVALQVAEQMSDYLLAGAISNAVNFPSIT
AEEAPRLKPFIALAEKLGSFAGQLTDTDIKTVRITYEGAVAEQKVKALTSAAIAGLLRPVLADVNVVSAPSVAKERGIVI
EETTRDAVGDYDSLVTLSVVADDFERHVAGTVFADGQPRIVDIKGIKVDAGFAPNMLYVTNEDKPGFIGRFASLLGDAGV
NIATFALGRDHPGGDAIALVEVDGPVPADVLGKVSALPHVRQVKQLRF

Sequences:

>Translated_528_residues
MAPRVLISDKLSDAAVQIFKDRGVEVDFRPDLGKDKDKLAEVIGDYDGLAIRSATKVTPKILEKASRLKVIGRAGIGVDN
VDIPAATARGVIVMNTPFGNSITTAEHAIAMMFALARQIPQADASTQAGKWEKNRFMGVELTAKTLGIIGCGNIGSIVAE
RGIGLKMKVIAFDPFLSPERALALGVEKVELDELLARADVITLHTPLTEKTKNVLSAENIARAKPGVRIINCARGGLVDE
VALRAALDSGHVAGAAFDVFSVEPAETNVLFGHPNVVCTPHLGAATTEAQENVALQVAEQMSDYLLAGAISNAVNFPSIT
AEEAPRLKPFIALAEKLGSFAGQLTDTDIKTVRITYEGAVAEQKVKALTSAAIAGLLRPVLADVNVVSAPSVAKERGIVI
EETTRDAVGDYDSLVTLSVVADDFERHVAGTVFADGQPRIVDIKGIKVDAGFAPNMLYVTNEDKPGFIGRFASLLGDAGV
NIATFALGRDHPGGDAIALVEVDGPVPADVLGKVSALPHVRQVKQLRF
>Mature_527_residues
APRVLISDKLSDAAVQIFKDRGVEVDFRPDLGKDKDKLAEVIGDYDGLAIRSATKVTPKILEKASRLKVIGRAGIGVDNV
DIPAATARGVIVMNTPFGNSITTAEHAIAMMFALARQIPQADASTQAGKWEKNRFMGVELTAKTLGIIGCGNIGSIVAER
GIGLKMKVIAFDPFLSPERALALGVEKVELDELLARADVITLHTPLTEKTKNVLSAENIARAKPGVRIINCARGGLVDEV
ALRAALDSGHVAGAAFDVFSVEPAETNVLFGHPNVVCTPHLGAATTEAQENVALQVAEQMSDYLLAGAISNAVNFPSITA
EEAPRLKPFIALAEKLGSFAGQLTDTDIKTVRITYEGAVAEQKVKALTSAAIAGLLRPVLADVNVVSAPSVAKERGIVIE
ETTRDAVGDYDSLVTLSVVADDFERHVAGTVFADGQPRIVDIKGIKVDAGFAPNMLYVTNEDKPGFIGRFASLLGDAGVN
IATFALGRDHPGGDAIALVEVDGPVPADVLGKVSALPHVRQVKQLRF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=539, Percent_Identity=38.404452690167, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI4557497, Length=299, Percent_Identity=31.7725752508361, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI61743967, Length=299, Percent_Identity=31.7725752508361, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI145580578, Length=273, Percent_Identity=34.0659340659341, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI4557499, Length=273, Percent_Identity=34.0659340659341, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI145580575, Length=273, Percent_Identity=34.0659340659341, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI6912396, Length=276, Percent_Identity=32.9710144927536, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1789279, Length=293, Percent_Identity=39.9317406143345, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI87082289, Length=320, Percent_Identity=30.625, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI1787645, Length=254, Percent_Identity=32.6771653543307, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788660, Length=267, Percent_Identity=30.7116104868914, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI87081824, Length=179, Percent_Identity=31.8435754189944, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=302, Percent_Identity=45.6953642384106, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI25147481, Length=259, Percent_Identity=32.046332046332, Blast_Score=143, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=330, Percent_Identity=36.3636363636364, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6320925, Length=329, Percent_Identity=35.8662613981763, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6324055, Length=272, Percent_Identity=29.0441176470588, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=268, Percent_Identity=26.4925373134328, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=114, Percent_Identity=36.8421052631579, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324980, Length=196, Percent_Identity=25.5102040816327, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=44.7019867549669, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24646446, Length=261, Percent_Identity=33.7164750957854, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24646448, Length=261, Percent_Identity=33.7164750957854, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24646452, Length=261, Percent_Identity=33.7164750957854, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24646450, Length=261, Percent_Identity=33.7164750957854, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI62472511, Length=277, Percent_Identity=32.4909747292419, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28574286, Length=242, Percent_Identity=29.7520661157025, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24585516, Length=304, Percent_Identity=26.6447368421053, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=30.9433962264151, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24585514, Length=267, Percent_Identity=26.9662921348315, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28574282, Length=267, Percent_Identity=26.9662921348315, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28574284, Length=267, Percent_Identity=26.9662921348315, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI45551003, Length=267, Percent_Identity=26.9662921348315, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45552429, Length=267, Percent_Identity=26.9662921348315, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 55711; Mature: 55579

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRVLISDKLSDAAVQIFKDRGVEVDFRPDLGKDKDKLAEVIGDYDGLAIRSATKVTPK
CCCCEEEECCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCCEEEECCCCCCHH
ILEKASRLKVIGRAGIGVDNVDIPAATARGVIVMNTPFGNSITTAEHAIAMMFALARQIP
HHHHHHHEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
QADASTQAGKWEKNRFMGVELTAKTLGIIGCGNIGSIVAERGIGLKMKVIAFDPFLSPER
CCCCCCCCCCCCCCCEEEEEEEHHEEEEEECCCHHHHHHHCCCCEEEEEEEECCCCCCCH
ALALGVEKVELDELLARADVITLHTPLTEKTKNVLSAENIARAKPGVRIINCARGGLVDE
HHHHCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHH
VALRAALDSGHVAGAAFDVFSVEPAETNVLFGHPNVVCTPHLGAATTEAQENVALQVAEQ
HHHHHHHCCCCCCEEEEEEEECCCCCCEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHH
MSDYLLAGAISNAVNFPSITAEEAPRLKPFIALAEKLGSFAGQLTDTDIKTVRITYEGAV
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCH
AEQKVKALTSAAIAGLLRPVLADVNVVSAPSVAKERGIVIEETTRDAVGDYDSLVTLSVV
HHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHCCEEEEECCCHHCCCCHHHEEEEHH
ADDFERHVAGTVFADGQPRIVDIKGIKVDAGFAPNMLYVTNEDKPGFIGRFASLLGDAGV
HHHHHHHHCEEEEECCCCEEEEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHCCCCC
NIATFALGRDHPGGDAIALVEVDGPVPADVLGKVSALPHVRQVKQLRF
CEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
APRVLISDKLSDAAVQIFKDRGVEVDFRPDLGKDKDKLAEVIGDYDGLAIRSATKVTPK
CCCEEEECCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCCEEEECCCCCCHH
ILEKASRLKVIGRAGIGVDNVDIPAATARGVIVMNTPFGNSITTAEHAIAMMFALARQIP
HHHHHHHEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
QADASTQAGKWEKNRFMGVELTAKTLGIIGCGNIGSIVAERGIGLKMKVIAFDPFLSPER
CCCCCCCCCCCCCCCEEEEEEEHHEEEEEECCCHHHHHHHCCCCEEEEEEEECCCCCCCH
ALALGVEKVELDELLARADVITLHTPLTEKTKNVLSAENIARAKPGVRIINCARGGLVDE
HHHHCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHH
VALRAALDSGHVAGAAFDVFSVEPAETNVLFGHPNVVCTPHLGAATTEAQENVALQVAEQ
HHHHHHHCCCCCCEEEEEEEECCCCCCEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHH
MSDYLLAGAISNAVNFPSITAEEAPRLKPFIALAEKLGSFAGQLTDTDIKTVRITYEGAV
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCH
AEQKVKALTSAAIAGLLRPVLADVNVVSAPSVAKERGIVIEETTRDAVGDYDSLVTLSVV
HHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHCCEEEEECCCHHCCCCHHHEEEEHH
ADDFERHVAGTVFADGQPRIVDIKGIKVDAGFAPNMLYVTNEDKPGFIGRFASLLGDAGV
HHHHHHHHCEEEEECCCCEEEEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHCCCCC
NIATFALGRDHPGGDAIALVEVDGPVPADVLGKVSALPHVRQVKQLRF
CEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]